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Showing 1-24 of 24 results for "71505" within Papers
Jan Kendall De Kruif et al.
Journal of pharmaceutical sciences, 104(10), 3351-3365 (2015-06-26)
The development of novel systems with oral protein delivery as ultimate goal represents an important field of pharmaceutics. Prilling of protein-loaded polymeric solutions into lipid-based hardening baths could provide here an attractive formulating technology. As the obtained microgel dispersion can
M K Quinn et al.
Physical chemistry chemical physics : PCCP, 17(46), 31177-31187 (2015-11-07)
A complete understanding of the role of molecular anisotropy in directing the self assembly of colloids and proteins remains a challenge for soft matter science and biophysics. For proteins in particular, the complexity of the surface at a molecular level
In vitro assay to determine SUMOylation sites on protein substrates
McManus F P, et al.
Nature Protocols, 11(2), 387-387 (2016)
Gold nanoparticle/nickel oxide/poly (pyrrole-N-propionic acid) hybrid multilayer film: Electrochemical study and its application in biosensing
Karazehir T, et al.
Express Polymer Letters, 11(6), 449-449 (2017)
Ceren Erdem et al.
Artificial cells, nanomedicine, and biotechnology, 42(4), 237-244 (2013-06-26)
In the present work, we designed an amperometric glucose biosensor based on nickel oxide nanoparticles (NiONPs)-modified carbon paste electrode. The biosensor was prepared by incorporation of glucose oxidase and NiONPs into a carbon paste matrix. It showed good analytical performances
L Escuder-Gilabert et al.
Journal of chromatography. A, 1363, 331-337 (2014-07-22)
The design of experiments (DOE) is a good option for rationally limiting the number of experiments required to achieve the enantioresolution (Rs) of a chiral compound in capillary electrophoresis. In some cases, the modeled Rs after DOE analysis can be
Soon Sik Kwon et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 92, 146-154 (2015-03-11)
We investigated the physicochemical properties of pH-sensitive hydroxyethyl cellulose (HEC)/hyaluronic acid (HA) complex hydrogels containing isoliquiritigenin (ILTG), and discussed potential applications as transdermal delivery systems for the treatment of skin lesions caused by pH imbalance. HA has skin compatibility and
Gregory J Baker et al.
Cell systems, 11(3), 272-285 (2020-09-09)
Accurately profiling systemic immune responses to cancer initiation and progression is necessary for understanding tumor surveillance and, ultimately, improving therapy. Here, we describe the SYLARAS software tool (systemic lymphoid architecture response assessment) and a dataset collected with SYLARAS that describes
Bruno Pinto et al.
Neuron, 108(5), 887-904 (2020-10-08)
Microglia are brain-resident immune cells and regulate mechanisms essential for cognitive functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is caused by a supernumerary chromosome 21, containing also genes related to the immune system. In the
Stefanos Stagkourakis et al.
Cell, 182(4), 960-975 (2020-08-09)
Parental behavior is pervasive throughout the animal kingdom and essential for species survival. However, the relative contribution of the father to offspring care differs markedly across animals, even between related species. The mechanisms that organize and control paternal behavior remain
Haider A J Al Lawati et al.
Luminescence : the journal of biological and chemical luminescence, 29(8), 1148-1153 (2014-05-02)
A highly sensitive, rapid and economical method for the determination of amlodipine (AM) in biological fluids was developed using a peroxyoxalate chemiluminescence (CL) system in a lab-on-a-chip device. Peroxyoxalate-CL is an indirect type of CL that allows the detection of
Yoshiki Seto et al.
The Journal of pharmacology and experimental therapeutics, 354(2), 195-202 (2015-05-29)
This study aimed to qualify photosafety screening on the basis of photochemical and pharmacokinetic (PK) data on dermally applied chemicals. Six benzophenone derivatives (BZPs) were selected as model compounds, and in vitro photochemical/phototoxic characterization and dermal cassette-dosing PK study were
Ziyi Yin et al.
Autophagy, 16(5), 900-916 (2019-07-18)
Cells are faced with various stresses during their growth and development, and autophagy is a degradative process in which cells can break down their own components to recycle macromolecules and provide energy under these stresses. For pathogenic fungi that utilize
Ana Serralheiro et al.
International journal of pharmaceutics, 490(1-2), 39-46 (2015-05-17)
Pharmacoresistance is considered one of the major causes underlying the failure of the anticonvulsant therapy, demanding the development of alternative and more effective therapeutic approaches. Due to the particular anatomical features of the nasal cavity, intranasal administration has been explored
Jan Muendges et al.
Biotechnology progress, 31(4), 925-936 (2015-04-11)
This article presents results of continuous multistage aqueous two-phase extraction of an immunoglobulin G1 from cell supernatant in a mixer-settler unit. An aqueous two-phase system consisting of polyethylene glycol 2000, phosphate salt, and water was applied without and with sodium
Mahmoud H El-Maghrabey et al.
Analytica chimica acta, 881, 139-147 (2015-06-05)
A fast, simple, and sensitive flow injection analysis method was developed for the measurement of semicarbazide-sensitive amine oxidase (SSAO) activity in human serum. Benzaldehyde, generated by the action of SSAO after incubation of serum with benzylamine, was derivatized with a
Jan Kendall De Kruif et al.
Journal of pharmaceutical sciences, 103(11), 3675-3687 (2014-09-23)
Oral delivery of biologicals is a thriving field in pharmaceutics and the first challenge is to achieve a stable drug product. Interesting is prilling of a drug-containing polymeric solution as microgel into an aqueous hardening bath where crosslinking occurs. However
Tobias Guckeisen et al.
Journal of colloid and interface science, 590, 38-49 (2021-02-02)
The secondary structure of proteins affects their functionality and performance in physiological environments or industrial applications. Change of the solution pH or the presence of protein denaturants are the main chemical means that can alter the secondary structure of proteins
Wenhu Zhou et al.
Analytical chemistry, 87(7), 4001-4007 (2015-03-11)
RNA-cleaving DNAzymes provide a unique platform for developing biosensors. However, a majority of the work has been performed in clean buffer solutions, while the activity of some important DNAzymes in biological sample matrices is still under debate. Two RNA-cleaving DNAzymes
E L Menzies et al.
Drug testing and analysis, 6(6), 506-515 (2014-02-28)
The classic approach of controlled volunteer studies to study drug metabolism is difficult or impossible to undertake for novel psychoactive substances (NPS), as there is generally very limited information available to allow appropriate dose finding and safety. A viable and
R.C. Ogden et al.
Methods in Enzymology, 152, 66-66 (1987)
Yan Shan Ang et al.
Nucleic acids research, 42(14), 9523-9530 (2014-07-25)
Biomolecular interactions have important cellular implications, however, a simple method for the sensing of such proximal events is lacking in the current molecular toolbox. We designed a dynamic DNA circuit capable of recognizing targets in close proximity to initiate a
Yi Deng et al.
Analytica chimica acta, 868, 45-52 (2015-03-31)
Rapid and ultrasensitive detection of trace heavy metal mercury(II) ions (Hg(2+)) are of significant importance due to the induced serious risks for environment and human health. This presented article reports the gold nanoparticle-based dual labeling colorimetric method (Dual-COLO) for ultrasensitive
3D FISH to analyse gene domain-specific chromatin re-modeling in human cancer cell lines
Kocanova S, et al.
Methods (2018)
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