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Showing 1-30 of 1097 results for "83273" within Papers
Kevin Y Lin et al.
ACS nano, 8(9), 8776-8785 (2014-08-15)
Antithrombotic therapy is a critical portion of the treatment regime for a number of life-threatening conditions, including cardiovascular disease, stroke, and cancer; yet, proper clinical management of anticoagulation remains a challenge because existing agents increase the propensity for bleeding in
Svetlana Iskovich et al.
Cell transplantation, 24(5), 879-890 (2014-01-02)
We have recently reported that small-sized bone marrow cells (BMCs) isolated by counterflow centrifugal elutriation and depleted of lineage markers (Fr25lin(-)) have the capacity to differentiate and contribute to regeneration of injured islets. In this study, we assess some of
Jaseer Muhamed et al.
Toxicologic pathology, 43(4), 536-545 (2014-10-17)
Comparative histomorphological assessment of local response to implanted reference biomaterial, also called biocompatibility testing/evaluation, in an appropriate animal model is a widely practiced safety evaluation procedure performed on biomaterials before clinical use. Standardized protocols and procedures, originally designed for testing
David Faraoni et al.
Anesthesia and analgesia, 121(2), 486-491 (2015-06-08)
In this pilot study, we hypothesized that velocity parameters obtained from changes in clot amplitude (A) and clot elasticity (E) measured with thromboelastometry (ROTEM, Tem International GmbH, Munich, Germany) could improve detection of fibrinolysis in whole blood obtained from children
Simon Fischer et al.
RNA biology, 12(3), 238-247 (2015-04-01)
Understanding the multifaceted nature of microRNA (miRNA) function in mammalian cells is still a challenge. Commonly accepted principles of cooperativity and multiplicity of miRNA function imply that individual mRNAs can be targeted by several miRNAs whereas a single miRNA may
Juraiporn Somboonwong et al.
Life sciences, 139, 46-51 (2015-08-19)
Diabetes mellitus is associated with disturbed zinc homeostasis and down-regulation of zinc transporter 8 (ZnT8); these changes contribute to the defective biosynthesis, storage, and secretion of insulin. Previous studies have reported an improvement in diabetic status and insulin levels in
L Anel-López et al.
Animal reproduction science, 162, 73-79 (2015-10-18)
The potential protective effect of reduced glutathione (GSH) and trolox (TRX), an analogue of vitamin E, supplementation during in vitro culture (2h, 39°C) of electroejaculated frozen/thawed red deer sperm was investigated. Cryopreserved sperm were thawed and incubated with no additive
Rabia Soussi et al.
Brain structure & function, 220(4), 2449-2468 (2014-06-04)
In mesial temporal lobe epilepsy (MTLE), spontaneous seizures likely originate from a multi-structural epileptogenic zone, including several regions of the limbic system connected to the hippocampal formation. In this study, we investigate the structural connectivity between the supramammillary nucleus (SuM)
Alireza Zandifar et al.
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 20(3), 233-238 (2015-06-26)
Diabetes is associated with endothelial dysfunction and impaired wound healing. The amino acid L-arginine is the only substrate for nitric oxide (NO) synthesis. The purpose of this study was to compare the topical versus systemic L-arginine treatment on total nitrite
D Tsakogiannis et al.
Journal of medical virology, 87(11), 1973-1980 (2015-05-12)
Integration of HPV16 DNA into the host chromosome usually disrupts the E1 and/or E2 genes. The present study investigated the disruption of E1, E2 genes in a total of eighty four HPV16-positive precancerous and cervical cancer specimens derived from Greek
Rodrigo Moretto Galazzi et al.
Talanta, 146, 795-800 (2015-12-24)
To determine whether the effect observed in a study is related to the nanoparticle only or to their synergic effect with the "free" metal ions, the real concentration of silver (104±8 and 100±2 mg L(-1)) after AgNP synthesis is obtained
Sanjeev Noel et al.
Shock (Augusta, Ga.), 42(5), 392-399 (2014-08-12)
Nuclear factor erythroid 2-related factor 2 (NRF2) has been shown to protect against experimental sepsis in mice and lipopolysaccharide (LPS)-induced inflammation in ex vivo white blood cells from healthy subjects by upregulating cellular antioxidant genes. The objective of this study
Gael Hamot et al.
Biopreservation and biobanking, 13(3), 152-163 (2015-04-02)
This article is part of a series of publications providing formal method validation for biospecimen processing in the context of accreditation in laboratories and biobanks. We report the optimization and validation for fitness-for-purpose of automated and manual protocols for isolating
F-P Chen et al.
Climacteric : the journal of the International Menopause Society, 17(6), 682-691 (2014-07-01)
To explore the effect and pathway of phytoestrogens in vitro on the growth of both normal and malignant breast cells. Normal breast MCF-10A cells and breast cancer MCF-7 cells were incubated with 10 (-10)-10(-4)  mol/l genistein, resveratrol, and quercetin (plasma
Fiona Connolly et al.
PloS one, 10(7), e0132113-e0132113 (2015-07-07)
Increased maternal androgen exposure during pregnancy programmes a polycystic ovary syndrome (PCOS)-like condition, with metabolic dysfunction, in adult female offspring. Other in utero exposures associated with the development of insulin resistance, such as intrauterine growth restriction and exposure to prenatal
Maria Magnusson et al.
Thrombosis research, 135(2), 382-387 (2014-12-30)
The aim of this study was to evaluate if real-time thrombin generation assay provides additional information to assess the hemostatic balance in children with liver disease as compared to routine coagulation tests. Sixty-three children with chronic liver disease were enrolled
Kenji Miki et al.
International immunopharmacology, 23(2), 499-504 (2014-10-07)
Dendritic cell (DC) vaccine is a promising immunotherapy for cancer due to its ability to induce antigen-specific CTLs efficiently. However, a number of clinical studies have implied insufficient therapeutic benefits with the use of MHC class 1 restricted peptide-pulsed DC
Yosuke Fukutani et al.
Analytical biochemistry, 471, 1-8 (2014-12-03)
Olfaction depends on the selectivity and sensitivity of olfactory receptors. Previous attempts at constructing a mammalian olfactory receptor-based artificial odorant sensing system in the budding yeast Saccharomyces cerevisiae suffered from low sensitivity and activity. This result may be at least
Jacek Klepacki et al.
Clinica chimica acta; international journal of clinical chemistry, 446, 43-53 (2015-04-15)
Previous studies have examined and documented fluctuations in urine metabolites in response to disease processes and drug toxicity affecting glomerular filtration, tubule cell metabolism, reabsorption, oxidative stress, purine degradation, active secretion and kidney amino acylase activity representative of diminished renal
Bongani B Nkambule et al.
Platelets, 26(3), 250-257 (2014-05-17)
Human immunodeficiency deficiency virus (HIV) infection is associated with chronic inflammation and an increased risk of thrombotic events. Activated platelets (PLTs) play an important role in both thrombosis and inflammation, and HIV has been shown to induce PLT activation by
Per Ole Iversen et al.
Thrombosis and haemostasis, 114(5), 964-968 (2015-07-24)
Tetraplegic patients have increased risk of venous thrombosis despite anti-thrombotic prophylaxis. Moreover, they have blunted plasma variations in melatonin and altered diurnal variation of several haemostatic markers, compared with able-bodied. However, whether healthy individuals and tetraplegic patients, with or without
Sergio de Cima et al.
Scientific reports, 5, 16950-16950 (2015-11-26)
Human carbamoyl phosphate synthetase (CPS1), a 1500-residue multidomain enzyme, catalyzes the first step of ammonia detoxification to urea requiring N-acetyl-L-glutamate (NAG) as essential activator to prevent ammonia/amino acids depletion. Here we present the crystal structures of CPS1 in the absence
Betzabeth Pereira et al.
Journal of ethnopharmacology, 160, 6-13 (2014-12-03)
Brownea grandiceps flowers are used in Venezuelan folk medicine as anti-hemorrhagic in women with heavy menstrual blood loss (menorrhagia). However, prior to this study, there were no scientific investigations to support this fact, because the aqueous extract from Brownea grandiceps
Jin Wu et al.
International journal of molecular sciences, 16(11), 26914-26926 (2015-11-17)
Kv1.5 (also known as KCNA5) is a protein encoded by the KCNA5 gene, which belongs to the voltage-gated potassium channel, shaker-related subfamily. Recently, a number of studies have suggested that Kv1.5 is overexpressed in numerous cancers and plays crucial roles
Xiaohua Dai et al.
Scientific reports, 5, 10180-10180 (2015-05-20)
TGF-β signaling plays critical roles in the pathogenesis of aneurysms; however, it is still unclear whether its role is protective or destructive. In this study, we investigate the role of SMAD3 in the pathogenesis of calcium chloride (CaCl2)-induced abdominal aortic
Jorge Arasa et al.
Experimental dermatology, 23(8), 555-560 (2014-06-04)
The nucleoside adenosine is a known regulator of immunity and inflammation that mediates, at least in part, the anti-inflammatory effect of methotrexate, an immunosuppressive agent widely used to treat autoimmune inflammatory diseases. Adenosine A2A receptors play a key role in
Xi-Feng Zhang et al.
International journal of nanomedicine, 10, 7057-7071 (2015-12-02)
Silver nanoparticles (AgNPs) have attracted much interest and have been used for antibacterial, antifungal, anticancer, and antiangiogenic applications because of their unique properties. The increased usage of AgNPs leads to a potential hazard to human health. However, the potential effects
Nick Anim-Nyame et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 31(10), 788-791 (2015-07-15)
Endothelial dysfunction and insulin resistance (IR) are established features of pre-eclampsia, however the cause and effect relationship between them remain unexplained. Circulating endothelial cells (CEC) are increased in pre-eclampsia and appear to correlate with the degree of endothelial dysfunction. We
Juhui Ko et al.
Journal of hazardous materials, 285, 11-17 (2014-12-03)
Aflatoxin B1 (AFB1) is a well-known carcinogenic contaminant in foods. It is classified as an extremely hazardous compound because of its potential toxicity to the human nervous system. AFB1 has also been extensively used as a biochemical marker to evaluate
Tao Guo et al.
Molecular medicine reports, 12(3), 3285-3296 (2015-05-26)
The present study was performed to examine the association of the angiopoietin-like protein 8 (ANGPTL8) rs2278426 single nucleotide polymorphism (SNP) and several environmental factors with serum lipid profiles in the Mulao and Han populations. A total of 879 individuals of
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