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Showing 1-30 of 337 results for "75090" within Papers
Michael Chorny et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(6), 2198-2206 (2013-02-15)
Gene therapeutic strategies have shown promise in treating vascular disease. However, their translation into clinical use requires pharmaceutical carriers enabling effective, site-specific delivery as well as providing sustained transgene expression in blood vessels. While replication-deficient adenovirus (Ad) offers several important
Bettina Mittendorfer et al.
Diabetes, 52(7), 1641-1648 (2003-06-28)
We evaluated the validity of using a single fatty acid tracer to assess total plasma long-chain free fatty acid (FFA) kinetics and the relationship between the rate of appearance (R(a)) of fatty acids in plasma and the fatty acid composition
G Hoffmann et al.
Clinical chemistry, 35(4), 587-595 (1989-04-01)
This new method for qualitative and quantitative determination of organic acids, aldehydes, and ketones in biological samples is effective for use with urine, plasma, and amniotic fluid, and it requires no deproteinization. Isolation by batch-wise liquid partition chromatography on silicic
R Valjakka-Koskela et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 11(4), 343-350 (2000-10-18)
The aim of this study was to determine if transdermal penetration of levosimendan, a novel positive inotropic drug, could be enhanced and controlled by formulation modifications. Penetration of levosimendan across human epidermis in vitro was determined using abdominal excised skin
Lin Han et al.
Dalton transactions (Cambridge, England : 2003), 43(31), 11981-11987 (2014-06-28)
Phase transfer techniques possess remarkable advantages for the synthesis of inorganic nanomaterials. In contrast to the abundant reports on the preparation of noble metal nanoparticles using phase transfer, the number of semiconductor nanocrystals syntheses based on phase transfer techniques is
Timothy J Sargeant et al.
Nature cell biology, 16(11), 1057-1068 (2014-10-07)
We have previously demonstrated that Stat3 regulates lysosomal-mediated programmed cell death (LM-PCD) during mouse mammary gland involution in vivo. However, the mechanism that controls the release of lysosomal cathepsins to initiate cell death in this context has not been elucidated.
Cédric Montigny et al.
The Journal of biological chemistry, 289(49), 33850-33861 (2014-10-11)
Sarcolipin (SLN) is a regulatory peptide present in sarcoplasmic reticulum (SR) from skeletal muscle of animals. We find that native rabbit SLN is modified by a fatty acid anchor on Cys-9 with a palmitic acid in about 60% and, surprisingly
Karen L Sweazea et al.
Zoology (Jena, Germany), 116(2), 85-89 (2013-02-07)
Plasma glucose and ketone concentrations are much higher in birds than in humans and birds exhibit resistance to insulin-mediated glucose uptake into muscle. Therefore, birds may offer a model in which to examine the effects of high plasma glucose and
Jilite Wang et al.
Bioscience, biotechnology, and biochemistry, 79(3), 456-461 (2014-11-07)
Dietary plant protein is well known to reduce serum cholesterol levels. Rice bran is a by-product of rice milling and is a good source of protein. The present study examined whether feeding rats a high-cholesterol diet containing 10% rice bran
C Carrillo et al.
Nutricion hospitalaria, 27(4), 978-990 (2012-11-21)
Although n-3 polyunsaturated fatty acids have been widely described as anti-inflammatory fats, little is known about the role of oleic acid in immune system. The aim of the present review is to join all the reports available in order to
Elizabeth Cocks et al.
Drug development and industrial pharmacy, 41(3), 522-528 (2014-03-22)
The effect of suspension stabilizers, internal aqueous phase volume and polymer amount were investigated for the production of protein loaded poly(d,l lactide-co-glycolide) (PLGA) microparticles suitable for pulmonary drug delivery. PLGA microparticles were produced adopting water-in-oil-in-water (W/O/W) solvent evaporation technique and were
James C S Ho et al.
The Journal of biological chemistry, 288(24), 17460-17471 (2013-05-01)
Long-chain fatty acids are internalized by receptor-mediated mechanisms or receptor-independent diffusion across cytoplasmic membranes and are utilized as nutrients, building blocks, and signaling intermediates. Here we describe how the association of long-chain fatty acids to a partially unfolded, extracellular protein
Nitro-oleic acid is a novel anti-oxidative therapy for diabetic kidney disease.
Madhav C Menon et al.
American journal of physiology. Renal physiology, 305(11), F1542-F1543 (2013-09-21)
Pablo J Giraudi et al.
Experimental and molecular pathology, 98(1), 85-92 (2014-12-24)
Non-alcoholic fatty liver disease is characterized by an initial accumulation of triglycerides that can progress to non-alcoholic steatohepatitis, which can ultimately evolve to cirrhosis and hepatocellular carcinoma. Hepatic stellate cells play a key role in liver fibrogenesis by an increased
Mika Hilvo et al.
International journal of cancer, 134(7), 1725-1733 (2013-10-12)
Changes in cellular lipid metabolism are a common feature in most solid tumors, which occur already in early stages of the tumor progression. However, it remains unclear if the tumor-specific lipid changes can be detected at the level of systemic
Chun-Yan Song et al.
Journal of gastroenterology and hepatology, 30(2), 405-412 (2014-08-05)
Sophocarpine, a tetracyclic quinolizidine alkaloid derived from Sophora alopecuroides L., has been documented that it can suppress pro-inflammatory cytokines synthesis in alleviating nonalcoholic steatohepatitis (NASH) in vivo. Toll-like receptor 4 (TLR4) is a pattern recognition receptor whose activation results in
Michael A Boles et al.
Journal of the American Chemical Society, 137(13), 4494-4502 (2015-03-17)
This work analyzes the role of hydrocarbon ligands in the self-assembly of nanocrystal (NC) superlattices. Typical NCs, composed of an inorganic core of radius R and a layer of capping ligands with length L, can be described as soft spheres
Bing Fang et al.
Biochimica et biophysica acta, 1841(4), 535-543 (2013-12-26)
α-Lactalbumin (α-LA) can bind oleic acid (OA) to form HAMLET-like complexes, which exhibited highly selective anti-tumor activity in vitro and in vivo. Considering the structural similarity to α-LA, we conjectured that lactoferrin (LF) could also bind OA to obtain a
A I Figueroa et al.
Nanotechnology, 24(15), 155705-155705 (2013-03-23)
We present radio frequency transverse susceptibility (TS) measurements on oleic acid-coated and SiO2-coated Fe3-xO4 magnetite nanoparticles. The effects of the type of coating on the interparticle interactions and magnetic anisotropy are evaluated for two different particle sizes in powder samples.
Marta Estrader et al.
Nanoscale, 7(7), 3002-3015 (2015-01-21)
The intimate relationship between stoichiometry and physicochemical properties in transition-metal oxides makes them appealing as tunable materials. These features become exacerbated when dealing with nanostructures. However, due to the complexity of nanoscale materials, establishing a distinct relationship between structure-morphology and
Justin I Odegaard et al.
Cell metabolism, 7(6), 496-507 (2008-06-05)
Macrophage infiltration and activation in metabolic tissues underlie obesity-induced insulin resistance and type 2 diabetes. While inflammatory activation of resident hepatic macrophages potentiates insulin resistance, the functions of alternatively activated Kupffer cells in metabolic disease remain unknown. Here we show
M D Jensen
The Journal of clinical investigation, 96(5), 2297-2303 (1995-11-01)
These studies were conducted to determine whether men and women differ with regards to their overnight postabsorptive (basal) and postprandial fatty acid kinetics. Systemic oleate turnover ([9,10(3)H]oleate) was measured before and after the consumption of a mixed meal. Leg and
C Colette et al.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 27(6), 648-656 (2003-07-02)
To investigate whether improvements in cardiovascular risk factors, as observed in energy-balance conditions after exchanging carbohydrates (CHO) for monounsaturated (MUFA) fats, are also observed in energy-restricted conditions. Longitudinal, clinical intervention study using two types of energy-restricted diets (-30% of initial
Kenichi Sakai et al.
Journal of oleo science, 60(4), 159-163 (2011-03-24)
Gemini surfactants recently developed by our research group are introduced from the standpoints of their syntheses, aqueous solution properties, and potential applications. Two series of gemini surfactants are introduced in this short review, the first of which is the oleic
Adriana Soto-Guzman et al.
Prostaglandins, leukotrienes, and essential fatty acids, 88(3), 243-249 (2013-01-22)
Epidemiological studies and animal models suggest an association between high levels of dietary fat intake and an increased risk of breast cancer. In breast cancer cells, the free fatty acid oleic acid (OLA) induces proliferation, migration, invasion and an increase
Elizabeth A Droke et al.
Biological trace element research, 95(3), 219-232 (2003-12-11)
The Caco-2 cell line was used as a model to determine if the type of fatty acid, unsaturated versus saturated, differentially altered the uptake and transport of iron in the human intestine and if the changes were the result of
Jordan Doumanov et al.
Toxicon : official journal of the International Society on Toxinology, 94, 36-44 (2014-12-24)
Snake venom Phospholipases A2 (svPLA2) are among the main toxic venom components with a great impact on different tissues and organs based on their catalytic specificity and a variety of pharmacological effects, whose mechanism is still under debate. The main
Ayman M Atta et al.
Molecules (Basel, Switzerland), 20(1), 1244-1261 (2015-01-17)
This work presents a new method to prepare poly(sodium acrylate) magnetite composite nanoparticles. Core/shell type magnetite nanocomposites were synthesized using sodium acrylate as monomer and N,N-methylenebisacrylamide (MBA) as crosslinker. Microemulsion polymerization was used for constructing core/shell structures with magnetite nanoparticles
J R Kumar et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 168, 28-38 (2014-12-06)
Three isoenzymes of phospholipase A2 (PLA2), VRV-PL-IIIc, VRV-PL-VII, and VRV-PL-IX were isolated from Daboia russelii snake venom. The venom, upon gel filtration on Sephadex G-75 column, resolved into six peaks (DRG75 I-VI). The VRV-PL-IIIc was purified by subjecting DRG75II to
E Zamora-Rojas et al.
Meat science, 95(3), 503-511 (2013-06-25)
A handheld micro-electro-mechanical system (MEMS) based spectrometer working in the near infrared region (NIR) (1600-2400nm) was evaluated for in-situ and non-destructive prediction of main fatty acids in Iberian pig (IP) carcasses. 110 IP carcasses were measured. Performance of the instrument
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