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Showing 1-30 of 127 results for "86734" within Papers
Peter Martin et al.
Leukemia & lymphoma, 56(11), 3065-3070 (2015-03-11)
Milatuzumab (hLL1), a humanized anti-CD74 monoclonal antibody, has activity in preclinical non-Hodgkin lymphoma (NHL) models. We conducted a phase 1 trial in previously treated B-cell malignancies. Dose escalation included four planned dose levels (1.5, 4, 6 and 8 mg/kg) with
Marc Y Stevens et al.
Journal of neuroinflammation, 17(1), 275-275 (2020-09-20)
B cells play a central role in multiple sclerosis (MS) through production of injurious antibodies, secretion of pro-inflammatory cytokines, and antigen presentation. The therapeutic success of monoclonal antibodies (mAbs) targeting B cells in some but not all individuals suffering from
Nan Lyu et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 7(21), 2002330-2002330 (2020-11-12)
Endothelium can secrete vasoactive mediators and produce specific extracellular matrix, which contribute jointly to the thromboresistance and regulation of vascular cell behaviors. From a bionic point of view, introducing endothelium-like functions onto cardiovascular stents represents the most effective means to
Mona Sharar et al.
Analytical and bioanalytical chemistry, 409(8), 2015-2027 (2017-01-18)
Oxidative transformation of cysteine thiol groups into different functional groups is considered a significant posttranslational modification of great importance in pathological and physiological processes. A cysteine sulfenic acid (SA) residue is the transient state for thiol group oxidation and it
The synthesis and chelation chemistry of DOTA- peptide conjugates.
De Leon-Rodriguez LM and Kovacs Z
Bioconjugate Chemistry, 19(2), 391-402 (2007)
Grace Kong et al.
Journal of pediatric hematology/oncology, 38(2), 87-96 (2015-08-22)
Pediatric patients with refractory neuroblastoma have limited therapeutic options. Neuroblastoma may express somatostatin receptors (SSTRs) allowing imaging with 68Ga-DOTA-Octreotate (GaTATE) positron emission tomography/computed tomography (PET/CT) and peptide receptor radionuclide therapy (PRRT). We reviewed our experience with this theranostic combination. GaTATE
Panteleimon J Marsouvanidis et al.
Journal of medicinal chemistry, 56(6), 2374-2384 (2013-02-23)
Novel bombesin (BBN) antagonists were synthesized by coupling the chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to H-d-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2 (JMV594) through linkers of increasing number of (βAla)x residues (x = 1-3). Labeling with (111)In afforded the respective radiotracers in high purity and high specific
Grace Kong et al.
European journal of nuclear medicine and molecular imaging, 46(3), 718-727 (2018-10-22)
Rectal neuroendocrine neoplasia (NEN) is more common than other NEN origins, but is less commonly metastatic. However, when present, distant disease carries a particularly poor prognosis. Evidence guiding optimal treatment of such patients is lacking. We assessed PRRT outcomes in
Anna Orlova et al.
European journal of nuclear medicine and molecular imaging, 40(3), 439-449 (2012-11-28)
Radionuclide imaging of insulin-like growth factor type 1 receptor (IGF-1R) expression in tumours might be used for selection of patients who would benefit from IGF-1R-targeted therapy. We have previously shown the feasibility of IGF-1R imaging using the Affibody molecule (111)In-DOTA-His(6)-Z(IGF1R:4551).
Ada Repetto-Llamazares et al.
Anticancer research, 34(7), 3263-3269 (2014-07-02)
We herein report a comparison of the radiolabels 177Lu and 125I bound to the monoclonal antibody HH1 that targets the CD37 antigen expressed on non-Hodgkin B-cell lymphomas. Mixtures of 177Lu and 125I-labeled HH1 antibody were co-injected into nude mice carrying
David Akhavan et al.
Cancer biotherapy & radiopharmaceuticals, 35(1), 10-15 (2020-01-08)
Background: M5A is a humanized monoclonal antibody (mAb) directed against carcinoembryonic antigen (CEA) The purpose of this first in
Stefan Nebl et al.
Journal of biomolecular NMR, 74(10-11), 595-611 (2020-08-08)
The presence of suitable cavities or pockets on protein structures is a general criterion for a therapeutic target protein to be classified as 'druggable'. Many disease-related proteins that function solely through protein-protein interactions lack such pockets, making development of inhibitors
Hundeep Kaur et al.
Biological chemistry, 396(9-10), 1135-1149 (2015-04-08)
ATP binding cassette (ABC) transporters form a superfamily of integral membrane proteins involved in translocation of substrates across the membrane driven by ATP hydrolysis. Despite available crystal structures and extensive biochemical data, many open questions regarding their transport mechanisms remain.
Wen-Yen Huang et al.
Chemical communications (Cambridge, England), 49(1), 60-62 (2012-11-21)
Internally Gd doped mesoporous nanoparticles have been prepared and exhibit unprecedented relaxivities that are retained on external biomodification. In tuning diffusive water access, image contrast can be reversibly switched in the presence of a specific protein target.
Cristina Penas et al.
Journal of the American Chemical Society, 135(10), 3812-3814 (2013-02-26)
We report the rational design of a 20-mer basic peptide, derived from the transcriptional antitermination protein N of bacteriophage P22, equipped with a luminescent DOTA[Tb(3+)] macrocyclic complex and a sensitizing tryptophan antenna. Folding of this peptide into an α helical
Alexandre Chicheportiche et al.
EJNMMI physics, 8(1), 13-13 (2021-02-14)
Image quality and quantitative accuracy of positron emission tomography (PET) depend on several factors such as uptake time, scanner characteristics and image reconstruction methods. Ordered subset expectation maximization (OSEM) is considered the gold standard for image reconstruction. Penalized-likelihood estimation (PL)
Yan Xiao et al.
Magnetic resonance imaging, 33(6), 822-828 (2015-04-04)
A new biodegradable and biocompatible gadolinium (III) -copolymer (ACL-A2-DOTA-Gd) has been developed as a potential liver magnetic resonance imaging (MRI) contrast agent. ACL-A2-DOTA-Gd consisted of a poly (aspartic acid-co-leucine) unit bound with 1,4,7,10-tetraazacyclododecan-1,4,7,10-tetraacetic acid-gadolinium (Gd-DOTA) via the linkage of ethylenediamine.
E Oh et al.
Clinical radiology, 72(7), 552-559 (2017-03-23)
To evaluate and compare the diagnostic performance of quantitative parameters derived from diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in differentiating benign and malignant bone tumours. Fifty-five patients (age range, 21-82 years; mean age, 55 years) underwent
Jing Zou et al.
Nanoscale research letters, 12(1), 372-372 (2017-05-28)
Liposome nanocarriers (LPNs) are potentially the future of inner ear therapy due to their high drug loading capacity and efficient uptake in the inner ear after a minimally invasive intratympanic administration. However, information on the biocompatibility of LPNs in the
Signe Christensen et al.
PloS one, 11(12), e0168485-e0168485 (2016-12-29)
The Gram negative bacteria Chlamydia trachomatis is an obligate intracellular human pathogen that can cause pelvic inflammatory disease, infertility and blinding trachoma. C. trachomatis encodes a homolog of the dithiol oxidoreductase DsbA. Bacterial DsbA proteins introduce disulfide bonds to folding
Yannick Crémillieux et al.
Magnetic resonance in medicine, 83(5), 1774-1782 (2019-10-28)
The objective of this study is to evaluate the suitability and performance of ultra-short echo time (UTE) sequences for imaging and quantifying the deposition of nebulized MRI contrast agents in human-sized lungs. Nebulization of clinically used contrast agent or gadolinium-based
Ji Hye Min et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 18(9), 2091-2100 (2019-12-18)
Computed tomography (CT) and magnetic resonance imaging (MRI) are used to detect hepatocellular carcinoma (HCC). We performed a prospective study to compare the diagnostic performance of CT, MRI with extracellular contrast agents (ECA-MRI), and MRI with hepatobiliary agents (HBA-MRI) in
Jessica Morlieras et al.
Chemical communications (Cambridge, England), 49(29), 3046-3048 (2013-03-08)
Ultrasmall gadolinium based particles have been functionalized with positively charged pyridinium quaternary ammonium and labelled with (111)In. Evidence of their active targeting properties towards proteoglycans has been demonstrated in vivo after intravenous injection into rats opening thus a route to
Paul J Yazaki et al.
Protein engineering, design & selection : PEDS, 26(3), 187-193 (2012-11-24)
A series of anti-tumor/anti-chelate bispecific antibody formats were developed for pre-targeted radioimmunotherapy. Based on the anti-carcinoembryonic antigen humanized hT84.66-M5A monoclonal antibody and the anti-DOTA C8.2.5 scFv antibody fragment, this cognate series of bispecific antibodies were radioiodinated to determine their tumor
Cristina Müller et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 53(12), 1951-1959 (2012-11-10)
Terbium offers 4 clinically interesting radioisotopes with complementary physical decay characteristics: (149)Tb, (152)Tb, (155)Tb, and (161)Tb. The identical chemical characteristics of these radioisotopes allow the preparation of radiopharmaceuticals with identical pharmacokinetics useful for PET ((152)Tb) and SPECT diagnosis ((155)Tb) and
Fengquan Liu et al.
Journal of immunological methods, 387(1-2), 228-236 (2012-11-13)
Monoclonal antibody (MAb) against chelated Cu(2+) was developed. The conjugate employed as immunogens in BALB/c mice to raise antibodies was synthesized using Cu(2+) coupling to keyhole limpet hemocyanin (KLH) via a bifunctional chelator (2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, p-SCN-Bn-DOTA). One of the hybridomas
Jon-Vidar Gaustad et al.
BMC cancer, 15, 900-900 (2015-11-18)
Antiangiogenic treatments have been shown to increase blood perfusion and oxygenation in some experimental tumors, and to reduce blood perfusion and induce hypoxia in others. The purpose of this preclinical study was to investigate the potential of dynamic contrast enhanced
An improved method for conjugating monoclonal antibodies with N-hydroxysulfosuccinimidyl DOTA.
Lewis MR, et al.
Bioconjugate Chemistry, 12(2), 320-324 (2001)
Pardeep Kumar et al.
Cancer biotherapy & radiopharmaceuticals, 31(1), 29-36 (2016-02-06)
The authors have conjugated chelating agents (DOTA and NODAGA) with a peptide (pituitary adenylate cyclase-activating peptide [PACAP] analogue) that has a high affinity for VPAC1 receptors expressed on cancer cells. To determine a suitable chelating agent for labeling with (68)Ga
Xiaolian Sun et al.
Theranostics, 7(2), 319-328 (2017-01-04)
Minimizing the sequestration of nanomaterials (NMs) by the reticuloendothelial system (RES) can enhance the circulation time of NMs, and thus increase their tumor-specific accumulation. Liposomes are generally regarded as safe (GRAS) agents that can block the RES reversibly and temporarily.
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