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Showing 1-29 of 29 results for "80342" within Papers
Yan Shen et al.
Cancer biology & therapy, 13(7), 542-552 (2012-03-15)
Accumulating evidence suggests that chemopreventive effects of some dietary polyphenols may in part be mediated by their ability to influence epigenetic mechanisms in cancer cells. Boswellic acids, derived from the plant Boswellia serrata, have long been used for the treatment
Ajay Kumar et al.
Bioorganic & medicinal chemistry letters, 22(1), 431-435 (2011-11-30)
Boswellic acid acylates including their epimers were synthesized and screened against a panel of human cancer cell lines. They exhibited a range of cytotoxicity against various human cancer cell lines thereby leading to the development of a possible SAR. One
H P T Ammon
Phytomedicine : international journal of phytotherapy and phytopharmacology, 17(11), 862-867 (2010-08-11)
Extracts from the gum resin of Boswellia serrata and some of is constituents including boswellic acids affect the immune system in different ways. Among the various boswellic acids 11-keto-beta-boswellic acid (KBA) and acetyl-11-keto-beta-boswellic acid have been observed to be active.
Dhaneshwar Suneela et al.
Bioorganic & medicinal chemistry letters, 22(24), 7582-7587 (2012-10-31)
Rhein, an active metabolite of diacerein, down-regulates the gene-expression and production of pro-matrix metalloproteinases and up-regulates the tissue inhibitors of metalloproteinase-1 production. The therapeutic effects of diacerein on osteoarthritis are, at least in part, due to the chondroprotective effect of
Jan Hüsch et al.
Journal of natural products, 75(10), 1675-1682 (2012-09-28)
Boswellia serrata gum resin extracts are used widely for the treatment of inflammatory diseases. However, very low concentrations in the plasma and brain were observed for the boswellic acids (1-6, the active constituents of B. serrata). The present study investigated
Miao Liu et al.
Parasitology research, 112(3), 1105-1111 (2012-12-29)
Granuloma formation has been shown to be induced and elicited by schistosome egg antigens, and it finally develops into fibrosis in intestine and the liver. Hepatic fibrosis is the main cause of increased morbidity and mortality in humans infected with
G K Reddy et al.
The Italian journal of biochemistry, 36(4), 205-217 (1987-07-01)
The effect of new non-steroidal anti-inflammatory agents on lysosomal stability was studied by determining the activity of beta-glucuronidase, a typical lysosomal enzyme, in various sub-cellular fractions and its release from the lysosome-rich fraction. Adjuvant arthritic animals showed a significant increase
Sheema Khan et al.
European journal of pharmacology, 660(2-3), 241-248 (2011-03-29)
The p53 tumor suppressor pathway is disrupted by human papillomavirus (HPV) in over 90% of cervical cancers. HPV E6 protein promotes the degradation of p53 thereby inhibiting its stabilization and activation. This study demonstrates that treatment with a novel cyano
Simon Kirste et al.
Cancer, 117(16), 3788-3795 (2011-02-03)
Patients irradiated for brain tumors often suffer from cerebral edema and are usually treated with dexamethasone, which has various side effects. To investigate the activity of Boswellia serrata (BS) in radiotherapy-related edema, we conducted a prospective, randomized, placebo-controlled, double-blind, pilot
Oveis Karima et al.
FEBS letters, 586(23), 4132-4138 (2012-10-27)
Structural integrity of microtubule protein (MTP) is pivotal for its physiological roles. Disruption of the MTP network is known to be involved in neurodegenerative disorders. The gum resin of plants of the boswellia species, with β-boswellic acid (BBA) as the
Dinesh Khanna et al.
Current opinion in pharmacology, 7(3), 344-351 (2007-05-04)
Arthritis, an inflammation of the joints, is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines (e.g. tumour necrosis factor and interleukin-1beta) and pro-inflammatory enzymes that mediate the production of prostaglandins (e.g. cyclooxygenase-2) and leukotrienes (e.g. lipooxygenase), together
S S Agrawal et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 49(9), 1924-1934 (2011-04-26)
Boswellic acid (BA), a triterpene, isolated from Boswellia serrata (Burseraceae) has been found to possess potent anti-inflammatory and anti-cancer activity. The present study aimed at exploring the possible role of BA on ascites and solid Ehrlich tumor. Ascitic tumor development
Ajmeera Rama Rao et al.
Phytotherapy research : PTR, 27(5), 753-760 (2012-07-25)
The polyol enzyme aldose reductase (AR) and advanced glycation endproducts (AGEs) play an important role in diabetic complications such as cataracts. The purpose of this study was to investigate four standardized plant extracts used for the treatment of diabetes and
Kathleen Gerbeth et al.
Journal of pharmaceutical and biomedical analysis, 56(5), 998-1005 (2011-08-23)
Until now, dexamethasone is the medication of choice to reduce peritumoral edema associated with primary and secondary brain tumors. Because of the severe side effects accompanying such a treatment the interest in alternative agents that may be co-administered with glucocorticoids
Amrita Sharma et al.
Drug delivery, 17(8), 587-595 (2010-07-14)
Boswellic acids (BAs) are isolated from oleo gum resin of Boswellia serrata and are reported to be effective as anti-inflammatory, hypolipidemic, immunomodulatory, and anti-tumor. Pharmacokinetic studies of boswellic acid reveal its poor absorption through the intestine. The objective of the
Acton A.Q et al.
Intracellular Membranes?Advances in Research and Application: 2013 Edition (2013)
Nishant Kumar Gupta et al.
Archives of dermatological research, 303(2), 89-101 (2010-11-19)
Creams and gels containing curcumin are popularized worldwide and marketed all over the world, but even after incorporation of high amount of curcumin in topical formulations, significant antioxidant and anti-aging effect could not be achieved. Objective of the present study
Angela Notarnicola et al.
Advances in therapy, 28(10), 894-906 (2011-10-12)
Osteoarthritis is a chronic rheumatoid disease mediated by metalloproteinases and inflammatory cytokines. Methylsulfonylmethane (MSM) and boswellic acids (BA) each show promise in the treatment of inflammatory processes, but the efficacy of combined treatment with these substances in the treatment of
Yasrib Qurishi et al.
Future oncology (London, England), 8(7), 867-881 (2012-07-27)
Apoptotic induction in cancer cells has become a major focus of anticancer therapeutics. In this regard, β-boswellic acids, naturally occurring pentacyclic triterpenes, have demonstrated antiproliferative and cytotoxic effects against different types of cancers. Surprisingly, not much has been reported regarding
Feng Wang et al.
Journal of Asian natural products research, 13(3), 193-197 (2011-03-17)
Two new triterpenoids, 3-oxotirucalla-7,9(11),24-trien-21-oic acid (1) and 18Hα,3β,20β-ursanediol (2), along with 15 known triterpenes, α-amyrin, α-boswellic acid, β-boswellic acid, acetyl α-boswellic acid, acetyl β-boswellic acid, 9,11-dehydro-β-boswellic acid, 9,11-dehydro-α-boswellic acid, acetyl 11α-methoxy-β-boswellic acid, 11-keto-β-boswellic acid, acetyl 11-keto-β-boswellic acid, acetyl α-elemolic acid
Sarita Saraswati et al.
Microvascular research, 82(3), 263-268 (2011-08-26)
The aim of the present study was to investigate the effects of boswellic acid (BA) on key components of inflammatory angiogenesis in the murine cannulated sponge implant angiogenesis model. Polyester-polyurethane sponges, used as a framework for fibrovascular tissue growth, were
Chun Wang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(10), 1330-1333 (2011-08-16)
To develop an HPLC method for determinating the contents of five boswellic acids in Boswellia serrata. Analysis was performed on a zorbax SB C18 column eluted with acetonitrile-0.1% phosphoric acid in water as mobile phases in gradient elution and the
Anti-tumor and anti-carcinogenic activities of triterpenoid,\beta-boswellic acid
Huang T-M, et al. et al.
Biofactors, 13, 225- 230 (2000)
U Siemoneit et al.
British journal of pharmacology, 162(1), 147-162 (2010-09-16)
Frankincense, the gum resin derived from Boswellia species, showed anti-inflammatory efficacy in animal models and in pilot clinical studies. Boswellic acids (BAs) are assumed to be responsible for these effects but their anti-inflammatory efficacy in vivo and their molecular modes
Arne Henkel et al.
Biochemical pharmacology, 83(1), 115-121 (2011-10-18)
Lipophilic extracts of gum resins of Boswellia species (BSE) are used in folk medicine to treat various inflammatory disorders and infections. The molecular background of the beneficial pharmacological effects of such extracts is still unclear. Various boswellic acids (BAs) have
Rajbir Kaur et al.
European journal of medicinal chemistry, 46(4), 1356-1366 (2011-02-22)
Semi-synthetic analogues of β-boswellic acid (BA) and 11-keto-β-boswellic acid (KBA) were comparatively evaluated for in vitro cytotoxicity against human myeloid leukaemia (HL-60) and human cervical carcinoma (HeLa) cells. 2-Cyano analogues of both the triterpenes were observed to have significant cytotoxicity
L Del Pup
Minerva ginecologica, 62(4), 287-291 (2010-09-10)
It is sometimes difficult to treat vulvovaginal itching and dryness, which represent frustrating symptoms for both patients and doctors. In case that the etiological agent is Candida albicans, effective antimycotic therapies are available; however, itching is often caused by aspecific
M Abasi et al.
Neuroscience, 222, 404-416 (2012-07-18)
Parkinson's disease (PD) is a neurodegenerative disorder in which the nigro-striatal dopaminergic (DAergic) neurons have been selectively lost. Due to side effects of levodopa, a dopamine precursor drug, recently cell replacement therapy for PD has been considered. Lack of sufficient
Masanobu Takahashi et al.
Carcinogenesis, 33(12), 2441-2449 (2012-09-18)
Colorectal cancer (CRC) is a complex disease with genetic and epigenetic alterations in many key oncogenes and tumor suppressor genes. The active principle of a gum resin from Boswellia serrata, 3-acetyl-11-keto-β-boswellic acid (AKBA), has recently gained attention as a chemopreventive
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