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Showing 1-30 of 35 results for "A9883" within Papers
Hydrogen ion buffers for biological research
Good NE, et al.
Biochemistry, 5( (2), 467-477 (1966)
Hsin-Bai Yin et al.
Poultry science, 94(9), 2183-2190 (2015-07-29)
Aflatoxins (AF) are toxic metabolites primarily produced by molds, Aspergillus flavus and Aspergillus parasiticus. Contamination of poultry feed with AF is a major concern to the poultry industry due to severe economic losses stemming from poor performance, reduced egg production
Mahmoud Sajjadi et al.
Digestive diseases and sciences, 60(6), 1755-1760 (2015-02-06)
Adenosine deaminase activity is proposed as a marker of inflammation in some inflammatory conditions. To investigate the association of serum adenosine deaminase activity and disease activity in Crohn's disease patients. In a cross-sectional study, 30 consecutive known cases of Crohn's
Gulen Yesilbag Tonga et al.
Nature chemistry, 7(7), 597-603 (2015-06-24)
Bioorthogonal catalysis broadens the functional possibilities of intracellular chemistry. Effective delivery and regulation of synthetic catalytic systems in cells are challenging due to the complex intracellular environment and catalyst instability. Here, we report the fabrication of protein-sized bioorthogonal nanozymes through
Estelle Fréling et al.
European journal of gastroenterology & hepatology, 27(10), 1200-1208 (2015-07-17)
Infliximab (IFX) is used for the treatment of inflammatory bowel diseases (IBD). Immediate hypersensitivity reactions (HR) to IFX are frequently reported. We investigated immunoglobulin E (IgE)-mediated mechanisms underlying immediate HR to IFX. We also evaluated the clinical utility of allergological
Bapi Sarker et al.
International journal of biological macromolecules, 78, 72-78 (2015-04-08)
Hydrogel-based biomaterials are ideal scaffolding matrices for microencapsulation, but they need to be modified to resemble the mechanical, structural and chemical properties of the native extracellular matrix. Here, we compare the mechanical properties and the degradation behavior of unmodified and
Robert Landewé et al.
Arthritis research & therapy, 17, 133-133 (2015-05-23)
Clinical synovitis is often associated with damage to bone and cartilage. Previous data have suggested that joint erosions (JE) are more prevalent than joint space narrowing (JSN) and that the two processes are partly independent of each other. The objective
Ken-ichi Otsuguro et al.
Neuropharmacology, 97, 160-170 (2015-06-13)
Adenosine kinase (AK) inhibitor is a potential candidate for controlling pain, but some AK inhibitors have problems of adverse effects such as motor impairment. ABT-702, a non-nucleoside AK inhibitor, shows analgesic effect in animal models of pain. Here, we investigated
Bing Zhang et al.
Cell, 176(3), 636-648 (2019-01-27)
Despite intensive efforts to discover highly effective treatments to eradicate tuberculosis (TB), it remains as a major threat to global human health. For this reason, new TB drugs directed toward new targets are highly coveted. MmpLs (Mycobacterial membrane proteins Large)
Bertrand Gondouin et al.
Nephron, 131(3), 167-174 (2015-10-02)
Chronic kidney disease (CKD) is associated with increased cardiovascular morbidity and mortality. Oxidative stress seems to play a pivotal role in this process, and purine metabolism may be involved in CKD-related oxidative stress. Xanthine oxidase (XO) is an enzyme involved
J N Mahlangu et al.
Journal of thrombosis and haemostasis : JTH, 13(11), 1989-1998 (2015-09-13)
Vatreptacog alfa, a recombinant human factor VIIa (rFVIIa) analog developed to improve the treatment of bleeds in hemophilia patients with inhibitors, differs from native FVIIa by three amino acid substitutions. In a randomized, double-blind, crossover, confirmatory phase III trial (adept(™)
D M Bers et al.
The American journal of physiology, 260(5 Pt 1), C900-C909 (1991-05-01)
Extracellular Ca (Cao) depletions that occur during cardiac muscle contractions are indicative of net Ca entry. Buffering Cao concentration ([Ca]o) with citrate can limit the magnitude of these Cao depletions [e.g., Shattock and Bers. Am. J. Physiol. 256 (Cell Physiol.
Jubao Duan et al.
Human molecular genetics, 24(16), 4674-4685 (2015-05-30)
We searched a gene expression dataset comprised of 634 schizophrenia (SZ) cases and 713 controls for expression outliers (i.e., extreme tails of the distribution of transcript expression values) with SZ cases overrepresented compared with controls. These outlier genes were enriched
Poonam Saraf et al.
Pharmaceutical research, 32(9), 3087-3101 (2015-06-13)
The objective of this work was to compare the efficacy of self-assembling cyclic and linear RGD peptide amphiphiles as carriers for delivering paclitaxel to αvβ3 integrin overexpressing tumors. Linear (C18-ADA5-RGD) and cyclic (C18-ADA5-cRGDfK) peptide amphiphiles were synthesized and characterized for
M K Magnusson et al.
Alimentary pharmacology & therapeutics, 41(11), 1149-1161 (2015-04-11)
Anti-tumour necrosis factor (TNF) therapy is used for treatment of ulcerative colitis (UC). As approximately 30% of patients with UC do not benefit from the treatment, it is of clinical interest to identify biomarkers of response before therapy is initiated.
J D Robinson et al.
Biochimica et biophysica acta, 912(3), 343-347 (1987-04-30)
A dog kidney (Na+ + K+)-ATPase preparation also catalyzes K+-independent and K+-activated phosphatase reactions with p-nitrophenyl phosphate as substrate. K+-independent activity increases with declining pH over the range 7.5 to 5.8, whereas the other two activities decrease. The increased K+-independent
Maria H Madeira et al.
Journal of neuroinflammation, 12, 115-115 (2015-06-10)
Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a degenerative disease characterized by the loss of retinal ganglion cells (RGCs). There is clinical and experimental evidence that neuroinflammation is involved in the pathogenesis of glaucoma. Since the
Laurie Bruzzese et al.
Journal of applied physiology (Bethesda, Md. : 1985), 119(2), 140-147 (2015-05-23)
The nucleoside adenosine acts on the nervous and cardiovascular systems via the A2A receptor (A2AR). In response to oxygen level in tissues, adenosine plasma concentration is regulated in particular via its synthesis by CD73 and via its degradation by adenosine
Jason M Hinzman et al.
Biosensors & bioelectronics, 74, 512-517 (2015-07-18)
Throughout the central nervous system extracellular adenosine serves important neuroprotective and neuromodulatory functions. However, current understanding of the in vivo regulation and effects of adenosine is limited by the spatial and temporal resolution of available measurement techniques. Here, we describe
A A Plumb et al.
Alimentary pharmacology & therapeutics, 42(3), 343-355 (2015-06-11)
Magnetic resonance enterography (MRE) can measure small bowel motility, reduction in which reflects inflammatory burden in Crohn's Disease (CD). However, it is unknown if motility improves with successful treatment. To determine if changes in segmental small bowel motility reflect response
Narjis Fikri-Benbrahim et al.
Diabetes research and clinical practice, 108(3), e49-e52 (2015-03-31)
The aim of this study was to assess the performance and feasibility of a protocol for screening type 2 diabetes in community pharmacy. Performance was primarily assessed by measuring stakeholders' adherence (pharmacists, patients and physicians) to the protocol's components.
Christopher J Smiley et al.
Journal of the American Dental Association (1939), 146(7), 508-524 (2015-06-27)
Conduct a systematic review and meta-analysis on nonsurgical treatment of patients with chronic periodontitis by means of scaling and root planing (SRP) with or without adjuncts. A panel of experts convened by the American Dental Association Council on Scientific Affairs
Renata Rodrigues de Souza et al.
Journal of ethnopharmacology, 168, 373-379 (2015-04-04)
Senecio brasiliensis (Spreng) Less (S. brasiliensis), known as "Flor-das-almas", "Margaridinha" or "Maria mole", is used in folk medicine as an anti-inflammatory and to treat gastric ulcers and stomach pain. While the Senecio genus has been widely studied for its pharmacological
Sam A Booker et al.
Neuropharmacology, 93, 103-115 (2015-02-07)
This study assessed the anticonvulsant and seizure generation effects of carbamazepine (CBZ), oxcarbazepine (OXC) and eslicarbazepine (S-Lic) in wild-type mice. Electrophysiological recordings were made to discriminate potential cellular and synaptic mechanisms underlying anti- and pro-epileptic actions. The anticonvulsant and pro-convulsant
Johannan F Brandse et al.
Journal of Crohn's & colitis, 9(11), 973-981 (2015-06-28)
High serum concentrations of infliximab [IFX] and adalimumab [ADA] may be associated with adverse effects in patients with inflammatory bowel disease [IBD]. We aimed to investigate whether high anti-tumour necrosis factor [TNF] trough levels [TLs] were associated with toxicity and
Cristina Lemos et al.
Purinergic signalling, 11(4), 561-569 (2015-10-09)
ATP consumption during intense neuronal activity leads to peaks of both extracellular adenosine levels and increased glucose uptake in the brain. Here, we investigated the hypothesis that the activation of the low-affinity adenosine receptor, the A2B receptor (A(2B)R), promotes glucose
E A Lance et al.
Analytical biochemistry, 133(2), 492-501 (1983-09-01)
Potentiometric, visible, infrared, electron spin, and nuclear magnetic resonance studies of the complexation of N-(2-acetamido)iminodiacetic acid (H2ADA) by Ca(II), Mg(II), Mn(II), Zn(II), Co(II), Ni(II), and Cu(II) are reported. Ca(II) and Mg(II) were found not to form 2:1 ADA2- to M(II)
Xi-Nan Shi et al.
Molecular medicine reports, 12(5), 6501-6508 (2015-09-24)
Cyclin-dependent kinase 2 (CDK2) has been reported to be overexpressed in human colorectal cancer; it is responsible for the G1‑to‑S‑phase transition in the cell cycle and its deregulation is a hallmark of cancer. The present study was the first to
Ganesh E Phad et al.
Journal of immunology (Baltimore, Md. : 1950), 194(12), 5903-5914 (2015-05-13)
Isolation of mAbs elicited by vaccination provides opportunities to define the development of effective immunity. Ab responses elicited by current HIV-1 envelope glycoprotein (Env) immunogens display narrow neutralizing activity with limited capacity to block infection by tier 2 viruses. Intense
Eoin Gillespie et al.
Journal of separation science, 32(15-16), 2659-2667 (2009-07-09)
The application of scanning capacitively coupled contactless conductivity detection (SC(4)D) for the determination of pH dependant behaviour of two aminopolycarboxylates immobilised onto the surface of a monolithic capillary column is described. The use of SC(4)D to visualise changes in conductivity
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