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Keyword:'A1949'
Showing 1-30 of 86 results for "A1949" within Papers
Yundan Wang et al.
PLoS pathogens, 9(1), e1003102-e1003102 (2013-01-18)
The stress of living conditions, similar to infections, alters animal immunity. High population density is empirically considered to induce prophylactic immunity to reduce the infection risk, which was challenged by a model of low connectivity between infectious and susceptible individuals
Targeted inhibition of EG-1 blocks breast tumor growth
Lu M, et al.
Cancer Biology & Therapy, 6(6), 936-941 (2007)
Oro Uchenunu et al.
FEBS open bio, 12(5), 959-982 (2022-03-19)
Mutations in genes encoding cytochrome c oxidase (mitochondrial complex IV) subunits and assembly factors [e.g., synthesis of cytochrome c oxidase 2 (SCO2)] are linked to severe metabolic syndromes. Notwithstanding that SCO2 is under transcriptional control of tumor suppressor p53, the
Ophélie Bernardi et al.
Frontiers in physiology, 13, 1012212-1012212 (2022-10-01)
Embryo mortality rate, which can reach up to 40% in avian species, is a major issue for breeding. It is therefore important to identify new embryo development biomarkers for genetic selection to improve reproductive performances. We have recently shown that
Leo Heyndrickx et al.
PloS one, 8(9), e74552-e74552 (2013-09-12)
Ten to 30% of HIV-1 infected subjects develop broadly neutralizing antibodies (bNAbs) during chronic infection. We hypothesized that immunizing rabbits with viral envelope glycoproteins (Envs) from these patients may induce bNAbs, when formulated as a trimeric protein and in the
Alexander V Zhdanov et al.
Cellular and molecular life sciences : CMLS, 79(8), 426-426 (2022-07-17)
Activated ghrelin receptor GHS-R1α triggers cell signalling pathways that modulate energy homeostasis and biosynthetic processes. However, the effects of ghrelin on mRNA translation are unknown. Using various reporter assays, here we demonstrate a rapid elevation of protein synthesis in cells
Zsolt Dürvanger et al.
ACS chemical biology, 17(4), 969-986 (2022-04-05)
MASP-1 and MASP-2 are key activator proteases of the complement lectin pathway. The first specific mannose-binding lectin-associated serine protease (MASP) inhibitors had been developed from the 14-amino-acid sunflower trypsin inhibitor (SFTI) peptide by phage display, yielding SFTI-based MASP inhibitors, SFMIs.
Dipanwita Das et al.
World journal of gastroenterology, 22(47), 10341-10352 (2017-01-07)
Toll like receptors plays a significant anti-viral role in different infections. The aim of this study was to look into the role of toll like receptor 4 (TLR4) in hepatitis B virus (HBV) infection. Real time PCR was used to
B Chen et al.
Insect molecular biology, 24(5), 517-527 (2015-05-27)
Haemocyanins are commonly known as copper-containing oxygen carriers within the haemolymph of arthropods, and have been found in many orders of insects. However, it remains unresolved why haemocyanins persist in insects that possess elaborate tracheal systems for oxygen diffusion to
Valeria Manganelli et al.
International journal of molecular sciences, 25(11) (2024-06-19)
Autophagy plays a key role in removing protein aggregates and damaged organelles. In addition to its conventional degradative functions, autophagy machinery contributes to the release of cytosolic proteins through an unconventional secretion pathway. In this research, we analyzed autophagy-induced extracellular
Laura Falasca et al.
Apoptosis : an international journal on programmed cell death, 20(12), 1577-1586 (2015-10-02)
Prostate cancer is among the most commonly diagnosed male diseases and a leading cause of cancer mortality in men. There is emerging evidence that autophagy plays an important role in malignant cell survival and offers protection from the anti-cancer drugs
Julia Hartwiger et al.
Veterinary sciences, 6(2) (2019-05-30)
In spring, transition from a total mixed ration (TMR) to a full grazing ration with moderate concentrate supply influences cow's metabolism. It has been shown that feeding moderate amounts of concentrate during fulltime grazing did not prevent energy shortage and
Manuel Sánchez López-Berges et al.
International journal of molecular sciences, 22(14) (2021-07-25)
The airborne fungus Aspergillus fumigatus causes opportunistic infections in humans with high mortality rates in immunocompromised patients. Previous work established that the bZIP transcription factor HapX is essential for virulence via adaptation to iron limitation by repressing iron-consuming pathways and
Paola Matarrese et al.
Autophagy, 10(5), 750-765 (2014-03-05)
Sphingolipids are structural lipid components of cell membranes, including membrane of organelles, such as mitochondria or endoplasmic reticulum, playing a role in signal transduction as well as in the transport and intermixing of cell membranes. Sphingolipid microdomains, also called lipid
M P Cranage et al.
Mucosal immunology, 3(1), 57-68 (2009-09-11)
Vaccine-mediated prevention of primary infection with human immunodeficiency virus (HIV) may require the sustained production of antibody at mucosal portals of entry. Here, we describe a novel approach of repeated mucosal immunization by delivering an HIV-1 envelope glycoprotein (gp) in
Beáta B Tóth et al.
Cells, 9(4) (2020-04-23)
Brown adipocytes, abundant in deep-neck (DN) area in humans, are thermogenic with anti-obesity potential. FTO pro-obesity rs1421085 T-to-C single-nucleotide polymorphism (SNP) shifts differentiation program towards white adipocytes in subcutaneous fat. Human adipose-derived stromal cells were obtained from subcutaneous neck (SC)
J Kesser et al.
Journal of dairy science, 98(10), 7044-7051 (2015-08-19)
Adiponectin, an adipokine, regulates metabolism and insulin sensitivity. Considering that the transplacental transfer of maternal proteins of high molecular weight is hindered in ruminants, this study tested the hypothesis that the blood concentration of adiponectin in neonatal calves largely reflects
Elizaveta A Klimanova et al.
International journal of molecular sciences, 21(21) (2020-10-31)
Stimulus-dependent elevation of intracellular Ca2+ affects gene expression via well-documented calmodulin-mediated signaling pathways. Recently, we found that the addition of extra- and intracellular Ca2+ chelators increased, rather than decreased, the number of genes expressed, and that this is affected by
Matthias Misslinger et al.
PLoS genetics, 15(9), e1008379-e1008379 (2019-09-17)
Efficient adaptation to iron starvation is an essential virulence determinant of the most common human mold pathogen, Aspergillus fumigatus. Here, we demonstrate that the cytosolic monothiol glutaredoxin GrxD plays an essential role in iron sensing in this fungus. Our studies
Rama K Mallampalli et al.
JCI insight, 5(2) (2020-01-31)
Our integrative genomic and functional analysis identified transforming acidic coiled-coil-containing protein 2 (TACC2) as a chronic obstructive pulmonary disease (COPD) candidate gene. Here, we found that smokers with COPD exhibit a marked decrease in lung TACC2 protein levels relative to
Julio R Fernández Massó et al.
Journal of amino acids, 2013, 251398-251398 (2013-02-13)
We have demonstrated that the peptide L-2 designed from an alanine scanning of the Limulus-derived LALF32-51 region is a potential candidate for the anticancer therapy and its cell-penetrating capacity is an associated useful property. By the modification in the primary
Marie Borggren et al.
Human vaccines & immunotherapeutics, 11(8), 1983-1990 (2015-03-10)
The threat posed by the 2009 pandemic H1N1 virus emphasized the need for new influenza A virus vaccines inducing a broad cross-protective immune response for use in both humans and pigs. An effective and broad influenza vaccine for pigs would
Petra Virtanen et al.
Molecular microbiology, 111(4), 1109-1125 (2019-02-03)
Contact-dependent growth inhibition (CDI) allows bacteria to recognize kin cells in mixed bacterial populations. In Escherichia coli, CDI mediated effector delivery has been shown to be species-specific, with a preference for the own strain over others. This specificity is achieved
Lijun Shi et al.
Molecular medicine reports, 18(4), 3949-3956 (2018-08-23)
Human papillomavirus (HPV) E7 protein expression is caused by HPV viral DNA integration into human cellular DNA, and is a prerequisite for the development and progression of cervical cancer. The present study aimed to evaluate the role of E7 protein
Takanori Furukawa et al.
Nucleic acids research, 48(7), 3567-3590 (2020-02-23)
To sustain iron homeostasis, microorganisms have evolved fine-tuned mechanisms for uptake, storage and detoxification of the essential metal iron. In the human pathogen Aspergillus fumigatus, the fungal-specific bZIP-type transcription factor HapX coordinates adaption to both iron starvation and iron excess
Ráhel Dani et al.
Frontiers in immunology, 14, 1197023-1197023 (2023-06-07)
Complement factor D (FD) is a serine protease present predominantly in the active form in circulation. It is synthesized as a zymogen (pro-FD), but it is continuously converted to FD by circulating active MASP-3. FD is a unique, self-inhibited protease.
Rachy Abraham et al.
PloS one, 8(9), e75854-e75854 (2013-10-03)
Chikungunya virus (CHIKV), an arthritogenic old-world alphavirus, has been implicated in the central nervous system (CNS) infection in infants and elderly patients. Astrocytes are the major immune cells of the brain parenchyma that mediate inflammation. In the present study we
David C Briggs et al.
Nature chemical biology, 12(10), 810-814 (2016-08-16)
Dystroglycan is a highly glycosylated extracellular matrix receptor with essential functions in skeletal muscle and the nervous system. Reduced matrix binding by α-dystroglycan (α-DG) due to perturbed glycosylation is a pathological feature of several forms of muscular dystrophy. Like-acetylglucosaminyltransferase (LARGE)
Sotiria Boukouvala et al.
Scientific reports, 9(1), 10937-10937 (2019-07-31)
Human NAT1 gene for N-acetyltransferase 1 modulates xenobiotic metabolism of arylamine drugs and mutagens. Beyond pharmacogenetics, NAT1 is also relevant to breast cancer. The population history of human NAT1 suggests evolution through purifying selection, but it is unclear whether this
Konrad Krzewski et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2568-2573 (2008-02-09)
Natural killer (NK) cells play important roles in host immunity by killing virus-infected and tumor cells. Killing of the target cell is achieved by formation of an immune synapse and localized secretion of lytic granules containing perforin and granzymes. Here
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