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Showing 1-20 of 20 results for "94-52-0" within Papers
Job Harenberg et al.
European journal of clinical investigation, 44(8), 743-752 (2014-06-17)
The determination of rivaroxaban and apixaban from serum samples of patients may be beneficial in specific clinical situations when additional blood sampling for plasma and thus the determination of factor Xa activity is not feasible or results are not plausible.
T Skaaby et al.
The British journal of dermatology, 171(6), 1407-1414 (2014-03-19)
Loss-of-function mutations in the filaggrin gene (FLG) could have opposing effects on cancer risk, as mutations are associated with both 10% higher serum vitamin D levels, which may protect against cancer, and with impaired skin barrier function, which may lead
Caio Max Rocha-Lima et al.
Cancer chemotherapy and pharmacology, 74(3), 479-486 (2014-07-18)
The G17DT is a novel human immunogen that raises antibodies to the growth factor gastrin 17 (G17). The purpose of this study was to determine the safety and efficacy of G17DT in combination with irinotecan in patients refractory to irinotecan
A Savva et al.
The British journal of dermatology, 168(2), 311-317 (2012-10-31)
Recent evidence has suggested that deranged immune responses play a role in the pathogenesis of hidradenitis suppurativa (HS). To investigate the role of single nucleotide polymorphisms (SNPs) of the tumour necrosis factor (TNF) and Toll-like receptor 4 (TLR4) genes in
Olivier Varenne et al.
Lancet (London, England), 391(10115), 41-50 (2017-11-06)
Elderly patients regularly receive bare-metal stents (BMS) instead of drug-eluting stents (DES) to shorten the duration of double antiplatelet therapy (DAPT). The aim of this study was to compare outcomes between these two types of stents with a short duration
Christian Schoergenhofer et al.
European journal of clinical investigation, 47(7), 504-512 (2017-05-31)
Despite decades of clinical use, the pharmacokinetics and the effects of acetylsalicylic acid (ASA) in critically ill patients remain ill-defined. We aimed to investigate the pharmacokinetics and the effects of different ASA formulations during critical illness. A cross-sectional study and
Monica L Castro-Acosta et al.
The Journal of nutritional biochemistry, 49, 53-62 (2017-09-09)
Postprandial glycemic responses to meals are inhibited by polyphenol-rich plant foods. Combinations of polyphenols may be particularly effective through complementary mechanisms. A randomized, controlled, double-blinded cross-over trial was conducted in healthy volunteers to test the hypothesis that apple and blackcurrant
C B Sanjeevi et al.
Annals of the New York Academy of Sciences, 958, 362-375 (2002-05-22)
IDDM is positively associated with HLA-DQA1*0301-DQB1*0302 (DQ8) and DQA1*0501-DQB1*0201 (DQ2) and negatively associated with DQA1*0102-DQB1*0602 (DQ6). The aim of the present study was to analyze the importance of several polymorphic residues and domains of DQalpha and DQbeta, in addition to
Tom P Freeman et al.
The lancet. Psychiatry, 7(10), 865-874 (2020-08-01)
Background A substantial and unmet clinical need exists for pharmacological treatment of cannabis use disorders. Cannabidiol could offer a novel treatment, but it is unclear which doses might be efficacious or safe. Therefore, we aimed to identify efficacious doses and
Karen M Edmond et al.
Lancet (London, England), 385(9975), 1315-1323 (2014-12-17)
Results of randomised controlled trials of newborn (age 1-3 days) vitamin A supplementation have been inconclusive. The WHO is coordinating three large randomised trials in Ghana, India, and Tanzania (Neovita trials). We present the findings of the Neovita trial in
Richard Pratley et al.
Lancet (London, England), 394(10192), 39-50 (2019-06-13)
Glucagon-like peptide-1 (GLP-1) receptor agonists are effective treatments for type 2 diabetes, lowering glycated haemoglobin (HbA1c) and weight, but are currently only approved for use as subcutaneous injections. Oral semaglutide, a novel GLP-1 agonist, was compared with subcutaneous liraglutide and
Katsuyuki Ando et al.
The lancet. Diabetes & endocrinology, 2(12), 944-953 (2014-12-04)
Renin-angiotensin system inhibitors have renoprotective effects in patients with chronic kidney disease, but most patients treated with these drugs have residual urinary albumin excretion. Some small clinical studies show that mineralocorticoid receptor blockade reduces albuminuria. Our study aimed to examine
Gretchen A Stevens et al.
The Lancet. Global health, 3(9), e528-e536 (2015-08-16)
Vitamin A deficiency is a risk factor for blindness and for mortality from measles and diarrhoea in children aged 6-59 months. We aimed to estimate trends in the prevalence of vitamin A deficiency between 1991 and 2013 and its mortality
Kris V Kowdley et al.
Lancet (London, England), 381(9883), 2100-2107 (2013-03-19)
The uridine nucleotide analogue sofosbuvir is a selective inhibitor of hepatitis C virus (HCV) NS5B polymerase. We assessed the safety and efficacy of sofosbuvir in combination with pegylated interferon alfa-2a (peginterferon) and ribavirin in non-cirrhotic treatment-naive, patients with HCV. For
Travis J Hollmann et al.
The American journal of surgical pathology, 36(6), 789-798 (2012-03-01)
Digital fibromyxoma (first described by Fetsch and colleagues as superficial acral fibromyxoma) is a distinctive soft tissue tumor with a predilection for the subungual or periungual region of the hands and feet. This report details the histologic, immunophenotypic, and clinical
Brit Mollenhauer et al.
The Lancet. Neurology, 10(3), 230-240 (2011-02-15)
Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy are brain disorders characterised by intracellular α-synuclein deposits. We aimed to assess whether reduction of α-synuclein concentrations in CSF was a marker for α-synuclein deposition in the brain, and therefore
Luca Gianni et al.
The Lancet. Oncology, 13(1), 25-32 (2011-12-14)
Studies with pertuzumab, a novel anti-HER2 antibody, show improved efficacy when combined with the established HER2-directed antibody trastuzumab in breast cancer therapy. We investigated the combination of pertuzumab or trastuzumab, or both, with docetaxel and the combination of pertuzumab and
Michele Macrelli et al.
Veterinary parasitology, 270, 1-6 (2019-06-20)
In 2016 suspected reduced ivermectin (IVM) efficacy in Oesophagostomum species in pigs was reported in England. Following this initial report, APHA raised awareness amongst private pig veterinary practitioners of the need to monitor the efficacy of the worm control on
S Rachel Skinner et al.
Lancet (London, England), 384(9961), 2213-2227 (2014-09-06)
Although adolescent girls are the main population for prophylactic human papillomavirus (HPV) vaccines, adult women who remain at risk of cervical cancer can also be vaccinated. We report data from the interim analysis of the ongoing VIVIANE study, the aim
Michael Manns et al.
Lancet (London, England), 384(9941), 414-426 (2014-06-08)
Pegylated interferon (peginterferon) alfa 2a or 2b plus ribavirin regimens were the standard of care in patients with hepatitis C virus (HCV) infection, but the sustained virological response can be suboptimum in patients with HCV genotype 1 infection. The efficacy
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