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Showing 1-30 of 92 results for "901594" within Papers
Bin Zhu et al.
Antiviral research, 118, 29-38 (2015-03-24)
Infectious diseases of viral origin cause major aquatic production losses in different parts of the world. Because of formidable barriers for gastrointestinal tract, skin and cell, large amounts of antiviral drugs have limited therapeutic effect. In the current study, functionalized
Scott Boitano et al.
PloS one, 9(6), e99140-e99140 (2014-06-14)
Protease-activated receptor-2 (PAR2) is a G-Protein Coupled Receptor (GPCR) activated by proteolytic cleavage to expose an attached, tethered ligand (SLIGRL). We evaluated the ability for lipid-tethered-peptidomimetics to activate PAR2 with in vitro physiological and Ca2+ signaling assays to determine minimal
Thierry Brun et al.
Human molecular genetics, 24(18), 5270-5284 (2015-07-01)
In pancreatic β-cells, mitochondria play a central role in coupling glucose metabolism to insulin secretion. Chronic exposure of β-cells to metabolic stresses impairs their function and potentially induces apoptosis. Little is known on mitochondrial adaptation to metabolic stresses, i.e. high
Rohini Sidhu et al.
Journal of lipid research, 56(6), 1222-1233 (2015-04-14)
24(S)-hydroxycholesterol [24(S)-HC] is a cholesterol metabolite that is formed almost exclusively in the brain. The concentrations of 24(S)-HC in cerebrospinal fluid (CSF) and/or plasma might be a sensitive marker of altered cholesterol metabolism in the CNS. A highly sensitive 2D-LC-MS/MS
Xikuang Yao et al.
Biomacromolecules, 16(7), 2059-2071 (2015-05-30)
Cisplatin-incorporating pseudoblock copolymer nanoparticles with high drug loading efficiency (ca. 50%) were prepared built on host-guest inclusion complexation between β-cyclodextrin end-capped poly(N-vinylpyrrolidone) block and admantyl end-capped poly(aspartic acid) block, followed by the coordination between cisplatin and carboxyl groups in poly(aspartic
Hiroyasu Tamura et al.
Bioscience, biotechnology, and biochemistry, 79(7), 1191-1199 (2015-03-20)
In the brewing of high-quality sake such as Daiginjo-shu, the cerulenin-resistant sake yeast strains with high producing ability to the flavor component ethyl caproate have been used widely. Genetic stability of sake yeast would be important for the maintenance of
Ayele H Negussie et al.
Journal of materials science. Materials in medicine, 26(6), 198-198 (2015-06-25)
Therapeutic embolization of blood vessels is a minimally invasive, catheter-based procedure performed with solid or liquid emboli to treat bleeding, vascular malformations, and vascular tumors. Hepatocellular carcinoma (HCC) affects about half a million people per year. When unresectable, HCC is
Colette M Smart et al.
Neuropsychology, 29(6), 971-987 (2015-05-27)
To ascertain whether the Iowa Gambling Task (IGT) could be used to detect and identify measurable cognitive differences between older adults with subjective cognitive decline (SCD) as compared with healthy older controls (HC). Older adults with self-identified SCD and age-matched
Aurélien Tidu et al.
Acta biomaterialia, 22, 50-58 (2015-05-02)
Several diseases can lead to opacification of cornea requiring transplantation of donor tissue to restore vision. In this context, transparent collagen I fibrillated matrices have been synthesized at 15, 30, 60 and 90 mg/mL. The matrices were evaluated for fibril
Kiley L Yeakel et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(47), 14512-14517 (2015-11-11)
Oceanic uptake of anthropogenic carbon dioxide (CO2) has acidified open-ocean surface waters by 0.1 pH units since preindustrial times. Despite unequivocal evidence of ocean acidification (OA) via open-ocean measurements for the past several decades, it has yet to be documented
J Izdebski et al.
Journal of peptide science : an official publication of the European Peptide Society, 3(2), 141-144 (1997-03-01)
A competitive reaction of activated Boc-Ala-OH and Boc-Phe-OH with H-Leu-resin has been developed for assessing the relative efficiencies of different carbodiimides. This allowed a comparison of the efficiency of the carbodiimides N,N'-dicyclohexylcarbodiimide,N,N'-diisopropylcarbodiimide, N-tert-butyl-N'-methylcarbodiimide and N-tert-butyl-N'-ethylcarbodiimide. Comparable results were obtained when
Collection of Czechoslovak Chemical Communications, 59, 691-691 (1994)
Yi Cao et al.
Environmental toxicology and pharmacology, 40(1), 164-171 (2015-07-01)
Exposure to diesel exhaust particles (DEP) has been associated with adverse cardiopulmonary health effects, which may be related to dysregulation of lipid metabolism and formation of macrophage foam cells. In this study, THP-1 derived macrophages were exposed to an automobile
P J Weber et al.
Bioorganic & medicinal chemistry letters, 8(6), 597-600 (1999-01-01)
A new method has been developed to synthesize fluorescein labeled peptides, compounds of increasing importance in bioorganic chemistry, cell biology, pharmacology, drug targeting and medicinal chemistry. We show, that 4(5)-carboxyfluorescein is much more efficient than the hitherto predominantly utilized reagents
Ramona Galatola et al.
European journal of medicinal chemistry, 86, 589-604 (2014-09-15)
The development of peptide fusion inhibitors based on short synthetic peptides represents a promising option in the fight against HIV-1 infection, especially in individuals infected with multiresistant HIV-1 strains. GBV-C has the beneficial effect of retarding the progression of AIDS
Wei Tao et al.
Advanced healthcare materials, 4(8), 1203-1214 (2015-03-25)
A novel blended nanoparticle (NP) system for the delivery of anticancer drugs and its surprisingly high efficacy for cancer chemotherapy by blending a targeting polymer folic acid-poly(ethylene glycol)-b-poly(lactide-co-glycolide) (FA-PEG-b-PLGA) and a miscible structurally similar polymer D-α-tocopheryl polyethylene glycol 1000 succinate-poly(lactide-co-glycolide)
Tianyi Zhang et al.
Journal of cell science, 128(15), 2938-2950 (2015-06-21)
The v-ATPase is a fundamental eukaryotic enzyme that is central to cellular homeostasis. Although its impact on key metabolic regulators such as TORC1 is well documented, our knowledge of mechanisms that regulate v-ATPase activity is limited. Here, we report that
Paul W R Harris et al.
Biopolymers, 104(2), 116-127 (2015-02-07)
The cancer protein NY-ESO-1 has been shown to be one of the most promising vaccine candidates although little is known about its cellular function. Using a chemical protein strategy, the 180 amino acid polypeptide, tagged with an arginine solubilizing tail
N R Shenoy et al.
Protein science : a publication of the Protein Society, 1(1), 58-67 (1992-01-01)
We have developed a method for the covalent immobilization of peptides, for the purpose of C-terminal sequencing, to a novel solid support, carboxylic acid-modified polyethylene (PE-COOH) film. The peptides are attached by coupling the N-terminal amino group to the activated
Egan J Lohman et al.
Biotechnology for biofuels, 8, 82-82 (2015-06-24)
Large-scale algal biofuel production has been limited, among other factors, by the availability of inorganic carbon in the culture medium at concentrations higher than achievable with atmospheric CO2. Life cycle analyses have concluded that costs associated with supplying CO2 to
A Adamus et al.
Colloids and surfaces. B, Biointerfaces, 145, 185-193 (2016-05-18)
This report demonstrates the feasibility of radiation grafting for the preparation of polymer layers functionalised with short peptide ligands which promote cell adhesion. Thermoresponsive poly [tri(ethylene glycol) monoethyl ether methacrylate] (PTEGMA) layers were synthesised on a polypropylene substrate by post-irradiation
Lavanya Y Peddada et al.
Journal of controlled release : official journal of the Controlled Release Society, 194, 103-112 (2014-09-07)
The clinical application of gene silencing is hindered by poor stability and low delivery efficiency of naked oligonucleotides. Here, we present the in vitro and in vivo behaviors of a rationally designed, ternary, self-assembled nanoparticle complex, consisting of an anionic
Inok Surh et al.
Cutaneous and ocular toxicology, 31(3), 177-187 (2011-11-09)
Dicyclohexylcarbodiimide (DCC) and Diisopropylcarbodiimide (DIC) are two representative chemicals in the carbodiimide class of chemicals used in industry as stabilizing agents. There is a potential of dermal exposure to these agents in chemical, pharmaceutical and recombinant DNA industries. The National
Jeromy Anglim et al.
Journal of experimental psychology. Learning, memory, and cognition, 41(4), 957-974 (2015-01-21)
The current study used Bayesian hierarchical methods to challenge and extend previous work on subtask learning consistency. A general model of individual-level subtask learning was proposed focusing on power and exponential functions with constraints to test for inconsistency. To study
César Remuzgo et al.
Amino acids, 46(11), 2573-2586 (2014-08-12)
Although glycine-rich antimicrobial peptides (AMPs) are found in animals and plants, very little has been reported on their chemistry, structure activity-relationship, and properties. We investigated those topics for Shepherin I (Shep I), a glycine-rich AMP with the unique amino acid
Francisca C Moreira et al.
Water research, 81, 375-387 (2015-07-05)
The current study has proved the technical feasibility of including electrochemical advanced oxidation processes (EAOPs) in a multistage strategy for the remediation of a sanitary landfill leachate that embraced: (i) first biological treatment to remove the biodegradable organic fraction, oxidize
Pavla Simerska et al.
Drug delivery and translational research, 4(3), 246-255 (2015-03-20)
Peptide-based vaccine delivery can be hampered by rapid peptidase activity and poor inherent immunogenicity. The self-adjuvanting lipid core peptide system (LCP) has been shown to confer improved stability and immunogenicity on peptide epitopes of group A Streptococcus, Chlamydia, hookworm, and
K L Witt et al.
Environmental and molecular mutagenesis, 33(1), 65-74 (1999-02-26)
The induction of micronucleated erythrocytes by diisopropylcarbodiimide (DIC) and dicyclohexylcarbodiimide (DCC) was investigated as part of a U.S. National Toxicology Program (NTP) evaluation of the subchronic toxicity of these chemicals. Analysis of peripheral blood smears from male and female B6C3F1
Arne Homann et al.
Journal of translational medicine, 13, 339-339 (2015-10-30)
Autoimmune diseases like rheumatoid arthritis and inflammatory bowel disease are treated with TNF-alpha-blocking antibodies such as infliximab and adalimumab. A common side effect of therapeutic antibodies is the induction of anti-drug antibodies, which may reduce therapeutic efficacy. In order to
Valentina Marchesin et al.
The Journal of cell biology, 211(2), 339-358 (2015-10-28)
Invasion of cancer cells into collagen-rich extracellular matrix requires membrane-tethered membrane type 1-matrix metalloproteinase (MT1-MMP) as the key protease for collagen breakdown. Understanding how MT1-MMP is delivered to the surface of tumor cells is essential for cancer cell biology. In
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