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Showing 1-30 of 218 results for "A3803" within Papers
Katrina Viloria et al.
Diabetes (2022-11-30)
GC-globulin (GC), or vitamin D-binding protein, is a multifunctional protein involved in transport of circulating vitamin 25(OH)D and fatty acids, as well as actin-scavenging. In the pancreatic islets, the gene encoding GC, GC, is highly-localized to glucagon-secreting α cells. Despite
M Szajnik et al.
Oncogene, 28(49), 4353-4363 (2009-10-15)
Toll-like receptors (TLRs) expressed on immune cells trigger inflammatory responses. TLRs are also expressed on ovarian cancer (OvCa) cells, but the consequences of signaling by the TLR4/MyD88 pathway in these cells are unclear. Here, TLR4 and MyD88 expression in OvCa
Christopher L Nobles et al.
Journal of microbiological methods, 118, 7-17 (2015-08-09)
Bacterial pathogens acquire host iron to power cellular processes and replication. Heme, an iron-containing cofactor bound to hemoglobin, is scavenged by bacterial proteins to attain iron. Methods to measure intracellular heme are laborious, involve complex chemistry, or require radioactivity. Such
Anne Kasus-Jacobi et al.
Biomolecules, 12(10) (2022-10-28)
Alzheimer's disease (AD) is a multifactorial disease with a complex pathogenesis. Developing multitarget drugs could be a powerful strategy to impact the progressive loss of cognitive functions in this disease. The purpose of this study is to select a multitarget
Michelle D Combs et al.
Circulation research, 105(6), 565-574 (2009-08-08)
NFATc1 (nuclear factor of activated T-cells cytoplasmic 1) activity in endocardial cushion (ECC) endothelial cells is required for normal ECC growth and extracellular matrix (ECM) remodeling during heart valve development. The mechanisms of NFATc1 activation and downstream effects on cell
Nikolay N Brandt et al.
Journal of biomedical optics, 20(5), 051015-051015 (2014-12-06)
The analysis of the structure-function relationship is extremely important in the study of proteins. The importance of function-related motions of large parts or subglobules of protein molecules stimulates the spectroscopic study in the low-frequency (terahertz) domain. However, only tentative assignments
Yuri L Boteon et al.
PloS one, 13(7), e0201419-e0201419 (2018-07-26)
Pharmacological defatting of rat hepatocytes and hepatoma cell lines suggests that the same method could be used to ameliorate macrovesicular steatosis in moderate to severely fatty livers. However there is no data assessing the effects of those drugs on primary
Improved in vitro culture conditions to enhance the survival, mitotic activity, and transplantability of rainbow trout type a spermatogonia
Shikina S and Yoshizaki G
Biology of Reproduction, 83(2), 268-276 (2010)
Yuan Yang et al.
Experimental and therapeutic medicine, 20(6), 257-257 (2020-11-18)
Mesenchymal stem cell (MSC) infusion has become a novel therapeutic strategy for complex autoimmune diseases; however, few detailed studies have been performed to investigate the benefit and mechanism of MSC treatment on systemic sclerosis (SSc). The present study aimed to
Induction of cell-cell fusion by ectromelia virus is not inhibited by its fusion inhibitory complex.
Noam Erez et al.
Virology journal, 6, 151-151 (2009-09-30)
Ectromelia virus, a member of the Orthopox genus, is the causative agent of the highly infectious mousepox disease. Previous studies have shown that different poxviruses induce cell-cell fusion which is manifested by the formation of multinucleated-giant cells (polykaryocytes). This phenomenon
Eva P Browne et al.
Aquatic toxicology (Amsterdam, Netherlands), 92(4), 281-287 (2009-04-07)
Polybrominated diphenyl ethers (PBDEs) are brominated flame retardants that persist in the environment and are present in geographically widespread fish species. PBDE concentrations can be particularly high in resident Chinook salmon (Onchorhynchus tshawytscha) in the Puget Sound, Washington. Although PBDE
Steven T Leach et al.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 22(5), 461-464 (2008-05-15)
The expression of the inflammatory S100 calgranulin proteins (S100A8, S100A9 and S100A12) in normal and Helicobacter pylori-infected gastric mucosa of children were examined. S100A8, S100A9 and S100A12, which were virtually absent in normal gastric mucosa, were highly expressed in H
Rapid confirmation and revision of the primary structure of bovine serum albumin by ESIMS and Frit-FAB LC/MS.
Hirayama K
Biochemical and Biophysical Research Communications, 173(2), 639-646 (1990)
Ashok Cattamanchi et al.
Clinical and vaccine immunology : CVI, 15(11), 1638-1643 (2008-09-12)
We conducted a double-blind, vehicle-controlled, dose escalation safety and immunogenicity trial of a candidate herpes simplex virus type 2 (HSV-2) surface glycoprotein D2 (gD2) DNA vaccine administered by use of a needle-free device. Sixty-two healthy adults were randomized using a
Study of the interaction between monoammonium glycyrrhizinate and bovine serum albumin.
Hu Y J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 36(4), 915-919 (2004)
Markus D Lacher et al.
Molecular cancer, 10, 91-91 (2011-07-28)
We have previously reported that RAS-MEK (Cancer Res. 2003 May 1;63(9):2088-95) and TGF-β (Cancer Res. 2006 Feb 1;66(3):1648-57) signaling negatively regulate coxsackie virus and adenovirus receptor (CAR) cell-surface expression and adenovirus uptake. In the case of TGF-β, down-regulation of CAR
Chao Wei et al.
Stem cells and development, 27(9), 624-636 (2018-04-13)
Continuous spermatogenesis from puberty to old age in males relies on spermatogonial stem cells (SSCs) that possess the property of self-renewal and differentiation. The delicate balance between self-renewal and differentiation is of great importance. In mice, SSCs exist as a
Ariana Jacome et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 17(6), 1083-1092 (2009-03-12)
Previous clinical trials based on the genetic correction of purified CD34(+) cells with gamma-retroviral vectors have demonstrated clinical efficacy in different monogenic diseases, including X-linked severe combined immunodeficiency, adenosine deaminase deficient severe combined immunodeficiency and chronic granulomatous disease. Similar protocols
Initial investigation of acoustic droplet vaporization for occlusion in canine kidney
Zhang M, et al.
Ultrasound in Medicine & Biology, 36(10), 1691-1703 (2010)
Birendra Kc et al.
Molecular biology of the cell, 28(17), 2241-2250 (2017-06-24)
The nuclear envelope (NE) is critical for numerous fundamental cellular functions, and mutations in several NE constituents can lead to a heterogeneous spectrum of diseases. We used proximity biotinylation to uncover new constituents of the inner nuclear membrane (INM) by
Daniela Cornacchia et al.
Cell stem cell, 25(1), 120-136 (2019-06-04)
Current challenges in capturing naive human pluripotent stem cells (hPSCs) suggest that the factors regulating human naive versus primed pluripotency remain incompletely defined. Here we demonstrate that the widely used Essential 8 minimal medium (E8) captures hPSCs at a naive-to-primed intermediate
Haiyan Dong et al.
BMC microbiology, 8, 223-223 (2008-12-18)
The usefulness of available vaccine and serological tests for leptospirosis is limited by the low cross-reactivity of antigens from numerous serovars of pathogenic Leptospira spp. Identification of genus-specific protein antigens (GP-Ag) of Leptospira would be important for development of universal
Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditis.
Mantri, et al.
Nature cardiovascular research, 1, 946-960 (2023)
Felix Yemanyi et al.
Investigative ophthalmology & visual science, 61(13), 16-16 (2020-11-11)
To determine the temporal effects of dexamethasone (DEX) and glucocorticoid-induced matrix (GIM) on integrins/integrin adhesomes, caveolins, cytoskeletal-related proteins, and stiffness in human trabecular meshwork (hTM) cells. Primary hTM cells were plated on plastic dishes (TCP), treated with vehicle (Veh) or
James C Y Dunn et al.
The Journal of surgical research, 156(2), 317-324 (2009-07-14)
The adrenal cortex may contain progenitor cells useful for tissue regeneration. Currently there are no established methods to isolate these cells. Murine adrenal cells were sorted into a Nile-red-bright (NR(bright)) and a Nile-red-dim (NR(dim)) population of cells according to their
Andrea Dichlberger et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1866(2), 158855-158855 (2020-11-13)
Lysosome Associated Protein Transmembrane 4B (LAPTM4B) is a four-membrane spanning ceramide interacting protein that regulates mTORC1 signaling. Here, we show that LAPTM4B is sorted into intraluminal vesicles (ILVs) of multivesicular endosomes (MVEs) and released in small extracellular vesicles (sEVs) into
Masaaki Adachi et al.
PloS one, 4(11), e7719-e7719 (2009-11-26)
Environmental changes, air pollution and ozone depletion are increasing oxidative stress, and global warming threatens health by heat stress. We now face a high risk of simultaneous exposure to heat and oxidative stress. However, there have been few studies investigating
Emily Turner-Brannen et al.
Arthritis research & therapy, 13(4), R129-R129 (2011-08-13)
Innate defence regulator (IDR) peptides are synthetic cationic peptides, variants of naturally occurring innate immune effector molecules known as host defence peptides. IDR peptides were recently demonstrated to limit infection-associated inflammation selectively without compromising host innate immune functions. This study
Kenneth A Dyar et al.
Cell, 174(6), 1571-1585 (2018-09-08)
Metabolic diseases are often characterized by circadian misalignment in different tissues, yet how altered coordination and communication among tissue clocks relate to specific pathogenic mechanisms remains largely unknown. Applying an integrated systems biology approach, we performed 24-hr metabolomics profiling of
Gerhard K E Scriba et al.
Methods in molecular biology (Clifton, N.J.), 984, 285-308 (2013-02-07)
In the past years, capillary electrophoresis has become a frequently used technique for enzyme assays due to the high separation efficiency and versatility as well as small sample size and low consumption of chemicals. The capillary electrophoresis assays can be
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