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Showing 1-30 of 55 results for "730114" within Papers
N Nakabayashi et al.
Bio-medical materials and engineering, 14(4), 345-354 (2004-10-09)
Copolymers of 2-methacryloyloxyethyl phosphorylcholine (MPC) showed good hemocompatibility as hypothesized. The hypothesis was surfaces having phosphorylcholine groups by polymerization of MPC could accumulate phospholipids from blood stream and show good blood compatibility. We designed and prepared a methacylate having a
Lizhen Qiao et al.
Journal of separation science, 43(6), 1071-1079 (2019-12-29)
Surface-bonded zwitterionic stationary phases have shown highlighted performances in separation of polar and hydrophilic compounds under hydrophilic interaction chromatography mode. So, it would be helpful to evaluate the characteristics of zwitterionic stationary phases with different arranged charged groups. The present
Jeffrey M Ting et al.
Molecules (Basel, Switzerland), 25(11) (2020-06-04)
A series of model polyelectrolyte complex micelles (PCMs) was prepared to investigate the consequences of neutral and zwitterionic chemistries and distinct charged cores on the size and stability of nanocarriers. Using aqueous reversible addition-fragmentation chain transfer (RAFT) polymerization, we synthesized
Weiwei Zhao et al.
ACS applied materials & interfaces, 12(46), 51236-51248 (2020-11-10)
Osteoarthritis (OA) is a chronic joint disease and its progression and pathogenesis are highly associated with the significant increase of joint friction and overproduction of reactive oxygen species (ROS) in inflammation. Combination of ROS elimination and lubrication enhancement may provide
Weifeng Lin et al.
Langmuir : the ACS journal of surfaces and colloids, 35(18), 6048-6054 (2019-04-18)
We have prepared phosphatidylcholine (PC) vesicles (liposomes) incorporating a novel lipid/poly-phosphocholine conjugate. This both stabilizes the liposomes against aggregation (for example, during storage or when being delivered) and allows them to act as very efficient lubricating elements readily attaining superlubric
Carla Vilela et al.
Materials (Basel, Switzerland), 12(9) (2019-05-06)
The development of efficient and environmentally-friendly nanomaterials to remove contaminants and pollutants (including harmful organic dyes) ravaging water sources is of major importance. Herein, zwitterionic nanocomposite membranes consisting of cross-linked poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) and bacterial nanocellulose (BNC) were prepared and
Yumi Imoto et al.
European journal of clinical pharmacology, 77(3), 369-379 (2020-10-10)
Serum markers of renal function have not been characterized in patients treated with itraconazole (ITZ). This study aimed to evaluate the associations between plasma ITZ and its hydroxylated metabolite (OH-ITZ) concentrations and serum markers of renal function in patients with
Caifeng Xiong et al.
Journal of chromatography. A, 1546, 56-65 (2018-03-11)
In this work, 2-methacryloyloxyethyl phosphorylcholine (MPC) was used as a ligand to prepare a novel mixed-mode chromatography (MMC) stationary phase by the thiol-ene click reaction onto silica (MPC-silica). It was found that this MPC-silica showed the retention characteristics of hydrophilic
A D Schwartz et al.
Biomaterials, 178, 73-82 (2018-06-18)
Cells sense and respond to mechanical cues from the extracellular matrix (ECM) via integrins. ECM stiffness is known to enhance integrin clustering and response to epidermal growth factor (EGF), but we lack information on when or if these mechanosensitive growth
Lu Gong et al.
Langmuir : the ACS journal of surfaces and colloids, 35(7), 2842-2853 (2019-01-30)
Zwitterionic groups have been widely used in antibiofouling surfaces to resist nonspecific adsorption of proteins and other biomolecules. The interactions among zwitterionic groups have attracted considerable attention in bioengineering, whereas the understanding of their nanomechanical mechanism still remains limited. In
Thuy V Nguyen et al.
Biomaterials, 35(22), 5749-5759 (2014-04-15)
Tumor progression is coincident with mechanochemical changes in the extracellular matrix (ECM). We hypothesized that tumor stroma stiffening, alongside a shift in the ECM composition from a basement membrane-like microenvironment toward a dense network of collagen-rich fibers during tumorigenesis, confers
Shengyang Pan et al.
Journal of colloid and interface science, 522, 20-28 (2018-03-27)
Raspberry-like polymer/inorganic compound hybrid colloidal spheres have attracted tremendous interest owing to their many potential applications, but most of them are concentrated on synthesis methods, controlling structures and morphologies. Herein, we synthesize raspberry-like poly(ethyl methacrylate)/SiO2 colloidal spheres and further graft
Honglei Guo et al.
Soft matter, 16(7), 1897-1907 (2020-01-30)
Soft tissue engineering requires antifouling materials that are biocompatible and mechanically flexible. Conventional hydrogels containing more than 70 wt% water are thus promising antifouling material candidates. However, some hydrogels are difficult to apply in internal body organs because of undesirable
Fatimata Dembele et al.
ACS applied materials & interfaces, 9(21), 18161-18169 (2017-05-04)
Fluorescent semiconductor quantum dots (QDs) exhibit several unique properties that make them suitable candidates for biomolecular sensing, including high brightness, photostability, broad excitation, and narrow emission spectra. Assembling these QDs into robust and functionalizable nanosized clusters (QD-NSCs) can provide fluorescent
Yumiko Obayashi et al.
Frontiers in microbiology, 8, 1952-1952 (2017-10-27)
Microbial extracellular hydrolytic enzymes that degrade organic matter in aquatic ecosystems play key roles in the biogeochemical carbon cycle. To provide linkages between hydrolytic enzyme activities and genomic or metabolomic studies in aquatic environments, reliable measurements are required for many
Dongbo Guo et al.
Biomaterials science, 8(2), 694-701 (2019-11-30)
Despite the great advances achieved in hypoxia-associated tumor therapy, the efficacy of hypoxia-activated prodrugs alone is usually limited owing to the moderate oxygen supply at the tumor area. Herein, we develop a polymerized platinum(iv) compound-based nanogel (polyprodrug) containing a bioreductive
Weihua Zhuang et al.
Regenerative biomaterials, 5(1), 1-8 (2018-02-10)
cis-dichlorodiammineplatinum(II) (CDDP)-loaded polymeric micelles for cancer therapy have been developed to reduce the serious side effects of cisplatin CDDP. Herein, polymeric micelles incorporated with cisplatin are prepared based on the complexation between CDDP and hydrophilic poly (L-glutamic acid)-b-poly (2-methacryloyloxyethyl phosphorylcholine)
Zeneida Díaz-Betancor et al.
Mikrochimica acta, 186(8), 570-570 (2019-07-25)
An approach is presented for covalent immobilization of biomolecules on an acrylate phosphorylcholine hydrogel. The immobilization and the hydrogel formation take place simultaneously by a thiol-acrylate coupling reaction, induced by UV-light (254 nm). The hydrogel is prepared on two polymeric surfaces
Takamasa Uekita et al.
Molecular cancer research : MCR, 12(10), 1449-1459 (2014-06-19)
Involvement of Ras in cancer initiation is known, but recent evidence indicates a role in cancer progression, including metastasis and invasion; however, the mechanism is still unknown. In this study, it was determined that human lung cancer cells with Ras
Jun Hu et al.
Bioconjugate chemistry, 29(6), 1897-1910 (2018-05-03)
Intelligent polymeric micelles have been developed as potential nanoplatforms for efficient drug delivery and diagnosis. Herein, we successfully prepared redox-sensitive polymeric micelles combined aggregation-induced emission (AIE) imaging as an outstanding anticancer drug carrier system for simultaneous chemotherapy and bioimaging. The
N Nakabayashi et al.
Biomaterials, 24(13), 2431-2435 (2003-04-18)
This review addresses the non-thrombogenic characteristics of copolymers based on 2-methacryloyloxyethyl phosphorylcholine (MPC), originally developed by Nakabayashi and colleagues. The hypothesis underlying these developments was that such materials would adsorb phospholipids from blood, yielding surfaces with good natural blood compatibility.
Alyssa D Schwartz et al.
Integrative biology : quantitative biosciences from nano to macro, 9(12), 912-924 (2017-11-22)
Traditional drug screening methods lack features of the tumor microenvironment that contribute to resistance. Most studies examine cell response in a single biomaterial platform in depth, leaving a gap in understanding how extracellular signals such as stiffness, dimensionality, and cell-cell
Megan A Jamiolkowski et al.
Journal of biomedical materials research. Part A, 103(4), 1303-1311 (2014-04-23)
Although the thrombogenic nature of the surfaces of cardiovascular devices is an important aspect of blood biocompatibility, few studies have examined platelet deposition onto opaque materials used for these devices in real time. This is particularly true for the metallic
Kai Yu et al.
Biomaterials, 166, 79-95 (2018-03-20)
The information regarding the nature of protein corona (and its changes) and cell binding on biomaterial surface under dynamic conditions is critical to dissect the mechanism of surface-induced thrombosis. In this manuscript, we investigated the nature of protein corona and
Shaojun Peng et al.
Biomaterials, 231, 119680-119680 (2019-12-22)
Long blood circulation is the basic requirement of advanced drug delivery systems for tumor treatment, which leads to enhanced tumor therapeutic efficiency and reduced side effects. However, the pharmacokinetics of the current nanoparticles in vivo is still unsatisfactory, which leads
Priyadarshini Singha et al.
ACS applied materials & interfaces, 12(8), 9070-9079 (2020-02-06)
The development of nonfouling and antimicrobial materials has shown great promise for reducing thrombosis and infection associated with medical devices with aims of improving device safety and decreasing the frequency of antibiotic administration. Here, the design of an antimicrobial, anti-inflammatory
Burcu Oktay et al.
Materials science & engineering. C, Materials for biological applications, 73, 569-578 (2017-02-12)
In this study, zwitterionic phosphorylcholine grafted electrospun chitosan fiber was accomplished in three steps: (1) Azide groups on the chitosan were regioselectively replaced with hydroxyl side group and then the product was electrospun. (2) Chitosan based macroinitiator was prepared using
Hidenori Takagi et al.
International journal of molecular sciences, 21(23) (2020-12-03)
Circulating tumor cells (CTCs) are a promising biomarker for cancer liquid biopsy. To evaluate the CTC capture bias and detection capability of the slit filter-based CTC isolation platform (CTC-FIND), we prospectively compared it head to head to a selection-free platform
Xing Han et al.
Journal of biomaterials applications, 35(3), 371-384 (2020-06-24)
Zwitterionic modification can prolong the blood circulation time of nanocarrier in vivo, but zwitterionic content will affect the functions of nanocarrier such as enzyme-responsive and intracellular or extracellular delivery. Therefore, it is necessary to explore the relationship between the zwitterionic
Subir Ghosh et al.
Journal of the mechanical behavior of biomedical materials, 87, 312-324 (2018-08-14)
A significant number of hip replacements (HR) fail permanently despite the success of the medical procedure, due to wear and progressive loss of osseointegration of implants. An ideal model should consist of materials with a high resistance to wear and
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