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Showing 1-30 of 230 results for "A5533" within Papers
Adam M Zahm et al.
Bone, 43(1), 25-31 (2008-05-20)
Oxygen availability is a critical signal for proper development of many tissues, however there is limited knowledge of its role in the maturation of bone cells. To test the hypothesis that low pO2 regulates bone cell mineralization, MLO-A5 and MLO-Y4
Lei Zhou et al.
Biochemical and biophysical research communications, 511(2), 307-311 (2019-02-24)
Discovering genes with regulatory effect of osteoblast differentiation and revealing mechanism of osteogenesis will enable us to find out more therapeutic methods for treating bone diseases. In this study, we supposed DHX58 may have a close relationship with osteogenesis and
Thomas H Ambrosi et al.
Aging cell, 19(7), e13164-e13164 (2020-06-17)
Fragility fractures have a limited capacity to regenerate, and impaired fracture healing is a leading cause of morbidity in the elderly. The recent identification of a highly purified bona fide human skeletal stem cell (hSSC) and its committed downstream progenitor
Xijuan Xiao et al.
BioMed research international, 2020, 3871496-3871496 (2021-01-26)
The repair of dental pulp injury relies on the odontogenic differentiation of dental pulp stem cells (DPSCs). To better understand the odontogenic differentiation of DPSCs and identify proteins involved in this process, tandem mass tags (TMTs) coupled with liquid chromatography-tandem
Jung-Min Kim et al.
Nature communications, 11(1), 2289-2289 (2020-05-10)
The osteoblast differentiation capacity of skeletal stem cells (SSCs) must be tightly regulated, as inadequate bone formation results in low bone mass and skeletal fragility, and over-exuberant osteogenesis results in heterotopic ossification (HO) of soft tissues. RUNX2 is essential for
Theresa Pohlkamp et al.
PloS one, 10(2), e0116701-e0116701 (2015-02-18)
Apolipoprotein E (ApoE) genotype is the strongest predictor of Alzheimer's Disease (AD) risk. ApoE is a cholesterol transport protein that binds to members of the Low-Density Lipoprotein (LDL) Receptor family, which includes LDL Receptor Related Protein 4 (Lrp4). Lrp4, together
Stain Technology, 1, 123-123 (1926)
Pengshan Cai et al.
American journal of translational research, 11(2), 865-874 (2019-03-23)
Inflammation, a common situation during the process of bone healing, is reported to play a negative role in bone regeneration. Up to date, therapeutic strategies for inflammation triggered inhibition of osteoblast differentiation are still limited. The aim of this study
Anna Di Vito et al.
Cell transplantation, 28(1), 129-139 (2018-10-30)
The periodontal ligament displays a reservoir of mesenchymal stem cells which can account for periodontal regeneration. Despite the numerous studies directed at the definition of optimal culture conditions for long-term expansion of periodontal ligament stem cells (PDLSCs), no consensus has
Christos Pandis et al.
Macromolecular bioscience, 15(2), 262-274 (2014-10-11)
A novel approach to reinforce polymer porous membranes is presented. In the prepared hybrid materials, the inorganic phase of silica is synthesized in-situ and inside the pores of aminolyzed polylactic acid (PLA) membranes by sol-gel reactions using tetraethylorthosilicate (TEOS) and
Mekayla A Storer et al.
Developmental cell, 52(4), 509-524 (2020-01-07)
Here, we investigate the origin and nature of blastema cells that regenerate the adult murine digit tip. We show that Pdgfra-expressing mesenchymal cells in uninjured digits establish the regenerative blastema and are essential for regeneration. Single-cell profiling shows that the
RGD peptides immobilized on a mechanically deformable surface promote osteoblast differentiation.
Cavalcanti-Adam EA, et al.
Journal of Bone and Mineral Research, 17, 2130-2130 (2002)
Nicolás Cumplido et al.
Frontiers in zoology, 17, 18-18 (2020-06-10)
With more than 30,000 species, teleosts comprise about half of today's living vertebrates, enriched with a wide set of adaptations to all aquatic systems. Their evolution was marked by modifications of their tail, that involved major rearrangements of the metameric
Nelson E Bruno et al.
Nature chemical biology, 17(3), 307-316 (2021-01-30)
Glucocorticoids display remarkable anti-inflammatory activity, but their use is limited by on-target adverse effects including insulin resistance and skeletal muscle atrophy. We used a chemical systems biology approach, ligand class analysis, to examine ligands designed to modulate glucocorticoid receptor activity
Marta García-Contreras et al.
PloS one, 9(11), e113288-e113288 (2014-11-21)
Mesenchymal stem cells from adipose tissue (ADSCs) are an important source of cells for regenerative medicine. The therapeutic effect of culture-expanded adipose derived stem cells has been shown; however, optimal xeno-free culture conditions remain to be determined. Cancer patients, specifically
Raquel Batlle et al.
Nature communications, 10(1), 3071-3071 (2019-07-13)
The formation of new blood vessels is essential for normal development, tissue repair and tumor growth. Here we show that inhibition of the kinase p38α enhances angiogenesis in human and mouse colon tumors. Mesenchymal cells can contribute to tumor angiogenesis
Jun Wu et al.
Cell research, 30(9), 794-809 (2020-06-18)
Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders, including COVID-19. However, there are still no effective drugs to treat lung injury and fibrosis. In this study, we report the generation of clinical-grade human
Miriam Filippi et al.
Materials (Basel, Switzerland), 14(17) (2021-09-11)
By permeabilizing the cell membrane with ultrasound and facilitating the uptake of iron oxide nanoparticles, the magneto-sonoporation (MSP) technique can be used to instantaneously label transplantable cells (like stem cells) to be visualized via magnetic resonance imaging in vivo. However
Ramon E Coronado et al.
Stem cell research, 38, 101471-101471 (2019-06-05)
Transplantation of primary hepatocytes has been used in treatments for various liver pathologies and end-stage liver disease. However, shortage of donor tissue and the inability of hepatocyte proliferation in vitro have lead to alternative methods such as stem cell-derived hepatocyte-like
Hong Chen et al.
Science advances, 6(15), eaay1514-eaay1514 (2020-04-15)
Dental pulp is critical to maintain the vitality of a tooth. Regeneration of pulpo-dentinal complex is of great interest to treat pulpitis and pulp necrosis. In this study, through three-dimensional spheroid culture, a group of unique multipotent stem cells were
Cuiping Zhang et al.
Cells, 10(11) (2021-11-28)
Mesenchymal stem cells (MSCs) are used in various studies to induce immunomodulatory effects in clinical conditions associated with immune dysregulation such as graft versus host disease (GvHD). However, most of these clinical trials failed to go beyond early phase 2
On the history and mechanism of alizarin and alizarin red S stains for calcium.
Puchtler H, et al.
The Journal of Histochemistry and Cytochemistry, 17, 110-124 (1969)
Jonna Weisell et al.
NMR in biomedicine, 32(8), e4108-e4108 (2019-05-22)
In calcific aortic valve disease (CAVD), progressive valvular sclerosis and calcification cause narrowing of the orifice and an impairment of the valve's function. We applied high-resolution cine-MRI to perform quantitative analysis of the dynamics of the aortic valve in a
T Iwayama et al.
Journal of periodontal research, 47(5), 563-571 (2012-02-22)
Adiponectin is a cytokine constitutively produced by adipocytes and exhibits multiple biological functions by targeting various cell types. However, the effects of adiponectin on primary gingival fibroblasts and periodontal ligament cells are still unexplored. Therefore, we investigated the effects of
Sung-Jin Kim et al.
Experimental & molecular medicine, 52(5), 793-803 (2020-05-10)
Neuronal regulation of energy and bone metabolism is important for body homeostasis. Many studies have emphasized the importance of synaptic adhesion molecules in the formation of synapses, but their roles in physiology still await further characterization. Here, we found that
Katarina Lopusna et al.
EBioMedicine, 63, 103191-103191 (2021-01-09)
DNA methylation regulates gene transcription in many physiological processes in mammals including development and haematopoiesis. It is catalysed by several DNA methyltransferases, including Dnmt3b that mediates both methylation-dependant and independent gene repression. Dnmt3b is critical for mouse embryogenesis and functions
Preety Dixit et al.
Phytochemistry, 81, 117-125 (2012-07-13)
Phytochemical investigation of seed coats of Pterospermum acerifolium afforded two phytoceramides (1, 2) and two acylated phytosterol glucosides (3, 4) together with five known compounds (5-9). Their structures were elucidated on the basis of extensive spectroscopic analysis using 1D, 2D
Stain Technology, 16, 23-23 (1941)
D-H Xu et al.
Journal of fish diseases, 35(12), 887-895 (2012-08-24)
This study compared the susceptibility of three blue catfish strains (D&B, USDA 101 and USDA 102) to the parasite Ichthyophthirius multifiliis (Ich). In Trial I, a cohabitation study (all strains stocked communally) was conducted and fish were exposed to theronts
Wahyu Widowati et al.
International journal of molecular and cellular medicine, 8(4), 283-294 (2020-06-27)
Mesenchymal stem cells (MSCs) have unique properties, including high proliferation rates, self-renewal, and multilineage differentiation ability. Their characteristics are affected by increasing age and microenvironment. This research is aimed to determine the proliferation, characteristics and differentiation capacity of adipose tissue-derived
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