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Showing 1-30 of 69 results for "A0310" within Papers
Miao-Jin Ji et al.
Molecular psychiatry, 24(2), 282-293 (2018-08-09)
Hypothalamic neuropeptide orexin has been implicated in the pathophysiology of psychiatric disorders and accumulating clinical evidence indicates a potential link between orexin and depression. However, the exact role of orexin in depression, particularly the underlying neural substrates and mechanisms, remains
Elena Baldascino et al.
Frontiers in physiology, 8, 1001-1001 (2018-01-13)
The gastric ganglion is the largest visceral ganglion in cephalopods. It is connected to the brain and is implicated in regulation of digestive tract functions. Here we have investigated the neurochemical complexity (through in silico gene expression analysis and immunohistochemistry)
Kerstin Wirkner et al.
Journal of neurochemistry, 95(5), 1421-1437 (2005-11-30)
Neuronally enriched primary cerebrocortical cultures were exposed to glucose-free medium saturated with argon (in vitro ischemia) instead of oxygen (normoxia). Ischemia did not alter P2X7 receptor mRNA, although serum deprivation clearly increased it. Accordingly, P2X7 receptor immunoreactivity (IR) of microtubuline-associated
Giovanni Casini et al.
Investigative ophthalmology & visual science, 47(4), 1682-1690 (2006-03-28)
To determine the expression pattern of the predominant gamma-aminobutyric acid (GABA) plasma membrane transporter GAT-1 in Old World monkey (Macaca mulatta) and human retina. GAT-1 was localized in retinal sections by using immunohistochemical techniques with fluorescence and confocal microscopy. Double-labeling
Xue-Mei Zhang et al.
Frontiers in neuroanatomy, 3, 17-17 (2009-10-29)
A novel population of cells that express typical immature neuronal markers including doublecortin (DCX+) has been recently identified throughout the adult cerebral cortex of relatively large mammals (guinea pig, rabbit, cat, monkey and human). These cells are more common in
Mili B Patel et al.
The Journal of comparative neurology, 525(4), 885-900 (2016-10-22)
Descending projections from the thalamus and related structures to the midbrain are evolutionarily highly conserved. However, the basic organization of this auditory thalamotectal pathway has not yet been characterized. The purpose of this study was to obtain a better understanding
Holly A Holman et al.
iScience, 23(8), 101407-101407 (2020-08-11)
Sense of motion, spatial orientation, and balance in vertebrates relies on sensory hair cells in the inner ear vestibular system. Vestibular supporting cells can regenerate hair cells that are lost from aging, ototoxicity, and trauma, although not all factors or
Song Li et al.
Oncotarget, 8(4), 6883-6895 (2016-12-31)
Focal cortical dysplasia (FCD) is a major cause of intractable epilepsy in children however the mechanisms underlying the pathogenesis of FCD and FCD induced epilepsy remain unclear. Increasing evidence suggests that the large-pore ion channels, pannexin 1 (Panx1) and 2
Yuan Jiang et al.
The Journal of biological chemistry, 293(50), 19317-19329 (2018-10-20)
Human pluripotent stem cells hold great promise for improving regenerative medicine. However, a risk for tumor formation and difficulties in generating large amounts of subtype derivatives remain the major obstacles for clinical applications of stem cells. Here, we discovered that
Matheus B Victor et al.
Nature neuroscience, 21(3), 341-352 (2018-02-07)
In Huntington's disease (HD), expansion of CAG codons in the huntingtin gene (HTT) leads to the aberrant formation of protein aggregates and the differential degeneration of striatal medium spiny neurons (MSNs). Modeling HD using patient-specific MSNs has been challenging, as
Motokazu Uchigashima et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(15), 4206-4211 (2016-04-02)
Midbrain dopamine neurons project densely to the striatum and form so-called dopamine synapses on medium spiny neurons (MSNs), principal neurons in the striatum. Because dopamine receptors are widely expressed away from dopamine synapses, it remains unclear how dopamine synapses are
Yan Liu et al.
Nature protocols, 8(9), 1670-1679 (2013-08-10)
Forebrain γ-aminobutyric acid (GABA) interneurons have crucial roles in high-order brain function via modulating network activities and plasticity, and they are implicated in many psychiatric disorders. Availability of enriched functional human forebrain GABA interneurons, especially those from people affected by
Ana Mendanha Falcão et al.
Cell reports, 27(4), 1090-1102 (2019-04-25)
Citrullination, the deimination of peptidylarginine residues into peptidylcitrulline, has been implicated in the etiology of several diseases. In multiple sclerosis, citrullination is thought to be a major driver of pathology through hypercitrullination and destabilization of myelin. As such, inhibition of
Teruyuki Fukushima et al.
Journal of neurophysiology, 102(3), 1459-1471 (2009-04-17)
Analgesic effects of serotonin (5-hydroxytryptamine [5-HT]) type 3 (5-HT3) receptors may involve the release of gamma-aminobutyric acid (GABA) in the spinal dorsal horn. However, the precise synaptic mechanisms for 5-HT3 receptor-mediated spinal analgesia are not clear. In this study, we
Yumi Murata et al.
Neuroscience research, 98, 64-69 (2015-05-12)
We recently showed that changes of brain activity in the ipsilesional ventral premotor cortex (PMv) and perilesional primary motor cortex (M1) of macaque monkeys were responsible for recovery of manual dexterity after lesioning M1. To investigate whether axonal remodeling is
Christine J Huh et al.
eLife, 5 (2016-10-18)
Aging is a major risk factor in many forms of late-onset neurodegenerative disorders. The ability to recapitulate age-related characteristics of human neurons in culture will offer unprecedented opportunities to study the biological processes underlying neuronal aging. Here, we show that
Newborn horizontal cells migrate bi-directionally across the neuroepithelium during retinal development
Edqvist PHD and Hallbook F
Development, 131(6), 1343-1351 (2004)
Zhen-Kai Xing et al.
Frontiers in cellular neuroscience, 14, 29-29 (2020-03-11)
Axonal development is essential to the establishment of neuronal morphology and circuitry, although the mechanisms underlying axonal outgrowth during the early developmental stages remain unclear. Here, we showed that the conserved disco-interacting protein B (DIP2B) which consists of a DMAP1
Tetsufumi Ito et al.
The Journal of comparative neurology, 524(13), 2604-2622 (2016-02-07)
Inhibitory feedforward projection is one of key features of the organization of the central auditory system. In mammals, the inferior colliculus (IC) is the origin of a substantial inhibitory feedforward projection as well as an excitatory projection to the auditory
Mahesh B Rao et al.
Stem cell reports, 8(4), 831-842 (2017-03-14)
Current efforts to repair damaged or diseased mammalian retinas are inefficient and largely incapable of fully restoring vision. Conversely, the zebrafish retina is capable of spontaneous regeneration upon damage using Müller glia (MG)-derived progenitors. Understanding how zebrafish MG initiate regeneration
Miwako Yamasaki et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(35), 11534-11548 (2014-08-29)
Development of correct topographical connections between peripheral receptors and central somatosensory stations requires activity-dependent synapse refinement, in which the NMDA type of glutamate receptors plays a key role. Here we compared functional roles of GluN2B (GluRε2 or NR2B) and GluN2D
Per-Henrik D Edqvist et al.
Development (Cambridge, England), 131(6), 1343-1351 (2004-02-20)
Cell migration plays an important role during the development of the retina. In this work we have studied the migration of newborn horizontal cells in avian embryonic retina. Using the pattern of the early expressed transcription factors Lim1 and Prox1
Julia Schiemann et al.
Nature neuroscience, 15(9), 1272-1280 (2012-08-21)
Phasic activation of the dopamine (DA) midbrain system in response to unexpected reward or novelty is critical for adaptive behavioral strategies. This activation of DA midbrain neurons occurs via a synaptically triggered switch from low-frequency background spiking to transient high-frequency
Regan S Ashby et al.
Investigative ophthalmology & visual science, 55(9), 5911-5921 (2014-07-24)
The immediate early gene Egr-1 is thought to form part of the pathway that mediates abnormal ocular growth. This study investigated whether the mRNA expression levels of Egr-1 in a mammalian retina are modulated differentially, depending on the direction of
Andrea M Harrington et al.
American journal of physiology. Gastrointestinal and liver physiology, 317(3), G285-G303 (2019-06-13)
The distal colon is innervated by the splanchnic and pelvic nerves, which relay into the thoracolumbar and lumbosacral spinal cord, respectively. Although the peripheral properties of the colonic afferent nerves within these pathways are well studied, their input into the
Limei Zhang et al.
Translational psychiatry, 8(1), 50-50 (2018-02-27)
The lateral habenula (LHb) has a key role in integrating a variety of neural circuits associated with reward and aversive behaviors. There is limited information about how the different cell types and neuronal circuits within the LHb coordinate physiological and
Jenne M Westberry et al.
Neuroscience, 331, 186-196 (2016-06-23)
Chemosensory stimuli from conspecific and heterospecific animals, elicit categorically different immediate-early gene response-patterns in medial amygdala in male hamsters and mice. We previously showed that conspecific signals activate posterior (MeP) as well as anterior medial amygdala (MeA), and especially relevant
Valerio Magnaghi et al.
Journal of neurochemistry, 112(4), 980-990 (2009-12-01)
Recent evidence showed that neurotransmitters are synthesised in glial cells, such as the Schwann cells, which form myelin sheaths in the PNS. While the presence of GABA type A (GABA-A) receptors has been previously demonstrated in these cells, the evidence
Marieke Meijer et al.
Cell reports, 27(7), 2199-2211 (2019-05-16)
Synaptic dysfunction is associated with many brain disorders, but robust human cell models to study synaptic transmission and plasticity are lacking. Instead, current in vitro studies on human neurons typically rely on spontaneous synaptic events as a proxy for synapse function.
Samuel S Pappas et al.
Human molecular genetics, 27(3), 407-420 (2017-12-01)
A critical challenge to deciphering the pathophysiology of neurodevelopmental disease is identifying which of the myriad abnormalities that emerge during CNS maturation persist to contribute to long-term brain dysfunction. Childhood-onset dystonia caused by a loss-of-function mutation in the AAA+ protein torsinA
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