Search Within


Applied Filters:
Showing 1-30 of 443 results for "A5006" within Papers
Martin Alejandro Krasnapolski et al.
Journal of cancer research and clinical oncology, 141(10), 1727-1738 (2015-02-18)
LM38 murine mammary adenocarcinoma model is formed by LM38-LP (myoepithelial and luminal), LM38-HP (luminal) and LM38-D2 (myoepithelial) cell lines. In a previous work, we had shown that LM38-HP and LM38-D2 cell lines are less malignant than the bicellular LM38-LP cell
Paula M C Mommersteeg et al.
Psychosomatic medicine, 77(3), 292-302 (2015-03-20)
Nitric oxide (NO) regulation plays a critical role in cardiovascular diseases including heart failure (HF). Markers of NO dysregulation have been found in individuals with depression without cardiovascular disease. Because depression is associated with poor HF outcomes, the present study
Jiang-Rui Zhou et al.
Journal of neuroimmunology, 260(1-2), 55-59 (2013-04-30)
Despite increasing evidence highlighting the role of NPY in the modulation of inflammatory reaction, surprisingly little is known about the direct effects of NPY on the release of proinflammatory mediators. In the present work, we have evaluated the effects of
Inger Jorid Berg et al.
The Journal of rheumatology, 42(4), 645-653 (2015-02-03)
To compare the risk of cardiovascular disease (CVD) in ankylosing spondylitis (AS) and population controls, and to examine the associations between disease activity and CVD risk. A cross-sectional study was done of patients with AS grouped according to Ankylosing Spondylitis
Anil Kumar et al.
The Journal of surgical research, 188(1), 268-279 (2014-02-04)
Traumatic head injury is turning out to be a major cause of disability and death. Nitric oxide (NO), an intercellular messenger plays a crucial role in the pathophysiology of several neurologic disorders. Therefore, the present study was designed to investigate
Kwang-Min Choi et al.
Fish & shellfish immunology, 45(2), 277-285 (2015-04-29)
Lectins are carbohydrate-binding proteins that play important roles in the recognition and elimination of pathogens via the innate immune system. Pentraxins (PTX) are humoral lectins, which are multifunctional proteins in vertebrates. Pentraxins can be divided into two groups based on
Seo Yun Kim et al.
Biotechnology and bioengineering, 112(2), 416-421 (2014-08-29)
L-ornithine is a non-essential amino acid for various industrial applications in food industry. In this study, Corynebacterium glutamicum ATCC 13032 was metabolically engineered for the production of L-ornithine. First, the proB and argF genes were deleted to block the competitive
Ting-lei Gu et al.
PloS one, 6(4), e19169-e19169 (2011-05-10)
Activating mutations of FMS-like tyrosine kinase-3 (FLT3) are found in approximately 30% of patients with acute myeloid leukemia (AML). FLT3 is therefore an attractive drug target. However, the molecular mechanisms by which FLT3 mutations lead to cell transformation in AML
Sabina Leanti La Rosa et al.
Infection and immunity, 83(5), 2156-2167 (2015-03-18)
In the present study, the commensal and pathogenic host-microbe interaction of Enterococcus faecalis was explored using a Caenorhabditis elegans model system. The virulence of 28 E. faecalis isolates representing 24 multilocus sequence types (MLSTs), including human commensal and clinical isolates
Amelia Barilli et al.
Biochimica et biophysica acta, 1842(9), 1364-1371 (2014-05-06)
Celiac disease (CD) is an autoimmune enteropathy triggered in susceptible individuals by the ingestion of gliadin-containing grains. Recent studies have demonstrated that macrophages play a key role in the pathogenesis of CD through the release of inflammatory mediators such as
Carina T Ribeiro et al.
The Journal of urology, 191(5 Suppl), 1578-1584 (2014-04-01)
We assessed reproductive and testicular function in adult rats after testicular torsion created before, during and after puberty, and with vs without resveratrol or arginine treatment. Age matched rats were divided into groups, including simulated surgery without testicular torsion, 720-degree
Daniela Melisi et al.
Journal of medicinal chemistry, 49(16), 4826-4833 (2006-08-04)
Nitric oxide (NO) is critical for the normal physiological regulation of the nervous system and other tissues. L-Arginine, but not D-arginine, is the natural substrate for nitric oxide synthase (NOS), for it is enzymatically converted to NO and L-citrulline. However
Pratima Tripathi et al.
Indian journal of biochemistry & biophysics, 50(2), 99-104 (2013-06-01)
Increased production of oxygen free radicals and decreased oxidant capacity occur in coronary artery diseases (CAD) This pro-oxidant shift in intracellular redox state may induce cell death by either direct cell membrane damage by lipic peroxidation or apoptosis through activation
István Télessy
Orvosi hetilap, 155(51), 2021-2027 (2014-12-17)
Reviewing the literature of nutrition therapy one can conclude that during the last decade the pharmacological action of several nutrients has been demonstrated. However, research activity is still at the beginning and it could be verified in a restricted number
Mizuki Watanabe et al.
Bioorganic & medicinal chemistry, 19(20), 5984-5988 (2011-09-16)
A series of optically active stereoisomers of 3,4-methanoarginine (1-4 and ent-1-ent-4) with trans/cis, D/L, and syn/anti stereochemical diversity, the side-chains of which were restricted in various special arrangements, was designed as biologically useful arginine mimetics. These conformationally restricted arginine analogues
Shewit Kalayou et al.
Cell biology and toxicology, 30(6), 361-376 (2014-11-25)
The mycotoxin alternariol (AOH) is an important contaminant of fruits and cereal products. The current study sought to address the effect of a non-toxic AOH concentration on the proteome of the steroidogenic H295R cell model. Quantitative proteomics based on stable
N André Sasaki et al.
Bioorganic & medicinal chemistry, 17(6), 2310-2320 (2009-03-06)
2,3-Diaminopropionic acid (Dap) and N-terminal Dap peptides have been found to inhibit in vitro protein-modifications by methylglyoxal (MG), one of the highly reactive alpha-dicarbonyl compounds. MG scavenging potency of the newly synthesized N-terminal Dap peptides is demonstrated by RP-HPLC, SDS-PAGE
Reply to FS Dioguardi.
François Mariotti et al.
The American journal of clinical nutrition, 98(2), 508-509 (2013-09-13)
Dan Hong et al.
Molecular and cellular biochemistry, 398(1-2), 31-38 (2014-09-12)
Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), is emerging as a key contributing factor in atherogenesis, a process in turn known to involve macrophage apoptosis. The aim of this study was to determine the effect of
Mariam Traoré et al.
Organic letters, 16(13), 3588-3591 (2014-06-25)
Aza-peptides with basic amino acid residues (lysine, ornithine, arginine) and derivatives were synthesized by an effective approach featuring alkylation of a hydrazone-protected aza-glycine residue with α-bromo ω-chloro propane and butane to provide the corresponding alkyl chloride side chains. Displacement of
Laura Myllynen et al.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 116(3), 423-430 (2015-10-01)
EGFR inhibition blocks DNA double strand break (DSB) repair but the detailed mechanisms are still unclear. We asked whether EGFR inhibition blocks DSB repair by reducing the X-ray-induced phosphorylation of repair proteins using a phosphoproteomic approach. Using UT-SCC5 and SAS
J L Medeiros et al.
Andrology, 2(6), 943-950 (2014-10-02)
Radiotherapy is widely used to treat pelvic malignancies, but normal tissues near the target tumour are often affected. Our aims were thus to determine whether the structural organization of the rat penis is altered by radiation, and whether supplementation with
Naoki Itoh et al.
Journal of chromatography. A, 1404, 141-145 (2015-06-11)
A rapid and mild purification method for nanoparticles using the commercially available monolithic silica disk, MonoSpin(®), was developed. The nanoparticles were purified from a dispersed solution by filtration with the aid of centrifugation at 2290×g for 2min. The purification conditions
Puja Gulati et al.
The Journal of surgical research, 189(1), 174-183 (2014-03-25)
The present study was conducted to pharmacologically investigate the role of protein kinase C (PKC) pathway in neuroprotective mechanism of ischemic postconditioning (iPoCo) and determine the influence of nitric oxide (NO) signaling in PKC-mediated effects. Bilateral carotid artery occlusion of
Dana Yaffe et al.
The Journal of biological chemistry, 289(49), 34229-34240 (2014-10-23)
Transporters essential for neurotransmission in mammalian organisms and bacterial multidrug transporters involved in antibiotic resistance are evolutionarily related. To understand in more detail the evolutionary aspects of the transformation of a bacterial multidrug transporter to a mammalian neurotransporter and to
Jose Córdoba-Chacón et al.
Endocrinology, 154(7), 2393-2398 (2013-05-23)
l-arginine (l-Arg) rapidly stimulates GH and insulin release in vivo. It has been hypothesized that l-Arg stimulates GH release by lowering hypothalamic somatostatin (SST) tone. l-Arg may also act directly at the pituitary to stimulate GH release. Moreover, l-Arg has
Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma.
Philippe Bahadoran et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), e324-e326 (2013-05-30)
Rachana Sainger et al.
The Journal of heart valve disease, 22(2), 156-165 (2013-06-27)
Aortic valve sclerosis (AVSc), the early asymptomatic stage of calcific aortic valve disease (CAVD), is characterized by a progressive thickening of the aortic cusps without obstruction of the left ventricular outflow. In spite of its high prevalence, there are no
Shan Lu et al.
Molecular pharmaceutics, 12(2), 621-629 (2015-01-16)
In this study, we formulated polyplexes with different compositions for codelivery of DNA and small-interfering RNA (siRNA). Since DNA and siRNA have distinctive and complementary morphological characteristics (DNA is long and winding and siRNA is short and rigid), we hypothesized
Naoki Aizawa et al.
Neurourology and urodynamics, 34(4), 368-374 (2014-02-18)
We measured single-unit mechanosensitive afferent activities (SAAs) during reflexic, rhythmic bladder contractions (RBCs), and examined whether L-arginine, an NO substrate, and mirabegron, a β3-adrenoceptor agonist, and oxybutynin, an antimuscarinic agent, can affect the SAAs in such condition. Twenty-nine female Sprague-Dawley
Page 1 of 15