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Showing 1-30 of 329 results for "A0580" within Papers
Tarvi Teder et al.
Archives of biochemistry and biophysics, 676, 108126-108126 (2019-10-08)
A catalase-related allene oxide synthase (cAOS) or a hydroperoxide lyase (cHPL) fused together with an 8R-lipoxygenase is involved in the stress signaling of corals via an arachidonic acid pathway. cAOS gives rise to α-ketol and cyclopentenone, while cHPL catalyzes the
Isabel Forner-Piquer et al.
Endocrinology, 158(10), 3462-3476 (2017-09-25)
Phthalates, used as plasticizers, have become a ubiquitous contaminant and have been reported for their potential to induce toxicity in living organisms. Among them, di-isononyl phthalate (DiNP) has been recently used to replace di(2-ethylhexyl) phthalate (DEHP). Nowadays, there is evidence
Arnold Markovics et al.
The Journal of investigative dermatology, 140(10), 1909-1918 (2020-03-07)
We have shown previously that endocannabinoids promote sebaceous lipogenesis, and sebocytes are involved in the metabolism of the endocannabinoid-like substance oleoylethanolamide (OEA). OEA is an endogenous activator of GPR119, a recently deorphanized receptor, which currently is being investigated as a
Aidan Levine et al.
Frontiers in pharmacology, 11, 615028-615028 (2021-02-16)
Recent findings suggested that Clinical Endocannabinoid Deficiency underlies the pathophysiology of pain disorders, including migraine and headache. In models of medication overuse headache induced by sustained administration of sumatriptan or morphine, 2-AG levels were selectively depleted in the periaqueductal gray
Emmanuel Dotsey et al.
Scientific reports, 7, 42584-42584 (2017-02-18)
The hallmark of vaccines is their ability to prevent the spread of infectious pathogens and thereby serve as invaluable public health tool. Despite their medical relevance, there is a gap in our understanding of the physiological factors that mediate innate
Cristina Miralpeix et al.
Journal of lipid research, 60(7), 1260-1269 (2019-05-30)
The endocannabinoid (eCB) system regulates energy homeostasis and is linked to obesity development. However, the exact dynamic and regulation of eCBs in the hypothalamus during obesity progression remain incompletely described and understood. Our study examined the time course of responses
Bright N Okine et al.
Pain, 157(12), 2687-2696 (2016-09-21)
The neural substrates and mechanisms mediating the antinociceptive effects of the endogenous bioactive lipid, N-palmitoylethanolamide (PEA), require further investigation. We investigated the effects of exogenous PEA administration into the anterior cingulate cortex (ACC), an important brain region linked with cognitive
M G Gervasi et al.
Journal of cellular biochemistry, 117(2), 320-333 (2015-07-02)
The oviduct acts as a functional sperm reservoir in many mammalian species. Both binding and release of spermatozoa from the oviductal epithelium are mainly modulated by sperm capacitation. Several molecules from oviductal fluid are involved in the regulation of sperm
Xingwu Jiang et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 67, 153160-153160 (2020-01-07)
Increasing evidence indicated that the cannabinoid receptors were involved in the pathogenesis of organ fibrogenesis. The purpose of this study was to discover novel cannabinoid receptor 2 (CB2) agonist and assess the potential of CB2 activation in treating systemic sclerosis.
Anna Chorniy et al.
Journal of health economics, 60, 1-15 (2018-05-19)
In the U.S., nearly 11% of school-age children have been diagnosed with ADHD, and approximately 10% of children suffer from asthma. In the last decade, the number of children diagnosed with these conditions has inexplicably been on the rise. This
Malena Lis Mul Fedele et al.
Frontiers in cellular and infection microbiology, 10, 100-100 (2020-04-01)
Sepsis is caused by a dysregulated host response to infection, and characterized by uncontrolled inflammation together with immunosuppression, impaired innate immune functions of phagocytes and complement activation. Septic patients develop fever or hypothermia, being the last one characteristic of severe
Silvia L Cruz et al.
International immunopharmacology, 64, 298-307 (2018-09-23)
Activation of high affinity receptor for IgE (FcεRI) by IgE/antigen complexes in mast cells (MCs) leads to the release of preformed pro-inflammatory mediators stored in granules by a Ca2+-dependent process known as anaphylactic degranulation. Degranulation inhibition has been proposed as
Simon Nicolussi et al.
Biochemical pharmacology, 92(4), 669-689 (2014-10-07)
Besides the suggested role of a putative endocannabinoid membrane transporter mediating the cellular uptake of the endocannabinoid anandamide (AEA), this process is intrinsically coupled to AEA degradation by the fatty acid amide hydrolase (FAAH). Differential blockage of each mechanism is
John-Mark Fitzpatrick et al.
Journal of neuroimmunology, 343, 577217-577217 (2020-04-04)
Toll-like receptors (TLRs) are sensors of pathogen-associated molecules that trigger inflammatory signalling in innate immune cells including macrophages. All TLRs, with the exception of TLR3, promote intracellular signalling via recruitment of the myeloid differentiation factor 88 (MyD88) adaptor, while TLR3
M Almada et al.
Reproduction (Cambridge, England), 152(4), 351-361 (2016-08-29)
Endocannabinoids (eCBs) are endogenous mediators that along with the cannabinoid receptors (CB1 and CB2), a membrane transporter and metabolic enzymes form the endocannabinoid system (ECS). Several eCBs have been discovered with emphasis on anandamide (AEA). They are involved in several
Jessica Karlsson et al.
PloS one, 9(7), e103589-e103589 (2014-07-26)
In addition to their effects upon prostaglandin synthesis, the non-steroidal anti-inflammatory drugs ibuprofen and flurbiprofen inhibit the metabolism of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA) by cyclooxygenase-2 (COX-2) and fatty acid amide hydrolase (FAAH), respectively. Here, we investigated whether
Georgia Balsevich et al.
Frontiers in neuroendocrinology, 47, 86-108 (2017-07-26)
For decades, there has been speculation regarding the interaction of cannabinoids with glucocorticoid systems. Given the functional redundancy between many of the physiological effects of glucocorticoids and cannabinoids, it was originally speculated that the biological mechanisms of cannabinoids were mediated
Andrea Martella et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(12), 4275-4288 (2016-09-15)
The developmental role of the endocannabinoid system still remains to be fully understood. Here, we report the presence of a complete endocannabinoid system during zebrafish development and show that the genes that code for enzymes that catalyze the anabolism and
Ya-Jen Chiu et al.
Aging, 12(23), 23619-23646 (2020-11-17)
Polyglutamine (polyQ)-mediated spinocerebellar ataxias (SCA) are caused by mutant genes with expanded CAG repeats encoding polyQ tracts. The misfolding and aggregation of polyQ proteins result in increased reactive oxygen species (ROS) and cellular toxicity. Inflammation is a common manifestation of
Nadi F Salaya-Velazquez et al.
Neuroreport, 31(3), 240-244 (2020-01-11)
Food reward has been studied with highly palatable stimuli that come from natural additives such as sucrose. The most common food additive is sucralose, a noncaloric sweetener present in many food products of daily intake. The role of anandamide [N-arachidonylethanolamide
Alessandro Deplano et al.
Journal of enzyme inhibition and medicinal chemistry, 35(1), 815-823 (2020-03-24)
Inhibition of fatty acid amide hydrolase (FAAH) reduces the gastrointestinal damage produced by non-steroidal anti-inflammatory agents such as sulindac and indomethacin in experimental animals, suggesting that a dual-action FAAH-cyclooxygenase (COX) inhibitor could have useful therapeutic properties. Here, we have investigated
Lucia M Krott et al.
Journal of lipid research, 57(3), 464-473 (2016-01-16)
The endocannabinoids and their main receptor, cannabinoid type-1 (CB1), suppress intracellular cyclic AMP levels and have emerged as key players in the control of energy metabolism. CB1 agonists and blockers have been reported to influence the thermogenic function of white
Setareh Sianati et al.
Frontiers in bioengineering and biotechnology, 8, 608951-608951 (2021-02-05)
Ion channels activated by mechanical inputs are important force sensing molecules in a wide array of mammalian cells and tissues. The transient receptor potential channel, TRPV4, is a polymodal, nonselective cation channel that can be activated by mechanical inputs but
Rebeca Caires et al.
Cell reports, 21(1), 246-258 (2017-10-06)
Dietary consumption of ω-3 polyunsaturated fatty acids (PUFAs), present in fish oils, is known to improve the vascular response, but their molecular targets remain largely unknown. Activation of the TRPV4 channel has been implicated in endothelium-dependent vasorelaxation. Here, we studied
Masaomi Takizawa et al.
Clinical therapeutics, 42(5), 906-923 (2020-05-28)
This study aimed to evaluate the safety, tolerability, and pharmacokinetic and pharmacodynamic properties of ASP3652, a peripherally acting inhibitor of peripheral fatty acid amide hydrolase (FAAH) after 30-, 100-, 300-, 600-, and 900-mg single and 100- and 300-mg BID multiple
Na Cui et al.
Frontiers in endocrinology, 8, 268-268 (2017-11-01)
We investigated the role of the endocannabinoid system (ECS) in the endometrium of unexplained infertility (UI) patients, and effect of anandamide (AEA) on leukemia inhibitory factor (LIF). Patients were divided into UI and control groups. Endometrium samples were collected at
J Maia et al.
The Journal of steroid biochemistry and molecular biology, 174, 40-47 (2017-07-27)
The endocannabinoid system (ECS) is involved in several physiological events that resulted in a growing interest in its modulation. Moreover, the uterine levels of anandamide (AEA), the major endocannabinoid, must be tightly regulated to create proper embryo implantation conditions. However
Maria Bobrich et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1161, 122371-122371 (2020-11-28)
The arachidonic acid derivatives N-arachidonoylethanolamine (anandamide; AEA), 2-arachidonoylglycerol (2-AG), N-arachidonoyldopamine (NADA), 2-arachidonoylglycerol ether (noladin ether; 2-AGE) and O-arachidonoylethanolamine (virodhamine; VA) were identified as physiological components of the endocannabinoid (EC) system. In order to gain further profound knowledge about the different
Enrico Dainese et al.
Scientific reports, 10(1), 2292-2292 (2020-02-12)
Fatty acid amide hydrolase (FAAH) is a membrane-bound homodimeric enzyme that in vivo controls content and biological activity of N-arachidonoylethanolamine (AEA) and other relevant bioactive lipids termed endocannabinoids. Parallel orientation of FAAH monomers likely allows both subunits to simultaneously recruit
Cinzia Rapino et al.
Human reproduction update, 20(4), 501-516 (2014-02-12)
Infertility is a condition of the reproductive system that affects ∼10-15% of couples attempting to conceive a baby. More than half of all cases of infertility are a result of female conditions, while the remaining cases can be attributed to
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