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Showing 1-30 of 47 results for "A3480" within Papers
Michaela G Cuneo et al.
Psychoneuroendocrinology, 106, 244-251 (2019-04-21)
Prior research demonstrates a protective role for oxytocin in ovarian cancer based on its anti-proliferative, anti-migratory, and anti-invasive effects in vitro and in vivo. However, the role of endogenous oxytocin has not been examined in ovarian cancer patients. Oxytocin also
Allison Doyle Brackley et al.
The Journal of pharmacology and experimental therapeutics, 378(2), 96-107 (2021-05-16)
Opioid overdose intervention by naloxone, a high affinity receptor antagonist, reverses opioid-induced respiratory depression (OIRD) and analgesia by displacing opioids. Systemic naloxone stimulates release of the hypothalamic neuropeptide oxytocin, which has analgesic properties and participates in cardiorespiratory homeostasis. To test
Vuong Thi Ngoc Lan et al.
Reproductive biomedicine online, 25(3), 254-260 (2012-07-24)
This prospective cohort study examined the effects of atosiban on uterine contraction, implantation rate (IR) and clinical pregnancy rate (CPR) in women undergoing IVF/embryo transfer. The study enrolled 71 women with repeated implantation failure (RIF; no pregnancies from an average
Lok-Hi Chow et al.
Peptides, 39, 21-28 (2012-11-13)
In our previous study, we showed that intrathecal (i.t.) administration of angiotensin IV (Ang IV), an insulin-regulated aminopeptidase (IRAP) inhibitor, attenuated inflammatory hyperalgesia in rats. Using the plantar test in rats with carrageenan-induced paw inflammation, we investigated the possible mechanism(s)
Maryam Moghimian et al.
Stress (Amsterdam, Netherlands), 15(4), 385-392 (2011-11-03)
Previous studies showed the protective effects of oxytocin (OT) on myocardial injury in ischemic and reperfused rat heart. Moreover, exposure to various stressors not only evokes sudden cardiovascular effects but also triggers the release of OT in the rat. The
Effectiveness and safety of the oxytocin antagonist atosiban versus beta-adrenergic agonists in the treatment of preterm labour
versus Beta-agonists, The Worldwide Atosiban and others
British Journal of Obstetrics and Gynaecology, 108(2), 133-142 (2001)
Seung Pil Yun et al.
Molecular endocrinology (Baltimore, Md.), 26(7), 1144-1157 (2012-05-09)
Previous studies shows that connexins appear very early during murine embryo development, the gap junctional intercellular communication found in the inner cell mass of early embryo is also maintained in embryonic stem cells (ESC), and expression of oxytocin receptor (OTR)
Vassilis Tsatsaris et al.
Drugs, 64(4), 375-382 (2004-02-19)
Oxytocin antagonists are synthetic analogues that have the nonapeptide structure of oxytocin. They act by competing with oxytocin for receptors in the myometrium. Animal experiments and pilot clinical studies have examined several agents and, of these, atosiban has been the
Biswadeep Das et al.
Life sciences, 90(19-20), 763-769 (2012-04-25)
Oxytocin (OXT) pretreatment protects the heart during ischemia-reperfusion injury by activating ATP-dependent potassium (K(ATP)) channels. The aim of the current study was to elucidate the roles of nitric oxide synthaseNOS and myocardial biochemistry in the cardioprotective effects of OXT and
Shotaro Hobo et al.
Anesthesia and analgesia, 114(2), 442-449 (2011-11-23)
Lumbar intrathecal injection of oxytocin produces antinociception in rats and analgesia in humans. Classically, oxytocin receptors couple to stimulatory G proteins, increase inositol-3-phosphate production, and result in neuronal excitation. Most work to date has focused on a spinal site of
Konstantinos Kalmantis et al.
Archives of gynecology and obstetrics, 285(1), 265-270 (2011-08-09)
To compare endometrial and subendometrial morphological changes and vascularity as measured by 3D Power Doppler sonography, based on a specific scoring system between women subjected or not to oxytocine receptor antagonist (OTRa) during IVF cycles. Twenty-six women were divided into
Raed Salim et al.
Obstetrics and gynecology, 120(6), 1323-1331 (2012-11-22)
To compare the tocolytic efficacy and tolerability of nifedipine with that of atosiban among pregnant women with preterm labor. Pregnant women admitted with preterm labor and intact membranes between 24 and 33 weeks 6 days of gestation, between January 2008
Yavuz Simsek et al.
Archives of gynecology and obstetrics, 286(3), 777-783 (2012-06-01)
The current study investigated the potential therapeutic efficiency of atosiban, an oxytocin receptor antagonist, in an experimental endometriosis model. Endometriosis was surgically induced in 35 female rats during estrus. Four weeks after this procedure, relaparotomy was performed. The viability and
Ming-Yih Wu et al.
Taiwanese journal of obstetrics & gynecology, 49(4), 495-499 (2011-01-05)
Pregnancies with extremely preterm premature rupture of membranes (EPPROM), especially before 20 weeks of gestation, are usually considered to be a termination of pregnancy. By improvement of obstetric and neonatal care, we can prolong the pregnancy across the threshold of
Paulina K Wrzal et al.
Cellular signalling, 24(1), 342-350 (2011-10-04)
The oxytocin receptor (OTR) and the β(2)-adrenergic receptor (β(2)AR) are key regulators of uterine contraction. These two receptors are targets of tocolytic agents used to inhibit pre-term labor. Our recent study on the nature of OTR- and β(2)AR-mediated ERK1/2 activation
Jens Lyndrup et al.
Expert opinion on investigational drugs, 16(6), 843-853 (2007-05-16)
Preterm birth is the major cause of neonatal mortality and morbidity in the developed world. The perfect tocolytic that is uniformly effective with complete fetomaternal safety does not exist. Tocolytic agents differ in cost, utero-specificity, safety, efficacy and whether they
Plato Mak et al.
Journal of psychopharmacology (Oxford, England), 26(4), 532-542 (2011-09-06)
Oxytocin (OT) and arginine vasopressin (AVP), in their capacities as neuromodulators, are believed to play an important role in mood control, including regulation of the anxiety response. In the present study, the contributions of oxytocin and vasopressin receptor modulation to
Oxytocin antagonist successfully prevents from threatened abortion in 15 weeks' gestation.
Hsing-I Wang et al.
Taiwanese journal of obstetrics & gynecology, 50(2), 220-222 (2011-07-28)
Mark P Hehir et al.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 25(11), 2234-2236 (2012-04-25)
Preterm delivery results in neonatal morbidity and mortality. We set out to estimate the difference in rates of preterm delivery in two institutions, serving a single population, with differing policies regarding use of tocolytic drugs for the prevention of preterm
Jaro Wex et al.
BMC pregnancy and childbirth, 9, 23-23 (2009-06-23)
The use of tocolytics is central in delaying birth; however, therapeutic options vary in effectiveness and adverse events profiles, which in turn could have consequences for medical resource use and cost of treatment. Betamimetics are commonly used tocolytic agents, but
Oxytocin modulates GABA A R subunits to confer neuroprotection in stroke in vitro
Kaneko Y, et al.
Scientific reports, 6(5), 35659-35659 (2016)
Aravinthan Coomarasamy et al.
BJOG : an international journal of obstetrics and gynaecology, 110(12), 1045-1049 (2003-12-11)
To explore the effectiveness of nifedipine compared with atosiban for tocolysis in preterm labour. A systematic review of randomised controlled trials with meta-analysis using adjusted indirect comparison. Six hundred and seventy-nine women recruited in nine randomised trials evaluating the effectiveness
N Nikolettos et al.
Clinical and experimental obstetrics & gynecology, 39(1), 36-42 (2012-06-09)
To investigate the response of pregnant and non pregnant rat myometrium to benzoylecgonine, a cocaine metabolite, and oxytocin and to investigate the efficiency of ritodrine and atosiban to overcome the effects of benzoylecgonine and oxytocin. Isolation of rat myometrial tissue
K C Santos et al.
Animal reproduction science, 164, 23-30 (2015-12-02)
Erythroxylum caatingae Plowman has a myorelaxing effect on smooth muscle tissue. We investigated the effect of the crude ethanolic extract of E. caatingae Plowman (Ec-EtOH) on the contractility of the ovine cervix. In an isometric system, circular strips were subjected
O Wellnitz et al.
The Journal of dairy research, 66(1), 1-8 (1999-04-07)
Plasma concentrations of the oxytocin receptor blocking agent Atosiban were measured at 2, 4, 10, 15 and 20 min after injection of 5, 10, 20 and 50 micrograms Atosiban/kg body weight in six dairy cows. The half life of Atosiban
High-throughput screening of myometrial calcium-mobilization to identify modulators of uterine contractility
Herington JL, et al.
PLoS ONE, 10(11), e0143243-e0143243 (2015)
Yavuz Simsek et al.
Archives of gynecology and obstetrics, 285(3), 655-661 (2011-08-26)
The purpose of this study was to evaluate the cardiac and cerebral oxidative stress in the offspings of pregnant rats treated with oxytocin antagonist atosiban. Experimentally naive, adult female Wistar-albino rats (200-250 g) were mated with adult male rats for
P J Shubert
Clinical obstetrics and gynecology, 38(4), 722-724 (1995-12-01)
The role of oxytocin and oxytocin receptors in preterm labor is perhaps more prominent than once thought. The blockade of oxytocin and/or oxytocin receptors has both a theoretical and clinical aspect. Initial trials with the oxytocin antagonist atosiban have been
Barbara Chruścicka et al.
ACS chemical neuroscience, 10(7), 3225-3240 (2019-05-01)
The oxytocin receptor (OTR) and the 5-hydroxytryptamine 2A receptor (5-HTR2A) are expressed in similar brain regions modulating central pathways critical for social and cognition-related behaviors. Signaling crosstalk between their endogenous ligands, oxytocin (OT) and serotonin (5-hydroxytryptamine, 5-HT), highlights the complex
A Tahara et al.
British journal of pharmacology, 129(1), 131-139 (2000-02-29)
[(3)H]-oxytocin was used to characterize the oxytocin receptor found in human uterine smooth muscle cells (USMC). Specific binding of [(3)H]-oxytocin to USMC plasma membranes was dependent upon time, temperature and membrane protein concentration. Scatchard plot analysis of equilibrium binding data
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