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Showing 1-30 of 927 results for "A3553" within Papers
Amit Baran Das et al.
Toxicology mechanisms and methods, 22(3), 163-169 (2011-10-26)
Research on acrylamide has been going on for the last four decades. However, its presence in carbohydrate-rich and high temperature processed foods was confirmed in 2002, after which a significant progress in this field has been made. A number of
Kazuko Takahashi-Niki et al.
The Journal of biological chemistry, 290(29), 17838-17847 (2015-06-07)
DJ-1 is an oncogene and also a causative gene for familial Parkinson disease. DJ-1 has various functions, and the oxidative status of cysteine at position 106 (Cys-106) is crucial for determination of the activation level of DJ-1. Although DJ-1 requires
Joseph P Salisbury et al.
BMC genomics, 16, 166-166 (2015-04-17)
The brown ghost knifefish (Apteronotus leptorhynchus) is a weakly electric teleost fish of particular interest as a versatile model system for a variety of research areas in neuroscience and biology. The comprehensive information available on the neurophysiology and neuroanatomy of
Minseok Seo et al.
Lab on a chip, 15(17), 3581-3590 (2015-07-30)
Perfluorocarbon (PFC) nanodroplet agents are exciting new biomaterials that can be remotely vapourized by ultrasound or light to change into micron-scale gas bubbles in situ. After PFC nanodroplet vapourization, the micron-scale gas bubble can interact strongly with ultrasound radiation, such
Donghee Lee et al.
Langmuir : the ACS journal of surfaces and colloids, 31(35), 9684-9693 (2015-08-14)
The stiffness of the extracellular matrix (ECM) plays an important role in controlling cell functions. As an alternative to the ECM, hydrogels of tunable elasticity are widely used for in vitro cell mechanobiology studies. Therefore, characterizing the Young's modulus of
Siegfried Wagner et al.
Anticancer research, 35(1), 145-148 (2015-01-01)
Canine prostate cancer (PC) is a highly aggressive malignancy. However, in contrast to man, neither standard screening strategies nor curative therapeutic options exist for the companion animal. A prostate-specific membrane antigen (PSMA) screening as molecular marker akin to human PC
Ali Nematollahzadeh et al.
Journal of chromatography. A, 1345, 154-163 (2014-05-03)
In the present work, we report a novel method for the reinforcement of hierarchically structured molecularly imprinted polymer (MIP) for the separation of human serum albumin (HSA) and immunoglobulin G (IgG) proteins under pressure driven flow conditions. The template proteins
Vasiliki Gkretsi et al.
Experimental cell research, 334(2), 219-227 (2015-03-17)
Migfilin is a novel cell-matrix adhesion protein known to interact with Vasodilator Stimulated Phosphoprotein (VASP) and be localized both at cell-matrix and cell-cell adhesions. To date there is nothing known about its role in hepatocellular carcinoma (HCC). As matrix is
Nilesh K Sharma et al.
PloS one, 10(11), e0141897-e0141897 (2015-11-06)
Camptothecin (CPT), a topoisomerase I poison, is an important drug for the treatment of solid tumors in the clinic. Nitric oxide (·NO), a physiological signaling molecule, is involved in many cellular functions, including cell proliferation, survival and death. We have
Gilbert Eriani et al.
PloS one, 10(6), e0130042-e0130042 (2015-06-13)
Aminoacyl-tRNA synthetases (AARSs) constitute a family of RNA-binding proteins, that participate in the translation of the genetic code, by covalently linking amino acids to appropriate tRNAs. Due to their fundamental importance for cell life, AARSs are likely to be one
Sorina Morar-Mitrica et al.
mAbs, 7(4), 792-803 (2015-06-16)
The physical and chemical integrity of a biopharmaceutical must be maintained not only during long-term storage but also during administration. Specifically for the intravenous (i.v.) delivery of a protein drug, loss of stability can occur when the protein formulation is
Yau-Hung Chen et al.
Toxicological sciences : an official journal of the Society of Toxicology, 147(1), 246-254 (2015-07-03)
Aristolochic acid (AA) nephropathy is complicated with early onset and severe anemia. The molecular pathological mechanism of AA-induced anemia remains unclear. The aim of this study was to evaluate the putative pathological roles of the erythropoietin receptor (EPOR) in AA-induced
Michael S Dittmar et al.
PloS one, 10(6), e0130408-e0130408 (2015-06-20)
The effects of anesthetics on the injured brain continue to be the subject of controversial discussion. Since isoflurane has recently been shown to induce apoptosis of cerebral endothelial cells, this study compared different anesthetic compounds regarding their potential to induce
Marc Swidergall et al.
Eukaryotic cell, 14(4), 359-370 (2015-02-01)
Candida albicans adapts to the human host by environmental sensing using the Msb2 signal mucin, which regulates fungal morphogenesis and resistance characteristics. Msb2 is anchored within the cytoplasmic membrane by a single transmembrane (TM) region dividing it into a large
Hannah Ogilvie et al.
Biology, 3(2), 368-382 (2014-06-03)
The muscle wasting and loss of specific force associated with Critical Illness Myopathy (CIM) is, at least in part, due to a preferential loss of the molecular motor protein myosin. This acquired myopathy is common in critically ill immobilized and
Lily Paemka et al.
PLoS genetics, 11(3), e1005022-e1005022 (2015-03-13)
Epilepsy is a common disabling disease with complex, multifactorial genetic and environmental etiology. The small fraction of epilepsies subject to Mendelian inheritance offers key insight into epilepsy disease mechanisms; and pathologies brought on by mutations in a single gene can
Esra Koklamaz et al.
Journal of the science of food and agriculture, 94(10), 2002-2008 (2013-12-07)
In conventional manufacturing of potato chips, achieving an extremely low moisture content (2% by weight) in the final product necessitates prolonged exposure of potato slices to high oil temperatures. This promotes acrylamide formation and causes an exponential increase in acrylamide
Jun Cheng et al.
Food chemistry, 168, 90-99 (2014-08-31)
The aim of this study was to investigate the applicability of artificial neural network (ANN) and multiple linear regression (MLR) models for the estimation of acrylamide reduction by flavonoids, using multiple antioxidant capacities of Maillard reaction products as variables via
Z Xishan et al.
Cancer gene therapy, 21(9), 397-404 (2014-09-13)
The aim of this study was to investigate the role and mechanism of miR-23a in the regulation of BCR/ABL and to provide a new prognostic biomarker for chronic myeloid leukemia (CML). The expression levels of miR-23a and BCR/ABL were assessed
Richard M LoPachin et al.
Environmental health perspectives, 120(12), 1650-1657 (2012-10-13)
Acrylamide (ACR) produces cumulative neurotoxicity in exposed humans and laboratory animals through a direct inhibitory effect on presynaptic function. In this review, we delineate how knowledge of chemistry provided an unprecedented understanding of the ACR neurotoxic mechanism. We also show
Ying Xu et al.
Proteomics, 15(13), 2177-2186 (2015-03-05)
Asparagine-linked glycosylation is a common post-translational modification of proteins catalyzed by oligosaccharyltransferase that is important in regulating many aspects of protein function. Analysis of protein glycosylation, including glycoproteomic measurement of the site-specific extent of glycosylation, remains challenging. Here, we developed
Kyeong Lee et al.
Organic & biomolecular chemistry, 11(5), 849-858 (2012-12-18)
A series of indolyl acrylamide derivatives was synthesized as potential diacylglycerol acyltransferase (DGAT) inhibitors. Furfurylamine containing indolyl acrylamide derivative 5h exhibited the most potent DGAT inhibitory activity using microsomes prepared from rat liver. Further evaluation against human DGAT-1 and DGAT-2
Xin Tang et al.
PLoS computational biology, 10(6), e1003631-e1003631 (2014-06-06)
Traction forces exerted by adherent cells on their microenvironment can mediate many critical cellular functions. Accurate quantification of these forces is essential for mechanistic understanding of mechanotransduction. However, most existing methods of quantifying cellular forces are limited to single cells
Amy K McNally et al.
Journal of biomedical materials research. Part A, 103(4), 1380-1390 (2014-07-22)
The effects of different material surfaces on phenotypic expression in macrophages and foreign body giant cells (FBGC) were addressed using our in vitro system of interleukin (IL)-4-induced macrophage fusion and FBGC formation. Arginine-glycine-aspartate (RGD)-, vitronectin (VN)-, and chitosan (CH)-adsorbed cell
Xiulan Sun et al.
Biosensors & bioelectronics, 44, 122-126 (2013-02-19)
We report on a sensitive, simple, label-free cell-based electrochemical sensor to monitor the toxic effect of acrylamide on the Pheochromocytoma cells. The surface of the electrode was modified with gold nanoparticles and electrochemically reduced graphene oxide. Cyclic voltammetry, impedance spectroscopy
Kayleigh J S Martin et al.
PloS one, 10(2), e0116250-e0116250 (2015-02-07)
The entry of neutrophils into tissue has been well characterised; however the fate of these cells once inside the tissue microenvironment is not fully understood. A variety of signal transduction pathways including those involving class I PI3 Kinases have been
Alexander Hellqvist et al.
Biomedical chromatography : BMC, 29(4), 504-513 (2014-08-12)
Renal function can be monitored by estimation of the glomerular filtration rate (GFR), for example, through measurement of the plasma clearance of a marker that is freely filtrated through the kidney without reabsorption. It has been proposed that iohexol is
Mohit Sachdeva et al.
Cancer letters, 369(1), 202-211 (2015-09-01)
Accumulating evidence indicates that microRNAs (miRs) regulate cancer metastasis. We have shown that miR-182 drives sarcoma metastasis in vivo by coordinated regulation of multiple genes. Recently, we also demonstrated that in a subset of primary sarcomas that metastasize to the
V A Furmento et al.
Placenta, 35(11), 937-946 (2014-09-25)
Although the expression of the granulocyte colony-stimulating factor (G-CSF) and its receptor (G-CSFR) in placental tissues suggests that the cytokine could play a role in placental development, the relevance of G-CSF:G-CSFR interaction in trophoblast cells remains to be studied. Thus
Maureen A Bjerke et al.
Developmental biology, 394(2), 340-356 (2014-08-17)
Collective cell movements are integral to biological processes such as embryonic development and wound healing and also have a prominent role in some metastatic cancers. In migrating Xenopus mesendoderm, traction forces are generated by cells through integrin-based adhesions and tension
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