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Showing 1-24 of 24 results for "91443" within Papers
Yusuke Izutani et al.
Carbohydrate research, 392, 25-30 (2014-05-23)
The structural properties of glycyrrhizic acid, a sweet-tasting constituent of Glycyrrhiza glabra, and its interaction with cyclodextrins were analyzed using dynamic light scattering, isothermal titration calorimetry, and NMR. The dynamic light scattering and NMR studies showed that glycyrrhizic acid forms
Determination of glycyrrhizic acid and 18-β-glycyrrhetinic acid in biological fluids by micellar electrokinetic chromatography
Wang P, et al.
Journal of Chromatography A, 811(1-2), 219-224 (1998)
Chuan-Xin Wu et al.
Shock (Augusta, Ga.), 43(4), 412-421 (2014-12-20)
High-mobility group box 1 (HMGB1) is a therapeutic target for sepsis. Glycyrrhizin (GL) is the aglycone of glycyrrhizin derived from licorice. We clarified the anti-inflammatory effects of GL. We explored the anti-HMGB1 effect of GL and elucidated its molecular mechanism
The determination of glycyrrhizic acid in Glycyrrhiza uralensis Fisch. ex DC.(Zhi Gan Cao) root and the dried aqueous extract by LC?DAD
Hennell.R.J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 47, 494-500 (2008)
Shaozhang Hou et al.
International journal of molecular sciences, 15(9), 15026-15043 (2014-08-28)
The aim of this study was to determine the beneficial effect of glycyrrhizic acid (GA) on type 2 diabetic nephropathy using renal tubular epithelial cell line (NRK-52E). The cells are divided into normal group (NG), high glucose group (HG), and
Hsin-Yi Lo et al.
PloS one, 9(8), e104650-e104650 (2014-08-19)
Diabetes is a chronic metabolic disorder that has a significant impact on the health care system. The reduction of glycated hemoglobin A1c is highly associated with the improvements of glycemic control and diabetic complications. In this study, we identified a
Anbin Zhang et al.
Transplant international : official journal of the European Society for Organ Transplantation, 27(10), 1077-1085 (2014-05-09)
Ischemia reperfusion (IR) injury is a major issue in cardiac transplantation and inflammatory processes play a major role in myocardial IR injury. Necrostatin-1 (Nec-1) is a small molecule capable of inhibiting RIP1 kinase activity and attenuates inflammation-mediated tissue injury. In
Pil-Sung Yang et al.
Respiratory research, 15, 148-148 (2014-11-26)
High mobility group box-1 (HMGB1), a proinflammatory cytokine, plays a pivotal role in tissue remodeling and angiogenesis, both of which are crucial for the pathogenesis of pulmonary arterial hypertension. In this study, we explored the relationship between HMGB1 and pulmonary
Changchun Cai et al.
Hepatology (Baltimore, Md.), 60(3), 990-1002 (2014-05-07)
Acetaminophen (APAP) toxicity is the most common cause of acute liver failure in industrialized countries. Understanding the mechanisms of APAP-induced liver injury as well as other forms of sterile liver injury is critical to improve the care of patients. Recent
Mélissa Erin Khan et al.
PLoS neglected tropical diseases, 8(11), e3308-e3308 (2014-11-14)
DNA sequences purified from distinct organisms, e.g. non vertebrate versus vertebrate ones, were shown to differ in their TLR9 signalling properties especially when either mouse bone marrow-derived- or human dendritic cells (DCs) are probed as target cells. Here we found
Chiung-Hung Chang et al.
PloS one, 9(8), e105362-e105362 (2014-08-19)
Salmonella, a common zoonotic pathogen, causes gastroenteritis in both humans and animals. Traditional Chinese Medicine (TCM) has been used to improve gastrointestinal dysfunction and to modify the immune response to inflammation for centuries. This study used six herbal plants and
Katherine H Parker et al.
Cancer research, 74(20), 5723-5733 (2014-08-29)
Chronic inflammation often precedes malignant transformation and later drives tumor progression. Likewise, subversion of the immune system plays a role in tumor progression, with tumoral immune escape now well recognized as a crucial hallmark of cancer. Myeloid-derived suppressor cells (MDSC)
Chengcheng Christine Zhang et al.
International journal of oncology, 46(2), 667-676 (2014-12-02)
The HMGB1 protein has multiple functions in tumor biology and can act both as a transcription factor and as a cytokine. HMGB1 is released during cell death, and in our previous studies we demonstrated that HMGB1 induces a distinct, necrosis-like
Yu Okuma et al.
Neuropharmacology, 85, 18-26 (2014-05-27)
Glycyrrhizin (GL) is a major constituent of licorice root and has been suggested to inhibit the release of high mobility group box-1 (HMGB1), a protein considered representative of damage-associated molecular patterns. We found that GL bound HMGB1 but not RAGE
Hwayong Park et al.
Journal of ethnopharmacology, 156, 182-189 (2014-09-15)
Guibi-tang (Guipi-tang in Chinese and Kihi-to in Japanese) is a multi-herb traditional medicine commonly prescribed to treat psychoneurosis in East Asia. Although this medicine has been widely used, there is little available information on the safety and toxicity of Guibi-tang
Deepak Mishra et al.
The Journal of pharmacy and pharmacology, 66(8), 1082-1093 (2014-03-20)
The present study was focused to prepare controlled release glycyrrhizin (GL) conjugated low molecular weight chitosan nanoparticles (CS-NPs) for liver targeting. The hydrophilic antiretroviral drug lamivudine was chosen as a model drug and encapsulated within glycyrrhizin conjugated low molecular weight
Christian Giordano et al.
Human molecular genetics, 24(8), 2147-2162 (2015-01-02)
Toll-like receptor 4 (TLR4) recognizes specific structural motifs associated with microbial pathogens and also responds to certain endogenous host molecules associated with tissue damage. In Duchenne muscular dystrophy (DMD), inflammation plays an important role in determining the ultimate fate of
Zhihui Zhu et al.
PloS one, 9(5), e96576-e96576 (2014-05-08)
The metazoan liver exhibits a remarkable capacity to regenerate lost liver mass without leaving a scar following partial hepatectomy (PH). Whilst previous studies have identified components of several different signaling pathways that are essential for activation of hepatocyte proliferation during
Sophie Dufay et al.
The Journal of pharmacy and pharmacology, 66(10), 1478-1490 (2014-05-16)
Ciclosporin and sirolimus, two immunosuppressive agents with narrow therapeutic windows, are mainly metabolized by Cytochrome 3A4 (CYP3A4). A clinical case of toxic blood levels of these drugs after the consumption of a '24-flavours' tea was reported. This study aims to
Nu Ry Song et al.
International journal of molecular sciences, 16(3), 4453-4470 (2015-02-25)
Licorice is a traditional botanical medicine, and has historically been commonly prescribed in Asia to treat various diseases. Glycyrrhizin (Gc), a triterpene compound, is the most abundant phytochemical constituent of licorice. However, high intake or long-term consumption of Gc has
Xiaoyun Li et al.
Molecular immunology, 65(1), 177-188 (2015-02-11)
Systemic lupus erythematosus (SLE) is a typical autoimmune disease with unclear etiology. Aberrant self-DNA recognition has been proven critical for the initiation of excessive immune responses in lupus. Consistently, we previously reported that a sort of self-DNA, activated lymphocyte-derived DNA
Hye Young Kim et al.
PloS one, 9(8), e104743-e104743 (2014-08-16)
High mobility group box chromosomal protein 1 (HMGB-1) released from injured cells plays an important role in the development of arthritis. This study investigated the anti-angiogenic effects of cilostazol in collagen-induced arthritis (CIA) of mice, and the underlying mechanisms involved.
Julijana Ivosevic-Zaper et al.
Pharmaceutical biology, 52(10), 1362-1365 (2014-05-03)
Anecdotic reports from Turkmenistan suggest an epilatory effect of sweet licorice extract after topical application. This study examines hair removal after topical application of glycyrrhizic acid, the main compound of sweet licorice. An aqueous solution containing 15% of the ammonium
Joana C Xavier et al.
Metabolic engineering, 39, 200-208 (2016-12-13)
The composition of a cell in terms of macromolecular building blocks and other organic molecules underlies the metabolic needs and capabilities of a species. Although some core biomass components such as nucleic acids and proteins are evident for most species
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