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Showing 1-30 of 41 results for "87117" within Papers
Nobuyuki Kasai et al.
The FEBS journal, 272(17), 4349-4361 (2005-09-01)
We have previously reported that sulfoquinovosylmonoacylglycerol (SQMG) is a potent inhibitor of mammalian DNA polymerases. DNA polymerase beta (pol beta) is one of the most important enzymes protecting the cell against DNA damage by base excision repair. In this study
Shizuka Murakami et al.
Biochemical and biophysical research communications, 350(1), 7-16 (2006-09-26)
We previously reported the mode of inhibition of DNA polymerase beta (pol. beta) by long chain fatty acids and a bile acid, involving binding analyses to the N-terminal 8-kDa DNA binding domain. Here we describe a site-directed mutational analysis in
Y Mizushina et al.
Journal of molecular biology, 304(3), 385-395 (2000-11-25)
Unsaturated long-chain fatty acids selectively bind to the DNA binding sites of DNA polymerase beta and DNA topoisomerase II, and inhibit their activities, although the amino acid sequences of these enzymes are markedly different from each other. Computer modeling analysis
Marie-Elisabeth Agazzi et al.
Analytical and bioanalytical chemistry, 376(3), 360-365 (2003-05-07)
An improved extraction and clean-up method for determination of brain-specific fatty acids, in particular lignoceric acid (C24:0) and the cis/ trans isomers of nervonic acid (15 c-t C24:1), in meat products has been developed. The method is based on isolation
Arja T Erkkilä et al.
The Journal of craniofacial surgery, 16(5), 764-769 (2005-09-30)
The fatty acid profiles of serum lipids were examined in 53 ten-year-old cleft children. The children presented with different cleft types (cleft lip, cleft lip and palate, isolated cleft palate and submucuous cleft palate) and were recruited from the Finnish
Madhavi V Dhobale et al.
Prostaglandins, leukotrienes, and essential fatty acids, 85(3-4), 149-153 (2011-08-06)
Reports suggest that the placenta in preterm birth may provide clues to predicting the risk of individuals developing chronic diseases in later life. Placental delivery of long chain polyunsaturated fatty acids (LCPUFA) (constituents of the cell membrane and precursors of
Eiji Oda et al.
International heart journal, 46(6), 975-985 (2006-01-06)
Relative increases in unsaturated fatty acids (USFA) in the diet are considered to exert beneficial effects on coronary risk factors (CRF). However, detailed analysis of the relationships between serum USFA and CRF are scanty and there is no report of
David C Taylor et al.
Plant biotechnology journal, 7(9), 925-938 (2009-10-22)
Nervonic acid 24:1 Delta15 (cis-tetracos-15-enoic acid) is a very long-chain monounsaturated fatty acid and exists in nature as an elongation product of oleic acid. There is an increasing interest in production of high nervonic acid oils for pharmaceutical, nutraceutical and
Fatty Acids Analysis Using Gas Chromatography-Mass Spectrometer Detector (GC/MSD)-Method Validation Based on Berry Seed Extract Samples.
Mazurek B, et al.
Food Analytical Methods, 10(8), 2868-2880 (2017)
J R Sargent et al.
Medical hypotheses, 42(4), 237-242 (1994-04-01)
Demyelination in adrenoleukodystrophy (ALD) is associated with an accumulation of very long chain saturated fatty acids such as 26:0 stemming from a genetic defect in the peroxisomal beta oxidation system responsible for the chain shortening of these fatty acids. Long
David S Wishart et al.
Nucleic acids research, 37(Database issue), D603-D610 (2008-10-28)
The Human Metabolome Database (HMDB, is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, nutritionists and members of the metabolomics community. Since its first release in 2007, the
S Snigdha et al.
Neuroscience, 202, 326-333 (2011-12-21)
Despite several recent studies suggesting that dysregulation of brain lipid metabolism might contribute to the mechanisms of aging and Alzheimer's disease (AD), lipid metabolism has not been evaluated extensively in the aging brain. Here, we use a lipidomic approach to
Assunta Zanfini et al.
Lipids, 49(11), 1115-1125 (2014-09-12)
Globoid cell leukodystrophy or Krabbe disease is an inherited autosomal recessive disorder caused by mutations in the galactosylceramidase gene. The objective of the study was to present information about the fatty acid (FA) composition of the brain and serum of
Demetris Bitsanis et al.
The Journal of nutrition, 135(11), 2566-2571 (2005-10-28)
The aim of this study was to determine whether the high concentration of arachidonic acid (AA) in term placentae accumulates during pregnancy or is an inherent characteristic of placental lipids. We investigated the lipid content and fatty acid composition of
Aurore Vluggens et al.
Laboratory investigation; a journal of technical methods and pathology, 90(5), 696-708 (2010-03-03)
Disruption of the peroxisomal acyl-CoA oxidase 1 (Acox1) gene in the mouse results in the development of severe microvesicular hepatic steatosis and sustained activation of peroxisome proliferator-activated receptor-alpha (PPARalpha). These mice manifest spontaneous massive peroxisome proliferation in regenerating hepatocytes and
Guan-yuan Chen et al.
Clinica chimica acta; international journal of clinical chemistry, 438, 126-134 (2014-08-26)
As fatty acids play an important role in biological regulation, the profiling of fatty acid expression has been used to discover various disease markers and to understand disease mechanisms. This study developed an effective and accurate comparative fatty acid analysis
Jun Yang et al.
Biochemistry. Biokhimiia, 74(7), 813-818 (2009-09-15)
The binding of human DNA polymerase beta (pol beta) to DNA template-primer duplex and single-stranded DNA in the absence or presence of pol beta inhibitors has been studied using a surface plasmon resonance biosensor. Two fatty acids, linoleic acid and
Ersin Odabasi et al.
Journal of alternative and complementary medicine (New York, N.Y.), 13(10), 1115-1118 (2008-01-02)
Mud, which contains organic and mineral ingredients, is used for the treatment of several degenerative diseases. It has been proposed that beneficial effects of mud are not only related to its local thermal effects, but also to its chemical components.
Jiun-Rong Chen et al.
The Journal of nutritional biochemistry, 15(8), 467-472 (2004-08-11)
Nutritional factors may be relative to attention-deficit hyperactive disorder (ADHD), although the pathogenic mechanism is still unknown. Based on the work of others, we hypothesized that children with ADHD have altered dietary patterns and fatty acid metabolism. Therefore, the aim
Nikolaos Psychogios et al.
PloS one, 6(2), e16957-e16957 (2011-03-02)
Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically important biofluids, such as cerebrospinal
Wide-ranging alterations in the brain fatty acid complement of subjects with late Alzheimer?s disease as detected by GC-MS.
Nasaruddin ML, et al.
American Journal of Translational Research, 8(1), 154-154 (2016)
Peroxisomal fatty acid oxidation and cellular redox.
Inderjit Singh
Methods in enzymology, 352, 361-372 (2002-07-20)
Oswald Quehenberger et al.
Journal of lipid research, 51(11), 3299-3305 (2010-07-31)
The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a regular part of every patient's blood test
Nobuyuki Kasai et al.
Journal of biochemistry, 132(5), 819-828 (2002-11-06)
Previously, we reported the three-dimensional molecular interactions of nervonic acid (NA) with mammalian DNA polymerase beta (pol beta) [Mizushina et al. (1998) J. Biol. Chem. 274, 25599-25607]. By three-dimensional structural model analysis and comparison with the spatial positioning of specific
Yunbao Liu et al.
Journal of natural products, 73(7), 1193-1195 (2010-06-23)
Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple formazan by mitochondrial enzymes. NADPH is the basis of established in vitro cell viability assays. An antioxidant assay
Catalase in microsporidian spores before and during discharge.
Earl Weidner et al.
The Biological bulletin, 205(2), 236-237 (2003-10-30)
B Singh et al.
Phytotherapy research : PTR, 20(10), 831-839 (2006-07-15)
The bioassay guided fractionation of the dried aerial part of Indigofera tinctoria Linn. led to the identification of an active fraction labelled as indigotin. On further chemical analysis, a compound isolated from indigotin was identified and characterized as trans-tetracos-15-enoic acid
Decreased nervonic acid levels in erythrocyte membranes predict psychosis in help-seeking ultra-high-risk individuals.
G P Amminger et al.
Molecular psychiatry, 17(12), 1150-1152 (2011-12-21)
Martin Karlsson et al.
Obesity (Silver Spring, Md.), 14(11), 1931-1939 (2006-12-01)
Fatty acid (FA) composition has a role in adipogenesis. The objective was to study serum phospholipid (PL) FAs in adolescents and their relation to abdominal adipose tissue (AT) compartments and metabolic markers. Abdominal AT was measured by magnetic resonance imaging
Gregory C Shearer et al.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 22(2), 277-283 (2011-07-22)
Although the value of red blood cell fatty acids (FAs) in estimating risk for acute coronary syndrome in the general population is evident, the value of FAs in chronic kidney disease (CKD) is unknown. Here, we provide a pilot analysis
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