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Showing 1-30 of 150 results for "A-911" within Papers
Hsin-Yu Bai et al.
The Analyst, 135(10), 2737-2742 (2010-09-08)
Microfluidic chip-based high-performance-liquid-chromatography coupled to mass spectrometry (chip-HPLC-MS) has been widely used in proteomic research due to its enhanced sensitivity. We employed a chip-HPLC-MS system for determining small molecules such as drug metabolites in biological fluids. This chip-HPLC-MS system integrates
A Negrusz et al.
Journal of forensic sciences, 46(5), 1143-1151 (2001-09-25)
In recent years, there has been a notable increase in the number of reports on drug-facilitated sexual assault. Benzodiazepines are the most common so-called "date-rape" drugs, with flunitrazepam (Rohypnol) being one of the most frequently mentioned. The aim of this
Mahaveer B Melwanki et al.
Talanta, 78(2), 618-622 (2009-02-11)
Dispersive liquid-liquid microextraction (DLLME) and liquid chromatography-electrospray-tandem mass spectrometry (LC-ES-MS/MS) procedure was presented for the extraction and determination of 7-aminoflunitrazepam (7-aminoFM2), a biomarker of the hypnotic flunitrazepam (FM2) in urine sample. The method was based on the formation of tiny
Jeffery Hackett et al.
Forensic science international, 157(2-3), 156-162 (2005-06-16)
The forensic toxicology community has recognized flunitrazepam and its metabolite (7-aminoflunitrazepam) as compounds of concern for several years. In this procedure, the analytes were extracted from whole blood and urine onto single mode solid phase cartridges (butyl) using nitrazepam as
H L Lord et al.
Journal of pharmaceutical and biomedical analysis, 40(3), 769-780 (2005-12-15)
We report on the development of solid phase microextraction probes for drug analysis, prepared with antibodies specific for benzodiazepines covalently immobilized to the surface. In the technique, immobilized antibody probes are exposed to a sample containing the drug for 30
Josh Gunn et al.
Methods in molecular biology (Clifton, N.J.), 603, 107-119 (2010-01-16)
The benzodiazepines are a large, commonly prescribed family of psychoactive drugs. We describe a method permitting the simultaneous detection and quantification of 12 benzodiazepines in serum using ultra-performance liquid chromatography (UPLC) coupled with tandem mass spectrometry (MS/MS). Analytes included alprazolam
Chiung-Wei Huang et al.
Journal of chromatography. A, 1110(1-2), 240-244 (2006-02-18)
A sweeping technique, in conjunction with micellar electrokinetic chromatography, for the simultaneous determination of flunitrazepam and its major metabolites, 7-aminoflunitrazepam and N-desmethylflunitrazepam, is described. The optimized conditions for the sweeping and separation were a pH 9.5 buffer, 25mM borate, 50mM
I Gafni et al.
Journal of clinical psychopharmacology, 23(2), 169-175 (2003-03-18)
Flunitrazepam, a hypnotic benzodiazepine, is widely prescribed around the world for the treatment of insomnia and as a preanesthetic. In vitro studies have shown that the metabolism of flunitrazepam to desmethylflunitrazepam and 3-hydroxyflunitrazepam is mediated in part by the polymorphic
H Snyder et al.
Journal of analytical toxicology, 25(8), 699-704 (2002-01-05)
A clinical study was conducted to assess the ability of commercially available immunoassays to detect flunitrazepam (FNP) in plasma and urine samples and to compare the results with those obtained by gas chromatography-mass spectrometry (GC-MS). The clinical study consisted of
Masaru Terada et al.
Legal medicine (Tokyo, Japan), 5 Suppl 1, S96-S100 (2003-08-26)
A method for the determination of flunitrazepam (FNZ) and 7-aminoflunitrazepam (7-AFNZ) in human serum was developed with ion trap gas chromatography (GC)-tandem mass spectrometry. The 7-AFNZ was derivatizated with 50 microl trifluoroacetic anhydride (TFAA), 60 degrees C-20 min. EI mass
Perng-Haur Wang et al.
Journal of analytical toxicology, 26(7), 411-418 (2002-11-09)
Confirmed and alleged misuses of flunitrazepam (FM2, Rohypnol) have brought about serious interest in the development of an analytical methodology that can be effectively used for preliminary screen and confirmatory test of FM2 (or its metabolites) in urine specimens under
Akira Namera et al.
The American journal of forensic medicine and pathology, 33(4), 293-296 (2011-03-05)
A 52-year-old woman was found dead on the floor of the living room on the first floor of a house, which belonged to the man with whom she shared the house. On visiting the site, her clothes were found to
Bill Guthery et al.
Rapid communications in mass spectrometry : RCM, 23(3), 340-348 (2009-01-07)
A technique using comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry (GC x GC/TOFMS) is applied to qualitative and quantitative drug testing. Human serum was 'spiked' with known quantities of benzodiazepines and a 'street heroin' mixture including some of the major metabolites
Yi-Chi Ho et al.
Analytica chimica acta, 697(1-2), 1-7 (2011-06-07)
Despite the advantages of simplicity and high-throughput detection that matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has over other methods, quantitative analysis of low-molecular-weight analyte is hampered by interference from matrix-derived background noise and signal fluctuation due to the
Franz E Dussy et al.
International journal of legal medicine, 120(6), 323-330 (2005-10-13)
A high-performance liquid chromatography method for the determination of benzodiazepines and their metabolites in whole blood and serum using mass spectrometry (MS) and photodiode array (PDA) detection is presented. The combination of both detection types can complement each other and
BĆ©la Kiss et al.
Talanta, 99, 649-659 (2012-09-13)
A simple, high-throughput, sensitive LC-ESI-MS/MS method is presented for the simultaneous determination of methadone (MET), flunitrazepam (FNZ) and their major metabolites, EDDP (2-ethilidene-1,5-dimethyl-3,3-diphenylpyrrolidone) and 7-aminoflunitrazepam (7-AFNZ), respectively, in human, rat and rabbit plasma. The isolation of the selected compounds involved
Yu-Hong Wu et al.
Se pu = Chinese journal of chromatography, 20(2), 182-184 (2003-01-25)
A rapid and highly sensitive method, based on high performance thin-layer chromatography, is described for the qualitative and semiquantitative determination of 7-aminoflunitrazepam, the main metabolite of flunitrazepam in human urine. 7-Aminoflunitrazepam in specimen was extracted by solid phase extraction using
Dong-Liang Lin et al.
Journal of analytical toxicology, 29(7), 718-723 (2006-01-20)
With 7-aminoflunitrazepam (7-amino-FM2)-specific ELISAs now readily available from several commercial sources (e.g., Cozart Bioscience, Immunalysis, this study was conducted to evaluate the performance characteristics of these products when applied to the two-step testing protocol as commonly practiced in today's workplace
AndrƩ L Castro et al.
Journal of forensic and legal medicine, 19(2), 77-82 (2012-01-28)
The use of psychoactive substances to improve social relations and increase body energy, in Rave Culture, has raised many legal and health public concerns, both for illicit trade and consumption. Therefore, forensic toxicology plays an important role in this area
Pascal Kintz
Forensic science international, 215(1-3), 73-76 (2011-03-01)
Excluding laboratory mistakes, a false positive hair result can be observed in case of contamination from environmental pollution (external contamination) or after drug incorporation into the hair from the individual body fluids, such as sweat or putrefactive fluid (post mortem
A fatal case due to combined toxicity of psychotropic drugs.
Hiroshi Kinoshita et al.
Forensic science international, 181(1-3), e7-e8 (2008-09-27)
Nele Samyn et al.
Journal of analytical toxicology, 26(4), 211-215 (2002-06-11)
Although administered as a short-acting hypnotic for sleeping disorders, flunitrazepam, often in combination with alcohol or other drugs, was one of the most frequently abused benzodiazepines over the last 10 years. It has been reported in cases of driving under
Robert Kronstrand et al.
Forensic science international, 145(2-3), 183-190 (2004-09-29)
Analyzing hair for many substances can be tedious and expensive, and a rapid screening method should prove helpful. Generally, screening has been performed using immunological tests, mainly in workplace drug testing, where the number of samples has been high. The
Kei Zaitsu et al.
Forensic science international, 174(2-3), 189-196 (2007-06-09)
The long-term stability of drugs and metabolites of forensic interest in urine, and preventive measures against their decomposition have been investigated, with special attention to filtration sterilization. An aseptic urine collection kit, which was recently developed based on filtration sterilization
StƩphane Pirnay et al.
Toxicological sciences : an official journal of the Society of Toxicology, 106(1), 64-73 (2008-08-16)
High-dosage buprenorphine (BUP) consumed concomitantly with benzodiazepines (BZDs) including flunitrazepam (FZ) may cause life-threatening respiratory depression despite a BUP ceiling effect and BZDs' limited effects on ventilation. However, the mechanism of BUP/FZ interaction remains unknown. We hypothesized that BUP may
K Svensson et al.
Naunyn-Schmiedeberg's archives of pharmacology, 344(3), 263-274 (1991-09-01)
The partial dopamine receptor agonists SDZ 208-911 (N-[(8-alpha)-2,6-dimethylergoline-8-yl]-2,2-dimethylpropanamid e), SDZ 208-912 (N-[8-alpha)-2-chloro-6-methylergoline-8-yl]-2,2- dimethylpropanamide) and terguride (transdihydrolisuride; TDHL) were tested in biochemical, behavioral (locomotor activity) and electrophysiological assays in male rats. In reserpine-pretreated rats, SDZ 208-911 and terguride dose-dependently reduced striatal
Amanda D Latimore et al.
The International journal on drug policy, 50, 82-89 (2017-10-19)
To address soaring opioid overdose fatality rates, 41U.S. states have passed Good Samaritan Laws (GSLs) extending legal immunity to overdose bystanders who call for emergency assistance. This study, conducted during the period that followed implementation of a GSL, aimed to
Vsevolod Telezhkin et al.
Pflugers Archiv : European journal of physiology, 461(6), 665-675 (2011-02-09)
The large conductance, voltage- and calcium-activated potassium channel, BK(Ca), is a known target for the gasotransmitter, carbon monoxide (CO). Activation of BK(Ca) by CO modulates cellular excitability and contributes to the physiology of a diverse array of processes, including vascular
Re: Combined ciprofloxacin and amikacin prophylaxis in the prevention of septicemia after transrectal ultrasound guided biopsy of the prostate: E. O. Kehinde, M. Al-maghrebi, M. Sheikh and J. T. Anim J Urol 2013, 189: 911-915.
Franklin Gaylis et al.
The Journal of urology, 190(4), 1443-1444 (2013-04-30)
Sofia Francia et al.
Current biology : CB, 16(15), 1551-1558 (2006-08-08)
Telomeres, the termini of linear chromosomes, are exceptional in that they are DNA ends that do not normally trigger a DNA-damage response (DDR) and are compatible with normal cellular proliferation. Mammalian telomeres are nevertheless a physiological substrate of the DDR
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