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Showing 1-30 of 112 results for "856177" within Papers
Claudia Montllor-Albalate et al.
Redox biology, 21, 101064-101064 (2018-12-24)
Cu/Zn Superoxide Dismutase (Sod1) is a highly conserved and abundant metalloenzyme that catalyzes the disproportionation of superoxide radicals into hydrogen peroxide and molecular oxygen. As a consequence, Sod1 serves dual roles in oxidative stress protection and redox signaling by both
Jiasheng Zhang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(3), 557-568 (2019-11-30)
Mitochondria are important sources of energy, but they are also the target of cellular stress, toxin exposure, and aging-related injury. Persistent accumulation of damaged mitochondria has been implicated in many neurodegenerative diseases. One highly conserved mechanism to clear damaged mitochondria
Ahruem Baek et al.
Autophagy, 13(2), 248-263 (2017-01-04)
Contribution of autophagy and regulation of related proteins to the degeneration of retinal pigment epithelium (RPE) in age-related macular degeneration (AMD) remain unknown. We report that upregulation of KRT8 (keratin 8) as well as its phosphorylation are accompanied with autophagy
Yan Wang et al.
Autophagy, 11(12), 2259-2274 (2015-11-15)
Microtubules, the major components of cytoskeleton, are involved in various fundamental biological processes in plants. Recent studies in mammalian cells have revealed the importance of microtubule cytoskeleton in autophagy. However, little is known about the roles of microtubules in plant
Andrey A Parkhitko et al.
eLife, 9 (2020-12-16)
Aging is characterized by extensive metabolic reprogramming. To identify metabolic pathways associated with aging, we analyzed age-dependent changes in the metabolomes of long-lived Drosophila melanogaster. Among the metabolites that changed, levels of tyrosine were increased with age in long-lived flies.
Aracely Garcia-Garcia et al.
Toxicological sciences : an official journal of the Society of Toxicology, 136(1), 166-182 (2013-09-03)
Controversial reports on the role of autophagy as a survival or cell death mechanism in dopaminergic cell death induced by parkinsonian toxins exist. We investigated the alterations in autophagic flux and the role of autophagy protein 5 (Atg5)-dependent autophagy in
Queenie Hu et al.
G3 (Bethesda, Md.), 8(12), 3857-3863 (2018-10-10)
The overproduction of reactive oxygen species (ROS) in cells can lead to the development of diseases associated with aging. We have previously shown that C. elegans BRAP-2 (Brca1 associated binding protein 2) regulates phase II detoxification genes such as gst-4
Dong Suk Yoon et al.
Bio-protocol, 8(6) (2018-05-11)
Reactive oxygen species (ROS) are generated during normal metabolic processes under aerobic conditions. Since ROS production initiates harmful radical chain reactions on cellular macromolecules, including lipid peroxidation, DNA mutation, and protein denaturation, it has been implicated in a wide spectrum
Michael M Mueller et al.
Nature cell biology, 16(12), 1168-1179 (2014-11-25)
Genome maintenance defects cause complex disease phenotypes characterized by developmental failure, cancer susceptibility and premature ageing. It remains poorly understood how DNA damage responses function during organismal development and maintain tissue functionality when DNA damage accumulates with ageing. Here we
Human Riahi et al.
PLoS biology, 17(3), e2006146-e2006146 (2019-03-13)
Stress responses are crucial processes that require activation of genetic programs that protect from the stressor. Stress responses are also energy consuming and can thus be deleterious to the organism. The mechanisms coordinating energy consumption during stress response in multicellular
S Dong et al.
Nature communications, 11(1), 645-645 (2020-02-02)
Autophagy malfunctioning occurs in multiple human disorders, making attractive the idea of chemically modulating it with therapeutic purposes. However, for many types of autophagy, a clear understanding of tissue-specific differences in their activity and regulation is missing because of lack
Laura Álvarez-Fraga et al.
Virulence, 9(1), 496-509 (2018-01-16)
Acinetobacter baumannii has emerged in the last decade as an important nosocomial pathogen. To identify genes involved in the course of a pneumonia infection, gene expression profiles were obtained from A. baumannii ATCC 17978 grown in mouse infected lungs and
David J Turner et al.
The CRISPR journal, 4(3), 427-437 (2021-06-08)
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 genome editing system has been broadly adopted for high-throughput genetic screens. However, the application of genome-wide single guide RNA (sgRNA) libraries can be challenging. We generated a custom sgRNA library, an order
Chih-Chuan Lin et al.
PloS one, 16(4), e0234591-e0234591 (2021-04-02)
Paraquat (PQ) is a highly lethal herbicide. Ingestion of large quantities of PQ usually results in cardiovascular collapse and eventual mortality. Recent pieces of evidence indicate possible involvement of oxidative stress- and inflammation-related factors in PQ-induced cardiac toxicity. However, little
Dorival Martins et al.
Frontiers in microbiology, 11, 576708-576708 (2020-10-27)
Stressors and environmental cues shape the physiological state of bacteria, and thus how they subsequently respond to antibiotic toxicity. To understand how superoxide stress can modulate survival to bactericidal antibiotics, we examined the effect of intracellular superoxide generators, paraquat and
Laura Knuppertz et al.
Autophagy, 10(5), 822-834 (2014-03-04)
The filamentous ascomycete Podospora anserina is a well-established aging model in which a variety of different pathways, including those involved in the control of respiration, ROS generation and scavenging, DNA maintenance, proteostasis, mitochondrial dynamics, and programmed cell death have previously
Shilpi Khare et al.
Mechanisms of ageing and development, 130(10), 670-680 (2009-08-18)
We have shown that Caenorhabditis elegans lacking the PCM-1 protein repair l-isoaspartyl methyltransferase are more sensitive to oxidative stress than wild-type nematodes. Exposure to the redox-cycling quinone juglone upon exit from dauer diapause results in defective egg-laying (Egl phenotype) in
Zaijun Ma et al.
eLife, 7 (2018-05-29)
Epigenetic alteration has been implicated in aging. However, the mechanism by which epigenetic change impacts aging remains to be understood. H3K27me3, a highly conserved histone modification signifying transcriptional repression, is marked and maintained by Polycomb Repressive Complexes (PRCs). Here, we
Hao Wang et al.
Plant physiology, 172(2), 1003-1018 (2016-08-18)
Post-Golgi protein sorting and trafficking to the plasma membrane (PM) is generally believed to occur via the trans-Golgi network (TGN). In this study using Nicotiana tabacum pectin methylesterase (NtPPME1) as a marker, we have identified a TGN-independent polar exocytosis pathway
Susanna Maria Früh et al.
Nature communications, 6, 7275-7275 (2015-06-05)
Fibronectin fibrils within the extracellular matrix play central roles in physiological and pathological processes, yet many structural details about their hierarchical and molecular assembly remain unknown. Here we combine site-specific protein labelling with single-molecule localization by stepwise photobleaching or direct
Teresa Z Rzezniczak et al.
G3 (Bethesda, Md.), 2(12), 1613-1623 (2013-01-01)
Interactions across biological networks are often quantified under a single set of conditions; however, cellular behaviors are dynamic and interactions can be expected to change in response to molecular context and environment. To determine the consistency of network interactions, we
Pin-Chao Liao et al.
STAR protocols, 1(3), 100160-100160 (2020-12-31)
The redox state of mitochondria is one indicator of the functional state of the organelles. Mitochondria are also the primary endogenous source of reactive oxygen species (ROS). Therefore, the redox state of the organelles also reflects their function in ROS
Isaak E Müller et al.
Nature communications, 10(1), 4028-4028 (2019-09-08)
Crosstalk is a major challenge to engineering sophisticated synthetic gene networks. A common approach is to insulate signal-transduction pathways by minimizing molecular-level crosstalk between endogenous and synthetic genetic components, but this strategy can be difficult to apply in the context
Yaofang Niu et al.
Plant, cell & environment, 37(12), 2795-2813 (2014-05-24)
Root hairs are reported to be plastic in response to nutrient supply, but relatively little is known about their development in response to magnesium (Mg) availability. Here, we showed that development of root hairs of Arabidopsis decreased progressively with increasing
Pablo Torti et al.
Plant science : an international journal of experimental plant biology, 300, 110626-110626 (2020-11-13)
The sunflower (Helianthus annuus L.) genome encodes six proteins containing a TLDc domain, typical of the eukaryotic OXidation Resistance (OXR) protein family. Expression of sunflower HaOXR2 in Arabidopsis generated plants with increased rosette diameter, higher number of leaves and increased
Prasanna V Ramachandran et al.
Developmental cell, 48(5), 685-696 (2019-02-05)
Lysosomes and mitochondria are both crucial cellular organelles for metabolic homeostasis and organism health. However, mechanisms linking their metabolic activities to promote organism longevity remain poorly understood. We discovered that the induction of specific lysosomal signaling mediated by a LIPL-4
Richard Meitern et al.
The Journal of experimental biology, 216(Pt 14), 2713-2721 (2013-04-13)
Oxidative stress (OS) is widely believed to be responsible for the generation of trade-offs in evolutionary ecology by means of constraining investment into a number of components of fitness. Yet, progress in understanding the true role of OS in ecology
Fumiaki Obata et al.
Nature communications, 9(1), 975-975 (2018-03-09)
Environmental stresses experienced during development exert many long-term effects upon health and disease. For example, chemical oxidants or genetic perturbations that induce low levels of reactive oxygen species can extend lifespan in several species. In some cases, the beneficial effects
Samantha W Alvarez et al.
Nature, 551(7682), 639-643 (2017-11-24)
Environmental nutrient levels impact cancer cell metabolism, resulting in context-dependent gene essentiality. Here, using loss-of-function screening based on RNA interference, we show that environmental oxygen levels are a major driver of differential essentiality between in vitro model systems and in
Yu-Chun Wang et al.
The Journal of biological chemistry, 286(24), 21742-21754 (2011-04-08)
Spinal cerebellar ataxia type 12 (SCA12) has been attributed to the elevated expression of ppp2r2b. To better elucidate the pathomechanism of the neuronal disorder and to search for a pharmacological treatment, Drosophila models of SCA12 were generated by overexpression of
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