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Showing 1-30 of 2586 results for "A2547" within Papers
Yu Tanaka et al.
American journal of physiology. Gastrointestinal and liver physiology, 321(4), G378-G388 (2021-08-19)
It was previously identified that systemic Nrf2 deletion attenuates pancreatic cancer progression in a mutant K-ras/p53-expressing mouse model (KPC mouse). In this study, the type of cell that is responsible for the retarded cancer progression was elucidated. Human pancreatic cancers
Mona Hanouni et al.
Physiological reports, 4(12) (2016-06-30)
Platelet-activating factor (PAF) acting via its receptor (PAFR) is implicated in the pathogenesis of persistent pulmonary hypertension of the newborn (PPHN). Effects of long-term oxygen therapy on newborn lung are not well understood; therefore, we studied the effect of oxygen
Giorgio Lagna et al.
The Journal of biological chemistry, 282(51), 37244-37255 (2007-10-20)
Vascular smooth muscle cells (VSMCs), unlike other muscle cells, do not terminally differentiate. In response to injury, VSMCs change phenotype, proliferate, and migrate as part of the repair process. Dysregulation of this plasticity program contributes to the pathogenesis of several
Christina Therapontos et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(21), 8573-8578 (2009-05-13)
Thalidomide is a potent teratogen that induces a range of birth defects, most commonly of the developing limbs. The mechanisms underpinning the teratogenic effects of thalidomide are unclear. Here we demonstrate that loss of immature blood vessels is the primary
Fei Xu et al.
Arteriosclerosis, thrombosis, and vascular biology, 35(10), 2145-2152 (2015-08-22)
To investigate the functional role of the microRNA (miR)-15b/16 in vascular smooth muscle (SM) phenotypic modulation. We found that miR-15b/16 is one of the most abundant mRs expressed in contractile vascular smooth muscle cells (VSMCs). However, when contractile VSMCs get
Yushan Li et al.
BMC biology, 12, 25-25 (2014-03-29)
Abnormalities in pyloric development or in contractile function of the pylorus cause reflux of duodenal contents into the stomach and increase the risk of gastric metaplasia and cancer. Abnormalities of the pyloric region are also linked to congenital defects such
Daniel L Myers et al.
Arteriosclerosis, thrombosis, and vascular biology, 23(6), 1021-1028 (2003-04-26)
In this study, we characterized the effects of an osteopontin (OPN)-null mutation in normal arterial function and remodeling in a murine model. OPN-null mutant mice were compared with wild-type mice before and after carotid artery ligation. Before ligation, OPN-null mice
Beatrice Foglia et al.
Frontiers in immunology, 15, 1342404-1342404 (2024-03-12)
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously non-alcoholic fatty liver disease (NAFLD), is a leading cause of chronic liver disease worldwide. In 20%-30% of MASLD patients, the disease progresses to metabolic dysfunction-associated steatohepatitis (MASH, previously NASH) which can lead to
Kirsten A Turlo et al.
Developmental biology, 365(1), 23-35 (2012-02-15)
β1 integrin has been shown to contribute to vascular smooth muscle cell differentiation, adhesion and mechanosensation in vitro. Here we showed that deletion of β1 integrin at the onset of smooth muscle differentiation resulted in interrupted aortic arch, aneurysms and
Liying Cai et al.
Stem cells (Dayton, Ohio), 27(1), 230-237 (2008-09-06)
The administration of therapeutic cell types, such as stem and progenitor cells, has gained much interest for the limitation or repair of tissue damage caused by a variety of insults. However, it is still uncertain whether the morphological and functional
Ken Goto et al.
Stem cells (Dayton, Ohio), 24(8), 1859-1868 (2006-04-29)
Prostate carcinoma and benign prostatic hypertrophy may both originate in stem cells, highlighting the importance of the characterization of these cells. The prostate gland contains a network of ducts each of which consists of a proximal (adjacent to the urethra)
Anki Knutsson et al.
Scientific reports, 6, 26220-26220 (2016-05-18)
Androgen-deprivation therapy (ADT) for prostate cancer has been associated with increased risk for development of cardiovascular events and recent pooled analyses of randomized intervention trials suggest that this primarily is the case for patients with pre-existing cardiovascular disease treated with
Milena Paw et al.
BMC molecular and cell biology, 22(1), 19-19 (2021-03-14)
The asthma-related airway wall remodeling is associated i.a. with a damage of bronchial epithelium and subepithelial fibrosis. Functional interactions between human bronchial epithelial cells and human bronchial fibroblasts are known as the epithelial-mesenchymal trophic unit (EMTU) and are necessary for
Yuanyuan Zhang et al.
Frontiers in cell and developmental biology, 8, 578790-578790 (2020-12-18)
Endothelial dysfunction plays an important role in promoting the progression of disease genesis such as atherosclerosis and abdominal aortic aneurysm (AAA). The physiological unbalance of endothelial cells is a major pathological basis. In this present study, we investigated Brahma-related gene
Artem Antoshin et al.
International journal of molecular sciences, 24(24) (2023-12-23)
The quality of soft tissue defect regeneration after dental surgeries largely determines their final success. Collagen membranes have been proposed for the healing of such defects, but in some cases, they do not guarantee a sufficient volume of the regenerated
Jung-Yeon Kim et al.
Antioxidants (Basel, Switzerland), 9(1) (2020-01-08)
Accumulating evidence suggests that the pineal hormone melatonin displays protective effects against renal fibrosis, but the mechanisms remain poorly understood. Here, we investigate the effect of the pineal hormone on transdifferentiation of renal fibroblasts to myofibroblasts invoked by transforming growth
Fanneke E Alkemade et al.
Arteriosclerosis, thrombosis, and vascular biology, 27(10), 2228-2235 (2007-07-28)
Maternal hypercholesterolemia is associated with a higher incidence and faster progression of atherosclerotic lesions in neonatal offspring. We aimed to determine whether an in utero environment exposing a fetus to maternal hypercholesterolemia and associated risk factors can prime the murine
Ba Reun Kim et al.
PloS one, 12(11), e0187464-e0187464 (2017-11-03)
Angiogenic peptides have therapeutic potential for the treatment of chronic ischemic diseases. Periostin, an extracellular matrix protein expressed in injured tissues, promotes angiogenesis and tissue repair. We previously reported that in vivo administration of both recombinant full-length protein and the
Kay-Dietrich Wagner et al.
Nature communications, 5, 5852-5852 (2014-12-17)
Angiogenesis, activation of metastasis and avoidance of immune destruction are important for cancer progression. These biological capabilities are, apart from cancer cells, mediated by different cell types, including endothelial, haematopoietic progenitor and myeloid-derived suppressor cells. We show here that all
Kohei Aoki et al.
Journal of the American Heart Association, 4(10), e002023-e002023 (2015-10-11)
Renal dysfunction is a major risk factor for atrial fibrillation (AF). The uremic toxin indoxyl sulfate may contribute to the progression of cardiac fibrosis and AF substrate in renal dysfunction. Male Sprague-Dawley rats were assigned randomly to the following groups:
Olivier Nuñez et al.
Breast cancer research and treatment, 156(1), 195-201 (2016-03-10)
Molecular evidence has linked the pathophysiology of lymphangioleiomyomatosis (LAM) to that of metastatic breast cancer. Following on this observation, we assessed the association between LAM and subsequent breast cancer. An epidemiological study was carried out using three LAM country cohorts
Danila Ivanov et al.
Cardiovascular research, 64(1), 132-143 (2004-09-15)
In vascular tissue, T-cadherin (T-cad) levels correlate with the progression of atherosclerosis, restenosis and tumour neovascularization. This study investigates whether T-cad influences proliferation of vascular cells. Cultures of human umbilical vein endothelial cells (HUVEC) and rat and human aortic smooth
Anastasia Gromova et al.
Stem cells translational medicine, 6(1), 88-98 (2017-02-09)
In humans, the lacrimal gland (LG) is the primary contributor to the aqueous layer of the tear film. Production of tears in insufficient quantity or of inadequate quality may lead to aqueous-deficiency dry eye (ADDE). Currently there is no cure
I P Hall et al.
British journal of pharmacology, 107(2), 422-428 (1992-10-01)
1. [3H]-adenosine 3':5'-cyclic monophosphate ([3H]-cyclic AMP) responses were studied in primary cultures of human tracheal smooth muscle cells derived from explants of human trachealis muscle and in short term cultures of acutely dissociated trachealis cells. 2. Isoprenaline induced concentration-dependent [3H]-cyclic
Le Tran Phuc Khoa et al.
Cell stem cell, 27(3), 441-458 (2020-07-02)
Self-renewing embryonic stem cells (ESCs) respond to environmental cues by exiting pluripotency or entering a quiescent state. The molecular basis underlying this fate choice remains unclear. Here, we show that histone acetyltransferase MOF plays a critical role in this process
Yang Zhang et al.
Journal of biomedical optics, 25(1), 1-14 (2020-01-27)
Obesity is associated with a higher risk of developing breast cancer and with worse disease outcomes for women of all ages. The composition, density, and organization of the breast tissue stroma are also known to play an important role in
Rachel E Carlisle et al.
Cell death & disease, 12(10), 921-921 (2021-10-10)
Chronic kidney disease (CKD) is characterized by the gradual loss of renal function and is a major public health concern. Risk factors for CKD include hypertension and proteinuria, both of which are associated with endoplasmic reticulum (ER) stress. ER stress-induced
Sigrid Vondra et al.
Cell reports, 42(1), 111977-111977 (2023-01-15)
During human pregnancy, placenta-derived extravillous trophoblasts (EVTs) invade the decidua and communicate with maternal immune cells. The decidua distinguishes into basalis (decB) and parietalis (decP). The latter remains unaffected by EVT invasion. By defining a specific gating strategy, we report
Jin Yang et al.
Cardiovascular research, 101(1), 120-129 (2013-08-16)
Congenital coronary artery anomalies produce serious events that include syncope, arrhythmias, myocardial infarction, or sudden death. Studying the mechanism of coronary development will contribute to the understanding of the disease and help design new diagnostic or therapeutic strategies. Here, we
Pei-Yu Chen et al.
Scientific reports, 6, 33407-33407 (2016-09-17)
Smooth muscle cells (SMCs) in normal blood vessels exist in a highly differentiate state characterized by expression of SMC-specific contractile proteins ("contractile phenotype"). Following blood vessel injury in vivo or when cultured in vitro in the presence of multiple growth
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