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Showing 1-30 of 69 results for "A4200" within Papers
Nanette Van Damme et al.
Cellular microbiology, 10(5), 1040-1057 (2007-12-14)
Several viruses encode ion channels that both modulate the trafficking of envelope glycoprotein(s) and stimulate the release of virions from cells. HIV-1 Vpu enhances virion release and inhibits the endosomal accumulation of the viral structural protein Gag. We investigated whether
Kanyarat Promchan et al.
PloS one, 15(1), e0226298-e0226298 (2020-01-03)
LZTFL1 participates in immune synapse formation, ciliogenesis, and the localization of ciliary proteins, and knockout of LZTFL1 induces abnormal distribution of heterotetrameric adaptor protein complex-1 (AP-1) in the Lztfl1-knockout mouse photoreceptor cells, suggesting that LZTFL1 is involved in intracellular transport.
Xufeng Wu et al.
Molecular biology of the cell, 14(2), 516-528 (2003-02-18)
We previously demonstrated, using fluorescence recovery after photobleaching, that clathrin in clathrin-coated pits at the plasma membrane exchanges with free clathrin in the cytosol, suggesting that clathrin-coated pits are dynamic structures. We now investigated whether clathrin at the trans-Golgi network
Katy Janvier et al.
The Journal of cell biology, 163(6), 1281-1290 (2003-12-24)
The sorting of transmembrane proteins to endosomes and lysosomes is mediated by signals present in the cytosolic tails of the proteins. A subset of these signals conform to the [DE]XXXL[LI] consensus motif and mediate sorting via interactions with heterotetrameric adaptor
Paloma Navarro Negredo et al.
The Journal of cell biology, 216(9), 2927-2943 (2017-07-27)
Acidic clusters act as sorting signals for packaging cargo into clathrin-coated vesicles (CCVs), and also facilitate down-regulation of MHC-I by HIV-1 Nef. To find acidic cluster sorting machinery, we performed a gene-trap screen and identified the medium subunit (µ1) of
Marielle Lebrun et al.
Journal of virology, 92(15) (2018-05-26)
ORF9p (homologous to herpes simplex virus 1 [HSV-1] VP22) is a varicella-zoster virus (VZV) tegument protein essential for viral replication. Even though its precise functions are far from being fully described, a role in the secondary envelopment of the virus
Jennifer Hirst et al.
Molecular biology of the cell, 16(5), 2554-2565 (2005-03-11)
Aftiphilin is a protein that was recently identified in database searches for proteins with motifs that interact with AP-1 and clathrin, but its function is unknown. Here we demonstrate that aftiphilin has a second, atypical clathrin binding site, YQW, that
Balraj Doray et al.
Molecular biology of the cell, 18(5), 1887-1896 (2007-03-16)
The clathrin adaptors AP-1 and AP-2 bind cargo proteins via two types of motifs: tyrosine-based Yxx phi and dileucine-based [DE]XXXL[LI]. Although it is well established that Yxx phi motifs bind to the mu subunits of AP-1 or AP-2, dileucine motifs
Zoe G Holloway et al.
American journal of physiology. Cell physiology, 293(6), C1753-C1767 (2007-10-05)
ATP7A (MNK) regulates copper homeostasis by translocating from a compartment localized within the trans-Golgi network to the plasma membrane (PM) in response to increased copper load. The mechanisms that regulate the biogenesis of the MNK compartment and the trafficking of
Jérôme Bouchet et al.
Journal of virology, 86(9), 4856-4867 (2012-02-22)
HIV-1 Nef is essential for AIDS pathogenesis, but this viral protein is not targeted by antiviral strategies. The functions of Nef are largely related to perturbations of intracellular trafficking and signaling pathways through leucine-based and polyproline motifs that are required
Li-Fong Seet et al.
Journal of cell science, 118(Pt 3), 575-587 (2005-01-20)
TOM1 and its related proteins, TOM1-like1 (TOM1-L1) and TOM1-like2 (TOM1-L2), constitute a subfamily of the VHS domain protein family. We have recently shown that endofin, a FYVE domain protein associated with the early endosome, is able to recruit cytosolic TOM1
Daniel Humphreys et al.
Cell reports, 17(3), 697-707 (2016-10-13)
To establish pathogenicity, bacteria must evade phagocytosis directed by remodeling of the actin cytoskeleton. We show that macrophages facilitate pathogen phagocytosis through actin polymerization mediated by the WAVE regulatory complex (WRC), small GTPases Arf and Rac1, and the Arf1 activator
A Nesterov et al.
The EMBO journal, 18(9), 2489-2499 (1999-05-06)
Although interactions between the mu2 subunit of the clathrin adaptor protein complex AP-2 and tyrosine-based internalization motifs have been implicated in the selective recruitment of cargo molecules into coated pits, the functional significance of this interaction for endocytosis of many
Hidekazu Tsutsui et al.
Molecular cell, 58(1), 186-193 (2015-03-17)
Crystallization of proteins may occur in the cytosol of a living cell, but how a cell responds to intracellular protein crystallization remains unknown. We developed a variant of coral fluorescent protein that forms diffraction-quality crystals within mammalian cells. This expression
Ramin Nazarian et al.
The Biochemical journal, 395(3), 587-598 (2006-02-02)
Dysbindin was identified as a dystrobrevin-binding protein potentially involved in the pathogenesis of muscular dystrophy. Subsequently, genetic studies have implicated variants of the human dysbindin-encoding gene, DTNBP1, in the pathogeneses of Hermansky-Pudlak syndrome and schizophrenia. The protein is a stable
Naava Naslavsky et al.
Journal of cell science, 122(Pt 3), 389-400 (2009-01-14)
Depletion of EHD3 affects sorting in endosomes by altering the kinetics and route of receptor recycling to the plasma membrane. Here we demonstrate that siRNA knockdown of EHD3, or its interaction partner rabenosyn-5, causes redistribution of sorting nexin 1 (SNX1)
Yasuko Mori et al.
Traffic (Copenhagen, Denmark), 9(10), 1728-1742 (2008-07-22)
The final envelopment of most herpesviruses occurs at Golgi or post-Golgi compartments, such as the trans Golgi network (TGN); however, the final envelopment site of human herpesvirus 6 (HHV-6) is uncertain. In this study, we found novel pathways for HHV-6
V Piguet et al.
Nature cell biology, 2(3), 163-167 (2000-03-09)
Major-histocompatibility-complex (MHC) proteins are used to display, on the surface of a cell, peptides derived from foreign material - such as a virus - that is infecting that cell. Cytotoxic T lymphocytes then recognize and kill the infected cell. The
Darren M Kamikura et al.
Genes & development, 17(22), 2798-2811 (2003-11-25)
Growth factors and morphogens need to be secreted to act on distant cells during development and in response to injury. Here, we report evidence that efficient export of a fibroblast growth factor (FGF), EGL-17, from the Caenorhabditis elegans developing vulva
J Hirst et al.
Molecular biology of the cell, 12(11), 3573-3588 (2001-11-06)
We have previously identified a novel family of proteins called the GGAs (Golgi-localized, gamma-ear-containing, ADP-ribosylation factor-binding proteins). These proteins consist of an NH(2)-terminal VHS domain, followed by a GAT domain, a variable domain, and a gamma-adaptin ear homology domain. Studies
Darren M Kamikura et al.
Traffic (Copenhagen, Denmark), 7(3), 324-336 (2006-02-25)
Growth factors must be secreted appropriately to co-ordinate cell proliferation, specification and movement during development and to control cell numbers and migrations in adult animals. Previous results showed that the secretion of the Caenorhabditis elegans fibroblast growth factor homologue, EGL-17
Daniel R Gulbranson et al.
Developmental cell, 50(4), 436-446 (2019-07-30)
Multimeric adaptors are broadly involved in vesicle-mediated membrane trafficking. AP2 adaptor, in particular, plays a central role in clathrin-mediated endocytosis (CME) by recruiting cargo and clathrin to endocytic sites. It is generally thought that trafficking adaptors such as AP2 adaptor
A S Dittié et al.
The EMBO journal, 16(16), 4859-4870 (1997-08-15)
The composition of secretory granules in neuroendocrine and endocrine cells is determined by two sorting events; the first in the trans-Golgi complex (TGN), the second in the immature secretory granule (ISG). Sorting from the ISG, which may be mediated by
Ximing Shao et al.
The Journal of biological chemistry, 292(50), 20628-20643 (2017-10-19)
The biological antagonism between the signaling proteins Numb and Notch has been implicated in the regulation of many developmental processes, especially in asymmetric cell division. Mechanistic studies show that Numb inactivates Notch via endocytosis and proteasomal degradation that directly reduce
Wiebke Stahlschmidt et al.
The Journal of biological chemistry, 289(8), 4906-4918 (2014-01-11)
Clathrin plays important roles in intracellular membrane traffic including endocytosis of plasma membrane proteins and receptors and protein sorting between the trans-Golgi network (TGN) and endosomes. Whether clathrin serves additional roles in receptor recycling, degradative sorting, or constitutive secretion has
Hye-Won Shin et al.
Molecular biology of the cell, 15(12), 5283-5294 (2004-09-24)
Small GTPases of the ADP-ribosylation factor (ARF) family play a key role in membrane trafficking by regulating coated vesicle formation, and guanine nucleotide exchange is essential for the ARF function. Brefeldin A blocks the ARF-triggered coat assembly by inhibiting the
Katy Janvier et al.
Molecular biology of the cell, 16(9), 4231-4242 (2005-07-01)
The limiting membrane of the lysosome contains a group of transmembrane glycoproteins named lysosome-associated membrane proteins (Lamps). These proteins are targeted to lysosomes by virtue of tyrosine-based sorting signals in their cytosolic tails. Four adaptor protein (AP) complexes, AP-1, AP-2
Daniel Pérez-Núñez et al.
PloS one, 10(4), e0123714-e0123714 (2015-04-29)
African swine fever virus (ASFV) CD2v protein is believed to be involved in virulence enhancement, viral hemadsorption, and pathogenesis, although the molecular mechanisms of the function of this viral protein are still not fully understood. Here we describe that CD2v
Agnes Lee Ang et al.
The Journal of cell biology, 163(2), 339-350 (2003-10-29)
The AP-1B clathrin adaptor complex plays a key role in the recognition and intracellular transport of many membrane proteins destined for the basolateral surface of epithelial cells. However, little is known about other components that act in conjunction with AP-1B.
Jarred J Bultema et al.
The Journal of biological chemistry, 287(23), 19550-19563 (2012-04-19)
Lysosome-related organelles (LROs) are synthesized in specialized cell types where they largely coexist with conventional lysosomes. Most of the known cellular transport machinery involved in biogenesis are ubiquitously expressed and shared between lysosomes and LROs. Examples of common components are
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