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Showing 1-30 of 101 results for "A6508" within Papers
B P Lockhart et al.
Brain research, 670(2), 313-316 (1995-01-30)
In a previous study (Lockhart et al., Brain Res., 630 (1993) 32-40) we demonstrated a NMDA receptor-mediated neurotoxic effect for the anti-HIV drugs D-aspartate beta-hydroxamate and structurally related analogues in rat primary cortical neurons. Herein, we have examined the neurotoxic
R H Porter et al.
Neuroscience letters, 144(1-2), 87-89 (1992-09-14)
L-aspartate-beta-hydroxamate, a glutamate uptake inhibitor, was investigated for activity at a glutamate metabotropic receptor (mGluR) in neonatal rat cerebral cortical slices. Stimulation of phosphatidylinositol hydrolysis by 100 microM (1S,3R)-ACPD was inhibited only very weakly, to a maximal extent of 28%
S A Chikarmane et al.
Clinical radiology, 75(3), 185-193 (2019-11-27)
To determine the accuracy of magnetic resonance imaging (MRI)-directed breast ultrasound and subsequent ultrasound-guided biopsy, and to evaluate patient and lesion factors associated with the detection of an ultrasound correlate for MRI findings. Health Insurance Portability and Accountability Act (HIPAA)-compliant
R J Roon et al.
Brain research, 734(1-2), 223-228 (1996-09-23)
Exposure of slices of rat hippocampus to quisqualic acid produces an enhanced sensitivity of neurons to depolarization by other excitatory amino acid analogues, particularly amino acid phosphonates. The phosphonates may act at extracellular sites, since their depolarizing effects are rapidly
Sona A Chikarmane et al.
Radiology, 280(3), 707-715 (2016-04-19)
Purpose To (a) evaluate the frequency of Breast Imaging Reporting and Data System (BI-RADS) category 3 assessment in screening and diagnostic breast magnetic resonance (MR) imaging, (b) review findings considered indicative of BI-RADS category 3, and (c) determine outcomes of
Jie Liu et al.
The Journal of cell biology, 219(12) (2020-11-13)
The delivery of glucose and antioxidants is vital to maintain homeostasis and lens transparency. Here, we report a new mechanism whereby mechanically activated connexin (Cx) hemichannels serve as a transport portal for delivering glucose and glutathione (GSH). Integrin α6β1 in
Takehiro Noda et al.
Hepatology (Baltimore, Md.), 55(1), 86-97 (2011-09-08)
Dendritic cells (DCs) capture and process proteins and present peptides on the cell surface in the context of major histocompatibility complex I and II molecules to induce antigen-specific T cell immune responses. The aims of this study were to (1)
Devrishi Goswami et al.
Methods (San Diego, Calif.), 144, 134-151 (2018-04-22)
Mass spectrometry (MS)-based methods for analyzing protein higher order structures have gained increasing application in the field of biopharmaceutical development. The predominant methods used in this area include native MS, hydrogen deuterium exchange-MS, covalent labeling, cross-linking and limited proteolysis. These
Irem Karliova et al.
Interactive cardiovascular and thoracic surgery, 31(4), 555-558 (2020-09-01)
Unicuspid aortic valve (UAV) morphology is a cause for aortic valve dysfunction in childhood or adolescence. Repair requires the use of patch material, and polytetrafluoroethylene (PTFE) has been proposed for this purpose because of lack of calcification. We reviewed our
A Kyriacou et al.
Applied biochemistry and biotechnology, 66(3), 281-289 (1997-06-01)
An acetylene utilizing Gordona (Rhodococcus) bronchialis strain, screened for the production of fine chemicals, was found to be capable of producing small amounts of lysine. Attempts to produce amino-acid analog-resistant and/or sensitive mutants and auxotrophs of this strain with increased
R Tournaire et al.
Leukemia, 8(10), 1703-1707 (1994-10-01)
D-aspartic beta-hydroxamate (DAH), an aspartic acid analog, exerts antitumoral activity on murine leukemia L5178Y, both in vitro and in vivo. In this study, we show that DAH is also active in vivo against Friend virus (FV-P)-induced erythroleukemia, and we report
Sona A Chikarmane et al.
AJR. American journal of roentgenology, 209(5), 1178-1184 (2017-08-24)
The purpose of this study is to assess the frequency of reclassification of nonmass enhancement (NME) as background parenchymal enhancement (BPE) and to determine positive predictive values (PPVs) of NME descriptors using the revised BI-RADS atlas. A retrospective review of
Rebecca Eells et al.
Biointerphases, 12(2), 02D408-02D408 (2017-05-18)
The structural characterization of peripheral membrane proteins represents a tremendous challenge in structural biology due to their transient interaction with the membrane and the potential multitude of protein conformations during this interaction. Neutron reflectometry is uniquely suited to address this
Franck Danel et al.
Current drug discovery technologies, 8(1), 66-75 (2010-11-26)
Aminoacyl-tRNA synthetases (AARSs) are a structurally heterogeneous family of enzymes present in prokaryotes, archaea and eukaryotes. They catalyze the attachment of tRNA to its corresponding amino acid via an aminoacyl adenylate intermediate. Errors in protein synthesis will occur if an
M A Benhaim et al.
Science advances, 6(18), eaaz8822-eaaz8822 (2020-06-05)
The influenza virus hemagglutinin (HA) fusion protein has long been viewed as a "spring-loaded" fusion machine whereby activation at low pH initiates a rapid and irreversible cascade of conformational changes that drives the membrane fusion reaction. This mechanism has shaped
Arash Hamidian et al.
Biochemical and biophysical research communications, 499(2), 291-298 (2018-03-27)
Presence of perivascular neuroblastoma cells with high expression of hypoxia inducible factor (HIF)-2α correlates with distant metastasis and aggressive disease. Regulation of HIFs are traditionally considered to occur post-translationally, but we have recently shown that HIF-2α is unconventionally regulated also
L Littman et al.
Journal of neurochemistry, 59(5), 1893-1904 (1992-11-01)
Excitatory amino acid (EAA) analogues activate receptors that are coupled to the increased hydrolysis of phosphoinositides (PIs). In these studies, hippocampal slices were prepared from neonatal rats (6-11 days old) to characterize the effects of EAA analogues on these receptors.
G C Ormandy
Brain research, 572(1-2), 103-107 (1992-02-14)
The effect of a series of glutamate uptake inhibitors was tested on ibotenate-stimulated phosphoinositide hydrolysis. The pharmacological profile of the inhibitory effect of these compounds on the ibotenate response was quite different from that on glutamate uptake. Aspartate-beta-hydroxamate was the
Miroslav P Ivanov et al.
The EMBO journal, 37(15) (2018-06-23)
Chromosome segregation depends on sister chromatid cohesion which is established by cohesin during DNA replication. Cohesive cohesin complexes become acetylated to prevent their precocious release by WAPL before cells have reached mitosis. To obtain insight into how DNA replication, cohesion
Aiswarya Premchandar et al.
Protein science : a publication of the Protein Society, 26(2), 343-354 (2016-11-22)
The intermediate filament protein keratin 8 (K8) interacts with the nucleotide-binding domain 1 (NBD1) of the cystic fibrosis (CF) transmembrane regulator (CFTR) with phenylalanine 508 deletion (ΔF508), and this interaction hampers the biogenesis of functional ΔF508-CFTR and its insertion into
Nilesh Gupta et al.
Pharmacognosy magazine, 11(Suppl 3), S474-S480 (2016-03-02)
Anisochilus carnosus (L.f.) wall belonging to the family Lamiaceae is a plant that is widely used in folk medicine for treating eczema, cold, cough, and fever. In the present study, we explored the anticancer potential of A. carnosus leaves against
R Tournaire et al.
International journal of cancer, 58(3), 420-425 (1994-08-01)
D-aspartic acid beta-hydroxamate (DAH), an aspartic acid analogue, exerts anti-tumoral activity against murine leukemia L5178Y both in vitro and in vivo. We show here that DAH displays activity against Friend leukemia cells (FLC) in vitro: a concentration of 2 mM
Ingvar R Möller et al.
Journal of proteomics, 225, 103845-103845 (2020-06-02)
Neurotransmitter:sodium symporters (NSS) are integral membrane proteins (IMP), responsible for reuptake of neurotransmitters from the synaptic cleft. Due to challenges in production of mammalian NSS in their active form, the prokaryotic hydrophobic amino acid transporter, LeuT, served here as a
N Thomasset et al.
International journal of cancer, 49(3), 421-424 (1991-09-30)
D and L isomers of aspartic acid beta-hydroxamate (respectively DAH and LAH) were compared for their in vitro and in vivo activity against the murine leukemia L5178Y and their tolerance in vivo in DBA/2 mice. DAH and LAH displayed comparable
Eric R. Braverman
The Healing Nutrients Within: Facts, Findings, and New Research on Amino Acids null
Yinlong Song et al.
Journal of cell science, 133(9) (2020-03-11)
In cells, microtubule dynamics are regulated by plus-end tracking proteins (+TIPs). End-binding protein 1 (EB1, also known as MAPRE1) acts as a master regulator of +TIP networks by targeting the growing ends of microtubules and recruiting other factors. However, the
Putzer J Hung et al.
Molecular cell, 71(2), 332-342 (2018-07-19)
The modulator of retrovirus infection (MRI or CYREN) is a 30-kDa protein with a conserved N-terminal Ku-binding motif (KBM) and a C-terminal XLF-like motif (XLM). We show that MRI is intrinsically disordered and interacts with many DNA damage response (DDR)
Delio E Martins et al.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 28(6), 1413-1422 (2019-05-10)
The objective of this study was to analyze the layers of yellow ligament in lumbar canal stenosis and disk herniation. Eighteen ligaments were harvested from patients with lumbar spinal canal stenosis. Twenty-nine normal samples from lumbar spine disk herniation patients
Babacar Diouf et al.
PloS one, 15(11), e0242576-e0242576 (2020-11-19)
Aedes aegypti is the primary vector of dengue, Zika, yellow fever and chikungunya viruses to humans. In Africa, two subspecies, Ae. aegypti aegypti (Aaa) and Ae. aegypti formosus (Aaf) have been described. Until very recently, it was considered that the
David M Pinkney et al.
Clinical imaging, 57, 50-55 (2019-05-28)
The objectives of this study were to examine the frequency and outcomes of short interval imaging follow up of benign, concordant breast MRI biopsies and review the published literature on this topic. This was an IRB-approved, HIPAA compliant retrospective review
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