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Showing 1-30 of 33 results for "671576" within Papers
J S Zhao et al.
Applied and environmental microbiology, 66(6), 2336-2342 (2000-06-01)
Biotransformation products of hydroxylaminobenzene and aminophenol produced by 3-nitrophenol-grown cells of Pseudomonas putida 2NP8, a strain grown on 2- and 3-nitrophenol, were characterized. Ammonia, 2-aminophenol, 4-aminophenol, 4-benzoquinone, N-acetyl-4-aminophenol, N-acetyl-2-aminophenol, 2-aminophenoxazine-3-one, 4-hydroquinone, and catechol were produced from hydroxylaminobenzene. Ammonia, N-acetyl-2-aminophenol, and
Copper-catalyzed amination of alkenes and ketones by phenylhydroxylamine.
Ho C-M and Lau T-C
New. J. Chem., 24(11), 859-863 (2000)
K R Maples et al.
Molecular pharmacology, 37(2), 311-318 (1990-02-01)
We have employed the ESR spin trapping technique in vivo to detect the formation of the 5,5-dimethyl-1-pyrroline-N-oxide (DMPO)/hemoglobin thiyl free radical adduct in the blood of rats following administration of either aniline, phenylhydroxylamine, nitrosobenzene, or nitrobenzene. This DMPO adduct was
Gilles Richner et al.
Physical chemistry chemical physics : PCCP, 13(27), 12463-12471 (2011-06-11)
The three-phase hydrogenation of nitrobenzene catalysed by nanosized gold over titania was investigated in a slurry. Simultaneous in situ ATR-FTIR monitoring of the liquid phase and at the solid/liquid catalyst interface identified the species adsorbed on the catalyst and those
T Nohmi et al.
Mutation research, 136(3), 159-168 (1984-06-01)
Phenylhydroxylamine (PHA) and its derivatives such as monomethyl (2-Me, 3-Me, 4-Me) and dimethyl (2,3-diMe, 2,4-diMe, 2,5-diMe, 2,6-diMe, 3,4-diMe, 3,5-diMe) were tested for their mutagenicity and for their inducing ability to inactivate transforming DNA. All these compounds except PHA and 3,5-diMePHA
Takuya Matsui et al.
Chemosphere, 252, 126530-126530 (2020-04-01)
Aromatic amines are a class of chemical carcinogens that are activated by cytochrome P450 enzymes to form arylhydroxylamines that are conjugated to form N-acetoxyarylamines or N-sulfonyloxyarylamines. These conjugates undergo N-O bond cleavage to become reactive nitrenium ions that may form
T P Bradshaw et al.
Free radical biology & medicine, 18(2), 279-285 (1995-02-01)
Previous studies have shown that incubation of rat red blood cells in vitro with phenylhydroxylamine (50-300 microM) induces rapid splenic sequestration of the red cells on reintroduction to isologous rats. EPR and the spin trapping agent, 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), were utilized
Au-catalyzed synthesis of 2-alkylindoles from N-arylhydroxylamines and terminal alkynes
Wang Y, et al.
Chemical Communications (Cambridge, England), 47(27), 7815-7817 (2011)
Y Endo et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 114(8), 565-576 (1994-08-01)
The acid-catalyzed reaction of N-acyl- and N-sulfonylhydroxylamines with benzene proceeded smoothly to give C-C products; 2- and 4-hydroxybiphenyls. The reaction and the thermolysis of N-aryloxypyridinium salts involve common intermediates. The results of product analysis, the orientation of the reaction, effects
Matthew R Arkebauer et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 22(8), 712-719 (2011-10-26)
Cigarette smoke and carbon monoxide (CO) released from tricarbonyldichlororuthenium (II) dimer (CORM-2) attenuate fibrinolysis. The purpose of the present study was to determine whether CO diminished fibrinolysis by enhancement of α₂-antiplasmin via a putative heme group. Plasma, isolated α₂-antiplasmin and
Christine S Olver et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 24(3), 273-278 (2012-12-12)
Carboxyheme and metheme states modulate hemostasis in humans and other species. Further, carbon monoxide and/or nitric oxide production increase in inflammatory disorders involving the gastrointestinal tract, with associated hypercoagulability or hypocoagulability. In particular, the horse suffers both thrombotic or coagulopathic
M F Khan et al.
Toxicological sciences : an official journal of the Society of Toxicology, 42(1), 64-71 (1998-05-30)
To elucidate the role of N-phenylhydroxylamine (PHA, N-hydroxylated metabolite of aniline) in the selective toxicity of aniline to the spleen, dose-dependent studies were conducted with PHA in rats. Male Sprague-Dawley rats were given four doses each (1 dose/day) of 0.025
An essential requirement for ferrous-haemoglobin in the hydrogen peroxide stimulated oxidation of red blood cell membrane lipids.
M R Clemens et al.
Biochemical pharmacology, 34(8), 1339-1341 (1985-04-15)
L Ciccoli et al.
Toxicology letters, 110(1-2), 57-66 (1999-12-11)
Incubation of rat erythrocytes with the hydroxylated metabolites of aniline and dapsone (4-4'-diaminodiphenylsulfone), phenylhydroxylamine and dapsone hydroxylamine, respectively, induced marked release of iron and methemoglobin formation. On the contrary, no release of iron nor methemoglobin formation was seen when the
Nilanjana Chowdhury et al.
Bioorganic & medicinal chemistry letters, 20(18), 5414-5417 (2010-08-21)
Photoinduced homolytic fission of nitrogen-oxygen bond in N,O-diacyl-4-benzoyl-N-phenylhydroxylamines using 310 nm UV light for 10 min produced acylaminyl and acyloxy radicals, which resulted in single strand cleavage of DNA at pH 7.0. Further the DNA cleaving ability of N,O-diacyl-4-benzoyl-N-phenylhydroxylamines found
A simple one-pot, three-component, catalytic, highly enantioselective isoxazolidine synthesis
Rios R, et al.
Tetrahedron Letters, 48(32), 5701-5705 (2007)
J H Harrison et al.
The Journal of pharmacology and experimental therapeutics, 238(3), 1045-1054 (1986-09-01)
Hemolytic anemia after aniline and aniline-related drugs such as dapsone and primaquine is thought to be mediated by active/reactive metabolite(s) formed during the hepatic clearance of the parent compounds. To determine whether any of the known metabolites of aniline contribute
Lloyd J Nadeau et al.
Applied and environmental microbiology, 69(5), 2786-2793 (2003-05-07)
Hydroxylamino aromatic compounds are converted to either the corresponding aminophenols or protocatechuate during the bacterial degradation of nitroaromatic compounds. The origin of the hydroxyl group of the products could be the substrate itself (intramolecular transfer mechanism) or the solvent water
J K Davis et al.
Applied and environmental microbiology, 66(7), 2965-2971 (2000-07-06)
Pseudomonas pseudoalcaligenes JS45 grows on nitrobenzene by a partially reductive pathway in which the intermediate hydroxylaminobenzene is enzymatically rearranged to 2-aminophenol by hydroxylaminobenzene mutase (HAB mutase). The properties of the enzyme, the reaction mechanism, and the evolutionary origin of the
Vance G Nielsen et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 22(8), 657-661 (2011-08-09)
Cigarette smoking is associated with plasmatic hypercoagulability, and carbon monoxide has been demonstrated to enhance coagulation by binding to a fibrinogen-bound heme. Our objective was to design and test a redox-based method to detect carboxyhemefibrinogen. Normal, pooled, citrated plasma was
Ernst M Bomhard et al.
Critical reviews in toxicology, 35(10), 783-835 (2006-02-14)
Aniline (in the form of its hydrochloride) has been shown to induce a rather rare spectrum of tumors in the spleen of Fischer 344 rats. The dose levels necessary for this carcinogenic activity were in a range where also massive
Diastereoselective synthesis of pyrrolidines using a nitrone/cyclopropane cycloaddition: synthesis of the tetracyclic core of nakadomarin A.
Young L S, et al.
Organic Letters, 7(5), 953-955 (2005)
C C Somerville et al.
Journal of bacteriology, 177(13), 3837-3842 (1995-07-01)
Pseudomonas pseudoalcaligenes JS45 grows on nitrobenzene as a sole source of carbon, nitrogen, and energy. The catabolic pathway involves reduction to hydroxylaminobenzene followed by rearrangement to o-amino-phenol and ring fission (S. F. Nishino and J. C. Spain, Appl. Environ. Microbiol.
K Hiramoto et al.
Carcinogenesis, 9(11), 2003-2008 (1988-11-01)
Aerobic oxidation of 3-hydroxyamino-1-methyl-5H-pyrido-[4,3-b]indole [Trp-P-2(NHOH)] in neutral aqueous solution was greatly accelerated by copper-zinc superoxide dismutase (SOD). The major product in this SOD-mediated reaction was identified as 3-nitroso-1-methyl-5H-pyrido[4,3-b]indole [Trp-P-2(NO)]. This conversion was accompanied by a decrease of the mutagenicity of
Three-component homo 3+ 2 dipolar cycloaddition. A diversity-oriented synthesis of tetrahydro-1, 2-oxazines and FR900482 skeletal congeners
Young IS and Kerr MA
Organic Letters, 6(1), 139-141 (2004)
Lorena Betancor et al.
Chemical communications (Cambridge, England), (34)(34), 3640-3642 (2006-10-19)
The coimmobilization of nitrobenzene nitroreductase and glucose-6-phosphate dehydrogenase in silica particles enables the continuous conversion of nitrobenzene to hydroxylaminobenzene with NADPH recycling.
Arylamine-induced hemolytic anemia: electron spin resonance spectrometry studies.
T P Bradshaw et al.
Advances in experimental medicine and biology, 283, 253-255 (1991-01-01)
J H Harrison et al.
Molecular pharmacology, 32(3), 423-431 (1987-09-01)
Methemoglobinemia after aniline and certain aniline derivatives is thought to be mediated by toxic metabolites formed during the hepatic clearance of the parent compounds. However, three aniline metabolites--phenylhydroxylamine, 2-aminophenol, and 4-aminophenol--catalyze methemoglobin formation in erythrocyte suspensions and, hence, could contribute
Harpal Singh et al.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 24(1), 57-65 (2005-02-18)
Methemoglobinemia and hemolysis are the most prominent side-effects of exposure to a wide variety of arylamine drugs, including agricultural and industrial chemicals. Recent studies with aniline and dapsone have identified N-hydroxyl metabolites as the red blood cell (RBC) mediators. This
M M Shah et al.
Biochemical and biophysical research communications, 241(3), 794-796 (1998-01-22)
Nitrobenzene was reduced in a solution containing ferredoxin NADP oxidoreductase (FNR) from spinach leaves and NADPH generating system. The product of nitrobenzene was identified as phenylhydroxylamine (PHA) on 1:1 basis.
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