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Showing 1-30 of 137 results for "93443" within Papers
Mo Chen et al.
Nature communications, 11(1), 1813-1813 (2020-04-15)
The oocyte cytoplasm can reprogram the somatic cell nucleus into a totipotent state, but with low efficiency. The spatiotemporal chromatin organization of somatic cell nuclear transfer (SCNT) embryos remains elusive. Here, we examine higher order chromatin structures of mouse SCNT
The size, shape, and hydration of nonionic surfactant micelles. Triton X-100.
Robson RJ and Dennis EA
The Journal of Physical Chemistry, 81, 1075-1078 (1977)
Anat Kahan et al.
Cell reports, 36(13), 109744-109744 (2021-10-01)
Optical implants to control and monitor neuronal activity in vivo have become foundational tools of neuroscience. Standard two-dimensional histology of the implant location, however, often suffers from distortion and loss during tissue processing. To address that, we developed a three-dimensional post
Sivaram Harendra et al.
Journal of environmental sciences (China), 25(3), 576-584 (2013-08-08)
Surfactants are soil washing agents and facilitators for subsurface remediation of hydrocarbon spills. It is important to understand the sorption and transport behavior of surfactants for enhanced soil remediation. The adsorption and desorption isotherms of cetyl trimethylammonium bromide (CTAB) and
Hongxia Wang et al.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 206(2), 289-307 (2020-01-07)
Voltage-gated sodium (NaV) channels, encoded by the gene para, play a critical role in the rapid processing and propagation of visual information related to collision avoidance behaviors. We investigated their localization by immunostaining the optic lobes and central brain of
Idil Orhon et al.
Autophagy, 1-16 (2021-05-20)
Relatively quiescent tissues like salivary glands (SGs) respond to stimuli such as injury to expand, replace and regenerate. Resident stem/progenitor cells are key in this process because, upon activation, they possess the ability to self-renew. Macroautophagy/autophagy contributes to and regulates
Justin A MacDonald et al.
Archives of biochemistry and biophysics, 535(1), 84-90 (2012-12-12)
The protein prostate-apoptosis response (Par)-4 has been implicated in the regulation of smooth muscle contraction, based largely on studies with the A7r5 cell line. A mechanism has been proposed whereby Par-4 binding to MYPT1 (the myosin-targeting subunit of myosin light
H-F Koay et al.
Science immunology, 4(41) (2019-11-24)
MR1-restricted mucosal-associated invariant T (MAIT) cells play a unique role in the immune system. These cells develop intrathymically through a three-stage process, but the events that regulate this are largely unknown. Here, using bulk and single-cell RNA sequencing-based transcriptomic analysis
Dilip Shrestha et al.
Biochimica et biophysica acta, 1840(1), 667-680 (2014-02-01)
Cluster of differentiation 1 (CD1) represents a family of proteins which is involved in lipid-based antigen presentation. Primarily, antigen presenting cells, like B cells, express CD1 proteins. Here, we examined the cell-surface distribution of CD1d, a subtype of CD1 receptors
Yuanyuan Ye et al.
Molecular genetics & genomic medicine, 8(7), e1284-e1284 (2020-05-16)
Acephalic spermatozoa is an extremely rare type of teratozoospermia that is associated with male infertility. Several genes have been reported to be relevant to acephalic spermatozoa. Thus, more genetic pathogenesis needs to be explored. Whole-exome sequencing was performed in a
Sheel Shah et al.
Cell, 174(2), 363-376 (2018-06-12)
Visualization of the transcriptome and the nuclear organization in situ has been challenging for single-cell analysis. Here, we demonstrate a multiplexed single-molecule in situ method, intron seqFISH, that allows imaging of 10,421 genes at their nascent transcription active sites in
Yun Xu et al.
Stem cell research & therapy, 12(1), 112-112 (2021-02-07)
Nicotinamide phosphoribosyltransferase (NAMPT) regulates cellular functions through the protein deacetylation activity of nicotinamide adenine dinucleotide (NAD+)-dependent sirtuins (SIRTs). SIRTs regulate functions of histones and none-histone proteins. The role of NAMPT/SIRT pathway in the regulation of maintenance and differentiation of human-induced
Yanwei Sha et al.
Frontiers in cell and developmental biology, 9, 676246-676246 (2021-08-24)
Acephalic spermatozoa syndrome is a rare type of teratozoospermia, but its pathogenesis is largely unknown. Here, we performed whole-exome sequencing for 34 patients with acephalic spermatozoa syndrome and identified pathogenic variants in the X-linked gene, ACTRT1, in two patients. Sanger
Denis L Lafontaine et al.
Current protocols, 1(7), e198-e198 (2021-07-22)
The intricate folding of chromatin enables living organisms to store genomic material in an extremely small volume while facilitating proper cell function. Hi-C is a chromosome conformation capture (3C)-based technology to detect pair-wise chromatin interactions genome-wide, and has become a
Yuko Katoh-Fukui et al.
Bone, 120, 219-231 (2018-11-06)
A set of key developmental genes is essential for skeletal growth from multipotent progenitor cells at weaning. Polycomb group proteins, which regulate such genes contributes to the cell lineage commitment and subsequent differentiation via epigenetic chromatin modification and remodeling. However
Su-Fang Zhang et al.
Molecular medicine reports, 16(3), 3581-3586 (2017-07-18)
Lung cancer accounts for a significant percentage of all cancer‑associated mortalities in men and women, with non‑small cell lung cancer being the most frequently occurring type of lung cancer. Melittin is the principal active component of apitoxin (bee venom) that
Baowei Zhao et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(10), 2154-2159 (2013-05-17)
The performance of copper ion removal using sodium dodecyl sulfate (SDS) and its mixtures with Brij 35, Tween 80 (TW80) and Triton X-100 (TX100) by micellar-enhanced ultrafiltration (MEUF) was investigated. The effects of the molar ratio of nonionic surfactant to
Stefan Bauernfried et al.
Science (New York, N.Y.), 371(6528) (2020-11-28)
Inflammasomes function as intracellular sensors of pathogen infection or cellular perturbation and thereby play a central role in numerous diseases. Given the high abundance of NLRP1 in epithelial barrier tissues, we screened a diverse panel of viruses for inflammasome activation
Hadi Shafiee et al.
Scientific reports, 5, 9919-9919 (2015-06-06)
We report a biosensing platform for viral load measurement through electrical sensing of viruses on a flexible plastic microchip with printed electrodes. Point-of-care (POC) viral load measurement is of paramount importance with significant impact on a broad range of applications
Debora Levy et al.
Biochemical and biophysical research communications, 505(4), 1043-1049 (2018-10-13)
Oxysterols are 27-carbon oxidation products of cholesterol metabolism. Oxysterols possess several biological actions, including the promotion of cell death. Here, we examined the ability of several oxysterols to induce short-term death in cancerous (human breast cancer and mouse skin melanoma
Le Tran Phuc Khoa et al.
Cell stem cell, 27(3), 441-458 (2020-07-02)
Self-renewing embryonic stem cells (ESCs) respond to environmental cues by exiting pluripotency or entering a quiescent state. The molecular basis underlying this fate choice remains unclear. Here, we show that histone acetyltransferase MOF plays a critical role in this process
Susanta Pahari et al.
Autophagy, 16(6), 1021-1043 (2019-08-30)
Host-directed therapies are gaining considerable impetus because of the emergence of drug-resistant strains of pathogens due to antibiotic therapy. Therefore, there is an urgent need to exploit alternative and novel strategies directed at host molecules to successfully restrict infections. The
Stefanie Ruf et al.
Autophagy, 13(3), 486-505 (2017-01-20)
Mechanistic target of rapamycin complex 1 (MTORC1) and polo like kinase 1 (PLK1) are major drivers of cancer cell growth and proliferation, and inhibitors of both protein kinases are currently being investigated in clinical studies. To date, MTORC1's and PLK1's
Helen E Farrell et al.
Journal of virology, 87(7), 4112-4117 (2013-01-25)
The mouse cytomegalovirus chemokine receptor homologue (CKR) M33 is required for salivary gland tropism and efficient reactivation from latency, phenotypes partially rescued by the human cytomegalovirus CKR US28. Herein, we demonstrate that complementation of salivary gland tropism is mediated predominantly
Paola Fabbrizio et al.
Brain pathology (Zurich, Switzerland), 30(2), 272-282 (2019-08-04)
Muscle weakness plays an important role in neuromuscular disorders comprising amyotrophic lateral sclerosis (ALS). However, it is not established whether muscle denervation originates from the motor neurons, the muscles or more likely both. Previous studies have shown that the expression
Rebecca A Wachs et al.
The spine journal : official journal of the North American Spine Society, 17(3), 435-444 (2016-12-19)
Disc degeneration is the leading cause of low back pain and is often characterized by a loss of disc height, resulting from cleavage of chondroitin sulfate proteoglycans (CSPGs) present in the nucleus pulposus. Intact CSPGs are critical to water retention
Holly A Schroeder et al.
Mucosal immunology, 13(5), 814-823 (2020-03-04)
The gastrointestinal (GI) mucosa is coated with a continuously secreted mucus layer that serves as the first line of defense against invading enteric bacteria. We have previously shown that antigen-specific immunoglobulin G (IgG) can immobilize viruses in both human airway
Dominic Paul Lee et al.
Circulation, 139(16), 1937-1956 (2019-02-06)
The human genome folds in 3 dimensions to form thousands of chromatin loops inside the nucleus, encasing genes and cis-regulatory elements for accurate gene expression control. Physical tethers of loops are anchored by the DNA-binding protein CTCF and the cohesin
T. Maniatis et al.
Molecular Cloning: A Laboratory Manual (1983)
Ashley Maynard et al.
Cell, 182(5), 1232-1251 (2020-08-22)
Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables adaptability, limits therapeutic success, and remains incompletely understood. Single-cell RNA sequencing (scRNA-seq) of metastatic lung cancer was performed using 49 clinical biopsies obtained from 30 patients before and
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