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Showing 1-30 of 34 results for "A1075" within Papers
M Citron et al.
Proceedings of the National Academy of Sciences of the United States of America, 93(23), 13170-13175 (1996-11-12)
Cerebral deposition of the amyloid beta protein (A beta) is an early and invariant feature of Alzheimer disease (AD). Whereas the 40-amino acid form of A beta (A beta 40) accounts for approximately 90% of all A beta normally released
Chia-Mei Chou et al.
Parasites & vectors, 10(1), 620-620 (2017-12-24)
Toxocariasis is a worldwide zoonotic parasitic disease mainly caused by Toxocara canis. Humans can be infected by accidental ingestion of T. canis embryonated ovum-contaminated food, water, or encapsulated larvae in paratenic hosts' viscera or meat. Since humans and mice are
Molecular pathogenesis of Alzheimer?s disease: reductionist versus expansionist approaches
Castellani R, et al.
International Journal of Molecular Sciences, 10(3), 1386-1406 (2009)
Yi R Hu et al.
Current Alzheimer research, 18(3), 208-221 (2021-06-10)
Alzheimer's disease (AD) is the most common type of dementia and has a complex pathogenesis with no effective treatment. Energy metabolism disorders, as an early pathological event of AD,have attracted attention as a promising area of AD research. Codonopsis pilosula
Yiran Hu et al.
Biological research, 55(1), 10-10 (2022-03-05)
In Alzheimer's disease (AD), the neuroinflammatory response mediated by the activation of senescent microglia is closely related to energy dysmetabolism. However, the mechanism underlying the interaction between the energy metabolism of aging microglia and neuroinflammation remains unclear. We used biochemical
Ladan Pourabdi et al.
Frontiers in chemistry, 9, 810233-810233 (2022-02-08)
A novel series of coumarin derivatives linked to the N-benzyl triazole group were synthesized and evaluated against 15-lipoxygenase (15-LOX), and acetyl- and butyrylcholinesterase (AChE and BuChE) to find the most potent derivative against Alzheimer's disease (AD). Most of the compounds
H Funato et al.
The American journal of pathology, 152(4), 983-992 (1998-04-18)
Amyloid beta-protein (Abeta) is the major component of senile plaques that emerge in the cortex during aging and appear most abundantly in Alzheimer's disease. In the course of our immunocytochemical study on a large number of autopsy cases, we noticed
Bin Li et al.
Molecular medicine reports, 23(4) (2021-02-20)
Yuan‑zhi‑san (YZS) is a classic type of Traditional Chinese Medicine, which has been reported to aid in the treatment of Alzheimer's disease (AD). The present study aimed to investigate the effects of YZS on tau protein aggregation, a hallmark of
Pei-Ning Wang et al.
Alzheimer's & dementia (Amsterdam, Netherlands), 12(1), e12029-e12029 (2020-05-05)
Pyroglutamate-modified amyloid β (AβpE3) could be a biomarker for Aβ plaque pathology in the brain. An ultra-high-sensitive assay is needed for detecting AβpE3-40. Immunomagnetic reduction was used for quantification of AβpE3-40 in plasma from 46 participants. The concentrations of AβpE3-40
Giulia Foschi et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 16(16), 3379-3384 (2015-09-06)
The amorphous aggregation of Aβ1-40 peptide is addressed by using micromolding in capillaries. Both the morphology and the size of the aggregates are modulated by changing the contact angle of the sub-micrometric channel walls. Upon decreasing the hydrophilicity of the
Lindsey Theda et al.
Neurobiology of aging, 38, 11-13 (2016-02-02)
There is a vast literature on the role of beta amyloid (Aβ) peptides in the pathogenesis of Alzheimer's disease. However, there is a paucity of research on the potential physiological functions of these evolutionarily conserved products of the Aβ precursor
D R Howlett et al.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration, 4(1), 23-32 (1995-03-01)
The behaviour of synthetic batches of beta-amyloid (beta A) 1-40 peptide in solution has been studied. The effects of beta A1-40 on a PC12 cell toxicity assay was dependent upon the time of preincubation of an aqueous solution of the
Solution Structure of Amyloid beta-Peptide (1- 40) in a Water- Micelle Environment. Is the Membrane-Spanning Domain Where We Think It Is?
Coles M, et al.
Biochemistry, 37(31), 11064-11077 (1998)
Madhura S Lotlikar et al.
STAR protocols, 3(1), 101028-101028 (2022-01-22)
This protocol describes the differentiation of human neural progenitor cells (hNPCs) in a microfluidic device containing a thin 3D matrix with two separate chambers, enabling a cleaner separation between axons and soma/bulk neurons. We have used this technique to study
Deborah L Heyl et al.
Protein and peptide letters, 26(7), 502-511 (2019-04-06)
Amyloid fibrils in Alzheimer's disease are composed of amyloid-β (Aβ) peptides of variant lengths. Humanin (HN), a 24 amino acid residue neuroprotective peptide, is known to interact with the predominant Aβ isoform in the brain, Aβ (1-40). Here, we constructed
Wenjun Deng et al.
Aging cell, 21(8), e13503-e13503 (2022-07-20)
β-amyloid (Aβ) deposits in brain blood vessel walls underlie the vascular pathology of Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). Growing evidence has suggested the involvement of cerebrovascular dysfunction in the initiation and progression of cognitive impairment in AD
Hong Wei et al.
Cell death & disease, 11(4), 290-290 (2020-04-29)
Hypoxia limits the survival and function of neurons in the development of Alzheimer's diseases. Exosome-dependent intercellular communication is an emerging signaling mechanism involved in tissue repair and regeneration; however, the effect and underlying mechanism of mesenchymal stem cell-derived exosomes in
Temperature-induced conformational changes in amyloid beta (1-40) peptide investigated by simultaneous FT-IR microspectroscopy with thermal system
Chu HL and Lin SY
Biophysical Chemistry, 89(2-3), 173-180 (2001)
Jie Xu et al.
Molecular vision, 23, 1015-1028 (2018-02-02)
To evaluate the changes in β-amyloid (Aβ) expression in age-related cataract (ARC) lens epithelia and the effect of Aβ on oxidative damage in human lens epithelial cells (HLECs). Specimens of lens epithelia and aqueous humor were obtained from 255 cataract
Amyloid beta protein 1-40 and 1-42 levels in matched cerebrospinal fluid and plasma from patients with Alzheimer disease
Mehta PD, et al.
Neuroscience Letters, 304(1-2), 102-106 (2001)
Mohammad Shahrivar-Gargari et al.
Archiv der Pharmazie, 354(7), e2000453-e2000453 (2021-04-20)
Inspired by the structures of donepezil and rivastigmine, a novel series of indanone-carbamate hybrids was synthesized using the pharmacophore hybridization-based design strategy, and their biological activities toward acetylcholinesterase (AChE) and butyrylcholinesterase were evaluated. Among the synthesized compounds, 4d and 4b
Lirong Chang et al.
Journal of Alzheimer's disease : JAD, 51(1), 197-212 (2016-02-03)
Synaptic dysfunction during early stages of Alzheimer's disease (AD) is triggered by soluble amyloid-β (Aβ) oligomers that interact with NMDA receptors (NMDARs). We previously showed that Aβ induces synaptic protein loss through NMDARs, albeit through undefined mechanisms. Accordingly, we here
Charlotte E Teunissen et al.
Journal of Alzheimer's disease : JAD, 62(4), 1857-1863 (2018-04-05)
The 42 amino acid form of amyloid-β (Aβ42) plays a key role in the pathogenesis of Alzheimer's disease (AD) and is a core biomarker for the diagnosis of AD. Numerous studies have shown that cerebrospinal fluid (CSF) Aβ42 concentrations are
Kelly K Ball et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 30(1), 162-176 (2009-10-02)
Metabolic brain imaging is widely used to evaluate brain function and disease, and quantitative assays require local retention of compounds used to register changes in cellular activity. As labeled metabolites of [1- and 6-(14)C]glucose are rapidly released in large quantities
Diversity of amyloid beta protein fragment [1-40]-formed channels
Kourie JI, et al.
Cellular and Molecular Neurobiology, 21(3), 255-284 (2001)
Hsin-Hsien Chen et al.
ACS measurement science au, 2(5), 485-492 (2023-02-15)
With the demands of the high-throughput assay of biomarkers of ultralow concentrations in clinics, a 36-channel instrument utilizing immunomagnetic reduction (IMR) has been developed. The instrument involves the use of a high-T c superconducting-quantum-interference-device (SQUID) magnetometer to detect the signals
Xujiao Huang et al.
Molecular medicine reports, 16(3), 2700-2706 (2017-07-18)
Alzheimer's disease (AD) is the most common type of senile dementia, which often develops in elderly or presenile individuals. As one of the pathological features of AD, amyloid β‑protein (Aβ) causes energy dysmetabolism, thereby inducing cellular damage and apoptosis. Salidroside
B A Yankner et al.
Science (New York, N.Y.), 250(4978), 279-282 (1990-10-12)
The amyloid beta protein is deposited in the brains of patients with Alzheimer's disease but its pathogenic role is unknown. In culture, the amyloid beta protein was neurotrophic to undifferentiated hippocampal neurons at low concentrations and neurotoxic to mature neurons
M Y Aksenov et al.
Journal of molecular neuroscience : MN, 10(3), 181-192 (1998-10-15)
Mechanism of amyloid beta-peptide (A beta) toxicity in cultured neurons involves the development of oxidative stress in the affected cells. A significant increase in protein carbonyl formation was detected in cultured hippocampal neurons soon after the addition of preaggregated A
Sandwich-Type Enzyme Immunoassay for Amyloid A4 Protein in Cerebrospinal Fluid From Patients with Head Trauma
PIRIM I
Turkish Journal of Medical Sciences, 31(1), 47-50 (2001)
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