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Showing 1-30 of 133 results for "A7642" within Papers
Kathrin Straubinger et al.
The Journal of allergy and clinical immunology, 134(6), 1271-1279 (2014-07-22)
Schistosomiasis, a chronic helminth infection, elicits distinct immune responses within the host, ranging from an initial TH1 and subsequent TH2 phase to a regulatory state, and is associated with dampened allergic reactions within the host. We sought to evaluate whether
Shelly Leung et al.
Cellular immunology, 282(2), 79-84 (2013-06-19)
OT-II mice were evaluated as a transgenic strain-specific model to assess T-cell help for B-cell responses. OT-II CD4(+) T-cells express transgenic OVA-specific Ī±Ī²-TCRs. This high frequency of antigen-specific helper T-lymphocytes may augment induction of B-cell responses. Unexpectedly, OT-II mice did
Hongwei Han et al.
Scientific reports, 7(1), 1706-1706 (2017-05-12)
Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as the "atopic march". While
Patrick TrƩpanier et al.
Immunology, 141(2), 233-241 (2013-10-17)
Intravenous immunoglobulin (IVIg) is successfully used in the treatment of autoimmune diseases involving self-reactive CD8(+) T cells. However, its direct influence on the cytotoxic response remains unknown. Using an antigen cross-presentation assay and a mouse model of ovalbumin (OVA) immunization
Niels-Erik Viby et al.
Endocrinology, 154(12), 4503-4511 (2013-10-05)
The incretin hormone glucagon-like peptide-1 (GLP-1) is an important insulin secretagogue and GLP-1 analogs are used for the treatment of type 2 diabetes. GLP-1 displays antiinflammatory and surfactant-releasing effects. Thus, we hypothesize that treatment with GLP-1 analogs will improve pulmonary
J Kelley Bentley et al.
The Journal of allergy and clinical immunology, 134(6), 1433-1442 (2014-07-06)
Periostin, a secreted extracellular matrix protein, has been localized to deposits of subepithelial fibrosis in asthmatic patients, and periostin levels have been linked to increases in IL-13. We hypothesized that periostin is required for airway inflammatory responses to a physiologic
N Watson et al.
The Journal of pharmacy and pharmacology, 58(7), 959-966 (2006-06-30)
Monovalent RGD (arginine-glycine-aspartic acid) peptides or polymers furnished with RGD in random distributions are employed as cell-scaffolds and gene delivery vehicles. However, integrin binding to RGD is dependent on the spatial distribution (clustering) of the ligand and intrinsic integrin affinity
Mohammad Hossein Boskabady et al.
Experimental biology and medicine (Maywood, N.J.), 238(2), 200-208 (2013-04-12)
The effects of carvacrol on tracheal responsiveness (TR) to methacholine and ovalbumin (OA), serum nitric oxide (NO) concentration, total and differential white blood cells (WBC) in blood of sensitized guinea pigs were examined. Five groups of guinea pigs sensitized to
Federica Moalli et al.
The Journal of experimental medicine, 211(13), 2507-2517 (2014-12-10)
Interactions between dendritic cells (DCs) and T cells control the decision between activation and tolerance induction. Thromboxane A2 (TXA2) and its receptor TP have been suggested to regulate adaptive immune responses through control of T cell-DC interactions. Here, we show
Afonso P Basto et al.
Molecular immunology, 64(1), 36-45 (2014-12-04)
The use of immunogenic formulations targeting pattern recognition receptors towards modulation of immune responses is a promising strategy to develop better vaccines against infectious and malignant diseases. Molecules targeting TLR2 offer interesting properties that are relevant for vaccine development, including
Sheng Zeng et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 51(4), 360-365 (2014-02-26)
It has been reported that adoptive transfer of Ī³Ī“ T cells increases the cellular infiltration, especially eosinophils, in the lungs of allergic mice, suggesting that Ī³Ī“ T cells may play a proinflammatory role in allergic airway inflammation. Respiratory syncytial virus
T Sakurai et al.
Clinical and experimental immunology, 178(1), 65-74 (2014-06-20)
Invariant natural killer T (iNKT) cells play important immunoregulatory functions in allergen-induced airway hyperresponsiveness and inflammation. To clarify the role of iNKT cells in allergic rhinitis (AR), we generated bone marrow-derived dendritic cells (BMDCs), which were pulsed by ovalbumin (OVA)
Jason S Weinstein et al.
Journal of immunology (Baltimore, Md. : 1950), 192(7), 3166-3179 (2014-03-13)
B cells are required for follicular Th (Tfh) cell development, as is the ICOS ligand (ICOS-L); however, the separable contributions of Ag and ICOS-L delivery by cognate B cells to Tfh cell development and function are unknown. We find that
Rylie P Flesher et al.
Clinical science (London, England : 1979), 126(11), 805-814 (2013-12-19)
Endogenous mediators, such as RvE1 (resolvin E1), promote resolution of an inflammatory response and have potential as novel therapeutic agents. In the present study, we investigated the activity of RvE1 in a model of an acute exacerbation of chronic allergic
Yosuke Kumamoto et al.
Immunity, 39(4), 733-743 (2013-10-01)
Unlike other types of T helper (Th) responses, whether the development of Th2 cells requires instruction from particular subset of dendritic cells (DCs) remains unclear. By using an in vivo depletion approach, we have shown that DCs expressing CD301b were
Nanna Fyhrquist et al.
The Journal of allergy and clinical immunology, 134(6), 1301-1309 (2014-09-30)
The human commensal microbiota interacts in a complex manner with the immune system, and the outcome of these interactions might depend on the immune status of the subject. Previous studies have suggested a strong allergy-protective effect for Gammaproteobacteria. Here we
Mehdi Fazlalipour et al.
Jundishapur journal of microbiology, 8(4), e17157-e17157 (2015-06-03)
Gradual development of a useful vaccine can be the main point in the control and eradication of Hepatitis C virus (HCV) infection. Hepatitis C Virus envelope glycoproteins are considered as the main HCV vaccine candidate. In this study, the Pichia
Hasan Yuksel et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110(3), 150-155 (2013-04-04)
Vascular endothelial growth factor (VEGF) is an important mediator of the neoangiogenesis component of remodeling in asthma. To evaluate the influence of VEGF blockage on airway remodeling, specifically epithelium thickness, subepithelial smooth muscle thickness, number of mast and goblet cells
G H Grit et al.
Parasite immunology, 36(4), 157-169 (2014-01-01)
Giardia duodenalis is an important intestinal parasite in animals and humans. The role of dendritic cells (DC) in the initiation of the immune response against G.Ā duodenalis is poorly documented. The aim of this study was to test the hypothesis that
Zheng-Rong Chen et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 111(4), 276-281 (2013-09-24)
B7 molecules play a key role in regulating allergen-induced T cell activation in asthma, which may occur through T cell recruitment and T helper cell differentiation on allergen provocation. Initial studies have shown that B7-H3 (CD276), a recently identified B7
M AntoÅ”ovĆ” et al.
Advances in experimental medicine and biology, 838, 1-10 (2014-09-26)
Nitric oxide (NO) effects in airways are influenced by the activity of NO-synthase isoforms and NO metabolism. Inducible NO-synthase (iNOS), which produces large amounts of NO, is active during the inflammatory process. NO quickly reacts, producing reactive oxygen species (ROS).
Madala Uma et al.
Protein expression and purification, 128, 115-122 (2016-08-28)
Poliomyelitis, caused by poliovirus, is on the verge of eradication, and the world is preparing to shift from live to inactivated polio vaccine. In view of the requirement of non-infectious reagents, especially protein antigens, for surveillance during the final phase
M Ritter et al.
Clinical and experimental immunology, 178(2), 212-223 (2014-06-20)
Overall asthmatic symptoms can be controlled with diverse therapeutic agents. However, certain symptomatic individuals remain at risk for serious morbidity and mortality, which prompts the identification of novel therapeutic targets and treatment strategies. Thus, using an adjuvant-free T helper type
Karin M Knudson et al.
Journal of immunology (Baltimore, Md. : 1950), 191(12), 5797-5801 (2013-11-19)
CD8 T cell memory critically contributes to long-term immunity. Both low- and high-affinity TCR signals are able to support the differentiation of memory CD8 T cells. However, it is unclear whether the requirements for memory development change when TCR signal
Ruchi Roy et al.
Toxicology letters, 230(3), 421-433 (2014-08-17)
Our previous studies indicated that zinc oxide nanoparticles (ZnO NPs) have adjuvant properties to a known allergen ovalbumin (OVA) in Balb/c mice. Therefore, in this study, we focused on the mechanisms involved in adjuvant responses induced by ZnO NPs. The
S B Wang et al.
Scandinavian journal of immunology, 78(6), 507-515 (2013-10-12)
Lactoferrin (LF) can downregulate allergic airway inflammation in asthma. However, the in vivo effect of exogenous LF on allergic rhinitis (AR), a disease attributed to airway inflammation, has yet to be determined. We investigated the effect of intranasal administration recombinant
Interleukin-25 induces pulmonary arterial remodeling via natural killer T cell-dependent mechanisms.
Saki Kawashima et al.
International archives of allergy and immunology, 161 Suppl 2, 118-124 (2013-06-05)
Recent studies have shown that prolonged Th2-type immune inflammation in the lung induces pulmonary arterial remodeling, in part through the induction of resistin-like molecule Ī± (RELMĪ±) expression. However, the role of interleukin-25 (IL-25; which promotes this inflammation) in the development
Ryoko Hamano et al.
European journal of immunology, 44(4), 1005-1015 (2013-12-18)
An intravenous administration of a high-dose antigen (Ag) can induce immune tolerance and suppress the immune response, but the mechanism remains unclear. We recently proved that a combined i.v. administration of OVA and IL-2-anti-IL-2 Ab immune complexes (IL-2 ICs) efficiently
Adam Williams et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(17), 6955-6960 (2013-04-10)
The T helper type 2 (Th2) cytokine genes Il4, Il5, and Il13 are contained within a 140-kb region of mouse chromosome 11 and their expression is controlled by a locus control region (LCR) embedded within this locus. The LCR is
H Han et al.
Mucosal immunology, 5(3), 342-351 (2012-02-23)
Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point
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