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Showing 1-30 of 175 results for "A1470" within Papers
Ariana Jacome et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 17(6), 1083-1092 (2009-03-12)
Previous clinical trials based on the genetic correction of purified CD34(+) cells with gamma-retroviral vectors have demonstrated clinical efficacy in different monogenic diseases, including X-linked severe combined immunodeficiency, adenosine deaminase deficient severe combined immunodeficiency and chronic granulomatous disease. Similar protocols
Markus D Lacher et al.
Molecular cancer, 10, 91-91 (2011-07-28)
We have previously reported that RAS-MEK (Cancer Res. 2003 May 1;63(9):2088-95) and TGF-β (Cancer Res. 2006 Feb 1;66(3):1648-57) signaling negatively regulate coxsackie virus and adenovirus receptor (CAR) cell-surface expression and adenovirus uptake. In the case of TGF-β, down-regulation of CAR
Christopher L Nobles et al.
Journal of microbiological methods, 118, 7-17 (2015-08-09)
Bacterial pathogens acquire host iron to power cellular processes and replication. Heme, an iron-containing cofactor bound to hemoglobin, is scavenged by bacterial proteins to attain iron. Methods to measure intracellular heme are laborious, involve complex chemistry, or require radioactivity. Such
M Szajnik et al.
Oncogene, 28(49), 4353-4363 (2009-10-15)
Toll-like receptors (TLRs) expressed on immune cells trigger inflammatory responses. TLRs are also expressed on ovarian cancer (OvCa) cells, but the consequences of signaling by the TLR4/MyD88 pathway in these cells are unclear. Here, TLR4 and MyD88 expression in OvCa
Daniela Fignani et al.
Frontiers in endocrinology, 11, 596898-596898 (2020-12-08)
Increasing evidence demonstrated that the expression of Angiotensin I-Converting Enzyme type 2 (ACE2) is a necessary step for SARS-CoV-2 infection permissiveness. In light of the recent data highlighting an association between COVID-19 and diabetes, a detailed analysis aimed at evaluating
Michelle D Combs et al.
Circulation research, 105(6), 565-574 (2009-08-08)
NFATc1 (nuclear factor of activated T-cells cytoplasmic 1) activity in endocardial cushion (ECC) endothelial cells is required for normal ECC growth and extracellular matrix (ECM) remodeling during heart valve development. The mechanisms of NFATc1 activation and downstream effects on cell
Masaaki Adachi et al.
PloS one, 4(11), e7719-e7719 (2009-11-26)
Environmental changes, air pollution and ozone depletion are increasing oxidative stress, and global warming threatens health by heat stress. We now face a high risk of simultaneous exposure to heat and oxidative stress. However, there have been few studies investigating
Eva P Browne et al.
Aquatic toxicology (Amsterdam, Netherlands), 92(4), 281-287 (2009-04-07)
Polybrominated diphenyl ethers (PBDEs) are brominated flame retardants that persist in the environment and are present in geographically widespread fish species. PBDE concentrations can be particularly high in resident Chinook salmon (Onchorhynchus tshawytscha) in the Puget Sound, Washington. Although PBDE
Papireddy Kancharla et al.
Journal of medicinal chemistry, 63(11), 6179-6202 (2020-05-12)
The global impact of malaria remains staggering despite extensive efforts to eradicate the disease. With increasing drug resistance and the absence of a clinically available vaccine, there is an urgent need for novel, affordable, and safe drugs for prevention and
Nikolay N Brandt et al.
Journal of biomedical optics, 20(5), 051015-051015 (2014-12-06)
The analysis of the structure-function relationship is extremely important in the study of proteins. The importance of function-related motions of large parts or subglobules of protein molecules stimulates the spectroscopic study in the low-frequency (terahertz) domain. However, only tentative assignments
Maiwen Caudron-Herger et al.
Nature protocols, 15(4), 1338-1370 (2020-02-26)
Analysis of RNA-protein complexes is central to understanding the molecular circuitry governing cellular processes. In recent years, several proteome-wide studies have been dedicated to the identification of RNA-binding proteins. Here, we describe in detail R-DeeP, an approach built on RNA
Zbigniew Darzynkiewicz et al.
Methods (San Diego, Calif.), 44(3), 250-254 (2008-03-04)
Activation of endonucleases that cleave chromosomal DNA preferentially at internucleosomal sections is a hallmark of apoptosis. DNA fragmentation revealed by the presence of a multitude of DNA strand breaks, therefore, is considered to be the gold standard for identification apoptotic
Paola Benaglio et al.
Cell genomics, 2(12), 100214-100214 (2023-02-14)
We combined functional genomics and human genetics to investigate processes that affect type 1 diabetes (T1D) risk by mediating beta cell survival in response to proinflammatory cytokines. We mapped 38,931 cytokine-responsive candidate cis-regulatory elements (cCREs) in beta cells using ATAC-seq
Steven T Leach et al.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 22(5), 461-464 (2008-05-15)
The expression of the inflammatory S100 calgranulin proteins (S100A8, S100A9 and S100A12) in normal and Helicobacter pylori-infected gastric mucosa of children were examined. S100A8, S100A9 and S100A12, which were virtually absent in normal gastric mucosa, were highly expressed in H
Ashok Cattamanchi et al.
Clinical and vaccine immunology : CVI, 15(11), 1638-1643 (2008-09-12)
We conducted a double-blind, vehicle-controlled, dose escalation safety and immunogenicity trial of a candidate herpes simplex virus type 2 (HSV-2) surface glycoprotein D2 (gD2) DNA vaccine administered by use of a needle-free device. Sixty-two healthy adults were randomized using a
Jonathan G Fernsler et al.
Langmuir : the ACS journal of surfaces and colloids, 25(14), 8131-8143 (2009-06-19)
Charged, surface-active serum proteins can severely reduce or eliminate the adsorption of lung surfactant from the subphase to the alveolar air-liquid interface via a kinetically controlled competitive adsorption process. The decreased surfactant concentration at the interface leads to higher surface
Mr Baghaban Eslaminejad et al.
Journal of dentistry (Tehran, Iran), 7(4), 185-195 (2011-10-15)
By date investigations have indicated the presence of stem cells within the pulp tissue of both temporary and permanent human teeth. In the present study, these stem cells were compared in terms of their growth kinetics and culture requirements. Stem
Emily Turner-Brannen et al.
Arthritis research & therapy, 13(4), R129-R129 (2011-08-13)
Innate defence regulator (IDR) peptides are synthetic cationic peptides, variants of naturally occurring innate immune effector molecules known as host defence peptides. IDR peptides were recently demonstrated to limit infection-associated inflammation selectively without compromising host innate immune functions. This study
Hui Li et al.
Small (Weinheim an der Bergstrasse, Germany), 15(28), e1901910-e1901910 (2019-06-05)
Birth control and family planning play pivotal roles in the economic growth and reduction of maternal, infant, and child mortality. Current contraceptives, such as hormonal agents and intrauterine devices, target only a small subset of reproductive processes and can have
Wilhelm Palm et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(41), E8628-E8636 (2017-10-05)
Ras-transformed cells can grow in amino acid-poor environments by recovering amino acids through macropinocytosis and lysosomal catabolism of extracellular proteins. However, when studying nontransformed fibroblasts, we found that Ras GTPases are dispensable for growth-factor-stimulated macropinocytosis and lysosomal catabolism of extracellular
Xiong Xiao et al.
Cell discovery, 5, 2-2 (2019-01-10)
The limited number of human hematopoietic stem cells (HSCs) has restrained their widespread clinical application. Despite great efforts in recent years, the in vitro expansion of HSCs remains a challenge due to incomplete understanding of the signaling networks underlying HSC
Induction of cell-cell fusion by ectromelia virus is not inhibited by its fusion inhibitory complex.
Noam Erez et al.
Virology journal, 6, 151-151 (2009-09-30)
Ectromelia virus, a member of the Orthopox genus, is the causative agent of the highly infectious mousepox disease. Previous studies have shown that different poxviruses induce cell-cell fusion which is manifested by the formation of multinucleated-giant cells (polykaryocytes). This phenomenon
Sean K Ryan et al.
Nature neuroscience, 26(1), 12-26 (2022-12-20)
Iron dysregulation has been implicated in multiple neurodegenerative diseases, including Parkinson's disease (PD). Iron-loaded microglia are frequently found in affected brain regions, but how iron accumulation influences microglia physiology and contributes to neurodegeneration is poorly understood. Here we show that
Craig Meagher et al.
Journal of immunology (Baltimore, Md. : 1950), 180(12), 7793-7803 (2008-06-05)
Autoimmune pancreatitis (AIP) is a heterogeneous autoimmune disease in humans characterized by a progressive lymphocytic and plasmacytic infiltrate in the exocrine pancreas. In this study, we report that regulatory T cell-deficient NOD.CD28KO mice spontaneously develop AIP that closely resembles the
Sang Hoon Kim et al.
Metabolites, 12(9) (2022-09-24)
Cancer cells utilize multiple nutrient scavenging mechanisms to support growth and survival in nutrient-poor, hypoxic tumor microenvironments. Among these mechanisms, macropinocytosis has emerged as an important pathway of extracellular nutrient acquisition in cancer cells, particularly in tumors with activated RAS
Phong A Tran et al.
International journal of nanomedicine, 6, 1553-1558 (2011-08-17)
Staphylococcus aureus is a key bacterium commonly found in numerous infections. S. aureus infections are difficult to treat due to their biofilm formation and documented antibiotic resistance. While selenium has been used for a wide range of applications including anticancer
Christian Baumgartner et al.
The American journal of pathology, 175(6), 2416-2429 (2009-11-07)
Recent data suggest that the signal transducer and activator of transcription (STAT)5 contributes to differentiation and growth of mast cells. It has also been described that constitutively phosphorylated STAT5 (pSTAT5) plays a pro-oncogenic role in various myeloid neoplasms. We examined
Andreas S Barth et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 16(5), 957-964 (2008-04-05)
Cardiosphere-derived resident cardiac stem cells (CDCs) are readily isolated from adult hearts and confer functional benefit in animal models of heart failure. To study cardiogenic differentiation in CDCs, we developed a method to genetically label and selectively enrich for cells
Michael B Dash et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(3), 620-629 (2009-01-23)
Neuronal firing patterns, neuromodulators, and cerebral metabolism change across sleep-waking states, and the synaptic release of glutamate is critically involved in these processes. Extrasynaptic glutamate can also affect neural function and may be neurotoxic, but whether and how extracellular glutamate
Stephanie K Aoki et al.
Molecular microbiology, 70(2), 323-340 (2008-09-03)
Contact-dependent growth inhibition (CDI) is a phenomenon by which bacterial cell growth is regulated by direct cell-to-cell contact via the CdiA/CdiB two-partner secretion system. Characterization of mutants resistant to CDI allowed us to identify BamA (YaeT) as the outer membrane
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