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Showing 1-30 of 50 results for "A3660" within Papers
Chanho Kwon et al.
Macromolecular bioscience, 12(11), 1452-1458 (2012-09-12)
Protein cages are spherical hollow macromolecules that are attractive platforms for the construction of nanoscale cargo delivery vehicles. Human heavy-chain ferritin (HHFn) is modified genetically to control the number and position of functional groups per cage. 24 β-CDs are conjugated
Richard Henderson et al.
Microscopy (Oxford, England), 62(1), 43-50 (2013-01-08)
Theoretical considerations together with simulations of single-particle electron cryomicroscopy images of biological assemblies in ice demonstrate that atomic structures should be obtainable from images of a few thousand asymmetric units, provided the molecular weight of the whole assembly being studied
Alexander Lehn et al.
Parkinsonism & related disorders, 18(8), 909-915 (2012-07-24)
Neuroferritinopathy is an autosomal dominantly inherited disorder caused by mutations in the gene encoding the ferritin light chain polypeptide. It leads to iron deposition particularly in the cerebellum, basal ganglia and motor cortex. The disease becomes clinically apparent in adulthood
Patrycja Kaczara et al.
Pigment cell & melanoma research, 25(6), 804-814 (2012-08-14)
Melanosomes were recently shown to protect ARPE-19 cells, a human retinal pigment epithelium (RPE) cell line, against oxidative stress induced by hydrogen peroxide. One postulated mechanism of antioxidant action of melanin is its ability to bind metal ions. The aim
Venkata P Dandey et al.
Nature methods, 17(9), 897-900 (2020-08-12)
We present an approach for preparing cryo-electron microscopy (cryo-EM) grids to study short-lived molecular states. Using piezoelectric dispensing, two independent streams of ~50-pl droplets of sample are deposited within 10 ms of each other onto the surface of a nanowire EM
Chiara Ullio et al.
Autophagy, 11(12), 2184-2198 (2015-11-14)
Lysosomal membrane permeabilization (LMP) induced by oxidative stress has recently emerged as a prominent mechanism behind TNF cytotoxicity. This pathway relies on diffusion of hydrogen peroxide into lysosomes containing redox-active iron, accumulated by breakdown of iron-containing proteins and subcellular organelles.
Jianxia Hou et al.
Biochemical and biophysical research communications, 426(4), 643-648 (2012-09-15)
This study investigated the expression and functions of ferritin, which is involved in osteoblastogenesis, in the periodontal ligament (PDL). The PDL is one of the most important tissues for maintaining the homeostasis of teeth and tooth-supporting tissues. Real-time PCR analyses
Elsa Valero et al.
Journal of medicinal chemistry, 57(13), 5686-5692 (2014-06-06)
New long-circulating maghemite nanoparticles of 4 and 6 nm, coated with an apoferritin protein capsid, exhibit useful properties to act as magnetic resonance imaging (MRI) contrast agents. A full in vivo study of the so-called apomaghemites reveals that their long-term
Tatini Rakshit et al.
Journal of colloid and interface science, 388(1), 282-292 (2012-09-25)
In this work, solid-state electron transport through the three metal core reconstituted ferritins, namely, Mn(III)-ferritin, Co(III)-ferritin, and Cu(II)-ferritin, has been probed and compared to the electron transport via the naturally-occurring iron-containing holoferritin and the metal-free apoferritin using current sensing atomic
Remarkable ability of horse spleen apoferritin to demetallate hemin and to metallate protoporphyrin IX as a function of pH.
Crichton, R.R., et al.
The Biochemical Journal, 36, 15049-15054 (1997)
Francesco Simone Ruggeri et al.
Nature communications, 11(1), 2945-2945 (2020-06-12)
The chemical and structural properties of biomolecules determine their interactions, and thus their functions, in a wide variety of biochemical processes. Innovative imaging methods have been developed to characterise biomolecular structures down to the angstrom level. However, acquiring vibrational absorption
Yunlong Tao et al.
British journal of haematology, 166(2), 279-291 (2014-04-23)
Ferritin plays important roles in iron metabolism and controls iron absorption in the intestine. The ferritin subunits ferritin heavy chain (Fth1) and ferritin light chain (Ftl1) are tightly regulated at both the transcriptional and post-transcriptional levels. However, mechanisms of maintaining
Fernando Carmona et al.
Metallomics : integrated biometal science, 5(3), 193-196 (2013-02-19)
A silica-protein hybrid material has been prepared by simultaneous covalent deposition of apoferritin and lactoferrin on functionalized silica. This material exhibits strong antibacterial activity against E. coli due to its high iron-uptake capacity.
Sumitaka Hasegawa et al.
Carcinogenesis, 33(11), 2269-2275 (2012-07-31)
H-ferritin (HF) is a core subunit of the iron storage protein ferritin and is related to the pathogenesis of malignant diseases. HF overexpression is present in human hematologic malignancies, suggesting that HF overexpression may contribute to the development of hematologic
Wint Nandar et al.
Biochimica et biophysica acta, 1832(6), 729-741 (2013-02-23)
Because of the increasing evidence that H63D HFE polymorphism appears in higher frequency in neurodegenerative diseases, we evaluated the neurological consequences of H63D HFE in vivo using mice that carry H67D HFE (homologous to human H63D). Although total brain iron
Enrico Ravera et al.
Journal of the American Chemical Society, 135(5), 1641-1644 (2013-01-22)
Using the 480 kDa iron-storage protein complex, apoferritin (ApoF), as an example, we demonstrate that sizable dynamic nuclear polarization (DNP) enhancements can be obtained on sedimented protein samples. In sedimented solute DNP (SedDNP), the biradical polarizing agent is co-sedimented with
Nida Siddiqui et al.
Nature communications, 10(1), 2693-2693 (2019-06-21)
The kinesin-3 KIF1C is a fast organelle transporter implicated in the transport of dense core vesicles in neurons and the delivery of integrins to cell adhesions. Here we report the mechanisms of autoinhibition and release that control the activity of
Edith Winkler et al.
Biochemistry, 48(6), 1183-1197 (2009-01-23)
Gamma-secretase is a unique intramembrane-cleaving protease complex, which cleaves the Alzheimer's disease-associated beta-amyloid precursor protein (APP) and a number of other type I membrane proteins. Human gamma-secretase consists of the catalytic subunit presenilin (PS) (PS1 or PS2), the substrate receptor
Jie Zhao et al.
Analytica chimica acta, 759, 53-60 (2012-12-25)
A novel and ultrasensitive sandwich-type electrochemical aptasensor has been developed for the detection of thrombin, based on dual signal-amplification using HRP and apoferritin. Core/shell Fe(3)O(4)/Au magnetic nanoparticles (AuMNPs) loading aptamer1 (Apt1) was used as recognition elements, and apoferritin dually labeled
Xin Wen et al.
BMC research notes, 6, 1-1 (2013-01-04)
An iron rich layer on the labial surface is characteristic of the enamel of rodent incisors. In order to address a role for iron content in continuously growing incisors during odontogenesis, we studied iron deposition patterns in enamel and dentine
Alexander Jacob et al.
Immunology, 139(3), 328-337 (2013-01-26)
Complement factor H (Cfh) is a key regulator of the complement cascade and protects C57BL/6 mice from immune complex-mediated complement-dependent glomerulonephritis. In chronic serum sickness (CSS) there are increased deposits of immune complexes in the glomeruli with inflammation and a
Sara Luscieti et al.
Orphanet journal of rare diseases, 8, 30-30 (2013-02-21)
Hereditary Hyperferritinaemia Cataract Syndrome (HHCS) is a rare autosomal dominant disease characterized by increased serum ferritin levels and early onset of bilateral cataract. The disease is caused by mutations in the Iron-Responsive Element (IRE) located in the 5' untranslated region
Ananya Nandy et al.
Infection and immunity, 86(6) (2018-04-11)
Mycobacterium tuberculosis, a successful human pathogen, utilizes multiple carbon sources from the host but adapts to a fatty-acid-rich environment in vivo We sought to delineate the physiologic response of M. tuberculosis to a lipid-rich environment by using differentiated adipocytes as
Mitsuhiro Okuda et al.
Nanotechnology, 23(41), 415601-415601 (2012-09-27)
The synthesis of magnetic, monodisperse nanoparticles has attracted great interest in nanoelectronics and nanomedicine. Here we report the fabrication of pure magnetite nanoparticles, less than ten nanometers in size, using the cage-shaped protein apoferritin (Fe(3)O(4)-ferritin). Crystallizable proteins were obtained through
Xindong Wang et al.
Biosensors & bioelectronics, 47, 171-177 (2013-04-11)
A novel sandwich electrochemical immunoassay was developed for ultrasensitive detection of avian leukosis virus subgroup J (ALVs-J) using graphene quantum dots (GQDs) and apoferritin-encapsulated Cu (Cu-apoferritin) nanoparticles for signal amplification. GQDs were used both for the conjugation of primary ALVs-J
[Hereditary hyperferritinemia-cataract syndrome. Unusual differential diagnosis of unexplainable high levels of ferritin].
Johan Vaktnäs et al.
Lakartidningen, 110(51-52), 2302-2303 (2014-02-08)
Fani Tsantoula et al.
Journal of pediatric hematology/oncology, 36(5), e304-e306 (2014-07-02)
A 2-year-old female was presented with high levels of serum ferritin (890 ng/mL) in a routine blood test. Clinical and laboratory investigations excluded the presence of iron overload and secondary causes of hyperferritinemia. A detailed family history and laboratory examinations
Noëlle Carette et al.
Journal of inorganic biochemistry, 100(8), 1426-1435 (2006-06-20)
Earlier crystallographic and spectroscopic studies had shown that horse spleen apoferritin was capable of removing the metal ion from hemin (Fe(III)-protoporphyrin IX) [G. Précigoux, J. Yariv, B. Gallois, A. Dautant, C. Courseille, B. Langlois d'Estaintot, Acta Cryst. D50 (1994) 739-743;
Martin Kistler et al.
Experimental hematology, 42(1), 59-69 (2013-10-22)
The objective was to explore how ferritin-H deletion influences (59)Fe-distribution and excretion-kinetics in mice. Kinetics of (59)Fe-release from organs, whole-body excretion, and distribution-kinetics of intravenously injected (59)Fe trace amounts were compared in iron-deficient and iron-replete mice with (Fth(Δ/Δ)) and without
Raffaella Gozzelino et al.
Cell host & microbe, 12(5), 693-704 (2012-11-20)
Disease tolerance is a defense strategy that limits the fitness costs of infection irrespectively of pathogen burden. While restricting iron (Fe) availability to pathogens is perceived as a host defense strategy, the resulting tissue Fe overload can be cytotoxic and
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