70050

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Showing 1-30 of 141 results for "70050" within Papers

Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase.

Shingo Arioka et al.

Bioorganic & medicinal chemistry, 18(4), 1633-1640 (2010-01-26)

The protozoan Trypanosoma cruzi, the causative agent of Chagas' disease, can infect the heart, causing cardiac arrest frequently followed by death. To treat this disease, a potential molecular drug target is T. cruzi trans-sialidase (TcTS). However, inhibitors found to date

Myricetin: A review of the most recent research.

Xiaominting Song et al.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 134, 111017-111017 (2020-12-19)

Myricetin(MYR) is a flavonoid compound widely found in many natural plants including bayberry. So far, MYR has been proven to have multiple biological functions and it is a natural compound with promising research and development prospects. This review comprehensively retrieved

Ocular inflammation and endoplasmic reticulum stress are attenuated by supplementation with grape polyphenols in human retinal pigmented epithelium cells and in C57BL/6 mice.

Jung-Heun Ha et al.

The Journal of nutrition, 144(6), 799-806 (2014-04-05)

Inflammation and endoplasmic reticulum (ER) stress are common denominators for vision-threatening diseases such as diabetic retinopathy and age-related macular degeneration. Based on our previous study, supplementation with muscadine grape polyphenols (MGPs) alleviated systemic insulin resistance and proinflammatory responses. In this

Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives.

Iris L K Wong et al.

Journal of medicinal chemistry, 52(17), 5311-5322 (2009-09-04)

Here we showed that bivalency approach is effective in modulating multidrug resistance protein 1 (MRP1/ABCC1)-mediated doxorubicin (DOX) and etoposide (VP16) resistance in human 2008/MRP1 ovarian carcinoma cells. Flavonoid dimers bearing five or six ethylene glycol (EG) units with 6-methyl (4e

Protective effect of bioflavonoid myricetin enhances carbohydrate metabolic enzymes and insulin signaling molecules in streptozotocin-cadmium induced diabetic nephrotoxic rats.

Neelamegam Kandasamy et al.

Toxicology and applied pharmacology, 279(2), 173-185 (2014-06-14)

Diabetic nephropathy is the kidney disease that occurs as a result of diabetes. The present study was aimed to evaluate the therapeutic potential of myricetin by assaying the activities of key enzymes of carbohydrate metabolism, insulin signaling molecules and renal

Improved quantitative structure-activity relationship models to predict antioxidant activity of flavonoids in chemical, enzymatic, and cellular systems.

Andrei I Khlebnikov et al.

Bioorganic & medicinal chemistry, 15(4), 1749-1770 (2006-12-15)

Quantitative structure-activity relationship (QSAR) models are useful in understanding how chemical structure relates to the biological activity of natural and synthetic chemicals and for design of newer and better therapeutics. In the present study, 46 flavonoids and related polyphenols were

Simultaneous extraction of flavonoids from Chamaecyparis obtusa using deep eutectic solvents as additives of conventional extractions solvents.

Baokun Tang et al.

Journal of chromatographic science, 53(5), 836-840 (2014-09-18)

Three flavones (quercetin, myricetin and amentoflavone) were extracted from Chamaecyparis obtusa leaves using deep eutectic solvents (DESs) as additives to conventional extractions solvents. Sixteen DESs were synthesized from different salts and hydrogen bond donors. In addition, C. obtusa was extracted

Ultra high performance liquid chromatography with mass spectrometry method for the simultaneous determination of phenolic constituents in honey from various floral sources using multiwalled carbon nanotubes as extraction sorbents.

Saikh Mohammad Wabaidur et al.

Journal of separation science, 38(15), 2597-2606 (2015-05-20)

An ultra high performance liquid chromatography with mass spectrometry method has been developed for the simultaneous separation, identification and determination of 22 phenolic constituents in honey from various floral sources from Yemen. Solid-phase extraction was used for extraction of the

Influence of dietary flavonoids on the glycation of plasma proteins.

Liheng Liu et al.

Molecular bioSystems, 8(8), 2183-2187 (2012-06-20)

It has been suggested that the increasing glycation in diabetes can influence the ability of plasma proteins to bind to small molecules. Herein, the influence of flavonoids on the glycation of plasma proteins was investigated. After being incubated with glucose

Dual Action of Myricetin on Porphyromonas gingivalis and the Inflammatory Response of Host Cells: A Promising Therapeutic Molecule for Periodontal Diseases.

Daniel Grenier et al.

PloS one, 10(6), e0131758-e0131758 (2015-06-30)

Periodontitis that affects the underlying structures of the periodontium, including the alveolar bone, is a multifactorial disease, whose etiology involves interactions between specific bacterial species of the subgingival biofilm and the host immune components. In the present study, we investigated

Fabrication of an electrochemical sensor based on gold nanoparticles/carbon nanotubes as nanocomposite materials: determination of myricetin in some drinks.

Reza Hajian et al.

PloS one, 9(5), e96686-e96686 (2014-05-09)

In this paper, the electrochemical behavior of myricetin on a gold nanoparticle/ethylenediamine/multi-walled carbon-nanotube modified glassy carbon electrode (AuNPs/en/MWCNTs/GCE) has been investigated. Myricetin effectively accumulated on the AuNPs/en/MWCNTs/GCE and caused a pair of irreversible redox peaks at around 0.408 V and

Investigating the potential of under-utilised plants from the Asteraceae family as a source of natural antimicrobial and antioxidant extracts.

O Kenny et al.

Food chemistry, 161, 79-86 (2014-05-20)

Antimicrobial properties of ethanol and water extracts from eight Asteraceae species were investigated against three Gram positive (Staphylococcus aureus, MRSA and Bacillus cereus) and two Gram negative (Escherichia coli and Salmonella typhimurium) bacterial strains. Ethanol extracts from Centaurea scabiosa, Arctium

Wild Blueberry (Vaccinium angustifolium Ait.) Polyphenols Target Fusobacterium nucleatum and the Host Inflammatory Response: Potential Innovative Molecules for Treating Periodontal Diseases.

Amel Ben Lagha et al.

Journal of agricultural and food chemistry, 63(31), 6999-7008 (2015-07-25)

Blueberries contain significant amounts of flavonoids to which a number of beneficial health effects in humans have been associated. The present study investigated the effect of a polyphenol-rich lowbush blueberry (Vaccinium angustifolium Ait.) extract on the two main etiologic components

Flavonoids are inhibitors of human organic anion transporter 1 (OAT1)-mediated transport.

Guohua An et al.

Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1357-1366 (2014-07-09)

Organic anion transporter 1 (OAT1) has been reported to be involved in the nephrotoxicity of many anionic xenobiotics. As current clinically used OAT1 inhibitors are often associated with safety issues, identifying potent OAT1 inhibitors with little toxicity is of great

Effects of UV-B radiation on anatomical characteristics, phenolic compounds and gene expression of the phenylpropanoid pathway in highbush blueberry leaves.

Claudio Inostroza-Blancheteau et al.

Plant physiology and biochemistry : PPB, 85, 85-95 (2014-11-15)

The effects of increased doses of UV-B radiation on anatomical, biochemical and molecular features of leaves of two highbush blueberry (Vaccinium corymbosum L. cv. Brigitta and Bluegold) genotypes were investigated. Plants were grown in a solid substrate and exposed to

Induction of hepatic apolipoprotein A-I gene expression by the isoflavones quercetin and isoquercetrin.

Michael J Haas et al.

Life sciences, 110(1), 8-14 (2014-06-26)

Phytochemicals such as flavonoids, vitamins, and polyphenols have been shown to have beneficial effects in metabolic disease. To determine if select flavonoids regulate hepatic apolipoprotein A-I (apo A-I) and high-density lipoprotein (HDL) synthesis, we examined the effects of quercetin, isoquercetin

Inhibitors of histone demethylases.

Brian Lohse et al.

Bioorganic & medicinal chemistry, 19(12), 3625-3636 (2011-05-21)

Methylated lysines are important epigenetic marks. The enzymes involved in demethylation have recently been discovered and found to be involved in cancer development and progression. Despite the relative recent discovery of these enzymes a number of inhibitors have already appeared.

Sulfonamide chalcone as a new class of alpha-glucosidase inhibitors.

Woo Duck Seo et al.

Bioorganic & medicinal chemistry letters, 15(24), 5514-5516 (2005-10-06)

Chalcones 1-20, a new class of glycosidase inhibitors, were synthesized, and their glycosidase inhibitory activities were investigated. Non-aminochalcones 1-12 had no inhibitory activity, however, aminochalcones 13-20 had strong glycosidase (alpha-glucosidase, alpha-amylase, and beta-amylase) inhibitory activities. In particular, sulfonamide chalcones 17-20

Myricetin inhibits Escherichia coli DnaB helicase but not primase.

Mark A Griep et al.

Bioorganic & medicinal chemistry, 15(22), 7203-7208 (2007-09-14)

Primase and DnaB helicase play central roles during DNA replication initiation and elongation. Both enzymes are drug targets because they are essential, persistent among bacterial genomes, and have different sequences than their eukaryotic equivalents. Myricetin is a ubiquitous natural product

Novel antibiofilm chemotherapy targets exopolysaccharide synthesis and stress tolerance in Streptococcus mutans to modulate virulence expression in vivo.

Megan L Falsetta et al.

Antimicrobial agents and chemotherapy, 56(12), 6201-6211 (2012-09-19)

Fluoride is the mainstay of dental caries prevention, and yet current applications offer incomplete protection and may not effectively address the infectious character of the disease. Therefore, we evaluated the effectiveness of a novel combination therapy (CT; 2 mM myricetin

Simultaneous extraction, optimization, and analysis of flavonoids and polyphenols from peach and pumpkin extracts using a TLC-densitometric method.

Ammar Altemimi et al.

Chemistry Central journal, 9, 39-39 (2015-06-25)

The use of medicinal plants has been reported throughout human history. In the fight against illnesses, medicinal plants represent the primary health care system for 60 % of the world's population. Flavonoids are polyphenolic compounds with active anti-microbial properties; they are

Mobilization of Copper ions by Flavonoids in Human Peripheral Lymphocytes Leads to Oxidative DNA Breakage: A Structure Activity Study.

Hussain Arif et al.

International journal of molecular sciences, 16(11), 26754-26769 (2015-11-17)

Epidemiological studies have linked dietary consumption of plant polyphenols with lower incidence of various cancers. In particular, flavonoids (present in onion, tomato and other plant sources) induce apoptosis and cytotoxicity in cancer cells. These can therefore be used as lead

Novel strategy for biofilm inhibition by using small molecules targeting molecular chaperone DnaK.

Ken-ichi Arita-Morioka et al.

Antimicrobial agents and chemotherapy, 59(1), 633-641 (2014-11-19)

Biofilms are complex communities of microorganisms that attach to surfaces and are embedded in a self-produced extracellular matrix. Since these cells acquire increased tolerance against antimicrobial agents and host immune systems, biofilm-associated infectious diseases tend to become chronic. We show

UHPLC-PDA-ESI-TOF/MS metabolic profiling of Arctostaphylos pungens and Arctostaphylos uva-ursi. A comparative study of phenolic compounds from leaf methanolic extracts.

Alessia Panusa et al.

Phytochemistry, 115, 79-88 (2015-02-24)

The aim of this study was to get a rapid metabolic fingerprinting and to gain insight into the metabolic profiling of Arctostaphylos pungens H. B. K., a plant morphologically similar to Arctostaphylos uva-ursi (L.) Spreng. (bearberry) but with a lower

Disclosure of a fundamental clue for the elucidation of the myricetin mechanism of action as amyloid aggregation inhibitor by mass spectrometry.

Jessica Fiori et al.

Electrophoresis, 33(22), 3380-3386 (2012-09-11)

Progression of Alzheimer's disease involves aggregation of amyloid-beta (Aβ) peptides, a complex process that involves the formation of several soluble intermediates and ends up with the deposition of ordered fibrillar architectures. The determination of the Aβ42 self-assembly species targeted by

Gas-phase dissociative electron attachment to flavonoids and possible similarities to their metabolic pathways.

Alberto Modelli et al.

Physical chemistry chemical physics : PCCP, 15(5), 1588-1600 (2012-12-18)

The gas-phase empty-level structures and formation of anion states via resonance attachment of low-energy electrons to the flavonoids naringenin (III), quercetin (IV) and myricetin (V) and the smaller reference molecules chromone (I) and flavone (II) are investigated experimentally for the

Myricetin: A Dietary Molecule with Diverse Biological Activities.

Deepak Kumar Semwal et al.

Nutrients, 8(2), 90-90 (2016-02-20)

Myricetin is a common plant-derived flavonoid and is well recognised for its nutraceuticals value. It is one of the key ingredients of various foods and beverages. The compound exhibits a wide range of activities that include strong anti-oxidant, anticancer, antidiabetic

Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities.

Ai-Lin Liu et al.

Bioorganic & medicinal chemistry, 16(15), 7141-7147 (2008-07-22)

Flavonoids are polyphenolic compounds that widely exist in plant kingdom, and the structure-activity relationship (SAR) of 25 flavonoids was studied on neuraminidase (NA) activity of influenza virus. Three typical influenza virus strains A/PR/8/34 (H1N1), A/Jinan/15/90 (H3N2), and B/Jiangshu/10/2003 were used

In vitro effects of myricetin, morin, apigenin, (+)-taxifolin, (+)-catechin, (-)-epicatechin, naringenin and naringin on cytochrome b5 reduction by purified NADH-cytochrome b5 reductase.

Haydar Çelik et al.

Toxicology, 308, 34-40 (2013-04-10)

The microsomal NADH-dependent electron transport system consisting of cytochrome b5 reductase and cytochrome b5 participates in a number of physiologically important processes including lipid metabolism as well as is involved in the metabolism of various drug and xenobiotics. In the

M. Iio, et al.

Agricultural and Biological Chemistry, 48, 1559-1559 (1984)

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