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Showing 1-30 of 1796 results for "A2218" within Papers
Napaphat Thadavirul et al.
Journal of biomaterials science. Polymer edition, 25(17), 1986-2008 (2014-10-08)
Polycaprolactone (PCL)/hydroxyapatite (HA) composite scaffolds were prepared by combining solvent casting and salt particulate leaching with a polymer leaching technique. The hydrophilicity of the dual-leached scaffold was improved by alkaline (NaOH) treatment. Well-defined interconnected pores were detected by scanning electron
Qingyou Meng et al.
Journal of cellular biochemistry, 116(8), 1613-1623 (2015-02-06)
Deep vein thrombosis (DVT) is a common complication of surgery. Endothelial progenitor cells (EPCs) are recruited into resolving venous thrombi. In this report, we investigated the effects of miR-126 on EPCs function and venous thrombus resolution. We demonstrated that overexpression
Amy M Griggs et al.
Toxicological sciences : an official journal of the Society of Toxicology, 140(1), 179-189 (2014-04-11)
Parkinson's disease (PD) is the second most common neurodegenerative disease. Much data has linked the etiology of PD to a variety of environmental factors. The majority of cases are thought to arise from a combination of genetic susceptibility and environmental
Xiaoping Su et al.
Cancer research, 75(14), 2875-2885 (2015-06-13)
microRNA (miRNA) dysregulation is involved in the development and progression of various human cancers, including hepatocellular carcinoma (HCC). However, how to identify the miRNAs targeting specific mRNA in cells is a significant challenge because of the interaction complexity and the
S Antonini et al.
Biomedical materials (Bristol, England), 10(3), 035010-035010 (2015-06-25)
Through the interaction with topographical features, endothelial cells tune their ability to populate target substrates, both in vivo and in vitro. Basal textures interfere with the establishment and maturation of focal adhesions (FAs) thus inducing specific cell-polarization patterns and regulating
Stacey C Schutte et al.
Reproductive sciences (Thousand Oaks, Calif.), 22(3), 308-315 (2014-07-18)
Endometrial stromal and epithelial cell cross talk is known to influence many of the dynamic changes that occur during the menstrual cycle. We modified our previous model and embedded telomerase-immortalized human endometrial stromal cells and Ishikawa adenocarcinoma epithelial cells in
Masataka Hosoi et al.
Experimental hematology, 42(9), 816-825 (2014-05-27)
Induced pluripotent stem cells (iPS) derived from disease cells are expected to provide a new experimental material, especially for diseases from which samples are difficult to obtain. In this study, we generated iPS from samples from patients with primary and
Orazio Vittorio et al.
Journal of drug targeting, 22(5), 408-415 (2014-01-18)
Catechin-dextran conjugates have recently attracted a lot of attention due to their anticancer activity against a range of cancer cells. Magnetic nanoparticles have the ability to concentrate therapeutically important drugs due to their magnetic-spatial control and provide opportunities for targeted
Ge Liu et al.
Prostaglandins, leukotrienes, and essential fatty acids, 91(6), 251-260 (2014-12-03)
Conventional assays of omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) status in humans involve venous blood collection and expensive, multi-step processes that limit their usefulness as screening tools. This study aimed to develop a capillary dried blood spot (DBS)
David R Cooper et al.
Biophysical journal, 109(1), 66-75 (2015-07-15)
The N-methyl-D-aspartate receptor (NMDAR) is a member of the glutamate receptor family of proteins and is responsible for excitatory transmission. Activation of the receptor is thought to be controlled by conformational changes in the ligand binding domain (LBD); however, glutamate
Limei Tian et al.
Biosensors & bioelectronics, 59, 208-215 (2014-04-15)
Printable multi-marker biochips that enable simultaneous quantitative detection of multiple target biomarkers in point-of-care and resource-limited settings are a holy grail in the field of biodiagnostics. However, preserving the functionality of biomolecules, which are routinely employed as recognition elements, during
Ling Yu et al.
Journal of colloid and interface science, 453, 151-158 (2015-05-20)
Poly[glycidyl methacrylate-co-poly (ethylene glycol) methacrylate] microspheres for the first time were successfully synthesized by atom transfer radical polymerization (ATRP) method at room temperature. The co-polymerization approach was investigated to delicately control the microsphere morphology and size-distribution by reaction conditions including
Ignacio Moraga et al.
Science signaling, 8(402), ra114-ra114 (2015-11-12)
Cytokines dimerize cell surface receptors to activate signaling and regulate many facets of the immune response. Many cytokines have pleiotropic effects, inducing a spectrum of redundant and distinct effects on different cell types. This pleiotropy has hampered cytokine-based therapies, and
Fei-Long Zhang et al.
CNS neuroscience & therapeutics, 20(12), 1036-1044 (2014-11-18)
To explore the effect of fucoidan treatment on oxidative stress-mediated dopaminergic neuronal damage and its potential mechanisms. The effect of fucoidan was investigated in a 6-hydroxydopamine (6-OHDA) rat model of PD, an animal model considered appropriate for preclinical studies of
Vivek V Pande et al.
Poultry science, 94(11), 2784-2796 (2015-10-27)
The biologically active form of vitamin D₃, calcitriol (1,25-(OH)₂D₃), plays a key role in mineral homeostasis and bone formation and dietary vitamin D₃deficiency is a major cause of bone disorders in poultry. Supplementary dietary cholecalciferol (25-hydroxyvitamin D, 25-OH), the precursor
Soo Jung Choi et al.
Journal of medicinal food, 17(11), 1222-1231 (2014-08-19)
Alzheimer's disease (AD) is pathologically characterized by the presence of amyloid plaques in brain and the overproduction of amyloid beta (Aβ), leading to learning and memory impairment and intense oxidative stress. In this study, the protective effect of Ligularia fischeri
Biological characteristics of muscle-derived satellite cells isolated from rats at different postnatal days
Yu R, et al.
Cytotechnology, 67(3), 397-408 (2015)
G Bart et al.
The British journal of dermatology, 171(2), 376-387 (2014-04-08)
Excessive skin exposure to solar radiation damages proteins and DNA, ultimately leading to skin ageing and cancers. To identify new ultraviolet B (UVB) target genes to understand the mechanisms behind the detrimental effects of UVB. Organotypic, stratified cultures of rat
Tong Chen et al.
Biochemical and biophysical research communications, 461(2), 237-242 (2015-04-22)
Human adipose-derived stem cells (hASCs) are multipotent progenitor cells with multi-lineage differentiation potential including osteogenesis and adipogenesis. While significant progress has been made in understanding the transcriptional control of hASC fate, little is known about how hASC differentiation is regulated
Robert T Brady et al.
Biochemical and biophysical research communications, 459(1), 118-123 (2015-02-28)
Bone formation requires the recruitment, proliferation and osteogenic differentiation of mesenchymal progenitors. A potent stimulus driving this process is mechanical loading, yet the signalling mechanisms underpinning this are incompletely understood. The objective of this study was to investigate the role
Ana Querejeta-Fernández et al.
ACS nano, 9(10), 10377-10385 (2015-09-05)
In the search for induced chiral plasmonic activity, cholesteric films formed by cellulose nanocrystals have attracted great interest as potential hosts for plasmonic nanoparticles. Circular dichroism (CD) spectra of the composite films exhibit two peaks, one of which is ascribed
Ping Xiao et al.
Journal of ethnopharmacology, 157, 55-61 (2014-09-27)
Radix Isatidis called "Ban-Lan-Gen" is one of the most commonly-used traditional Chinese medicines for antiviral, anti-inflammatory, antioxidant and antipyretic purposes. Investigate the bioaccessibility of uridine, epigoitrin, adenosine, clemastanin B, indigoticoside A and isolariciresinol as well as the antioxidant and anti-inflammatory
K Bhattacharya et al.
Dalton transactions (Cambridge, England : 2003), 44(19), 9221-9229 (2015-04-25)
Research on energy storage devices has created a niche owing to the ever increasing demand for alternative energy production and its efficient utilisation. Here, a novel composite of Fe3O4 nanospheres and carbon quantum dots (C-dots) have been synthesized by a
W N Addison et al.
Bone, 71, 244-256 (2014-12-03)
Bone cell culture systems are essential tools for the study of the molecular mechanisms regulating extracellular matrix mineralization. MC3T3-E1 osteoblast cell cultures are the most commonly used in vitro model of bone matrix mineralization. Despite the widespread use of this
Cheng-Yi Chen et al.
Biology of reproduction, 93(4), 103-103 (2015-09-12)
We studied the smooth muscle cell differentiation capability of human placental multipotent mesenchymal stromal cells (hPMSCs) and identified how endothelial cells recruit hPMSCs participating in vessel formation. hPMSCs from term placentas were induced to differentiate into smooth muscle cells under
Nicole A Hofmann et al.
British journal of pharmacology, 172(16), 4107-4118 (2015-05-20)
Highly vascularized ovarian carcinoma secretes the putative endocannabinoid and GPR55 agonist, L-α-lysophosphatidylinositol (LPI), into the circulation. We aimed to assess the involvement of this agonist and its receptor in ovarian cancer angiogenesis. Secretion of LPI by three ovarian cancer cell
O A Adaramoye et al.
The West Indian medical journal, 63(5), 408-415 (2015-03-18)
To evaluate and compare the antioxidant and acetylcholinestrase (AChE)-inhibitory properties of aerial parts of Strophanthus preussii (leaves, stem and root named as SPL, SPS and SPR, respectively) while catechin served as standard. The antioxidant and AchE-inhibitory properties of the methanol
Yu-Hsiang Lee et al.
Annals of biomedical engineering, 43(9), 2220-2230 (2015-01-30)
Nicotine is the major component in cigarette smoke and has been recognized as a risk factor for various cardiovascular diseases such as atherosclerosis. However, the definite pathogenesis of nicotine-mediated endothelial dysfunction remains unclear because hemodynamic factor in most of prior
Kai Jiang et al.
Oncology reports, 33(6), 2711-2718 (2015-04-22)
Silibinin, derived from the milk thistle plant (Silybum marianum), has anticancer and chemopreventive properties. Silibinin has been reported to inhibit the growth of various types of cancer cells. However, the mechanisms by which silibinin exerts an anticancer effect are poorly
Francisco J Prado-Prado et al.
Bioorganic & medicinal chemistry, 18(6), 2225-2231 (2010-02-27)
There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one parasite species. Consequently, predicting the probability with which a drug is active against
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