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Showing 1-7 of 7 results for "A4352" within Papers
Hey-Kyoung Lee et al.
Cell, 112(5), 631-643 (2003-03-12)
Plasticity of the nervous system is dependent on mechanisms that regulate the strength of synaptic transmission. Excitatory synapses in the brain undergo long-term potentiation (LTP) and long-term depression (LTD), cellular models of learning and memory. Protein phosphorylation is required for
Hey-Kyoung Lee et al.
Journal of neurophysiology, 103(1), 479-489 (2009-11-13)
Activity-dependent changes in excitatory synaptic transmission in the CNS have been shown to depend on the regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs). In particular, several lines of evidence suggest that reversible phosphorylation of AMPAR subunit glutamate receptor 1 (GluR1
Xiang Cai et al.
Nature neuroscience, 16(4), 464-472 (2013-03-19)
The causes of major depression remain unknown. Antidepressants elevate concentrations of monoamines, particularly serotonin, but it remains uncertain which downstream events are critical to their therapeutic effects. We found that endogenous serotonin selectively potentiated excitatory synapses formed by the temporoammonic
M W Lopes et al.
Translational psychiatry, 6(12), e986-e986 (2016-12-14)
Glucocorticoids (GC) released during stress response exert feedforward effects in the whole brain, but particularly in the limbic circuits that modulates cognition, emotion and behavior. GC are the most commonly prescribed anti-inflammatory and immunosuppressant medication worldwide and pharmacological GC treatment
Loukia Parisiadou et al.
Nature neuroscience, 17(3), 367-376 (2014-01-28)
Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with
Promotion of bone cancer pain development by decorin is accompanied by modification of excitatory synaptic molecules in the spinal cord.
Huan Wang et al.
Molecular pain, 15, 1744806919864253-1744806919864253 (2019-07-02)
Rodrigo Bainy Leal et al.
Molecular psychiatry, 25(3), 655-665 (2018-06-09)
Fear is a conscious state caused by exposure to real or imagined threats that trigger stress responses that affect the body and brain, particularly limbic structures. A sub-group of patients with mesial temporal lobe epilepsy related to hippocampus sclerosis (MTLE-HS)
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