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82870
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Showing 1-30 of 91 results for "82870" within Papers
Assay of Ornithine Decarboxylase and Spermidine/Spermine N1-acetyltransferase Activities
Bio-protocol (2014)
Anaerobe, 35(Pt A), 21-27 (2014-10-05)
Periodontitis is a polymicrobial anaerobe infection. Little is known about the dysbiotic microbiota and the role of bacterial metabolites in the disease process. It is suggested that the production of certain waste products in the proteolytic metabolism may work as
Regulation and function of pyridoxal phosphate in CNS
Neurochemistry International, 3(3-4), 207-209 (1981)
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(47), 15764-15778 (2014-11-21)
Rheb1 is an immediate early gene that functions to activate mammalian target of rapamycin (mTor) selectively in complex 1 (mTORC1). We have demonstrated previously that Rheb1 is essential for myelination in the CNS using a Nestin-Cre driver line that deletes
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(43), 14501-14516 (2015-10-30)
Canavan disease (CD) is a severe, lethal leukodystrophy caused by deficiency in aspartoacylase (ASPA), which hydrolyzes N-acetylaspartate (NAA). In the brains of CD patients, NAA accumulates to high millimolar concentrations. The pathology of the disease is characterized by loss of
Cancer research, 74(24), 7442-7452 (2014-10-23)
Few studies have examined associations between plasma choline metabolites and risk of colorectal cancer. Therefore, we investigated associations between plasma biomarkers of choline metabolism [choline, betaine, dimethylglycine, and trimethylamine N-oxide (TMAO)] and colorectal cancer risk among postmenopausal women in a
Journal of dairy science, 99(3), 1884-1894 (2016-01-18)
Effects of forage family (legume vs. grass) on apparent ruminal synthesis (ARS) and postruminal supply of B vitamins were evaluated in 2 experiments. Diets containing either alfalfa (AL) or orchardgrass (OG) silages as the sole forage were offered to ruminally
Vitamin B6 biosynthesis: charting the mechanistic landscape.
Chembiochem : a European journal of chemical biology, 11(9), 1185-1193 (2010-04-17)
Applied and environmental microbiology, 81(5), 1610-1615 (2014-12-21)
Abrin is a toxic protein produced by the ornamental plant Abrus precatorius, and it is of concern as a biothreat agent. The small coextracting molecule N-methyl-l-tryptophan (l-abrine) is specific to members of the genus Abrus and thus can be used
The new microbiologica, 38(2), 259-266 (2015-05-06)
The bacterial species Streptococcus mutans is known as the main cause of dental caries in humans. Therefore, much effort has focused on preventing oral colonization by this strain or clearing it from oral tissues. The oral cavity is colonized by
The Journal of general virology, 96(Pt 2), 294-310 (2014-10-30)
Chikungunya virus (CHIKV) has recently affected millions of people in the Indian Ocean, with rare cases of encephalopathy and encephalitis occurring in neonates. In the study described herein, the capacity of mouse brain cells to control infection through innate immune
Microbial cell factories, 14, 86-86 (2015-06-14)
The overexpression of key enzymes in a metabolic pathway is a frequently used genetic engineering strategy for strain improvement. Metabolic control analysis has been proposed to quantitatively determine key enzymes. However, the lack of quality data often makes it difficult
The FEBS journal, 282(13), 2512-2526 (2015-04-08)
We have analyzed the natural evolution of transaminase structure and sequence between an Ī±-transaminase serine-pyruvate aminotransferase and an Ļ-transaminase from Chromobacterium violaceum with < 20% sequence identity, and identified the active-site regions that are least conserved structurally. We also show
Transplantation, 99(4), 687-692 (2015-01-22)
For managing major limb amputation, it is important to consider ischemic time and reperfusion injury by free radicals after the blood supply is reestablished. State of preservation during transplant surgery is crucial for the survival and function of the tissue
Glia, 63(10), 1840-1849 (2015-05-07)
Wnt signaling plays an essential role in developmental and regenerative myelination of the CNS, therefore it is critical to understand how the factors associated with the various regulatory layers of this complex pathway contribute to these processes. Recently, Apcdd1 was
Hydrogen sulfide accelerates the recovery of kidney tubules after renal ischemia/reperfusion injury.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30(9), 1497-1506 (2015-07-05)
Progression of acute kidney injury to chronic kidney disease (CKD) is associated with inadequate recovery of damaged kidney. Hydrogen sulfide (H2S) regulates a variety of cellular signals involved in cell death, differentiation and proliferation. This study aimed to identify the
Neurology, 84(2), 148-158 (2014-12-17)
To assess, in a surgical biopsy cohort of active demyelinating lesions, the diagnostic utility of aquaporin-4 (AQP4) immunohistochemistry in identifying neuromyelitis optica (NMO) or NMO spectrum disorder (NMOSD) and describe pathologic features that should prompt AQP4 immunohistochemical analysis and AQP4-immunoglobulin
Biotechnology and applied biochemistry, 62(4), 514-522 (2014-10-03)
L-Homoalanine, a nonnatural amino acid that is rarely found in human and microorganisms, is used in the synthesis of various medically pivotal antiepileptic drugs and antituberculosis compounds. l-Homoalanine can be synthesized by different enzymatic approaches. In this article, the synthesis
Glia, 63(2), 242-256 (2014-08-27)
Central nervous system remyelination by oligodendrocyte progenitor cells (OPCs) ultimately fails in the majority of multiple sclerosis (MS) lesions. Remyelination benefits from transient expression of factors that promote migration and proliferation of OPCs, which may include fibronectin (Fn). Fn is
Journal of pharmaceutical sciences, 104(2), 714-721 (2014-12-03)
Soluble antigen arrays (SAgAs) were developed for treating mice with experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. SAgAs are composed of hyaluronan with grafted EAE antigen and LABL peptide (a ligand of ICAM-1). SAgA dose was tested
PloS one, 10(5), e0127222-e0127222 (2015-05-13)
NG2 protein-expressing oligodendrocyte progenitor cells (OPC) are a persisting and major glial cell population in the adult mammalian brain. Direct synaptic innervation of OPC by neurons throughout the brain together with their ability to sense neuronal network activity raises the
Pharmacology, biochemistry, and behavior, 126, 146-151 (2014-09-17)
N(6)-(3-methoxyl-4-hydroxybenzyl) adenine riboside (B2) is an analog of N(6)-(4-hydroxybenzyl) adenine riboside (NHBA), which was originally isolated from Gastrodia elata Blume. Our laboratory has previously demonstrated that B2 can produce strong sedative and hypnotic effects, but the mechanism remains to be
Clinica chimica acta; international journal of clinical chemistry, 506, 129-134 (2020-03-22)
The active coenzymes of the water soluble vitamins B1 and B6 (thiamine pyrophosphate (TPP) and pyridoxal-5-phosphate (P5P) respectively) play an important role in numerous bodily functions. The simultaneous analysis of both these analytes is limited to either mass spectrometry based
Apoptosis : an international journal on programmed cell death, 20(10), 1388-1409 (2015-08-20)
Allicin, an extremely active constituent of freshly crushed garlic, is produced upon reaction of substrate alliin with the enzyme alliinase (EC 4.4.1.4). Allicin has been shown to be toxic to several mammalian cells in vitro in a dose-dependent manner. In
Microbiome, 8(1), 120-120 (2020-08-21)
Autism spectrum disorder (ASD) is a developmental disorder, and the effective pharmacological treatments for the core autistic symptoms are currently limited. Increasing evidence, particularly that from clinical studies on ASD patients, suggests a functional link between the gut microbiota and
Nutritional Deficiencies and Syndromes Associated with Alcoholism
Textbook of Clinical Neurology, 897-917 (2007)
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(5), 2246-2254 (2015-02-06)
Rapid nerve conduction in myelinated nerves requires the clustering of voltage-gated sodium channels at nodes of Ranvier. The Neurofascin (Nfasc) gene has a unique role in node formation because it encodes glial and neuronal isoforms of neurofascin (Nfasc155 and Nfasc186
Pyridoxal-5′-phosphate-dependent enzymes involved in biotin biosynthesis: Structure, reaction mechanism and inhibition.
Biochemical and Biophysical Research Communications, 1814(11), 1459-1466 (2010)
Biochemistry, 56(10), 1518-1528 (2017-02-12)
Cuprizone intoxication is a common animal model used to test myelin regenerative therapies for the treatment of diseases such as multiple sclerosis. Mice fed this copper chelator develop reversible, region-specific oligodendrocyte loss and demyelination. While the cellular changes influencing the
Journal of neuropathology and experimental neurology, 74(8), 756-766 (2015-06-27)
Remyelination capacity decreases with age in adult mice, but data comparing remyelination capacity after toxic demyelination in developing mice versus adult mice are not available. We treated 3-week-old and adult C57BL/6 mice with cuprizone for 1 to 5 weeks and
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