Search Within


Applied Filters:
Showing 1-30 of 55 results for "A5043" within Papers
Neutropenia and myeloid dysplasia in a patient with delayed-onset adenosine deaminase deficiency.
Keiko Nomura et al.
Pediatric blood & cancer, 60(5), 885-886 (2013-01-22)
Eduard Gracia et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(3), 1048-1061 (2012-11-30)
The enzyme adenosine deaminase (ADA) is a multifunctional protein that can both degrade adenosine and bind extracellularly to adenosine receptors, acting as an allosteric modulator regulating the hormonal effects of adenosine. The molecular regions of ADA responsible for the latter
Lauren A Sugden et al.
Bioinformatics (Oxford, England), 29(22), 2844-2851 (2013-09-21)
Validation and reproducibility of results is a central and pressing issue in genomics. Several recent embarrassing incidents involving the irreproducibility of high-profile studies have illustrated the importance of this issue and the need for rigorous methods for the assessment of
A Islam et al.
Mymensingh medical journal : MMJ, 23(1), 24-27 (2014-03-04)
The diagnosis of pleural tuberculosis (TB) continues to be a challenge in clinical practice. Traditional diagnostic methods are very useful for the diagnosis of pulmonary TB but have a low yield when applied to pleural fluid. It is produced during
Oz Solomon et al.
RNA (New York, N.Y.), 19(5), 591-604 (2013-03-12)
Alternative mRNA splicing is a major mechanism for gene regulation and transcriptome diversity. Despite the extent of the phenomenon, the regulation and specificity of the splicing machinery are only partially understood. Adenosine-to-inosine (A-to-I) RNA editing of pre-mRNA by ADAR enzymes
V Stalin Raj et al.
Journal of virology, 88(3), 1834-1838 (2013-11-22)
Middle East respiratory syndrome coronavirus (MERS-CoV) replicates in cells of different species using dipeptidyl peptidase 4 (DPP4) as a functional receptor. Here we show the resistance of ferrets to MERS-CoV infection and inability of ferret DDP4 to bind MERS-CoV. Site-directed
Mary Carmen Pérez-Aguilar et al.
Investigacion clinica, 53(3), 315-324 (2012-12-20)
Adenosine deaminase is an enzyme of the purine metabolism whose function is to convert adenosine to inosine and deoxyadenosine to deoxyinosine. The ecto-ADA1 binding to the cell surface through CD26 contributes to the regulation of cytokines and stimulates the proliferation
Yun Yang et al.
Science China. Life sciences, 56(10), 944-952 (2013-09-07)
Adenosine to inosine (A-to-I) RNA editing is the most abundant editing event in animals. It converts adenosine to inosine in double-stranded RNA regions through the action of the adenosine deaminase acting on RNA (ADAR) proteins. Editing of pre-mRNA coding regions
Ahmet Karakeci et al.
Urology, 82(3), 625-629 (2013-08-31)
To evaluate the early therapeutic alternatives such as bosentan, an endothelin receptor blocker, theophylline, an adenosin receptor blocker, and a nonselective phosphodiesterase enzyme inhibitor, zinc protoporphyrin (ZnPP), a heme oxygenase 1 inhibitor, for the therapy of ischemic priapism in the
Immacolata Brigida et al.
The Journal of allergy and clinical immunology, 133(3), 799-806 (2014-02-11)
Adenosine deaminase (ADA) deficiency causes severe cellular and humoral immune defects and dysregulation because of metabolic toxicity. Alterations in B-cell development and function have been poorly studied. Enzyme replacement therapy (ERT) and hematopoietic stem cell (HSC) gene therapy (GT) are
H Bobby Gaspar et al.
Blood, 122(23), 3749-3758 (2013-10-12)
Severe combined immunodeficiency (SCID) arises from different genetic defects associated with lymphocyte development and function and presents with severe infections. Allogeneic hematopoietic stem cell transplantation is an extremely effective way of restoring immunity in these individuals. Numerous multicenter studies have
Jesús García-López et al.
Nucleic acids research, 41(10), 5483-5493 (2013-04-11)
Adenosine deaminases-acting-on-RNA (ADAR) proteins induce adenosine-to-inosine editing in double-stranded RNA molecules. This editing generates RNA diversity at the post-transcriptional level, and it has been implicated in the control of cell differentiation and development. The editing of microRNA (miRNA) precursors, along
Qing Lu et al.
American journal of physiology. Lung cellular and molecular physiology, 304(5), L361-L370 (2013-01-15)
Pulmonary endothelial cell (EC) apoptosis has been implicated in the pathogenesis of emphysema. Cigarette smoke (CS) causes lung EC apoptosis and emphysema. In this study, we show that CS exposure increased lung tissue adenosine levels in mice, an effect associated
Hiromitsu Ota et al.
Cell, 153(3), 575-589 (2013-04-30)
Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosine residues to inosine specifically in double-stranded RNAs. In this study, we investigated the interaction of the RNA editing mechanism with the RNA interference (RNAi) machinery and
Aamira Tariq et al.
Nucleic acids research, 41(4), 2581-2593 (2013-01-01)
RNA editing by adenosine deaminases that act on RNA (ADARs) diversifies the transcriptome by changing adenosines to inosines. In mammals, editing levels vary in different tissues, during development, and also in pathogenic conditions. From a screen for repressors of editing
Rajpal S Kashyap et al.
PloS one, 8(9), e74652-e74652 (2013-09-27)
Malnutrition is a major risk factor for the development of tuberculosis (TB). In India, Melghat is among the tribal regions which consist of highest number of malnutrition cases. Because of the paucity of TB data from these malnourished areas there
Qiong Wang et al.
RNA (New York, N.Y.), 19(11), 1525-1536 (2013-09-27)
Rho GTPase activating protein 26 (ARHGAP26) is a negative regulator of the Rho family that converts the small G proteins RhoA and Cdc42 to their inactive GDP-bound forms. It is essential for the CLIC/GEEC endocytic pathway, cell spreading, and muscle
Unveiling the binding mode of adenosine deaminase inhibitors to the active site of the enzyme: implication for rational drug design : presented by Maria P. Abbracchio.
Maria Letizia Trincavelli
Purinergic signalling, 9(1), 1-3 (2013-01-29)
Enzymatic deamination of adenosine derivatives.
N O KAPLAN et al.
The Journal of biological chemistry, 194(2), 579-591 (1952-02-01)
Tingting Weng et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(5), 2013-2026 (2013-02-09)
Chronic obstructive pulmonary disease (COPD) is characterized by persistent inflammation and tissue remodeling and is a leading cause of death in the United States. Increased apoptosis of pulmonary epithelial cells is thought to play a role in COPD development and
John H Fargo et al.
British journal of haematology, 160(4), 547-554 (2012-12-21)
Diamond-Blackfan anaemia (DBA) is an inherited bone marrow failure syndrome (IBMFS) characterized by red cell aplasia. Mutations in ribosomal genes are found in more than 50% of cases. Elevated erythrocyte adenosine deaminase (eADA) was first noted in DBA in 1983.
Rafael Liz et al.
The Journal of pharmacy and pharmacology, 65(1), 115-122 (2012-12-12)
To evaluate the effect of β-sitosterol on ⁴⁵Ca²⁺ uptake in activated murine neutrophils, and upon myeloperoxidase and adenosine deaminase activity, and interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) levels, in carrageenan-induced inflammation in the mouse air pouch model. Dried Esenbeckia
Ying Cheng et al.
Diabetes, 59(1), 17-25 (2009-10-17)
White adipose tissue (WAT) and brown adipose tissue (BAT) play distinct roles in adaptation to changes in nutrient availability, with WAT serving as an energy store and BAT regulating thermogenesis. We previously showed that mice maintained on a leucine-deficient diet
Nobuhide Tsuruoka et al.
The Journal of biological chemistry, 288(2), 826-836 (2012-12-05)
Somatic mutations accumulate in senescent cells. Bcl6, which functions as a transcriptional repressor, has been identified as a potent inhibitor of cell senescence, but a role of Bcl6 in the accumulation of somatic mutations has remained unclear. Ig class-switch recombination
Wenbin Zhou et al.
Nucleic acids research, 41(5), 3362-3372 (2013-01-29)
In all organisms, transfer RNAs (tRNAs) undergo extensive post-transcriptional modifications. Although base modifications in the anticodon are known to alter decoding specificity or improve decoding accuracy, much less is known about the functional relevance of modifications in other positions of
Lingli Li et al.
American journal of physiology. Renal physiology, 304(4), F382-F389 (2012-12-28)
A(1) adenosine receptors (A1AR) are required for the modulation of afferent arteriolar tone by changes in luminal NaCl concentration implying that extracellular adenosine concentrations need to change in synchrony with NaCl. The present experiments were performed in mice with a
Rafet Mete et al.
Medical science monitor : international medical journal of experimental and clinical research, 19, 762-766 (2013-09-14)
The aim of this study was to evaluate the plasma concentrations of malondialdehyde (MDA) and nitric oxide (NO) and the plasma activities of oxidant and antioxidant enzymes in patients with IBS. A total of 36 patients with IBS were included
S Bielsa et al.
Clinical laboratory, 60(3), 501-504 (2014-04-05)
Storing pleural fluid samples for research purposes is a common practice, but whether adenosine deaminase (ADA), an enzyme used for the diagnosis of tuberculous pleuritis, is stable over long periods of time is unknown. We evaluated the stability of pleural
Characterisation of Aicardi-Goutières syndrome.
Ingeborg Krägeloh-Mann
The Lancet. Neurology, 12(12), 1131-1132 (2013-11-05)
Suneeta Tumati et al.
The Journal of pharmacology and experimental therapeutics, 330(3), 810-817 (2009-06-06)
Studies have shown that long-term (5alpha,6alpha)-7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol (morphine) treatment increases the sensitivity to painful heat stimuli (thermal hyperalgesia). The cellular adaptations contributing to sustained morphine-mediated pain sensitization are not fully understood. It was shown previously (J Neurosci 22:6747-6755, 2002) that sustained
Page 1 of 2