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Showing 1-30 of 117 results for "A8656" within Papers
Daniel Roston et al.
Journal of the American Chemical Society, 135(37), 13624-13627 (2013-09-12)
The physical mechanism of C-H bond activation by enzymes is the subject of intense study, and we have tested the predictions of two competing models for C-H activation in the context of alcohol dehydrogenase. The kinetic isotope effects (KIEs) in
Toshio Ota et al.
Nature genetics, 36(1), 40-45 (2004-01-01)
As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clones and found that 14,490 cDNAs (10,897 clusters) were unique to
G Duester et al.
The Journal of biological chemistry, 261(5), 2027-2033 (1986-02-15)
Human alcohol dehydrogenase (ADH) exists as a heterogeneous group of isozymes capable of oxidizing a wide variety of aliphatic and aromatic alcohols. The five distinct human ADH subunits, each encoded by a separate gene, are differentially expressed during development and
Gaofeng Wu et al.
Advances in experimental medicine and biology, 776, 21-28 (2013-02-09)
Excessive alcohol consumption is dangerous and causes serious damage to health. The main organ capable of alcohol oxidizing is liver which is also the main organ synthesizing taurine, a sulfur-containing β-amino acid, which is the major free intracellular amino acid
Gui Yin Li et al.
International journal of biological macromolecules, 42(5), 405-412 (2008-05-06)
The covalently immobilized of Saccharomyces cerevisiae alcohol dehydrogenase (SCAD) to magnetic Fe(3)O(4) nanoparticles via glutaraldehyde coupling reaction was studied. The magnetic Fe(3)O(4) nanoparticles were prepared by hydrothermal method using H(2)O(2) as an oxidizer. Functionalization of surface-modified magnetic particles was performed
Y L Xu et al.
Genomics, 2(3), 209-214 (1988-04-01)
Humans are polymorphic at two of the alcohol dehydrogenase (ADH) loci important in ethanol metabolism, ADH2 and ADH3. Although the coding regions of these genes are 94% identical, they produce subunits that differ greatly in kinetic properties in vitro. These
Sarah C Mutka et al.
PloS one, 7(12), e52995-e52995 (2013-01-04)
Endogenous S-nitrosothiols, including S-nitrosoglutathione (GSNO), mediate nitric oxide (NO)-based signaling, inflammatory responses, and smooth muscle function. Reduced GSNO levels have been implicated in several respiratory diseases, and inhibition of GSNO reductase, (GSNOR) the primary enzyme that metabolizes GSNO, represents a
Jung-Eun Kim et al.
Frontiers in immunology, 11, 593748-593748 (2021-01-26)
Patients with severe eosinophilic asthma (SEA; characterized by persistent eosinophilia in blood and airway tissues) experience frequent asthma exacerbations with poor clinical outcomes. Interleukin 5 (IL-5) and IL-5 receptor alpha subunit (IL-5α) play key roles in eosinophilia maintenance, and relevant
Jong Ho Park et al.
Bioscience, biotechnology, and biochemistry, 76(12), 2294-2300 (2012-12-12)
Here, the impact of an extract derived from green tea (Camellia sinensis) and fermentation with Lactobacilli fermentum strain OCS19 was explored with acute alcohol-induced liver damage. The study employed the HepG2 hepatic cell line and an in vivo murine model
Xiao-Li Zhang et al.
Die Pharmazie, 68(12), 951-954 (2014-01-10)
We previously showed that Adh1p participates in fluconazole (FLC) resistance in Candida albicans through a mechanism that may involve efflux pumps. We also found that the concomitant use of tetrandrine (TET) and FLC provided a synergistic action against C. albicans
Jianquan Luo et al.
Bioresource technology, 147, 260-268 (2013-09-03)
A simple enzyme immobilization method accomplished by promoting membrane fouling formation is proposed. The immobilization method is based on adsorption and entrapment of the enzymes in/on the membrane. To evaluate the concept, two membrane orientations, skin layer facing feed (normal
P Xie et al.
The Journal of biological chemistry, 272(30), 18558-18563 (1997-07-25)
The structural determinants of substrate recognition in the human class IV, or sigmasigma, alcohol dehydrogenase (ADH) isoenzyme were examined through x-ray crystallography and site-directed mutagenesis. The crystal structure of sigmasigma ADH complexed with NAD+ and acetate was solved to 3-A
Kazuhiro Tokuda et al.
Neuroscience letters, 537, 40-43 (2013-01-29)
Consistent with the ability of severe alcohol intoxication to impair memory, high concentrations of ethanol (60mM) acutely inhibit long-term potentiation (LTP) in the CA1 region of rat hippocampal slices. To account for this, we hypothesized that local metabolism to acetaldehyde
M Zgombić-Knight et al.
The Journal of biological chemistry, 270(9), 4305-4311 (1995-03-03)
Human alcohol dehydrogenase (ADH) consists of a family of five evolutionarily related classes of enzymes that collectively function in the metabolism of a wide variety of alcohols including ethanol and retinol. Class IV ADH has been found to be the
H Jörnvall
European journal of biochemistry, 72(3), 443-452 (1977-02-01)
Comparisons of the primary structures of yeast and horse liver alcohol dehydrogenases reveal that the enzymes are homologous but distantly related. The overall positional identity is 25% between common regions, and several deletions/insertions occur in either enzyme, the longest apparently
Osvaldo P Almeida et al.
Neurology, 82(12), 1038-1044 (2014-02-21)
To determine whether alcohol consumption is causally associated with cognitive impairment in older men as predicted by mendelian randomization. Retrospective analysis of a cohort study of 3,542 community-dwelling men aged 65 to 83 years followed for 6 years. Cognitive impairment
J C Burnell et al.
Biochemical and biophysical research communications, 146(3), 1127-1133 (1987-08-14)
The beta 3 beta 3 (formerly called beta Indianapolis) and beta 1 beta 1 isoenzymes of human alcohol dehydrogenase differ substantially in their catalytic properties. Specifically, the KM value for NAD+ of beta 3 beta 3 is 70 times greater
Yoshiyuki Kimura et al.
Fitoterapia, 84, 163-169 (2012-11-20)
The Curcuma zedoaria rhizome has been used traditionally to treat gastrointestinal diseases as an aromatic stomachic drug, and this is currently used to treat alcohol-induced loss of appetite and nausea in Japan. We examined the effects of various fractions and
R Bühler et al.
European journal of biochemistry, 145(3), 447-453 (1984-12-17)
The primary structure of the gamma 1 subunit of human liver alcohol dehydrogenase isoenzyme gamma 1 gamma 1 was deduced by characterization of 36 tryptic and 2 CNBr peptides. The polypeptide chain is composed of 373 amino acid residues. gamma
Ji-Sun Lim et al.
Nanotechnology, 23(8), 085101-085101 (2012-02-02)
We prepared cell membrane-permeable hollow mesoporous silica capsules (HMSCs) by a simple new method. CTAB micellar assembly in cholesterol emulsion gave rise to a novel capsular morphology of the HMSC particles. The HMSCs consisted of mesostructured silica walls with a
H Yokoyama et al.
Genomics, 31(2), 243-245 (1996-01-15)
The ADH7 gene encoding human Class IV (sigma) alcohol dehydrogenase (ADH) was cloned from a Caucasian genomic DNA library and characterized. It has nine exons and eight introns that span about 22 kb, and its intron insertion is identical to
Thomas R Burkard et al.
BMC systems biology, 5, 17-17 (2011-01-29)
On the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitously expressed in all human cells. Composition and properties
Tamara Heermann et al.
Nature methods, 18(10), 1239-1246 (2021-10-06)
In spite of their great importance in biology, methods providing access to spontaneous molecular interactions with and on biological membranes have been sparse. The recent advent of mass photometry to quantify mass distributions of unlabeled biomolecules landing on surfaces raised
N L Vekshin
Biofizika, 57(5), 741-745 (2012-11-10)
The dynamics of proteins, detected by fluorescence, consists of three components: spontaneous dynamics, dipole-dipole photo-induced dynamics, thermal photo-induced dynamics. The photo-induced dynamics can lead to activation as well as inactivation of enzymes.
Zulfiya Yunus et al.
Gene, 529(1), 88-93 (2013-08-21)
Pharmacogenomic variant information is well known for major human populations; however, this information is less commonly studied in minorities. In the present study, we genotyped 85 very important pharmacogenetic (VIP) variants (selected from the PharmGKB database) in the Kyrgyz population
Erika Pineda et al.
FEBS letters, 587(2), 178-184 (2012-12-04)
By applying metabolic control analysis and inhibitor titration we determined the degree of control (flux control coefficient) of pyruvate:ferredoxin oxidoreductase (PFOR) and bifunctional aldehyde-alcohol dehydrogenase (ADHE) over the fluxes of fermentative glycolysis of Entamoeba histolytica subjected to aerobic conditions. The
T D Hurley et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(18), 8149-8153 (1991-09-15)
The three-dimensional structure of human beta 1 beta 1 alcohol dehydrogenase (ADH; EC 1.1.1.1) complexed with NAD+ has been determined by x-ray crystallography to 3.0-A resolution. The amino acids directly involved in coenzyme binding are conserved between horse EE and
H Jörnvall et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(10), 3024-3028 (1984-05-01)
The homodimeric Oriental beta 2 beta 2 isozyme of human liver alcohol dehydrogenase, corresponding to an allelic variant at the ADH2 gene locus, was studied in order to define the amino acid exchange in relation to the beta 1 beta
Polat Dura et al.
Journal of human genetics, 58(11), 742-748 (2013-09-21)
Esophageal cancer (EC), mainly consisting of squamous cell carcinoma (ESCC) in the Eastern world and adenocarcinoma (EAC) in the Western world, is strongly associated with dietary factors such as alcohol use. We aimed to clarify the modifying role in EC
T Ikuta et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(3), 634-638 (1986-02-01)
Class I human alcohol dehydrogenase (ADH; alcohol:NAD+ oxidoreductase, EC 1.1.1.1) consists of several homo- and heterodimers of alpha, beta, and gamma subunits that are governed by the ADH1, ADH2, and ADH3 loci. We previously cloned a full length of cDNA
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