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Showing 1-30 of 787 results for "861650" within Papers
Maurizio Portaluri et al.
International journal of radiation biology, 95(2), 201-206 (2018-11-16)
Left-sided breast cancer patients treated with radiotherapy (RT) are at risk for late radiation-induced cardiovascular complications. The aim of this study was to investigate the BNP plasma levels in long-term breast cancer survivors who received only RT as well to
Xu-Yong Zheng et al.
Acta pharmacologica Sinica, 41(8), 1093-1101 (2020-04-29)
Mechanisms of cardiomyopathy caused by obesity/hyperlipidemia are complicated. Obesity is usually associated with chronic low-grade inflammation and may lead to the onset and progression of myocardial fibrosis and remodeling. TLR4/MyD88 signaling pathway, as a key regulator of inflammation, plays an
Pilar Rodríguez-Rodríguez et al.
PloS one, 12(2), e0171544-e0171544 (2017-02-18)
Fetal undernutrition is a risk factor for heart disease in both genders, despite the protection of women against hypertension development. Using a rat model of maternal undernutrition (MUN) we aimed to assess possible sex differences in the development of cardiac
Vikas Kumar et al.
Scientific reports, 9(1), 13170-13170 (2019-09-13)
We examined the hitherto unexplored role of mitochondrial transporters and iron metabolism in advancing metabolic and mitochondrial dysfunction in the heart during long term pressure overload. We also investigated the link between mitochondrial dysfunction and fluctuation in mitochondrial transporters associated
Yi Wang et al.
Nature communications, 8, 13997-13997 (2017-01-04)
Obesity increases the risk for a number of diseases including cardiovascular diseases and type 2 diabetes. Excess saturated fatty acids (SFAs) in obesity play a significant role in cardiovascular diseases by activating innate immunity responses. However, the mechanisms by which
Fujie Zhao et al.
Cardiovascular therapeutics, 32(6), 283-296 (2014-10-17)
It is unclear whether nicorandil, a metabolic therapeutic drug, can be applied clinically to therapy of heart failure (HF). This meta-analysis evaluated therapeutic effects of nicorandil on HF patients. We performed a systematic review and meta-analysis of published studies evaluating
Alberto Palazzuoli et al.
Clinical research in cardiology : official journal of the German Cardiac Society, 109(11), 1423-1433 (2020-04-17)
The inverse relationship between body mass index (BMI) and natriuretic peptide levels complicates the diagnosis of heart failure (HF) in obese patients. Assessment of congestion with ultrasound could facilitate HF diagnosis but it is unclear if any relationship exists amongst
Tom J O'Donohoe et al.
Heart, lung & circulation, 28(4), 583-590 (2018-04-15)
Anti-myosin antibodies (AMAs) are often formed in response to myocardial infarction (MI) and have been implicated in maladaptive cardiac remodelling. We aimed to: (1) compare AMA formation in patients with Non-ST-Elevation MI (NSTEMI) and ST-Elevation MI (STEMI); (2) evaluate factors
Peder L Myhre et al.
Circulation. Heart failure, 13(1), e006638-e006638 (2020-01-21)
Spironolactone has been demonstrated to reduce heart failure (HF) hospitalization in patients with HF with preserved ejection fraction in the Americas region of the TOPCAT trial (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial). We assessed
Shunsuke Sasaki et al.
Journal of cardiology, 64(6), 476-481 (2014-05-08)
Elevated plasma B-type natriuretic peptide (BNP) is a predictor of outcome and helpful for risk stratification in aortic stenosis (AS). However, left ventricular (LV) diastolic dysfunction progresses with aging and may also influence plasma BNP levels in elderly patients. We
Yemao Zhang et al.
Frontiers in public health, 8, 87-87 (2020-04-23)
Background: Whether electromagnetic field (EMF) exposure affects the function of the cardiovascular system is under debate. The present study aimed to investigate the effects of 500 μT EMF exposure on the cardiovascular system in rats. Methods: Forty-eight-week-old male Sprague-Dawley rats
Yuen-Kwun Wong et al.
Cardiovascular diabetology, 18(1), 171-171 (2019-12-19)
High-sensitivity troponin I (hs-Tnl) and B-type natriuretic peptide (BNP) are promising prognostic markers for coronary artery disease (CAD). This prospective cohort study investigated whether a combination of these cardiac biomarkers with conventional risk factors would add incremental value for the
Wei Hu et al.
Experimental and therapeutic medicine, 9(5), 1901-1908 (2015-07-03)
This study was designed to assess any changes in the plasma concentrations of adrenomedullin (ADM) and atrial and brain natriuretic peptide (ANP and BNP, respectively), and to investigate their pathophysiological roles in patients with essential hypertension (EH). The plasma ADM
Elena Geuna et al.
Cancers, 12(2) (2020-02-07)
Angiotensin Converting Enzyme inhibitors (ACEis) and beta-blockers (BB) are suggested to prevent and treat trastuzumab-related cardiac toxicity. We performed a prospective clinical trial in women experiencing mild cardiac toxicity (MCT) while on adjuvant treatment with trastuzumab. MCT was defined as
Xiaoying Dong et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43(6), 2479-2488 (2017-11-14)
Cholecystokinin (CCK) is expressed in cardiomyocytes and may also play an important role in cardiovascular regulation. Clinical studies have shown that plasma CCK levels are an independent marker of cardiovascular mortality in cardiac disease. However, whether the development of postinfarction
Merrick Miles et al.
Journal of cardiac failure, 24(8), 525-532 (2018-05-20)
To determine the feasibility of peripheral intravenous volume analysis (PIVA) of venous waveforms for assessing volume overload in patients admitted to the hospital with acute decompensated heart failure (ADHF). Venous waveforms were captured from a peripheral intravenous catheter in subjects
Hiroyuki Naruse et al.
Journal of clinical medicine, 9(2) (2020-02-14)
We prospectively investigated the prognostic value of urinary liver-type fatty-acid-binding protein (L-FABP) levels on hospital admission, both independently and in combination with serum creatinine-defined acute kidney injury (AKI), to predict long-term adverse outcomes in 1119 heterogeneous patients (mean age; 68
John G F Cleland et al.
European journal of heart failure, 19(6), 739-747 (2017-03-16)
Plasma concentrations of B-type natriuretic peptide (BNP) and troponin are often measured for diagnostic purposes when patients are admitted with heart failure, but their prognostic value when measured soon after admission is uncertain. We aimed to investigate the added prognostic
Ethan Bernstein et al.
Journal of cardiothoracic and vascular anesthesia, 29(3), 611-616 (2015-04-08)
To assess the association of preoperative brain natriuretic peptide with atrial arrhythmias and length of stay after cardiac surgery. A retrospective data analysis. All data were collected from patients who underwent cardiac surgery at a single institution, an academic hospital
Yohsuke Hayama et al.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 33(5), 612-621 (2020-02-25)
In biventricular physiology, abnormal septal motion is a hallmark of mechanical dyssynchrony in the left bundle branch block. However, in single-ventricle (SV) physiology, morphologic variations in systemic ventricles pose a challenge in evaluating the negative impact of mechanical dyssynchrony. The
Evangelos Oikonomou et al.
Current vascular pharmacology, 17(4), 396-400 (2018-07-04)
Cardiac performance depends on optimum ventriculoarterial coupling which is impaired in patients with heart failure (HF). Galectin-3 is a mediator of myocardial fibrosis and remodeling, and is associated with clinical status in patients with chronic HF. We examined the association
Yili Chen et al.
Die Pharmazie, 69(11), 833-837 (2015-05-20)
Previous studies suggest that B-type natriuretic peptide (BNP) exerts inhibitory effects on cardiac hypertrophy. Our studies have shown that long-term treatment of rats with BNP attenuated cardiac hypertrophy via down-regulation of TGF-β1 and up-regulation of smad7. However, the mechanisms have
Masatoshi Minamisawa et al.
International heart journal, 57(1), 11-17 (2016-01-09)
Inflammatory biomarkers have been proposed for use in the risk stratification of patients with acute myocardial infarction (AMI). We examined the value of inflammatory biomarkers over clinical features for predicting cardiovascular (CV) events in stable outpatients with MI. We enrolled
Yao Wang et al.
Cardiovascular diagnosis and therapy, 10(5), 1313-1324 (2020-11-24)
Periprocedural myocardial infarction (PMI) after percutaneous coronary intervention (PCI) is associated with the bad prognosis in patients. Current approaches to predict PMI fail to identify many people who would benefit from preventive treatment, and machine learning (ML) offers opportunity to
Aditi Nayak et al.
Journal of the American Heart Association, 9(11), e016055-e016055 (2020-05-28)
Background Patients with ischemic cardiomyopathy (ICM) have worse outcomes than those with coronary artery disease alone and those with non-ICM. N8-acetylspermidine (N8AS) is a polyamine that regulates ischemic cardiac apoptosis and resultant cardiac dysfunction. We hypothesized that N8AS is a
Huimin Yang et al.
Diabetes, metabolic syndrome and obesity : targets and therapy, 13, 1147-1159 (2020-04-30)
A high-fat diet (HFD) can lead to cardiac dysfunction, hypertrophy, and fibrosis. This study aimed to explore microRNA expression profiles in the myocardium of HFD-induced obesity rat. Wistar rats were randomly divided into two groups, and fed with normal chow
Naoki Hayase et al.
Shock (Augusta, Ga.), 46(6), 642-648 (2016-07-06)
Excessive sympathetic stress has multiple adverse effects during critical illness including sepsis. Recent studies showed that heart rate control had a significant effect on reducing mortality in septic shock patients. Furthermore, elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in septic
Tsung-Jung Ho et al.
Environmental toxicology, 35(10), 1043-1049 (2020-05-18)
In this study, we used ICI 182 780 (ICI), an estrogen receptor (ER) antagonist, to investigate the estrogenic activity of Danshen, and to further explored whether Danshen extract can block Leu27IGF-II-induced hypertrophy in H9c2 cardiomyoblast cells. We first used an
Solid-State 17O NMR Spectroscopy of Large Protein-Ligand Complexes.
Zhu J, et al.
Angewandte Chemie (International Edition in English), 49(45), 8399-8402 (2010)
Insa E Emrich et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 34(1), 100-108 (2018-04-11)
Since the introduction of sacubitril/valsartan in clinical cardiology, neprilysin has become a major target for heart failure treatment. Plasma neprilysin concentration has been discussed as a novel biomarker that predicts cardiac events. Natriuretic peptides may inhibit plasma neprilysin. As they
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