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Showing 1-17 of 17 results for "A1231" within Papers
Isabella Barbiero et al.
Scientific reports, 7(1), 6228-6228 (2017-07-26)
The cyclin-dependent kinase-like 5 (CDKL5) gene has been associated with rare neurodevelopmental disorders characterized by the early onset of seizures and intellectual disability. The CDKL5 protein is widely expressed in most tissues and cells with both nuclear and cytoplasmic localization.
Weizhe Li et al.
Science advances, 5(3), eaau7566-eaau7566 (2019-03-12)
Polo-like kinase 1 (Plk1) is a crucial regulator of cell cycle progression; but the mechanism of regulation of Plk1 activity is not well understood. We present evidence that Plk1 activity is controlled by a balanced methylation and phosphorylation switch. The
Fei Peng et al.
Cell research, 31(3), 345-361 (2020-08-30)
RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms. Here, we demonstrate that DROSHA interacts with β-Catenin to transactivate STC1 in an RNA cleavage-independent manner, contributing to breast cancer stem-like cell (BCSC)
Selena G Burgess et al.
PLoS genetics, 11(7), e1005345-e1005345 (2015-07-03)
The essential mammalian gene TACC3 is frequently mutated and amplified in cancers and its fusion products exhibit oncogenic activity in glioblastomas. TACC3 functions in mitotic spindle assembly and chromosome segregation. In particular, phosphorylation on S558 by the mitotic kinase, Aurora-A
Aurora-A Identifies Early Recurrence and Poor Prognosis and Promises a Potential Therapeutic Target in Triple Negative Breast Cancer
Xu J, et al.
PLoS ONE, 8(2), e56919-e56919 (2013)
Daniel C Lim et al.
Science signaling, 13(641) (2020-07-23)
Cell cycle-dependent redox changes can mediate transient covalent modifications of cysteine thiols to modulate the activities of regulatory kinases and phosphatases. Our previously reported finding that protein cysteine oxidation is increased during mitosis relative to other cell cycle phases suggests
Zhi-Gang Liu et al.
Oncology letters, 3(6), 1237-1244 (2012-07-12)
Aurora-A kinase (Aur-A), a member of a family of mitotic serine/threonine kinases, is known to be amplified in epithelial malignancies. In this study, we focused our investigation on Aur-A expression and its prognostic significance in nasopharyngeal carcinoma (NPC). Immunohistochemical staining
Qian He et al.
Molecular biology of the cell, 25(11), 1715-1729 (2014-04-04)
We show here that human embryonic stem (ES) and induced pluripotent stem cell-derived neuroprogenitors (NPs) develop primary cilia. Ciliogenesis depends on the sphingolipid ceramide and its interaction with atypical PKC (aPKC), both of which distribute to the primary cilium and
Hiroshi Katayama et al.
Cancer cell, 21(2), 196-211 (2012-02-22)
Elevated Aurora kinase-A expression is correlated with abrogation of DNA damage-induced apoptotic response and mitotic spindle assembly checkpoint (SAC) override in human tumor cells. We report that Aurora-A phosphorylation of p73 at serine235 abrogates its transactivation function and causes cytoplasmic
Expression and purification of active human kinases using Pichia pastoris as a general-purpose host.
May H Abdel Aziz et al.
Protein expression and purification, 179, 105780-105780 (2020-10-30)
The heterologous expression of human kinases in good purity and in a monomeric, soluble and active form can be challenging. Most of the reported successful attempts are carried out in insect cells as a host. The use of E. coli
Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2M transition
Dutertre S, et al.
Journal of Cell Science, 117(12), 2523-2531 (2004)
Alexander Sosunov et al.
Acta neuropathologica communications, 8(1), 47-47 (2020-04-16)
Although abnormal mitosis with disarranged metaphase chromosomes or many micronuclei in astrocytes (named "Alzheimer I type astrocytes" and later "Creutzfeldt-Peters cells") have been known for nearly 100 years, the origin and mechanisms of this pathology remain elusive. In experimental brain insults
Shulan Sun et al.
Cancer communications (London, England), 41(9), 851-866 (2021-07-13)
Increasing studies have reported that oncogenes regulate components of the immune system, suggesting that this is a mechanism for tumorigenesis. Aurora kinase A (AURKA), a serine/threonine kinase, is involved in cell mitosis and is essential for tumor cell proliferation, metastasis
MaKendra Umstead et al.
Oncotarget, 8(17), 28359-28372 (2017-02-09)
In cancer, upregulated Ras promotes cellular transformation and proliferation in part through activation of oncogenic Ras-MAPK signaling. While directly inhibiting Ras has proven challenging, new insights into Ras regulation through protein-protein interactions may offer unique opportunities for therapeutic intervention. Here
Edward J Morris et al.
Nature communications, 8, 15289-15289 (2017-05-06)
Cancer cells frequently have amplified centrosomes that must be clustered together to form a bipolar mitotic spindle, and targeting centrosome clustering is considered a promising therapeutic strategy. A high-content chemical screen for inhibitors of centrosome clustering identified Stattic, a Stat3
Jie Xu et al.
PloS one, 8(2), e56919-e56919 (2013-02-26)
Triple negative breast cancer (TNBC) acquires an unfavorable prognosis, emerging as a major challenge for the treatment of breast cancer. In the present study, 122 TNBC patients were subjected to analysis of Aurora-A (Aur-A) expression and survival prognosis. We found
Likun Li et al.
Molecular oncology, 7(3), 484-496 (2013-01-22)
In this study we report that expression of glioma pathogenesis-related protein 1 (GLIPR1) regulated numerous apoptotic, cell cycle, and spindle/centrosome assembly-related genes, including AURKA and TPX2, and induced apoptosis and/or mitotic catastrophe (MC) in prostate cancer (PCa) cells, including p53-mutated/deleted
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