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Showing 1-30 of 58 results for "731099" within Papers
Martina Righi et al.
Scientific reports, 8(1), 502-502 (2018-01-13)
In the last decade, the use of flexible biosensors for neuroprosthetic and translational applications has widely increased. Among them, the polyimide (PI)-based thin-film electrodes got a large popularity. However, the usability of these devices is still hampered by a non-optimal tissue-device
Preparation and characterization of narrow compositional distribution polyampholytes as potential biomaterials: Copolymers of N-(3-aminopropyl) methacrylamide hydrochloride (APM) and methacrylic acid (MAA)
Dubey A, et al.
Journal of Polymer Science Part A: Polymer Chemistry, 53(2), 353-365 (2015)
Elena V Piletska et al.
Journal of molecular recognition : JMR, 33(4), e2824-e2824 (2019-11-20)
A library of 17 nanoparticles made of acrylate and methacrylate copolymers is prepared, characterized, and screened against six epitopes of adeno-associated viruses (AAV)-neutralizing antibodies to assess their affinity and specificity. Peptide epitopes are immobilized onto the surface of glass beads
Pascaline Nguemgo Kouam et al.
BMC cancer, 19(1), 958-958 (2019-10-18)
We analyzed the changes in permeability of endothelial cell layers after photon irradiation, with a focus on the metalloproteases ADAM10 and ADAM17, and on VE-cadherin, components crucial for the integrity of endothelial intercellular junctions, and their roles in the transmigration
Polymer mediated peptide immobilization onto amino-containing N-isopropylacrylamide-styrene core-shell particles
Rossi S, et al.
Colloid and Polymer Science, 282(3), 215-222 (2004)
Chenfeng Xu et al.
Nanoscale, 11(3), 1177-1194 (2019-01-03)
An intravenously administered drug delivery system should undergo a five-step 'CAPIR' cascade (circulation, accumulation, penetration, internalization and release), and the maximal efficiency of each step is of great importance to obtain the improved final therapeutic benefits and overall survival rate.
Xiangyu Sun et al.
Scientific reports, 9(1), 9585-9585 (2019-07-05)
3-hydroxybutyrate-co-3-hydroxyhexanoate (PHBHHx), which is naturally generated by biodegradable polyhydroxyalkanoates synthesized by bacteria, is an attractive material for drug delivery due to its controllable physical properties, non-toxicity, environmental friendliness, degradable properties and good biocompatibility. However, the intracellular trafficking network pathways, especially
Hasim Munawar et al.
Food chemistry, 298, 125044-125044 (2019-07-02)
Fumonisin B1 (FB1) is a carcinogenic mycotoxin produced by Fusarium species contaminating maize. At present, fumonisin determination is performed using costly and demanding chromatography techniques or immunoassays. Recently, a molecularly imprinted polymer nanoparticles (nanoMIPs) - based assay (MINA) has been
Wenwen Jiang et al.
Journal of materials chemistry. B, 8(44), 10117-10125 (2020-10-20)
Operation therapy is a common treatment for many cancers, but malignant tumors likely recur and metastasize after surgery, resulting in treatment failure. In this study, we aimed at synthesizing a multifunctional hydrogel patch that features multifunctions for synergistic surgery-photothermal therapy.
Mariana Tasso et al.
ACS nano, 9(11), 11479-11489 (2015-10-28)
Long-term inspection of biological phenomena requires probes of elevated intra- and extracellular stability and target biospecificity. The high fluorescence and photostability of quantum dot (QD) nanoparticles contributed to foster their promise as bioimaging tools that could overcome limitations associated with
Byung Young Park et al.
PloS one, 10(11), e0141612-e0141612 (2015-11-26)
It has been suggested that angiogenesis modulates adipogenesis and obesity. This study was undertaken to determine whether ALS-L1023 (ALS) prepared by a two-step organic solvent fractionation from Melissa leaves, which exhibits antiangiogenic activity, can regulate adipose tissue growth. The effects
Jinfeng Ma et al.
BioMed research international, 2015, 147468-147468 (2015-08-01)
The aim of the study was to determine the effect of H2 relaxin (RLN2) on invasion, migration, and chemosensitivity to cisplatin in human osteosarcoma U2-OS and MG-63 cells and then to investigate the effect of RLN2 on the AKT/NF-κB signaling
Janet M C Ngu et al.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 23(6), 335-343 (2014-07-26)
Tissue inhibitor of metalloproteinase-2 (TIMP-2) is an endogenous inhibitor of matrix metalloproteinases (MMPs) that attenuates maladaptive cardiac remodeling in ischemic heart failure. We examined the effects of TIMP-2 on human cardiac fibroblast activation and extracellular matrix (ECM) remodeling. Human cardiac
Melissa N Zimel et al.
Molecular cancer therapeutics, 16(12), 2701-2710 (2017-08-24)
Polymeric nanocarriers such as
Ryota Tamate et al.
Advanced materials (Deerfield Beach, Fla.), 27(5), 837-842 (2014-12-17)
Biomimetic cross-linked polymersomes that exhibit a self-beating motion without any on-off switching are developed. The polymersomes are made from a well-defined synthetic thermoresponsive diblock copolymer, and the thermoresponsive segment includes ruthenium catalysts for the oscillatory chemical reaction and vinylidene groups
So Jung Park et al.
ACS applied materials & interfaces, 12(43), 49165-49173 (2020-09-30)
Control of the cross-linking reaction is imperative when developing a sophisticated in situ forming hydrogel in the body. In this study, a heteroarmed thermoresponsive (TR) nanoparticle was designed to investigate the mechanism of controlling reactivity of the functional groups introduced
Tyler Duellman et al.
Traffic (Copenhagen, Denmark), 16(10), 1108-1126 (2015-07-25)
Matrix metalloproteinase-9 (MMP-9) is a secreted endoproteinase with a critical role in the regulation of the extracellular matrix and proteolytic activation of signaling molecules. Human (h)MMP-9 has two well-defined N-glycosylation sites at residues N38 and N120; however, their role has
Josune Orbe et al.
Journal of medicinal chemistry, 58(7), 2941-2957 (2015-02-17)
Discovery of potent and safe therapeutics that improve upon currently available antifibrinolytics, e.g., tranexamic acid (TXA, 1) and aprotinin, has been challenging. Matrix metalloproteinases (MMPs) participate in thrombus dissolution. Then we designed a novel series of optimized MMP inhibitors that
Jie Hong Hu et al.
Cardiovascular research, 105(3), 372-382 (2015-01-27)
Elevated activity of urokinase plasminogen activator (uPA) and MMPs in human arteries is associated with accelerated atherosclerosis, aneurysms, and plaque rupture. We used Apoe-null mice with macrophage-specific uPA overexpression (SR-uPA mice; a well-characterized model of protease-accelerated atherosclerosis) to investigate whether
Mohamed M Elsutohy et al.
Nanoscale, 9(18), 5904-5911 (2017-04-25)
Intracellular pH is a key parameter that influences many biochemical and metabolic pathways that can also be used as an indirect marker to monitor metabolic and intracellular processes. Herein, we utilise ratiometric fluorescent pH-sensitive nanosensors with an extended dynamic pH
Katarzyna Pietraszek et al.
FEBS letters, 588(23), 4319-4324 (2014-10-12)
We previously showed that lumican regulates MMP-14 expression. The aim of this study was to compare the effect of lumican and decorin on MMP-14 activity. In contrast to decorin, the glycosylated form of lumican was able to significantly decrease MMP-14
Torri E Rinker et al.
Acta biomaterialia, 56, 91-101 (2016-12-26)
Development of multifunctional biomaterials that sequester, isolate, and redeliver cell-secreted proteins at a specific timepoint may be required to achieve the level of temporal control needed to more fully regulate tissue regeneration and repair. In response, we fabricated core-shell heparin-poly(ethylene-glycol)
Yuan Yuan et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 42(6), 2159-2168 (2017-09-06)
Krüppel-like factor 2 (KLF2) plays an essential role in the inhibition of endothelial cell and macrophage activation during the inflammatory process. However, the roles of KLF2 in chondrocytes and the pathological progression of osteoarthritis (OA) remain unknown. The aim of
Dannielle S Figueroa et al.
Journal of biomechanical engineering, 136(10), 101010-101010 (2014-07-18)
Hyperglycemia is a defining characteristic of diabetes, and uncontrolled blood glucose in diabetes is associated with accelerated cardiovascular disease. Chronic hyperglycemia glycates extracellular matrix (ECM) collagen, which can lead to endothelial cell dysfunction. In healthy conditions, endothelial cells respond to
Lijia Li et al.
Nanoscale, 9(1), 314-325 (2016-12-03)
Cationic materials have been reported as promising tools for targeting to mitochondria which are the "power houses" and "metabolic garbage keepers" of cells. However, their positive nature also restricts their in vivo application due to the quick clearance. Herein, we
Ingebrigt Sylte et al.
PloS one, 13(8), e0200237-e0200237 (2018-08-04)
Inhibitors targeting bacterial enzymes should not interfere with enzymes of the host, and knowledge about structural determinants for selectivity is important for designing inhibitors with a therapeutic potential. We have determined the binding strengths of two hydroxamate compounds, galardin and
Abdoulaye J Dabo et al.
PloS one, 10(8), e0135970-e0135970 (2015-08-19)
Increased lung levels of matrix metalloproteinase 9 (MMP9) are frequently observed during respiratory syncytial virus (RSV) infection and elevated MMP9 concentrations are associated with severe disease. However little is known of the functional role of MMP9 during lung infection with
S Rudnick-Glick et al.
Journal of nanobiotechnology, 13, 80-80 (2015-11-19)
Bisphosphonate (BP) compounds are widely used in the treatment of bone disorders. This group of drugs with a high affinity to Ca(+2) ions is rapidly attracted to bone mineral, especially in areas of high resorption. We have engineered unique biodegradable
Gaurasundar M Conley et al.
Nature communications, 10(1), 2436-2436 (2019-06-06)
Thermosensitive microgels are widely studied hybrid systems combining properties of polymers and colloidal particles in a unique way. Due to their complex morphology, their interactions and packing, and consequentially the viscoelasticity of suspensions made from microgels, are still not fully
Wen Shi et al.
Biomaterials, 35(22), 5760-5770 (2014-04-24)
N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymers have shown promise for application in the detection and staging of cancer. However, non-target accumulation, particularly in the liver and spleen, hinders the detection of resident or nearby metastatic lesions thereby decreasing diagnostic effectiveness. Our laboratory has
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