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Showing 1-30 of 2224 results for "A6390" within Papers
María M Milesi et al.
Molecular and cellular endocrinology, 401, 248-259 (2014-12-09)
We investigated whether neonatal exposure to low doses of endosulfan affects fertility and uterine functional differentiation at pre-implantation in rats. Newborn female rats received the vehicle, 0.2 µg/kg/d of diethylstilbestrol (DES), 6 µg/kg/d of endosulfan (Endo6) or 600 µg/kg/d of endosulfan (Endo600) on
Bei-Bei Cao et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 10(1), 162-178 (2015-02-05)
We previously have shown that cerebellar fastigial nucleus (FN) modulates immune function, but pathways or mechanisms underlying this immunomodulation require clarification. Herein, an anterograde and retrograde tracing of nerve tracts between the cerebellar FN and hypothalamus/thalamus was performed in rats.
Sebastian Königsberger et al.
European journal of immunology, 45(2), 603-611 (2014-11-11)
Syk and Zap-70 constitute a closely related nonreceptor protein tyrosine kinase family, of which both members are functionally indispensable for conferring their respective antigen receptors with enzymatic activity. In this study, we analyze the impact of altering BCR signaling output
Daniela Impellizzeri et al.
Journal of neuroinflammation, 11, 136-136 (2014-08-29)
The fatty acid amide palmitoylethanolamide (PEA) has been studied extensively for its anti-inflammatory and neuroprotective actions. The lipidic nature and large particle size of PEA in the native state may limit its solubility and bioavailability when given orally, however. Micronized
Joseph F Collin et al.
Genes, chromosomes & cancer, 54(5), 288-302 (2015-02-24)
To increase our knowledge of leukaemia-associated antigens, especially in acute myeloid leukaemia (AML) M4, we prepared a phage display cDNA library using mRNA from the bone marrow cells of a patient with AML M4 at diagnosis. We immunoscreened 10(6) pfu
Kovanya Moodley et al.
Expert opinion on drug delivery, 12(5), 693-713 (2014-12-24)
The purpose of this study was to formulate novel triple-layered tablet (TLT) matrices employing modified polyamide 6,10 (mPA6,10) and salted-out poly(lactic-co-glycolic acid) (s-PLGA) in an attempt to achieve stratified zero-order drug release. mPA6,10 and s-PLGA were employed as the outer
A D Graustein et al.
Tuberculosis (Edinburgh, Scotland), 95(2), 190-196 (2015-01-27)
Humans exposed to Mycobacterium tuberculosis (Mtb) show variation in susceptibility to infection and differences in tuberculosis (TB) disease outcome. Toll-like receptor 9 (TLR9) is a pattern recognition receptor that mediates recognition of Mtb and modulates Mtb-specific T-cell responses. Using a
Hong-Qiang Wang et al.
Bioinformatics (Oxford, England), 31(4), 572-580 (2014-11-21)
Tremendous amount of omics data being accumulated poses a pressing challenge of meta-analyzing the heterogeneous data for mining new biological knowledge. Most existing methods deal with each gene independently, thus often resulting in high false positive rates in detecting differentially
Chi-Hao Chang et al.
Oncotarget, 6(3), 1478-1489 (2015-01-19)
Urothelial carcinoma is the most common type of malignancy in long-term dialysis patients and kidney transplant recipients in Taiwan. mTORCs (mammalian target of rapamycin complexes) and EGF are important in urothelial carcinoma. To identify the regulation of mTORCs upon EGF
Anna M Grawenda et al.
Cancer research, 75(4), 698-708 (2015-02-05)
TP53 gene mutation is associated with poor prognosis in breast cancer, but additional biomarkers that can further refine the impact of the p53 pathway are needed to achieve clinical utility. In this study, we evaluated a role for the HDMX-S/FL
Helena Kaihola et al.
PloS one, 10(1), e0116459-e0116459 (2015-01-23)
Depressive symptoms during pregnancy are common and may have impact on the developing child. Selective serotonin reuptake inhibitors (SSRIs) are the most prescribed antidepressant treatment, but unfortunately, these treatments can also negatively affect the behavioral development and health of a
Sara Bersani et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 670-682 (2014-08-27)
Novel, acid-sensitive liposomes that respond to physiopathological pH for tumour targeting applications were obtained by surface decoration with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)] (mPEG-DSPE) and stearoyl-poly(ethylene glycol)-poly(methacryloyl sulfadimethoxine) copolymer (stearoyl-PEG-polySDM). The pH-sensitive stearoyl-PEG-polySDM copolymer contained an average of seven methacryloyl sulfadimethoxines per molecule
Heyun Zhang et al.
Oncology reports, 33(3), 1481-1492 (2015-01-13)
Studies have reported that the CCN family of proteins plays an important role in stimulating tumorigenesis. However, the relationship between the CCN protein family members and the features of hepatocellular carcinoma (HCC) remains unclear. The objective of this study was
Barney M Bishop et al.
PloS one, 10(2), e0117394-e0117394 (2015-02-12)
Cationic antimicrobial peptides and their therapeutic potential have garnered growing interest because of the proliferation of bacterial resistance. However, the discovery of new antimicrobial peptides from animals has proven challenging due to the limitations associated with conventional biochemical purification and
Andrea Hegedus et al.
Retrovirology, 11, 98-98 (2014-11-26)
HIV-1, like all viruses, is entirely dependent on the host cell for providing the metabolic resources for completion of the viral replication cycle and the production of virions. It is well established that HIV-1 replicates efficiently in activated CD4+ T
Qi Wu et al.
Marine drugs, 12(12), 6125-6141 (2014-12-23)
Astaxanthin (ATX) has been proven to ameliorate early brain injury (EBI) after experimental subarachnoid hemorrhage (SAH) by modulating cerebral oxidative stress. This study was performed to assess the effect of ATX on the Nrf2-ARE pathway and to explore the underlying
K Kai McKinstry et al.
Nature communications, 5, 5377-5377 (2014-11-06)
It is unclear how CD4 T-cell memory formation is regulated following pathogen challenge, and when critical mechanisms act to determine effector T-cell fate. Here, we report that following influenza infection most effectors require signals from major histocompatibility complex class II
Howard Lockwood et al.
Investigative ophthalmology & visual science, 56(3), 1618-1637 (2015-02-05)
To introduce quantitative postmortem lamina cribrosa (LC) microarchitecture (LMA) assessment and characterize beam diameter (BD), pore diameter (PD), and connective tissue volume fraction (CTVF) in 21 normal monkey eyes. Optic nerve heads (ONHs) underwent digital three-dimensional (3D) reconstruction and LC
Sabine Navis et al.
Aquatic toxicology (Amsterdam, Netherlands), 159, 176-183 (2014-12-30)
Although Daphnia magna is a key species in many lentic freshwater ecosystems and is commonly used as model organism in ecology and ecotoxicology, very little is known about the effects of chemicals on their dormant life stages. Dormant eggs (ephippia)
Sarah F Andrews et al.
Journal of virology, 89(6), 3308-3317 (2015-01-16)
Reactivation of memory B cells allows for a rapid and robust immune response upon challenge with the same antigen. Variant influenza virus strains generated through antigenic shift or drift are encountered multiple times over the lifetime of an individual. One
Marina Koulikovska et al.
Tissue engineering. Part A, 21(5-6), 1116-1130 (2014-11-21)
Severe shortage of donor corneas for transplantation, particularly in developing countries, has prompted the advancement of bioengineered tissue alternatives. Bioengineered corneas that can withstand transplantation while maintaining transparency and compatibility with host cells, and that are additionally amenable to standardized
Aus T Ali et al.
Clinica chimica acta; international journal of clinical chemistry, 438, 382-387 (2014-10-05)
Alkaline phosphatase (ALP) increases lipid accumulation in human pre-adipocytes. This study was performed to assess whether ethnic differences in the prevalence of obesity in African and European females are related to differences in pre-adipocyte lipid accretion and ALP activity. Pre-adipocytes
Michael Stitz et al.
The Plant cell, 26(10), 3964-3983 (2014-10-19)
Jasmonic acid and its derivatives (jasmonates [JAs]) play central roles in floral development and maturation. The binding of jasmonoyl-L-isoleucine (JA-Ile) to the F-box of CORONATINE INSENSITIVE1 (COI1) is required for many JA-dependent physiological responses, but its role in anthesis and
Liang Meng et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 989, 46-53 (2015-03-25)
Two microextraction techniques based on hollow fiber liquid-phase microextraction (HF-LPME) and ultrasound-assisted low-density solvent dispersive liquid-liquid microextraction (UA-LDS-DLLME) had been applied for the determination of drugs of abuse (methamphetamine, amphetamine, 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxyamphetamine, methcathinone, ketamine, meperidine, and methadone) in urine and
Min Wang et al.
Nature communications, 6, 5600-5600 (2015-01-13)
Since December 2013, at least three cases of human infections with H10N8 avian influenza virus have been reported in China, two of them being fatal. To investigate the epidemic potential of H10N8 viruses, we examined the receptor binding property of
Nur Akmarina B M Said et al.
Assay and drug development technologies, 12(7), 385-394 (2014-09-03)
Metastasis accounts for the poor prognosis of the majority of solid tumors. The phenotypic transition of nonmotile epithelial tumor cells to migratory and invasive "mesenchymal" cells (epithelial-to-mesenchymal transition [EMT]) enables the transit of cancer cells from the primary tumor to
Isabel Rauscher et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(3), 430-435 (2015-02-14)
Our objective was to compare the quality and diagnostic performance of (18)F-fluoride PET/MR imaging with that of (18)F-fluoride PET/CT imaging in patients with foot pain of unclear cause. Twenty-two patients (9 men, 13 women; mean age, 48 ± 18 y;
Jelena Djokic et al.
Journal of immunotoxicology, 12(2), 115-123 (2014-05-16)
Although numerous investigations have demonstrated a direct effect of cadmium (Cd) on peripheral blood mononuclear cell (PBMC) activity in humans, there is virtually no data concerning the in vivo impact of this metal on circulatory mononuclear cells. In this study
Yaping Zhang et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 19(8), 667-673 (2014-10-31)
Changes in the levels of free fatty acids (FFAs) are closely associated with physiological status. Serum levels of C16:1, C18:3, C18:2, C18:1, C20:4, and C22:6 in 164 gastric cancer (GC) patients and 111 benign gastric disease (BGD) patients were significantly
Rémi Dulermo et al.
PloS one, 10(4), e0124358-e0124358 (2015-04-18)
Here, we have developed an extremely efficient in vivo Tn5-based mutagenesis procedure to construct a Deinococcus radiodurans insertion mutant library subsequently screened for sensitivity to genotoxic agents such as γ and UV radiations or mitomycin C. The genes inactivated in
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