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Showing 1-26 of 26 results for "A1293" within Papers
Max Renner et al.
Nature immunology, 19(11), 1248-1256 (2018-10-17)
Dengue virus is a major pathogen, and severe infections can lead to life-threatening dengue hemorrhagic fever. Dengue virus exists as four serotypes, and dengue hemorrhagic fever is often associated with secondary heterologous infections. Antibody-dependent enhancement (ADE) may drive higher viral
Ahmad Shariftabrizi et al.
Molecular medicine reports, 5(2), 545-551 (2011-10-21)
Microtubules are important components of the cell cytoskeleton, participating in protein localization and cell signaling. The capacity of leukemia cells to
Qing-Jiu Ma et al.
Experimental and therapeutic medicine, 7(3), 635-639 (2014-02-13)
P-glycoprotein (P-gp) and glutathione S-transferase π (GST-π) are not only drug-resistance markers, but also prognostic markers of various cancers. The aim of the present study was to investigate the clinical significance of P-gp and GST-π in gallbladder carcinoma (GBC). Tissue
Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system.
Blanc, et al.
PLoS Pathogens, 19, e1011368-e1011368 (2023)
Clinical significance of P?glycoprotein and glutathione S?transferase ? expression in gallbladder carcinoma.
Ma Q J, et al.
Experimental and Therapeutic Medicine, 7(3), 635-639 (2014)
S E Wohlgemuth et al.
Journal of dairy science, 99(6), 4875-4880 (2016-04-12)
Heat stress (HT) during the dry period compromises mammary gland (MG) growth, thus negatively affecting subsequent milk yield. Cooling during the late dry period, when mammary tissue proliferates, is a common management practice. However, it neglects MG involution during the
Ilaria Zuliani et al.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 18(1), 340-363 (2020-12-02)
Protein O-GlcNAcylation is a nutrient-related post-translational modification that, since its discovery some 30 years ago, has been associated with the development of neurodegenerative diseases. As reported in Alzheimer's disease (AD), flaws in the cerebral glucose uptake translate into reduced hexosamine biosynthetic
Antibody structure, instability, and formulation.
Wang W
Journal of Pharmaceutical Sciences, 96(1), 1-26 (2007)
Structure and function of human and murine receptors for IgG.
J C Unkeless et al.
Annual review of immunology, 6, 251-281 (1988-01-01)
Reynald Thinard et al.
Pharmaceutics, 14(7) (2022-07-28)
The failures of anti-β-amyloid immunotherapies suggested that the very low fraction of injected antibodies reaching the brain parenchyma due to the filtering effect of the BBB may be a reason for the lack of therapeutic effect. However, there is no
Anne Poder Andersen et al.
International journal of cancer, 142(12), 2529-2542 (2018-01-25)
High metabolic and proliferative rates in cancer cells lead to production of large amounts of H+ and CO2 , and as a result, net acid extruding transporters are essential for the function and survival of cancer cells. We assessed protein
Iben R Veland et al.
PloS one, 8(4), e60193-e60193 (2013-04-18)
Inversin is a ciliary protein that critically regulates developmental processes and tissue homeostasis in vertebrates, partly through the degradation of Dishevelled (Dvl) proteins to coordinate Wnt signaling in planar cell polarity (PCP). Here, we investigated the role of Inversin in
Kenneth B Schou et al.
Nature communications, 8, 14177-14177 (2017-01-31)
Ciliary membrane composition is controlled by transition zone (TZ) proteins such as RPGRIP1, RPGRIPL and NPHP4, which are vital for balanced coordination of diverse signalling systems like the Sonic hedgehog (Shh) pathway. Activation of this pathway involves Shh-induced ciliary accumulation
Amy L Skibiel et al.
Journal of dairy science, 101(1), 705-716 (2017-11-13)
Heat stress negatively affects cow performance, compromises immune function, and increases susceptibility to metabolic disorders, particularly during the dry period and as cows transition from gestation to lactation. Metabolic adaptations of the liver are critical for successful transition, yet it
Anne Poder Andersen et al.
Molecular cancer, 15(1), 45-45 (2016-06-09)
The 3-dimensional (3D) microenvironment of breast carcinomas is characterized by profoundly altered pH homeostasis, reflecting increased metabolic acid production and a confined extracellular space characterized by poor diffusion, yet the relative contributions of specific pH-regulatory transporters to 3D growth are
Guangqin Cai et al.
Molecular plant, 13(7), 984-1000 (2020-04-26)
Lipid catabolism in germinating seeds provides energy and substrates for initial seedling growth, but how this process is regulated is not well understood. Here, we show that an AT-hook motif-containing nuclear localized (AHL) protein regulates lipid mobilization and fatty acid
Liver proteomic analysis of postpartum Holstein cows exposed to heat stress or cooling conditions during the dry period
Skibiel AL, et al.
Journal of Dairy Science, 101(1), 705-716 (2018)
Sang-Chul Kim et al.
The Plant cell, 31(2), 399-416 (2019-01-25)
Circadian clocks play important roles in regulating cellular metabolism, but the reciprocal effect that metabolism has on the clock is largely unknown in plants. Here, we show that the central glycerolipid metabolite and lipid mediator phosphatidic acid (PA) interacts with
S Lee et al.
Oncogene, 35(16), 2112-2122 (2015-07-28)
Increased metabolism and insufficient blood supply cause acidic waste product accumulation in solid cancers. During carcinogenesis, cellular acid extrusion is upregulated but the underlying molecular mechanisms and their consequences for cancer growth and progression have not been established. Genome-wide association
Soheila Rahgozar et al.
PloS one, 10(8), e0135905-e0135905 (2015-08-28)
Angiotensinogen exists in two distinct redox forms in plasma, the oxidized sulfhydryl-bridge form and the reduced, unbridged, free thiol form. The oxidized form of angiotensinogen compared to the free thiol form preferentially interacts with renin resulting in increased generation of
Peng-cheng Xu et al.
BMC immunology, 16, 10-10 (2015-04-17)
C-reactive protein (CRP) exerts prothrombotic effects through dissociating from pentameric CRP (pCRP) into modified or monomeric CRP (mCRP). However, although the high prevalence of venous thromboembolism (VTE) in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has been identified, it
Kyoung Yong Jeong et al.
Molecular medicine reports, 15(5), 3264-3270 (2017-03-25)
Silkworm pupae are widely consumed in Asian countries and allergic reactions following consumption have been described. However, false‑positive responses in skin prick allergy tests or non‑specific immunoglobulin E (IgE) responses to total extract of silkworm pupa make diagnosis difficult. Although
Complement-fixing IgG1 constitutes a new subclass of mouse IgG.
P L Ey et al.
Nature, 281(5731), 492-493 (1979-10-11)
Chiara Lanzillotta et al.
Antioxidants (Basel, Switzerland), 9(8) (2020-07-31)
Biliverdin reductase-A (BVR-A) impairment is associated with increased accumulation of oxidatively-damaged proteins along with the impairment of autophagy in the brain during neurodegenerative disorders. Reduced autophagy inhibits the clearance of misfolded proteins, which then form neurotoxic aggregates promoting neuronal death.
Sang-Chul Kim et al.
The Plant journal : for cell and molecular biology, 112(3), 786-799 (2022-09-17)
Cytosolic glyceraldehyde-3-phosphate dehydrogenase (GAPC) is a glycolytic enzyme, but undergoes stress-induced nuclear translocation for moonlighting. We previously reported that in response to heat stress, GAPC accumulated in the nucleus to modulate transcription and thermotolerance. Here we show a cellular and
Role of tropomyosin in silkworm allergy
Jeong KY, et al.
Molecular Medicine Reports, 15(5), 3264-3270 (2017)
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