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Showing 1-30 of 80 results for "76-28-8" within Papers
E Volikos et al.
Journal of medical genetics, 43(5), e18-e18 (2006-05-02)
LKB1/STK11 germline mutations cause Peutz-Jeghers syndrome (PJS). The existence of a second PJS locus is controversial, the evidence in its favour being families unlinked to LKB1 and the low frequency of LKB1 mutations found using conventional methods in several studies.
John J Nemunaitis et al.
Cancer journal (Sudbury, Mass.), 9(1), 58-66 (2003-02-27)
The purpose of this study was to determine the maximum tolerated dose, pharmacokinetic profile, and evidence of antitumor activity of CI-994 used in combination with gemcitabine. This was a dose escalation trial in which gemcitabine (1,000 mg/m2) was given as
C B Eap et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 802(2), 339-345 (2004-03-17)
Midazolam is a widely accepted probe for phenotyping cytochrome P4503A. A gas chromatography-mass spectrometry (GC-MS)-negative chemical ionization method is presented which allows measuring very low levels of midazolam (MID), 1-OH midazolam (1OHMID) and 4-OH midazolam (4OHMID), in plasma, after derivatization
E Maria Donner et al.
Drug and chemical toxicology, 26(2), 125-133 (2003-06-21)
Phenylphosphinic acid was fed in graded concentrations of either 0 (control), 100, 1,000, or 10,000 ppm to rats for 28 days. These concentrations provided average daily doses of 8, 76, and 779 mg/kg (males) and 9, 83, and 859 mg/kg
Bahman Pourabbas et al.
The American journal of tropical medicine and hygiene, 88(5), 868-871 (2013-02-13)
Meglumine antimoniate (Glucantime) remains the therapeutic cornerstone of visceral leishmaniasis (VL). Twenty-one VL patients were treated with Glucantime, extending for 1 week after defervescence. For monitoring the response, Leishmania infantum kinetoplast DNA loads were evaluated using real-time polymerase chain reaction
Jodi C McDaniel et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 25(4), 680-690 (2017-08-02)
Sustained high levels of activated polymorphonuclear leukocytes (PMNs) and PMN-derived proteases in the microenvironment of chronic venous leg ulcers (CVLUs) are linked to chronic inflammation and delayed healing. Uncontrolled PMN activity eventually destroys newly developed tissue and degrades critical growth
Inn-Wen Chong et al.
Oncology reports, 18(1), 17-24 (2007-06-06)
The ability to detect K-ras oncogene may provide additional information for the management of patients with non-small cell lung cancer (NSCLC). In the present study, we detected the K-ras oncogene in 76 patients with NSCLC by two methods: direct sequencing
Jia-Gang Liu et al.
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 37(6), 868-871 (2007-01-24)
To detect and analysis epidermal growth factor receptor (EGFR) and phosphatase and tensin homolog deleted on chromosome ten (PTEN) in different malignancy brain tumors, and to evaluate their prognostic significance. Using immunohistochemistry to detect the expression of EGFR and PTEN
U-B Jönsson et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 32(7), 1092-1095 (2002-07-09)
We have found a polymorphism in the ECP (eosinophil cationic protein)-gene at position 434 according to GenBank accession number NM 002935. This polymorphism would cause the change of the amino acid arginine (base at position 434 is G) at position
A M Lorenzo et al.
Journal of neuroscience research, 88(6), 1252-1261 (2009-11-13)
Even though caffeine can be excreted in breast milk, few studies have analyzed the effect of maternal caffeine consumption during lactation on neonatal brain. In the present work pregnant rats were treated daily with 1 g/L of caffeine in their
Makoto Suzuki et al.
Human pathology, 36(10), 1127-1134 (2005-10-18)
The molecular mechanisms for frequent epidermal growth factor receptor (EGFR, a tyrosine kinase [TK]) and HER2 (the preferred coreceptor of EGFR) overexpression in lung cancer are poorly understood. Recent studies have shown the mutations of the TK domain in EGFR
K A Al-Barazanji et al.
Obesity research, 8(4), 317-323 (2000-08-10)
To investigate whether chronic administration of the long-acting glucagon-like peptide-1 receptor agonist exendin-4 can elicit sustained reductions in food intake and body weight and whether its actions require an intact leptin system. Male lean and obese Zucker (fa/fa) rats were
R Tian et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(23), 13536-13541 (1999-11-11)
Activation of protein kinase C (PKC) protects the heart from ischemic injury; however, its mechanism of action is unknown, in part because no model for chronic activation of PKC has been available. To test whether chronic, mild elevation of PKC
Guido Rindi et al.
Histochemistry and cell biology, 117(6), 521-525 (2002-07-11)
We aimed to assess the occurrence of ghrelin, a new gut hormone, in endocrine growths of the stomach. In addition, since ghrelin has been detected in other gut derivatives during adult and/or fetal life, we also studied endocrine tumours of
Edward C Keystone et al.
Annals of the rheumatic diseases, 74(2), 333-340 (2014-11-29)
To investigate baricitinib (LY3009104, formerly INCB028050), a novel, oral inhibitor of JAK1/JAK2 in patients with moderate to severe rheumatoid arthritis (RA) despite treatment with methotrexate. In this phase IIb study, 301 patients were randomised 2:1:1:1:1 to receive once daily doses
Javier Álvarez Aldeán et al.
Vaccine, 32(30), 3740-3751 (2014-05-20)
Severe rotavirus gastroenteritis is common in children under 5 years of age. A literature review was performed to investigate the economic and psychosocial impact of rotavirus infection in children in this age group. We retrieved 56 articles on the economic
Piotr Kubler et al.
International journal of cardiology, 129(3), 373-378 (2007-12-07)
Optimal risk stratification in heart failure patients surviving an episode of acute decompensation has not yet been established. We investigated whether a lack of significant decrease in plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) during hospital stay can identify
Lei Guo et al.
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 26(4), 223-226 (2008-08-30)
To investigate the effect of the environmental carcinogenic factor-TCDD (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin) on cell apoptosis and gene regulation of insulin-like growth factor binding protein 6 (IGFBP-6) in osteogenic sarcoma (SaOS-2) cells. The SaOS-2 cells were cultured with TCDD (1
J Becker et al.
American journal of human genetics, 58(4), 657-670 (1996-04-01)
The clinical manifestation of hemophilia A is caused by a wide range of different mutations. In this study the factor VIII genes of 147 severe hemophilia A patients--all exclusively from sporadic families--were screened for mutations by use of the complete
Chandima Jeewandara et al.
Scientific reports, 11(1), 2062-2062 (2021-01-23)
In order to support vaccine development, and to aid convalescent plasma therapy, it would be important to understand the kinetics, timing and persistence of SARS-CoV-2 neutralizing antibodies (NAbs), and their association with clinical disease severity. Therefore, we used a surrogate
Sung Won Choi et al.
Blood, 130(15), 1760-1767 (2017-08-09)
The oral histone deacetylase (HDAC) inhibitor (vorinostat) is safe and results in low incidence of acute graft-versus-host disease (GVHD) after reduced-intensity conditioning, related donor hematopoietic cell transplantation (HCT). However, its safety and efficacy in preventing acute GVHD in settings of
C Flummer et al.
Journal of animal science, 90 Suppl 4, 372-374 (2013-02-13)
This trial was conducted to investigate whether β-hydroxy β-methyl butyrate (HMB) supplementation during late gestation and throughout lactation would influence colostrum and milk production of sows and neonatal piglet survival (0 to 24 h). Control sows (CON; n = 8)
Poor performance of BACTEC NR 730 blood culture system in early detection of Neisseria meningitidis.
E R Schnur et al.
Journal of clinical microbiology, 27(4), 654-656 (1989-04-01)
During an 8-month period at Children's Hospital, Oakland, Calif., a 9% rate for positive blood culture for children with Neisseria meningitidis meningitis was identified. The blood culture system used in each case was the BACTEC NR 730. This rate seemed
F Ducray et al.
Neurology, 72(2), 156-161 (2009-01-14)
alpha-Internexin (INA) is a proneural gene encoding a neurofilament interacting protein that is upregulated in some gliomas, particularly oligodendrogliomas. INA expression was evaluated by immunohistochemistry in a series of 122 gliomas, and correlated to the 1p19q codeletion, a favorable prognostic
Emad Hamdy et al.
Journal of laparoendoscopic & advanced surgical techniques. Part A, 25(6), 460-464 (2015-05-08)
Achalasia is an incurable primary motor disorder of the esophagus. The best treatment modality for achalasia is still controversial. This study compared the short- and intermediate-term outcome between endoscopic pneumatic dilatation (EPD) versus laparoscopic esophageal myotomy (LEM) for the management
Tobias Broger et al.
The Lancet. Infectious diseases, 19(8), 852-861 (2019-06-04)
Most tuberculosis-related deaths in people with HIV could be prevented with earlier diagnosis and treatment. The only commercially available tuberculosis point-of-care test (Alere Determine TB LAM Ag [AlereLAM]) has suboptimal sensitivity, which restricts its use in clinical practice. The novel
G Boden et al.
The Journal of clinical investigation, 73(3), 785-793 (1984-03-01)
The effects of glucagon deficiency and excess on plasma concentrations of 21 amino acids were studied in six normal human subjects for 8 h. During glucagon deficiency, produced by intravenous infusion of somatostatin (0.5 mg/h) and insulin (5 mU/kg per
Yan Zheng et al.
Omics : a journal of integrative biology, 13(4), 301-306 (2009-07-25)
Differentiated embryo-chondrocyte expressed gene 1 (DEC1), as a bHLH transcriptional factor, plays important roles in cell differentiation, proliferation, and apoptosis. The expression of DEC1 and its role in human gastric cancer are unknown. This study was designed to characterize the
Thomas Lang et al.
Drug metabolism and disposition: the biological fate of chemicals, 34(9), 1582-1599 (2006-06-10)
Biliary excretion of bile salts and other bile constituents from hepatocytes is mediated by the apical (canalicular) transporters P-glycoprotein 3 (MDR3, ABCB4) and the bile salt export pump (ABCB11). Mutations in ABCB4 and ABCB11 contribute to cholestatic diseases [e.g., progressive
Chowdhury F Miah et al.
Surgery, 156(6), 1491-1496 (2014-12-03)
The American Thyroid Association recommends lymph node mapping (LNM) ultrasonography 6-12 months after thyroidectomy for patients with papillary thyroid cancer (PTC). The yield of LNM over thyroglobulin (TG) screening is not well defined. We sought to investigate this relationship. Post
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