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Showing 1-30 of 656 results for "A2052" within Papers
S M Perez et al.
Molecular psychiatry, 18(11), 1193-1198 (2013-08-28)
Schizophrenia patients exhibit increased hippocampal activity that is correlated with positive symptoms. Although the cause of this hippocampal hyperactivity has not been demonstrated, it likely involves a decrease in GABAergic signaling. Thus, we posit that restoring GABAergic function may provide
Lluis Miquel-Rio et al.
iScience, 27(5), 109787-109787 (2024-05-07)
Depression is a devastating mood disorder that causes significant disability worldwide. Current knowledge of its pathophysiology remains modest and clear biological markers are lacking. Emerging evidence from human and animal models reveals persistent alterations in endoplasmic reticulum (ER) homeostasis, suggesting
Navneet A Vasistha et al.
Cerebral cortex (New York, N.Y. : 1991), 25(10), 3290-3302 (2014-06-15)
The individual contribution of different progenitor subtypes towards the mature rodent cerebral cortex is not fully understood. Intermediate progenitor cells (IPCs) are key to understanding the regulation of neuronal number during cortical development and evolution, yet their exact contribution is
Maxine R Nelson et al.
Nature neuroscience, 26(12), 2104-2121 (2023-11-14)
Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (LOAD), leading to earlier age of clinical onset and exacerbating pathologies. There is a critical need to identify protective targets. Recently, a rare APOE variant, APOE3-R136S (Christchurch)
Qian Zhou et al.
Journal of neurochemistry, 163(3), 220-232 (2022-07-22)
BDNF and its expressing neurons in the brain critically control feeding and energy expenditure (EE) in both rodents and humans. However, whether BDNF neurons would function in thermoregulation during temperature challenges is unclear. Here, we show that BDNF neurons in
Yosuke Niibori et al.
Human gene therapy, 31(5-6), 339-351 (2019-12-14)
Dravet syndrome (DS) is a neurodevelopmental genetic disorder caused by mutations in the SCN1A gene encoding the Ī± subunit of the NaV1.1 voltage-gated sodium channel that controls neuronal action potential firing. The high density of this mutated channel in GABAergic
Coralie Fassier et al.
The Journal of cell biology, 217(5), 1719-1738 (2018-03-15)
During neural circuit assembly, extrinsic signals are integrated into changes in growth cone (GC) cytoskeleton underlying axon guidance decisions. Microtubules (MTs) were shown to play an instructive role in GC steering. However, the numerous actors required for MT remodeling during
Koji Ohira et al.
Molecular brain, 3(1), 26-26 (2010-09-08)
New granule cells are continuously generated in the dentate gyrus of the adult hippocampus. During granule cell maturation, the mechanisms that differentiate new cells not only describe the degree of cell differentiation, but also crucially regulate the progression of cell
Allen R Rodriguez et al.
The Journal of comparative neurology, 522(6), 1411-1443 (2013-12-10)
There are few neurochemical markers that reliably identify retinal ganglion cells (RGCs), which are a heterogeneous population of cells that integrate and transmit the visual signal from the retina to the central visual nuclei. We have developed and characterized a
Qi Han et al.
Experimental neurology, 267, 194-208 (2015-03-21)
Despite the obvious clinical interest, our understanding of how developmental mechanisms are redeployed during degeneration and regeneration after brain and spinal cord injuries remains quite rudimentary. In animal models of spinal cord injury, although spontaneous regeneration of descending axons is
Jan Kaslin et al.
Development (Cambridge, England), 144(8), 1462-1471 (2017-03-16)
Zebrafish can regenerate after brain injury, and the regenerative process is driven by resident stem cells. Stem cells are heterogeneous in the vertebrate brain, but the significance of having heterogeneous stem cells in regeneration is not understood. Limited availability of
Dongchang Xiao et al.
Frontiers in molecular neuroscience, 11, 271-271 (2018-08-22)
During mammalian retinal development, the multipotent progenitors differentiate into all classes of retinal cells under the delicate control of transcriptional factors. The deficiency of a transcription cofactor, the LIM-domain binding protein Ldb1, has been shown to cause proliferation and developmental
Uthra Rajamani et al.
Cell stem cell, 22(5), 698-712 (2018-04-24)
The hypothalamus contains neurons that integrate hunger and satiety endocrine signals from the periphery and are implicated in the pathophysiology of obesity. The limited availability of human hypothalamic neurons hampers our understanding of obesity disease mechanisms. To address this, we
Wangyi Fang et al.
Frontiers in molecular neuroscience, 15, 930599-930599 (2022-08-27)
The aim of this study was to investigate the role and mechanism of berberine (BBR) in the protection of injured retinal ganglion cells (RGCs) in diabetic retinopathy (DR). Experimental diabetic retinopathy rat model was successfully induced by a single intraperitoneal
Kei Hori et al.
Cell reports, 9(6), 2166-2179 (2014-12-24)
Mutations in the Autism susceptibility candidate 2 gene (AUTS2), whose protein is believed to act in neuronal cell nuclei, have been associated with multiple psychiatric illnesses, including autism spectrum disorders, intellectual disability, and schizophrenia. Here we show that cytoplasmic AUTS2
Cynthia T Hsu et al.
Scientific reports, 6, 20259-20259 (2016-02-04)
Neural processing in the brain controls behavior through descending neurons (DNs) - neurons which carry signals from the brain to the spinal cord (or thoracic ganglia in insects). Because DNs arise from multiple circuits in the brain, the numerical simplicity
Maryse E Thomas et al.
Cerebral cortex (New York, N.Y. : 1991), 29(3), 1032-1046 (2018-02-09)
The prolonged masking of auditory inputs with white noise has been shown to reopen the critical period for spectral tuning in the adult rat auditory cortex. Here, we argue that the masking of salient temporal inputs in particular is responsible
Marianna K Sayeg et al.
ACS synthetic biology, 4(7), 788-795 (2015-04-08)
Targeting transgene expression to specific cell types in vivo has proven instrumental in characterizing the functional role of defined cell populations. Genetic classifiers, synthetic transgene constructs designed to restrict expression to particular classes of cells, commonly rely on transcriptional promoters
Nitin Gupta et al.
Current biology : CB, 24(19), 2247-2256 (2014-09-30)
Sparse codes are found in nearly every sensory system, but the role of spike timing in sparse sensory coding is unclear. Here, we use the olfactory system of awake locusts to test whether the timing of spikes in Kenyon cells
Martina Proietti Onori et al.
PLoS biology, 19(5), e3001279-e3001279 (2021-05-27)
Hyperactivation of the mammalian target of rapamycin (mTOR) pathway can cause malformation of cortical development (MCD) with associated epilepsy and intellectual disability (ID) through a yet unknown mechanism. Here, we made use of the recently identified dominant-active mutation in Ras
Zaida Ćlvarez et al.
Cell stem cell, 30(2), 219-238 (2023-01-14)
Human induced pluripotent stem cell (hiPSC) technologies offer a unique resource for modeling neurological diseases. However, iPSC models are fraught with technical limitations including abnormal aggregation and inefficient maturation of differentiated neurons. These problems are in part due to the
Ruth Yamawaki et al.
The Journal of comparative neurology, 523(2), 281-297 (2014-09-23)
Inhibiting the mammalian target of rapamycin (mTOR) signaling pathway with rapamycin blocks granule cell axon (mossy fiber) sprouting after epileptogenic injuries, including pilocarpine-induced status epilepticus. However, it remains unclear whether axons from other types of neurons sprout into the inner
Andreas Burkhalter et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(47), 12274-12282 (2006-11-24)
In cortical neurons, pore-forming alpha-subunits of the Kv4 subfamily underlie the fast transient outward K+ current (I(A)). Considerable evidence has accumulated demonstrating specific roles for I(A) channels in the generation of individual action potentials and in the regulation of repetitive
Lydia Ouellet et al.
Frontiers in neuroanatomy, 8, 40-40 (2014-06-12)
In both humans and rodents, decline in cognitive function is a hallmark of the aging process; the basis for this decrease has yet to be fully characterized. However, using aged rodent models, deficits in auditory processing have been associated with
Bianca BrĆ¼ggen et al.
The European journal of neuroscience, 44(1), 1700-1713 (2016-04-19)
Complex sphingolipids are strongly expressed in neuronal tissue and contain ceramides in their backbone. Ceramides are synthesized by six ceramide synthases (CerS1-6). Although it is known that each tissue has a unique profile of ceramide synthase expression and ceramide synthases
Hong Jun Rhee et al.
Cell reports, 27(7), 2212-2228 (2019-05-16)
iPSC-derived human neurons are expected to revolutionize studies on brain diseases, but their functional heterogeneity still poses a problem. Key sources of heterogeneity are the different cell culture systems used. We show that an optimized autaptic culture system, with single
Tanja Herrmann et al.
Frontiers in molecular neuroscience, 14, 807090-807090 (2022-02-22)
GABAA receptors are ligand-gated ion channels, which are predominantly permeable for chloride. The neuronal K-Cl cotransporter KCC2 lowers the intraneuronal chloride concentration and thus plays an important role for GABA signaling. KCC2 loss-of-function is associated with seizures and epilepsy. Here
Charuni A Gunaratne et al.
The Journal of comparative neurology, 524(6), 1181-1192 (2015-09-12)
Phylogenetic comparisons of neurotransmitter distribution are important for understanding the ground plan organization of nervous systems. This study describes the Ī³-aminobutyric acid (GABA)-immunoreactive (GABA-ir) neurons in the buccal ganglia of six sea slug species (Mollusca, Gastropoda, Euthyneura, Nudipleura). In the
Yoshinori Aso et al.
eLife, 3, e04577-e04577 (2014-12-24)
We identified the neurons comprising the Drosophila mushroom body (MB), an associative center in invertebrate brains, and provide a comprehensive map describing their potential connections. Each of the 21 MB output neuron (MBON) types elaborates segregated dendritic arbors along the
Robin Nguyen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(11), 2314-2331 (2020-02-02)
Distinct components of working memory are coordinated by different classes of inhibitory interneurons in the PFC, but the role of cholecystokinin (CCK)-positive interneurons remains enigmatic. In humans, this major population of interneurons shows histological abnormalities in schizophrenia, an illness in
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