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Showing 1-30 of 239 results for "A1270000" within Papers
Anil Kumar et al.
The Journal of surgical research, 188(1), 268-279 (2014-02-04)
Traumatic head injury is turning out to be a major cause of disability and death. Nitric oxide (NO), an intercellular messenger plays a crucial role in the pathophysiology of several neurologic disorders. Therefore, the present study was designed to investigate
Rob M Moonen et al.
International journal of molecular sciences, 16(1), 19-39 (2014-12-30)
Endogenously produced inhibitors of nitric oxide (NO) synthase, in particular asymmetric dimethylarginine (ADMA), are currently considered of importance in various disease states characterized by reduced NO availability. We investigated the association between plasma levels of ADMA, symmetric dimethylarginine (SDMA), L-arginine
Kristen A Baltgalvis et al.
American journal of physiology. Heart and circulatory physiology, 306(8), H1128-H1145 (2014-02-25)
Intermittent claudication is a form of exercise intolerance characterized by muscle pain during walking in patients with peripheral artery disease (PAD). Endothelial cell and muscle dysfunction are thought to be important contributors to the etiology of this disease, but a
Kerem Bingol et al.
Analytical chemistry, 87(7), 3864-3870 (2015-02-13)
A novel strategy is introduced that combines high-resolution mass spectrometry (MS) with NMR for the identification of unknown components in complex metabolite mixtures encountered in metabolomics. The approach first identifies the chemical formulas of the mixture components from accurate masses
Roshani Patel et al.
Biochimica et biophysica acta, 1843(9), 1978-1986 (2014-05-31)
The Tat system transports folded proteins across the bacterial plasma membrane. The mechanism is believed to involve coalescence of a TatC-containing unit with a separate TatA complex, but the full translocation complex has never been visualised and the assembly process
Jia-Yi Dong et al.
American heart journal, 162(6), 959-965 (2011-12-06)
Previous studies suggest that L-arginine, an amino acid and a substrate of nitric oxide synthase, may have blood pressure (BP)-lowering effect. Because some studies were performed with limited number of patients with hypertension and therefore limited statistical power with sometimes
Leila Belle et al.
Science signaling, 8(364), ra18-ra18 (2015-02-19)
Factors secreted by tumor cells shape the local microenvironment to promote invasion and metastasis, as well as condition the premetastatic niche to enable secondary-site colonization and growth. In addition to this secretome, tumor cells have increased abundance of growth-promoting receptors
Letter by Pinheiro et al regarding article, "unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine".
Lucas C Pinheiro et al.
Circulation, 129(13), e427-e427 (2014-04-02)
Amelia Barilli et al.
Biochimica et biophysica acta, 1842(9), 1364-1371 (2014-05-06)
Celiac disease (CD) is an autoimmune enteropathy triggered in susceptible individuals by the ingestion of gliadin-containing grains. Recent studies have demonstrated that macrophages play a key role in the pathogenesis of CD through the release of inflammatory mediators such as
Uzma Shahab et al.
Chemico-biological interactions, 219, 229-240 (2014-06-27)
Glyoxal, methylglyoxal and 3-deoxyglucosones are reactive dicarbonyl compounds, which transform free amino groups of proteins and lipoproteins macromolecule into advanced glycation end-products (AGEs). AGEs play a significant role in the pathophysiology of aging and diabetic complications because of their genotoxic
Carina T Ribeiro et al.
The Journal of urology, 191(5 Suppl), 1578-1584 (2014-04-01)
We assessed reproductive and testicular function in adult rats after testicular torsion created before, during and after puberty, and with vs without resveratrol or arginine treatment. Age matched rats were divided into groups, including simulated surgery without testicular torsion, 720-degree
István Télessy
Orvosi hetilap, 155(51), 2021-2027 (2014-12-17)
Reviewing the literature of nutrition therapy one can conclude that during the last decade the pharmacological action of several nutrients has been demonstrated. However, research activity is still at the beginning and it could be verified in a restricted number
Rasmita Samal et al.
PloS one, 10(3), e0120360-e0120360 (2015-03-24)
Resident cardiac progenitor cells show homing properties when injected into the injured but not to the healthy myocardium. The molecular background behind this difference in behavior needs to be studied to elucidate how adult progenitor cells can restore cardiac function
Hanning You et al.
American journal of physiology. Renal physiology, 307(11), F1292-F1301 (2014-10-17)
Our recent publication showed that pharmacological blockade of arginases confers kidney protection in diabetic nephropathy via a nitric oxide (NO) synthase (NOS)3-dependent mechanism. Arginase competes with endothelial NOS (eNOS) for the common substrate L-arginine. Lack of L-arginine results in reduced
Yvette C Luiking et al.
Clinical science (London, England : 1979), 128(1), 57-67 (2014-07-19)
Arginine deficiency in sepsis may impair nitric oxide (NO) production for local perfusion and add to the catabolic state. In contrast, excessive NO production has been related to global haemodynamic instability. Therefore, the aim of the present study was to
Kevin Y Kim et al.
Molecular and cellular biology, 35(1), 238-248 (2014-10-29)
The retinoblastoma protein (pRb/p105) tumor suppressor plays a pivotal role in cell cycle regulation by blockage of the G1-to-S-phase transition. pRb tumor suppressor activity is governed by a variety of posttranslational modifications, most notably phosphorylation by cyclin-dependent kinase (Cdk) complexes.
Brenda C O'Connell et al.
PloS one, 9(12), e115228-e115228 (2014-12-30)
HSP90 inhibitors are currently undergoing clinical evaluation in combination with antimitotic drugs in non-small cell lung cancer (NSCLC), but little is known about the cellular effects of this novel drug combination. Therefore, we investigated the molecular mechanism of action of
Marc M Schumacher et al.
eLife, 4 (2015-03-06)
Schnyder corneal dystrophy (SCD) is an autosomal dominant disorder in humans characterized by abnormal accumulation of cholesterol in the cornea. SCD-associated mutations have been identified in the gene encoding UBIAD1, a prenyltransferase that synthesizes vitamin K2. Here, we show that
Vitaly V Vostrikov et al.
Biochimica et biophysica acta, 1848(1 Pt B), 315-322 (2014-09-25)
Phospholamban (PLN) is a single-pass membrane protein that regulates the sarco(endo)plasmic reticulum Ca²⁺-ATPase (SERCA). Phosphorylation of PLN at Ser16 reverses its inhibitory function under β-adrenergic stimulation, augmenting Ca²⁺ uptake in the sarcoplasmic reticulum and muscle contractility. PLN exists in two
Jason R McKnight et al.
Amino acids, 39(2), 349-357 (2010-05-04)
Over the past 20 years, growing interest in the biochemistry, nutrition, and pharmacology of L-arginine has led to extensive studies to explore its nutritional and therapeutic roles in treating and preventing human metabolic disorders. Emerging evidence shows that dietary L-arginine
Francesca Ferrelli et al.
Acta diabetologica, 52(1), 55-64 (2014-06-26)
Diabetic hyperglycaemia causes endothelial dysfunction mainly by impairing endothelial nitric oxide (NO) production. Moreover, hyperglycaemia activates several noxious cellular pathways including apoptosis, increase in reactive oxygen species (ROS) levels and diminishing Na(+)-K(+) ATPase activity which exacerbate vascular damage. Serum glucocorticoid
Yasutoshi Koga et al.
Annals of the New York Academy of Sciences, 1201, 104-110 (2010-07-24)
Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is a maternally inherited multisystem mitochondrial disorder. Although many molecular and cellular mechanisms have been discovered leading to mitochondrial cytopathy, the pathogenic mechanism of stroke-like episodes seen in MELAS has not
X Zheng et al.
Journal of dental research, 94(2), 344-353 (2014-12-06)
Dental caries is closely associated with the microbial disequilibrium between acidogenic/aciduric pathogens and alkali-generating commensal residents within the dental plaque. Fluoride is a widely used anticaries agent, which promotes tooth hard-tissue remineralization and suppresses bacterial activities. Recent clinical trials have
Nobuyuki Masaki et al.
Journal of cardiology, 65(4), 311-317 (2014-07-22)
Endothelial dysfunction causes vasomotor dysregulation and vascular stiffening in addition to structural changes. By influencing NO synthesis, deficiency of l-arginine relative to asymmetric dimethylarginine (ADMA), which is an l-arginine derivative that acts as a competitive NO synthase inhibitor, may lead
Mariam Traoré et al.
Organic letters, 16(13), 3588-3591 (2014-06-25)
Aza-peptides with basic amino acid residues (lysine, ornithine, arginine) and derivatives were synthesized by an effective approach featuring alkylation of a hydrazone-protected aza-glycine residue with α-bromo ω-chloro propane and butane to provide the corresponding alkyl chloride side chains. Displacement of
Zhenlong Wu et al.
Current opinion in clinical nutrition and metabolic care, 15(6), 529-538 (2012-10-19)
Brown adipose tissue (BAT), which is present in humans, plays an important role in oxidation of fatty acids and glucose. The purpose of this review is to highlight an important role for L-arginine in regulating BAT growth and development, thereby
L-Arginine modulates neonatal lymphocyte proliferation through an interleukin-2 independent pathway.
Yu HR, Kuo HC, Huang LT, et al.
Immunology, 143(2), 184-192 (2014)
David M Neskey et al.
Cancer research, 75(7), 1527-1536 (2015-01-31)
TP53 is the most frequently altered gene in head and neck squamous cell carcinoma, with mutations occurring in over two-thirds of cases, but the prognostic significance of these mutations remains elusive. In the current study, we evaluated a novel computational
Maria Rita Cozzi et al.
Blood, 125(4), 697-705 (2014-12-07)
Nitric oxide (NO) exerts vasodilatatory, antiplatelet, antioxidant, and antiproliferative effects. Endothelium-derived NO has been shown to be of crucial importance in cardiovascular protection, whereas evidence that NO is synthesized by platelets and regulates platelet function is still controversial. By using
Kathleen J Claes et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29(10), 1965-1972 (2014-06-25)
Although renal transplantation (Tx) improves the outcome of patients with renal disease, cardiovascular (CV) risk remains high. Recently, it was demonstrated that asymmetric dimethylarginine (ADMA) levels predict CV events and graft survival in renal transplant recipients (RTRs). Little is known
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