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Showing 1-30 of 2483 results for "A2547" within Papers
Mona Hanouni et al.
Physiological reports, 4(12) (2016-06-30)
Platelet-activating factor (PAF) acting via its receptor (PAFR) is implicated in the pathogenesis of persistent pulmonary hypertension of the newborn (PPHN). Effects of long-term oxygen therapy on newborn lung are not well understood; therefore, we studied the effect of oxygen
Giorgio Lagna et al.
The Journal of biological chemistry, 282(51), 37244-37255 (2007-10-20)
Vascular smooth muscle cells (VSMCs), unlike other muscle cells, do not terminally differentiate. In response to injury, VSMCs change phenotype, proliferate, and migrate as part of the repair process. Dysregulation of this plasticity program contributes to the pathogenesis of several
Jung-Yeon Kim et al.
Antioxidants (Basel, Switzerland), 9(1) (2020-01-08)
Accumulating evidence suggests that the pineal hormone melatonin displays protective effects against renal fibrosis, but the mechanisms remain poorly understood. Here, we investigate the effect of the pineal hormone on transdifferentiation of renal fibroblasts to myofibroblasts invoked by transforming growth
Fanneke E Alkemade et al.
Arteriosclerosis, thrombosis, and vascular biology, 27(10), 2228-2235 (2007-07-28)
Maternal hypercholesterolemia is associated with a higher incidence and faster progression of atherosclerotic lesions in neonatal offspring. We aimed to determine whether an in utero environment exposing a fetus to maternal hypercholesterolemia and associated risk factors can prime the murine
Ba Reun Kim et al.
PloS one, 12(11), e0187464-e0187464 (2017-11-03)
Angiogenic peptides have therapeutic potential for the treatment of chronic ischemic diseases. Periostin, an extracellular matrix protein expressed in injured tissues, promotes angiogenesis and tissue repair. We previously reported that in vivo administration of both recombinant full-length protein and the
Kay-Dietrich Wagner et al.
Nature communications, 5, 5852-5852 (2014-12-17)
Angiogenesis, activation of metastasis and avoidance of immune destruction are important for cancer progression. These biological capabilities are, apart from cancer cells, mediated by different cell types, including endothelial, haematopoietic progenitor and myeloid-derived suppressor cells. We show here that all
Ana C Durán et al.
Journal of anatomy, 213(5), 597-606 (2008-09-23)
It has been generally assumed that the outflow tract of the chondrichthyan heart consists of the conus arteriosus, characterized by cardiac muscle in its walls. However, classical observations, neglected for many years, indicated that the distal component of the cardiac
Anish Mukherjee et al.
The Journal of physiology, 599(10), 2699-2721 (2021-03-02)
We present the first in vivo evidence that lymphatic contraction can entrain with an external oscillatory mechanical stimulus. Lymphatic injury can alter collecting lymphatic contractility, but not much is known about how its mechanosensitivity to external pressure is affected, which
Tong Wen et al.
Cell death and differentiation, 26(12), 2790-2806 (2019-04-27)
TEAD1 (TEA domain transcription factor 1), a transcription factor known for the functional output of Hippo signaling, is important for tumorigenesis. However, the role of TEAD1 in the development of vascular smooth muscle cell (VSMC) is unknown. To investigate cell-specific
Scott Earley et al.
American journal of physiology. Heart and circulatory physiology, 287(6), H2677-H2686 (2004-08-21)
Communication between vascular smooth muscle (VSM) cells via low-resistance gap junctions may facilitate vascular function by synchronizing the contractile state of individual cells within the vessel wall. We hypothesized that inhibition of gap junctional communication would impair constrictor responses of
Gerald R Cunha et al.
Differentiation; research in biological diversity, 115, 37-52 (2020-08-30)
The goal of this paper is to explore the ability of the human female urogenital sinus immediately below the bladder (proximal urethra) to undergo prostatic development in response to dihydrotestosterone (DHT). To establish this idea, xenografts of human fetal female
Aparna Vidyasagar et al.
American journal of physiology. Renal physiology, 295(3), F707-F716 (2008-07-04)
We hypothesized that heat shock protein 27 (HSP27), a small heat shock protein with actin-remodeling properties, is involved in the pathogenesis of kidney tubulointerstitial fibrosis. We first examined its expression in the rat unilateral ureteral obstruction (UUO) model of kidney
Filipa Moraes et al.
Circulation research, 113(9), 1076-1086 (2013-07-31)
Arteriogenesis is the process of formation of arterial conduits. Its promotion is an attractive therapeutic strategy in occlusive atherosclerotic diseases. Despite the functional and clinical importance of arteriogenesis, the biology of the process is poorly understood. Synectin, a gene previously
Surya Cayre et al.
Development (Cambridge, England), 147(19) (2020-09-09)
The Golgi-associated RAB GTPases, RAB6A and RAB6A', regulate anterograde and retrograde transport pathways from and to the Golgi. In vitro, RAB6A/A' control several cellular functions including cell division, migration, adhesion and polarity. However, their role remains poorly described in vivo
Herbert B Schiller et al.
Molecular systems biology, 11(7), 819-819 (2015-07-16)
The extracellular matrix (ECM) is a key regulator of tissue morphogenesis and repair. However, its composition and architecture are not well characterized. Here, we monitor remodeling of the extracellular niche in tissue repair in the bleomycin-induced lung injury mouse model.
Christina Therapontos et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(21), 8573-8578 (2009-05-13)
Thalidomide is a potent teratogen that induces a range of birth defects, most commonly of the developing limbs. The mechanisms underpinning the teratogenic effects of thalidomide are unclear. Here we demonstrate that loss of immature blood vessels is the primary
Fei Xu et al.
Arteriosclerosis, thrombosis, and vascular biology, 35(10), 2145-2152 (2015-08-22)
To investigate the functional role of the microRNA (miR)-15b/16 in vascular smooth muscle (SM) phenotypic modulation. We found that miR-15b/16 is one of the most abundant mRs expressed in contractile vascular smooth muscle cells (VSMCs). However, when contractile VSMCs get
Yushan Li et al.
BMC biology, 12, 25-25 (2014-03-29)
Abnormalities in pyloric development or in contractile function of the pylorus cause reflux of duodenal contents into the stomach and increase the risk of gastric metaplasia and cancer. Abnormalities of the pyloric region are also linked to congenital defects such
Moises Freitas-Andrade et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 32(4), 663-675 (2011-12-01)
In this study, we have investigated the potential role of placental growth factor (PlGF) in hypoxia-induced brain angiogenesis. To this end, PlGF wild-type (PlGF(+/+)) and PlGF knockout (PlGF(-/-)) mice were exposed to whole body hypoxia (10% oxygen) for 7, 14
Francisco Zurita-Díaz et al.
Stem cell research, 16(1), 124-127 (2016-06-28)
Human iPSC line GFM1SV.25 was generated from fibroblasts of a child with a severe mitochondrial encephalopathy associated with mutations in the GFM1 gene, encoding the mitochondrial translation elongation factor G1. Reprogramming factors OCT3/4, SOX2, CMYC and KLF4 were delivered using
Ximena Aguilar et al.
Acta ophthalmologica, 88(4), 407-412 (2009-09-15)
To investigate the occurrence of myofibroblasts (MFBs) in the normal conjunctival surface and to evaluate any anatomical and time-related variations. MFBs were screened among healthy individuals (35 eyes) by collecting impression cytology (IC) samples from the bulbar conjunctiva. A cohort
Kohei Aoki et al.
Journal of the American Heart Association, 4(10), e002023-e002023 (2015-10-11)
Renal dysfunction is a major risk factor for atrial fibrillation (AF). The uremic toxin indoxyl sulfate may contribute to the progression of cardiac fibrosis and AF substrate in renal dysfunction. Male Sprague-Dawley rats were assigned randomly to the following groups:
Olivier Nuñez et al.
Breast cancer research and treatment, 156(1), 195-201 (2016-03-10)
Molecular evidence has linked the pathophysiology of lymphangioleiomyomatosis (LAM) to that of metastatic breast cancer. Following on this observation, we assessed the association between LAM and subsequent breast cancer. An epidemiological study was carried out using three LAM country cohorts
A Djamali et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 9(1), 74-82 (2008-11-04)
We studied the role of classical phagocytic NADPH oxidase (Nox) in the pathogenesis of kidney allograft tubulointerstitial fibrosis. Immunofluorescence studies showed that Nox-2 and p22phox (electron transfer subunits of Nox) colocalized in the tubulointerstitium of human kidney allografts. Tubular Nox-2
Davide Povero et al.
JCI insight, 5 (2019-06-12)
Progression of fibrosis and the development of cirrhosis are responsible for the liver related morbidity and mortality associated with chronic liver diseases. There is currently a great unmet need for effective anti-fibrotic strategies. Stem cells play a central role in
Melville B Vaughan et al.
Cell biology international, 38(8), 981-986 (2014-04-26)
Myofibroblasts are resident cells of wound healing, contractures and fibroses; these tissues are often referred to as fibroproliferative. Whether myofibroblasts themselves proliferate is of interest. Since many in vitro cultures are heterogeneous, staining in situ is required to identify the
Patricia García-Parra et al.
Frontiers in cellular neuroscience, 6, 10-10 (2012-03-22)
Topographical and biochemical characteristics of the substrate are critical for neuronal differentiation including axonal outgrowth and regeneration of neural circuits in vivo. Contact stimuli and signaling molecules allow neurons to develop and stabilize synaptic contacts. Here we present the development
Helen Sheldon et al.
Molecular cancer research : MCR, 19(11), 1957-1969 (2021-08-06)
ELTD1/ADGRL4 expression is increased in the vasculature of a number of tumor types and this correlates with a good prognosis. Expression has also been reported in some tumor cells with high expression correlating with a good prognosis in hepatocellular carcinoma
Ryan E Tomlinson et al.
Bone, 52(1), 212-219 (2012-10-10)
Although angiogenesis and osteogenesis are critically linked, the importance of angiogenesis for stress fracture healing is unknown. In this study, mechanical loading was used to create a non-displaced stress fracture in the adult rat forelimb. Fumagillin, an anti-angiogenic agent, was
Alexander I Ward et al.
mBio, 11(4) (2020-08-06)
Infections with Trypanosoma cruzi are usually lifelong despite generating a strong adaptive immune response. Identifying the sites of parasite persistence is therefore crucial to understanding how T. cruzi avoids immune-mediated destruction. However, this is a major technical challenge, because the
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