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Showing 1-16 of 16 results for "A5106" within Papers
Xing Judy Chen et al.
Developmental cell, 30(5), 569-584 (2014-09-10)
Ena/VASP proteins and the WAVE regulatory complex (WRC) regulate cell motility by virtue of their ability to independently promote actin polymerization. We demonstrate that Ena/VASP and the WRC control actin polymerization in a cooperative manner through the interaction of the
Yanmei Qi et al.
The Journal of cell biology, 219(9) (2020-07-17)
The tumor suppressor PTEN is essential for early development. Its lipid phosphatase activity converts PIP3 to PIP2 and antagonizes the PI3K-Akt pathway. In this study, we demonstrate that PTEN's protein phosphatase activity is required for epiblast epithelial differentiation and polarization.
c-Abl Interacts with the WAVE2 Signaling Complex to Induce Membrane Ruffling and Cell Spreading
Stuart JR, et al.
The Journal of Biological Chemistry, 281(42), 31290-31297 (2006)
Upregulation of Abelson interactor protein 1 predicts tumor progression and poor outcome in epithelial ovarian cancer
Zhang J, et al.
Human Pathology, 46(9), 1331-1340 (2015)
Ena/VASP proteins cooperate with the WAVE complex to regulate the actin cytoskeleton
Chen XJ, et al.
Developmental Cell, 30(5), 569-584 (2014)
Expression and Y435-phosphorylation of Abelson interactor 1 (Abi1) promotes tumour cell adhesion, extracellular matrix degradation and invasion by colorectal carcinoma cells
Steinestel K, et al.
Molecular Cancer, 13(1), 145-145 (2014)
Kihoon Han et al.
Human molecular genetics, 24(7), 1813-1823 (2014-11-30)
Silencing of fragile X mental retardation 1 (FMR1) gene and loss of fragile X mental retardation protein (FMRP) cause fragile X syndrome (FXS), a genetic disorder characterized by intellectual disability and autistic behaviors. FMRP is an mRNA-binding protein regulating neuronal
Yanmei Qi et al.
Scientific reports, 10(1), 12685-12685 (2020-07-31)
The epithelial-mesenchymal transition (EMT) is an embryonic program frequently reactivated during cancer progression and is implicated in cancer invasion and metastasis. Cancer cells can also acquire stem cell properties to self-renew and give rise to new tumors through the EMT.
Hriday P Bhambhvani et al.
Neuroreport, 27(3), 145-150 (2015-12-23)
Schizophrenia is a severe psychiatric disorder that is characterized by a wide array of symptoms and a complex neuropathology. A well-characterized neurobiological feature of schizophrenia is abnormal synaptic plasticity, although the mechanisms underlying this are not fully understood. Numerous studies
Daniel Humphreys et al.
Cell reports, 17(3), 697-707 (2016-10-13)
To establish pathogenicity, bacteria must evade phagocytosis directed by remodeling of the actin cytoskeleton. We show that macrophages facilitate pathogen phagocytosis through actin polymerization mediated by the WAVE regulatory complex (WRC), small GTPases Arf and Rac1, and the Arf1 activator
Decreased expression of cortactin in schizophrenia brain
Bhambhvani HP, et al.
Neuroreport, 27(3), 145-145 (2016)
Daniel Humphreys et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(42), 16880-16885 (2013-10-03)
ADP ribosylation factor (Arf) 6 anchors to the plasma membrane, where it coordinates membrane trafficking and cytoskeleton remodelling, but how it assembles actin filaments is unknown. By reconstituting membrane-associated actin assembly mediated by the WASP family veroprolin homolog (WAVE) regulatory
Michael A Rak et al.
Journal of virology, 92(20) (2018-08-10)
Human cytomegalovirus, HCMV, is a betaherpesvirus that establishes a lifelong latent infection in its host that is marked by recurrent episodes of reactivation. The molecular mechanisms by which the virus and host regulate entry into and exit from latency remain
ENL, the MLL fusion partner in t (11; 19), binds to the c-Abl interactor protein 1 (ABI1) that is fused to MLL in t (10; 11)+
Garcia-Cuellar MP, et al.
Oncogene, 19(14), 1744-1744 (2000)
Vikash Singh et al.
International journal of molecular sciences, 21(7) (2020-04-08)
The small GTPase ADP-ribosylation factor 6 (Arf6) anchors at the plasma membrane to orchestrate key functions, such as membrane trafficking and regulating cortical actin cytoskeleton rearrangement. A number of studies have identified key players that interact with Arf6 to regulate
Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes
Innocenti M, et al.
Nature Cell Biology, 7(10), 969-976 (2005)
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