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Showing 1-23 of 23 results for "88571" within Papers
D Pandolfi et al.
Nucleosides & nucleotides, 18(9), 2051-2069 (1999-11-05)
Synthetic oligonucleotides are increasingly used because of their potential activity as regulators of gene expression. One of their major drawbacks is instability toward nucleases, in particular exonucleases. In this article, we studied some terminal modifications that can enhance exonuclease resistance
Nataliya Shulga et al.
Molecular and cellular biology, 23(2), 534-542 (2003-01-02)
The nuclear pore complex (NPC) is a permeable sieve that can dilate to facilitate the bidirectional translocation of a wide size range of receptor-cargo complexes. The binding of receptors to FG nucleoporin docking sites triggers channel gating by an unknown
W Spahl et al.
Journal of dentistry, 26(2), 137-145 (1998-04-16)
The purpose of our study was to determine the quality and quantity of leachable residual (co)monomers and additives eluted from various commercial dental composite resins after polymerization. Polymerized specimens from four universal hybrid-type composite resins were eluted for 3 days
M J Politis et al.
Journal of neurocytology, 9(4), 505-516 (1980-08-01)
This study examined the thesis that 2,5-dexanedione (2,5-HD) produces distal (dying-back) axonopathy by direct toxic action on nerve fibers. Single or repeated application of undiluted or 10% 2,5-HD to exposed rat sciatic nerves caused some fibres to develop focal axonal
M A Rahman et al.
Dental materials journal, 14(2), 230-235 (1995-12-01)
The optimum concentration and application time for an experimental dentin primer composed of an aqueous solution of 1,6-hexanediol were determined by measuring the wall-to-wall polymerization contraction gap width of a commercial light-activated resin composite in a cylindrical dentin cavity prepared
H D Durham et al.
Muscle & nerve, 11(2), 160-165 (1988-02-01)
We reported previously that 2,5-hexanedione (2,5-HD), the neurotoxic metabolite of methyl-n-butylketone (MnBK) and n-hexane, induced aggregation of intermediate filaments of the vimentin type in cultured fibroblasts. To determine if these findings have relevance to the mechanism by which these hexacarbons
Maciej Podgórski
Dental materials : official publication of the Academy of Dental Materials, 26(6), e188-e194 (2010-03-20)
In this study three novel dimethacrylates of different chain lengths having bulky bicycloaliphatic rings were synthesized and proposed as possible dental monomers for dental resin mixtures. The monomers were prepared by the reaction of glycidyl methacrylate with dicarboxylic acid esters
Jennifer Tuma et al.
The journal of physical chemistry. B, 111(45), 13101-13106 (2007-10-26)
The solution structure of a synthetic DNA mini-hairpin possessing a stilbenediether linker and three G:C base pairs has been obtained using (1)H NMR spectral data and constrained torsion angle molecular dynamics. Notable features of this structure include a compact hairpin
C Arunan et al.
Peptides, 21(6), 773-777 (2000-08-26)
A novel 1,6-hexanediol diacrylate cross-linked resin was prepared that was subsequently functionalized by using chloromethyl methyl ether to afford a high-capacity resin. The resin exhibited good swelling and its application in the successful synthesis of a 13-residue peptide corresponding to
Arantxa Agote-Aran et al.
The EMBO journal, 39(20), e104467-e104467 (2020-07-25)
Nucleoporins (Nups) build highly organized nuclear pore complexes (NPCs) at the nuclear envelope (NE). Several Nups assemble into a sieve-like hydrogel within the central channel of the NPCs. In the cytoplasm, the soluble Nups exist, but how their assembly is
Roosmarijn E Vandenbroucke et al.
The journal of gene medicine, 10(7), 783-794 (2008-05-13)
Small interfering (si)RNA mediated inhibition of oncogenes or viral genes may offer great opportunities for the treatment of several diseases such as hepatocellular carcinoma and viral hepatitis. However, the development of siRNAs as therapeutic agents strongly depends on the availability
Alfonso Pérez-Garrido et al.
Bioorganic & medicinal chemistry, 17(2), 896-904 (2008-12-06)
This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the molecular structure of the compounds under investigation
C Tani et al.
Dental materials journal, 15(1), 39-44 (1996-06-01)
Physical changes in the surface characteristics of dentin during bonding procedures were evaluated by measuring the contact angles of three standard liquids, to determine the surface free energy, and that of a commercially available dual cured dentin bonding agent dropped
Kaj A E Stenberg et al.
Proteins, 75(3), 748-759 (2008-11-13)
We report the structure of a novel tetrameric form of the lactose repressor (LacI) protein from Escherichia coli refined to 2.1 A resolution. The tetramer is bound to 1.6-hexanediol present in the crystallization solution and the final R(free) for the
J M Paz et al.
Clinical chemistry, 36(2), 355-358 (1990-02-01)
We have evaluated the determination of lactate dehydrogenase (EC 1.1.1.27) isoenzyme 1 activity by chemical inhibition of the other isoenzymes with perchlorate and with 1,6-hexanediol. In the hexanediol method, we studied the effect of the duration of incubation with the
A Kurihara et al.
Dental materials journal, 15(2), 226-232 (1996-12-01)
The purpose of the present study was to evaluate the safety of ethylene glyco (EG) and 1,6-hexanediol (HD) solutions as experimental dentin primers when subjected to the guinea pig maximization test (GPMT), primary irritation test, cumulative skin irritation test and
P E Vorobjev et al.
Antisense & nucleic acid drug development, 11(2), 77-85 (2001-05-04)
The properties of new chimeric oligodeoxynucleotides made of short sequences (tetramers, pentamers, octamers, and decamers) bridged by hexamethylenediol and hexaethylene glycol linkers have been investigated. These chimeric oligonucleotides showed an improved resistance toward snake venom 3'-phosphodiesterase, with an increased stability
K Tanishima et al.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 25(10), 729-732 (1987-10-01)
A rapid selective method for measuring the activity of lactate dehydrogenase isoenzyme LD-1 in serum by using 1,6-hexanediol as an inhibitor of the M-subunit was developed. Hexanediol was added to serum at a final concentration of 0.7 mol/l. After incubation
K Tanishima et al.
Clinical chemistry, 31(7), 1175-1177 (1985-07-01)
To measure activities of lactate dehydrogenase (EC 1.1.1.27) isoenzymes LD1 and LD2 in serum, we developed a method involving 1,6-hexanediol as specific inhibitor of the M-subunit. Addition of hexanediol, 0.6 mol/L, to five LD isoenzyme fractions purified from human liver
R J Shamberger
Clinical chemistry, 33(4), 589-591 (1987-04-01)
In this assay for lactate dehydrogenase (EC 1.1.1.27) isoenzyme 1 (LD-1), 1,6-hexanediol is added to serum after total LD has been measured. After incubation for 5 min the total LD remaining is determined. Samples from patients who had a myocardial
Robert W Peoples et al.
Molecular pharmacology, 61(1), 169-176 (2001-12-26)
n-Alkanol inhibition of N-methyl-D-aspartate (NMDA) receptors exhibits a "cutoff" effect: alcohols with up to eight to nine carbon atoms inhibit the receptor, whereas larger alcohols do not. This phenomenon was originally proposed to result from size exclusion; i.e., alcohols above
Joachim B Havla et al.
Toxicology in vitro : an international journal published in association with BIBRA, 24(3), 849-853 (2009-12-17)
Tissue engineering of autologous cartilage transplants is suggested as a new approach in reconstruction of external auricular deformities. 1.6-Hexanediol (HD), 1.8-diazabicyclo[5.4.0]undec-7-ene (DBU) and 6-hydroxyhexanoic acid (HHA) are matrices of the open-pored polyurethane three-dimensional scaffold. Since these bioresorbable materials may interact
M Durand et al.
Nucleic acids research, 18(21), 6353-6359 (1990-11-11)
An oligodeoxyribonucleotide, d(GCTCACAAT-X-ATTGTGAGC), where X represents a hexaethylene glycol chain, was studied using circular dichroism spectroscopy. Its conformation and conformational stability were compared to those of compounds where X was replaced by four thymines and to the duplex of same
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