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Showing 1-30 of 76 results for "74104" within Papers
Natalia J Sumi et al.
Cell chemical biology, 26(9), 1240-1252 (2019-07-02)
Despite recent successes of precision and immunotherapies there is a persisting need for novel targeted or multi-targeted approaches in complex diseases. Through a systems pharmacology approach, including phenotypic screening, chemical and phosphoproteomics, and RNA-seq, we elucidated the targets and mechanisms
Elita Montanari et al.
Macromolecular bioscience, 16(12), 1815-1823 (2016-10-14)
Nanoparticles based on hyaluronic acid (HA) are designed to deliver tannic acid (TA) as an antimicrobial agent. The presence of HA makes these particles potentially useful to target bacteria that colonize cells presenting HA membrane receptors (e.g. CD44), such as
Kenta Arai et al.
Organic & biomolecular chemistry, 18(19), 3724-3733 (2020-05-05)
Glycosphingolipids (GSLs) are a group of molecules composed of a hydrophilic glycan part and a hydrophobic ceramide creating a diverse family. GSLs are de novo synthesised from ceramides at the endoplasmic reticulum and Golgi apparatus, and transported to the outer
Esterification of carboxylic acids with alcohols by 4-(4, 6-dimethoxy-1, 3, 5-triazin-2-yl)-4-methyl-morpholinium chloride (DMTMM).
Kunishima M
Synlett, 1999(08), 1255-1256 (1999)
Chameen Samarawickrama et al.
Cornea, 37(5), 609-616 (2017-11-28)
To describe the use of collagen-based alternatives to cyanoacrylate glue for the sealing of acute corneal perforations. A collagen analog comprising a collagen-like peptide conjugated to polyethylene glycol (CLP-PEG) and its chemical crosslinker were tested for biocompatibility. These CLP-PEG hydrogels
Raquel Palao-Suay et al.
Journal of materials science. Materials in medicine, 28(10), 152-152 (2017-09-02)
Active targeting not only of a specific cell but also a specific organelle maximizes the therapeutic activity minimizing adverse side effects in healthy tissues. The present work describes the synthesis, characterization, and in vitro biological activity of active targeting nanoparticles (NP)
Kyung Ho Kim et al.
Micromachines, 11(4) (2020-04-26)
Stress biomarkers such as hormones and neurotransmitters in bodily fluids can indicate an individual's physical and mental state, as well as influence their quality of life and health. Thus, sensitive and rapid detection of stress biomarkers (e.g., cortisol) is important
Eiki Hara et al.
International journal of molecular sciences, 19(10) (2018-10-24)
Bone quality is a significant indicator of the result of bone treatments. However, information regarding the quality of regenerated bones is limited. The study investigates the effect of different compositions of vacuum heated epigallocatechin gallate-modified gelatins sponge (vhEGCG-GS) on the
Anissa Pisani et al.
Nanomaterials (Basel, Switzerland), 10(11) (2020-11-26)
Chemokine-induced chemotaxis mediates physiological and pathological immune cell trafficking, as well as several processes involving cell migration. Among them, the role of CXCL12/CXCR4 signaling in cancer and metastasis is well known, and CXCR4 has been often targeted with small molecule-antagonists
Kyungsook Kim et al.
Advanced healthcare materials, 5(24), 3105-3117 (2016-12-03)
Here, a click-cross-linked small intestine submucosa (SIS) drug depot is described for the treatment of rheumatoid arthritis (RA). To the best of the knowledge, there have been no studies related to the intra-articular injection of methotrexate (Met)-loaded click-cross-linkable SIS (Met-loaded
Maria Paola Santini et al.
Cell reports, 30(2), 555-570 (2020-01-16)
PDGFRα+ mesenchymal progenitor cells are associated with pathological fibro-adipogenic processes. Conversely, a beneficial role for these cells during homeostasis or in response to revascularization and regeneration stimuli is suggested, but remains to be defined. We studied the molecular profile and
Yingying Xiong et al.
The Analyst, 144(15), 4545-4551 (2019-07-04)
Sialic acid (SA), usually located at the termini of glycan chains, is one of the most important monosaccharide blocks for glycosylation of proteins. The expression level of sialoglycoconjugates (SiaGCs) in cellular secretome is of great significance in diagnosis of tumor
Raquel Palao-Suay et al.
Acta biomaterialia, 57, 70-84 (2017-05-18)
The aim of this work was the generation of a multifunctional nanopolymeric system that incorporates IR-780 dye, a near-infrared (NIR) imaging probe that exhibits photothermal and photodynamic properties; and a derivate of α-tocopheryl succinate (α-TOS), a mitochondria-targeted anticancer compound. IR-780
Ling Hao et al.
American journal of physiology. Renal physiology, 316(6), F1236-F1243 (2019-04-18)
Inflammation is involved in many prostate pathologies including infection, benign prostatic hyperplasia, and prostate cancer. Preclinical models are critical to our understanding of disease mechanisms, yet few models are genetically tractable. Here, we present a comparative quantitative proteomic analysis of
Tetrahedron, 55, 13159-13159 (1999)
Hannah R Shanks et al.
Soft matter, 17(4), 1048-1055 (2020-12-09)
The ability to remotely and non-invasively monitor and measure the strain within injectable gels used to augment soft tissue is highly desirable. Such information could enable real-time monitoring of gel performance and bespoke gel design. We report progress towards this
Jie Ding et al.
Oncology reports, 34(4), 1825-1834 (2015-08-05)
Previous studies have demonstrated that the α5β1 integrin-mediated interaction with fibronectin (FN) occurs through the Arg-Gly-Asp (RGD) cell-binding sequence in repeat III10. Indocyanine green (ICG) is a near-infrared (NIR) optical dye that has been approved by the US Food and
Kirk J Samaroo et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 35(3), 548-557 (2016-07-16)
The glycoprotein, lubricin, is the primary boundary lubricant of articular cartilage and has been shown to prevent cartilage damage after joint injury. In this study, a library of eight bottle-brush copolymers were synthesized to mimic the structure and function of
Peter D Jones et al.
Arteriosclerosis, thrombosis, and vascular biology, 38(8), 1711-1722 (2018-05-26)
Objective- A large number of genetic loci have been associated with risk of coronary artery disease (CAD) through genome-wide association studies, however, for most loci the underlying biological mechanism is unknown. Determining the molecular pathways and cellular processes affected by
Koji Nagahama et al.
Nature communications, 9(1), 2195-2195 (2018-06-08)
To date, many scientists have thoroughly investigated both cells and cellular functions, resulting in the identification of numerous molecular mechanisms underlying the cellular functions. Based on these findings, medical scientists and pharmacologists have developed many technological applications for cells and
Eiji Yuba et al.
Pharmaceutics, 12(8) (2020-08-17)
Specific delivery to antigen presenting cells (APC) and precise control of the intracellular fate of antigens are crucial to induce cellular immunity that directly and specifically attacks cancer cells. We previously achieved cytoplasmic delivery of antigen and activation of APC
Talitha F Stefanello et al.
Nanoscale, 9(33), 12150-12162 (2017-08-15)
Multi-stimuli responsive nanogels based on biocompatible hydrophilic polymers have emerged as promising drug delivery systems to improve anticancer therapy with hydrophobic drugs, through increase of circulating-time in the bloodstream, tumor-targeting and reduction of systemic toxicity. This paper reports on the
Wataru Katagiri et al.
Advanced healthcare materials, 8(15), e1900035-e1900035 (2019-06-06)
Efficient and timely delivery of vaccine antigens to the secondary lymphoid tissue is crucial to induce protective immune responses by vaccination. However, determining the longitudinal biodistribution of injected vaccines in the body has been a challenge. Here, the near-infrared (NIR)
Hyeon Jin Ju et al.
Materials (Basel, Switzerland), 13(14) (2020-07-15)
In this study, we developed injectable intratympanic hyaluronic acid (HA) depots for the treatment of hearing loss. We prepared an injectable click-crosslinking formulation by modifying HA with tetrazine (HA-TET) and trans-cyclooctene (HA-TCO), which crosslinked to form an HA depot (Cx-HA).
Chan Ho Chung et al.
ACS nano, 14(6), 6887-6896 (2020-05-26)
Rosmarinic acid (RA), one of the most important polyphenol-based antioxidants, has received growing interest because of its bioactive properties, including anti-inflammatory, anticancer, and antibacterial activities. Despite the high therapeutic potential of RA, its intrinsic properties of poor water solubility and
Yutaka Nishimoto et al.
Polymers, 12(7) (2020-07-08)
Delivery systems to lymph node-resident T cells around tumor tissues are essential for cancer immunotherapy, in order to boost the immune responses. We previously reported that anionic dendrimers, such as carboxyl-, sulfonyl-, and phosphate-terminal dendrimers, were efficiently accumulated in lymph
Antoine Frayssinet et al.
Carbohydrate polymers, 236, 116042-116042 (2020-03-17)
A platform of enzymatically-crosslinked Collagen/Tyramine hyaluronan derivative (Col/HA-Tyr) hydrogels with tunable compositions and gelation conditions was developed to evaluate the impact of the preparation conditions on their physical, chemical and biological properties. At low HA-Tyr content, hydrogels exhibited a fibrillar
Feng Yu et al.
ACS applied materials & interfaces, 7(43), 24023-24031 (2015-10-16)
Hydrogel, as a good cartilage tissue-engineered scaffold, not only has to possess robust mechanical property but also has to have an intrinsic self-healing property to integrate itself or the surrounding host cartilage. In this work a double cross-linked network (DN)
Yong Xu et al.
Nature communications, 12(1), 2407-2407 (2021-04-25)
Many features of extracellular matrices, e.g., self-healing, adhesiveness, viscoelasticity, and conductivity, are associated with the intricate networks composed of many different covalent and non-covalent chemical bonds. Whereas a reductionism approach would have the limitation to fully recapitulate various biological properties
Ming Fan et al.
Materials science & engineering. C, Materials for biological applications, 56, 311-317 (2015-08-08)
A robust synthetic strategy of biopolymer-based hydrogels has been developed where hyaluronic acid derivatives reacted through aqueous Diels-Alder chemistry without the involvement of chemical catalysts, allowing for control and sustain release of dexamethasone. To conjugate the hydrogel, furan and maleimide
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