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Showing 1-30 of 404 results for "94046" within Papers
Marwa H Shukr et al.
Drug delivery and translational research, 5(1), 51-62 (2015-03-20)
This work aimed at studying a novel controlled drug delivery proniosomal formulation of pioglitazone for treatment of diabetes type-2. The effects of independent variables like type of surfactant and ratio of surfactants/cholesterol were studied using 3(2) factorial design. The provesicular
Muneeb U Rehman et al.
Pharmacological reports : PR, 66(6), 1050-1059 (2014-12-03)
Cisplatin is an effective and extensively used chemotherapeutic agent to treat range of malignancies, but its therapeutic use is limited because of dose-dependent nephrotoxicity and hepatotoxicity. Several published reports advocate that supplementation with antioxidant can influence cisplatin induced hepatic damage.
Alban Bujard et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 77, 273-278 (2015-06-30)
The Parallel Artificial Membrane Permeability Assay (PAMPA) is a well-known high throughput screening (HTS) technique for predicting in vivo passive absorption. In this technique, two compartments are separated by an artificial membrane that mimics passive permeability through biological membranes such
Liyun Ma et al.
Journal of chromatography. A, 1376, 64-73 (2014-12-22)
Cucurbit[7]uril (CB7), one host macromolecule, possesses a hydrophobic inner cavity and two identical hydrophilic carbonyl fringe portals, thus interacting with a variety of guest molecules through hydrophobic, hydrogen bonding and ion-dipole interactions. These characteristics make CB7 a good candidate as
Alban Bujard et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 63, 36-44 (2014-07-11)
The parallel artificial membrane permeability assay (PAMPA) is a high-throughput screening (HTS) method that is widely used to predict in vivo passive permeability through biological barriers, such as the skin, the blood brain barrier (BBB) and the gastrointestinal tract (GIT).
Young-Sun Nam et al.
World journal of gastroenterology, 21(7), 2030-2039 (2015-02-27)
To investigate the effects of mesenchymal stem cells (MSCs) on dextran sulfate sodium-induced inflammatory bowel disease (IBD). C57BL/6 mice were fed 3.5% (g/L) dextran sulfate sodium. On day seven, the mice received intraperitoneal injections of 1Ć10(6) MSCs. The survival rate
Xavier Matabosch et al.
Drug testing and analysis, 7(8), 663-672 (2014-12-30)
Glucocorticosteroids are prohibited in sports when administered by systemic routes and allowed using other administrations for therapeutic reasons. Therefore, markers to distinguish between routes of administration through the analysis of urine samples are needed in anti-doping control. As a first
Wen-Nee Tan et al.
Fitoterapia, 97, 261-267 (2014-06-14)
A triflavanone, Garcineflavanone A (1) and a biflavonol, Garcineflavonol A (2) have been isolated from the stem bark of Garcinia atroviridis (Clusiaceae), collected in Peninsular Malaysia. Their structures were established using one and two-dimensional NMR, UV, IR and mass spectrometry
Srinivasa M Sammeta et al.
Pharmaceutical development and technology, 20(2), 169-175 (2013-11-14)
The main objective of the present study was to develop formulations of noscapine hydrochloride hydrate with enhanced solubility and bioavailability using co-solvent- and cyclodextrin-based approaches. Different combinations of co-solvents, which were selected on the basis of high-throughput solubility screening, were
Chaoran Wang et al.
Journal of chromatography. A, 1281, 60-66 (2013-02-16)
While tailing and overloading of basic compounds remain problematic on most RP columns, a new kind of positively charged RP column named XCharge C18 was found to be superior good for the separation of alkaloids in our practical use. In
Gayatri K Joshi et al.
ACS nano, 9(11), 11075-11089 (2015-10-08)
MicroRNAs are short noncoding RNAs consisting of 18-25 nucleotides that target specific mRNA moieties for translational repression or degradation, thereby modulating numerous biological processes. Although microRNAs have the ability to behave like oncogenes or tumor suppressors in a cell-autonomous manner
Yufei Chen et al.
Drug design, development and therapy, 8, 1801-1815 (2014-10-23)
Hydroxychloroquine (HCQ) has been shown to demonstrate anti-inflammatory properties and direct anti-HIV activity. In this study, we describe for the first time the fabrication and in vitro evaluation of two types of intravaginal ring (IVR) devices (a surfaced-modified matrix IVR
Sima Rahimian et al.
Biomaterials, 37, 469-477 (2014-12-03)
Particulate antigen delivery systems aimed at the induction of antigen-specific T cells form a promising approach in immunotherapy to replace pharmacokinetically unfavorable soluble antigen formulations. In this study, we developed a delivery system using the model protein antigen ovalbumin (OVA)
Mehrorang Ghaedi et al.
Journal of chromatographic science, 53(7), 1222-1231 (2015-02-01)
A novel vortex-assisted surfactant-enhanced dispersive liquid-liquid microextraction combined with high-performance liquid chromatography (VASEDLLME-HPLC) was developed for the determination of thymol and carvacrol (phenolic compound). In this method, the extraction solvent (CHCl3) was dispersed into the aqueous samples via a vortex
Justin P Ludeman et al.
Organic & biomolecular chemistry, 13(7), 2162-2169 (2014-12-24)
Tyrosine sulfation is a widespread post-translational modification that mediates the interactions of secreted and membrane-associated proteins in such varied biological processes as peptide hormone action, adhesion, blood coagulation, complement activation and regulation of leukocyte trafficking. Due to the heterogeneous nature
Josep Marcos et al.
The Journal of steroid biochemistry and molecular biology, 152, 53-61 (2015-04-29)
The presence of two cysteinyl progestogens, 16-cysteinyl-progesterone (16-Cys-Prog) and 16-cysteinyl-pregnenolone (16-Cys-Preg), in human urine is described for the first time. Their occurrence was unequivocally confirmed by comparison with synthesized material by using mass spectrometric detectors. Several experiments were performed in
Xavier Matabosch et al.
Rapid communications in mass spectrometry : RCM, 28(16), 1829-1839 (2015-01-07)
Glucocorticosteroids are prohibited in sports when used by systemic administrations (e.g. intramuscular, IM), whereas they are allowed using other ways of administration. Strategies to discriminate between administrations routes have to be developed by doping control laboratories. For this reason, the
Brian J Song et al.
Food chemistry, 173, 305-312 (2014-12-04)
Interactions between polyphenols and macromolecules may impact polyphenol stability and bioavailability from foods. The impact of milk on tea flavan-3-ol stability to thermal treatment was investigated. Single strength (36.2 protein per L), quarter strength (9.0 g protein per L) milk
John O Suberu et al.
ChemMedChem, 9(12), 2791-2797 (2014-09-12)
In parts of Africa and Asia, self-medication with a hot water infusion of Artemisia annua (Artemisia tea) is a common practice for a number of ailments including malaria and cancer. In our earlier work, such an extract showed better potency
Monica Mazzarino et al.
Journal of pharmaceutical and biomedical analysis, 117, 47-60 (2015-09-08)
This work presents an analytical method for the simultaneous analysis in human urine of 38 pharmacologically active compounds (19 benzodiazepine-like substances, 7 selective serotonin reuptake inhibitors, 4 azole antifungal drugs, 5 inhibitors of the phosphodiesterases type 4 and 3 inhibitors
Miho Nakamura et al.
Biomedical materials (Bristol, England), 10(1), 011001-011001 (2015-01-15)
The surface modification of ceramic biomaterials used for medical devices is expected to improve osteoconductivity through control of the interfaces between the materials and living tissues. Polarisation treatment induced surface charges on hydroxyapatite, Ī²-tricalcium phosphate, carbonate-substituted hydroxyapatite and yttria-stabilized zirconia
H T P Nguyen et al.
Nanotechnology, 26(25), 255101-255101 (2015-06-03)
The cutaneous penetration of hydrophobic active molecules is of foremost concern in the dermatology and cosmetic formulation fields. The poor solubility in water of those molecules limits their use in hydrophilic forms such as gels, which are favored by patients
Ewa Oledzka et al.
International journal of molecular sciences, 16(9), 22205-22222 (2015-09-22)
The present study evaluated a new concept of combined scaffolds as a promising bone replacement material for patients with a bone tumour or bone metastasis. The scaffolds were composed of hydroxyapatite doped with selenium ions and a biodegradable polymer (linear
Genye He et al.
Journal of chromatographic science, 52(8), 848-851 (2013-09-14)
Formoterol is a new threshold substance in the prohibited list 2012 according to World Anti-Doping Agency. Extracted by ethyl acetate using formoterol-D6 as internal standard, formoterol underwent a constant flow rate gradient elution separation in reversed-phase liquid chromatography. Subsequently, mass
Binbin Zhang et al.
Biofouling, 31(6), 493-502 (2015-07-29)
Diatoms are a major component of microbial biofouling layers that develop on man-made surfaces placed in aquatic environments, resulting in significant economic and environmental impacts. This paper describes surface functionalisation of the inherently conducting polymers (ICPs) polypyrrole (PPy) and polyaniline
Josephine Al-Alam et al.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 50(11), 788-796 (2015-09-12)
Pesticides are a real concern for the society as their use has become critical, leading sometimes to their accumulation as residues in fruits and vegetables. After examining the pesticides sold in Northern Lebanon, this study is focused on the analysis
Jenna L Terebetski et al.
AAPS PharmSciTech, 15(5), 1334-1344 (2014-06-13)
To maximize the pharmacological effect of a pain reliever such as ibuprofen, early onset of action is critical. Unfortunately, the acidic nature of ibuprofen minimizes the amount of drug that can be solubilized under gastric conditions and would be available
Austin C Lowder et al.
Meat science, 94(1), 9-18 (2013-01-29)
This study was conducted using response surface methodology to predict fluid loss from injected beef strip steaks as influenced by levels of salt and sodium phosphates (SP) in the injection brine. Also, a beef-based dehydrated beef protein (DBP) water binding
Yuqin Li et al.
Die Pharmazie, 67(9), 768-773 (2012-09-29)
A new capillary electrophoresis method with field-amplified sample stacking (FASS) was developed for the analysis of sulfadiazine and sulfamethoxazole. After optimization of the separation and concentration conditions, the two compounds can be separated within 7 min and quantified with high
Hirokazu Wakuda et al.
Biological & pharmaceutical bulletin, 37(12), 1866-1871 (2014-12-03)
Although hyperlipidemia, high blood pressure, and diabetes increase the risk of arteriosclerosis, it is not clear whether hyperuricemia increases the risk of arteriosclerosis or not. We examined the effects of uric acid and curative drugs for hyperuricemia on atherosclerosis-susceptible C57BL/6J
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