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Showing 1-21 of 21 results for "AB15360" within Papers
Erica Rodriguez et al.
eNeuro, 6(6) (2019-10-31)
Food consumption is necessary for organisms to maintain metabolic homeostasis. Both extrinsic and intrinsic processes, relayed via intricate neural circuitry, orchestrate the initiation and termination of food intake. More specifically, there are functionally distinct neural circuits that mediate either homeostatic
Devin M Barry et al.
Nature communications, 11(1), 1397-1397 (2020-03-15)
Gastrin-releasing peptide (GRP) functions as a neurotransmitter for non-histaminergic itch, but its site of action (sensory neurons vs spinal cord) remains controversial. To determine the role of GRP in sensory neurons, we generated a floxed Grp mouse line. We found
Carina Guimarães de Souza Melo et al.
Scientific reports, 7(1), 1070-1070 (2017-04-23)
Ingested fluoride (F) is absorbed mainly in the small intestine, which is controlled by the Enteric Nervous System (ENS). Although important intestinal symptomatology has been described after excessive F exposure, there have been no studies reporting the effects of F
Andrea M Sartori et al.
Experimental neurology, 348, 113937-113937 (2021-11-27)
Neurogenic lower urinary tract dysfunction typically develops after spinal cord injury. We investigated the time course and the anatomical changes in the spinal cord that may be causing lower urinary tract symptoms following injury. Rats were implanted with a bladder
Andrew H Cooper et al.
Pain reports, 5(6), e872-e872 (2020-12-05)
Inflammation during the neonatal period can exacerbate pain severity following reinjury in adulthood. This is driven by alterations in the postnatal development of spinal and supraspinal nociceptive circuitry. However, the contribution of alterations in peripheral nociceptor function remains underexplored. We
Sandra Boesmueller et al.
Journal of clinical medicine, 8(12) (2019-12-11)
The type II superior labrum anterior to posterior (SLAP) repair is a viable option in young and demanding patients, although a prolonged period of pain after surgery is described in the literature. The reason for this fact remains unknown. Thus
Dekel Rosenfeld et al.
Science advances, 6(15), eaaz3734-eaaz3734 (2020-04-18)
The field of bioelectronic medicines seeks to modulate electrical signaling within peripheral organs, providing temporally precise control of physiological functions. This is usually accomplished with implantable devices, which are often unsuitable for interfacing with soft and highly vascularized organs. Here
Aya Takeoka et al.
Cell reports, 27(1), 71-85 (2019-04-04)
Somatosensory feedback from proprioceptive afferents (PAs) is essential for locomotor recovery after spinal cord injury. To determine where or when proprioception is required for locomotor recovery after injury, we established an intersectional genetic model for PA ablation with spatial and
Ching Chang et al.
International journal of molecular sciences, 22(4) (2021-03-07)
Recently, Toll-like receptors (TLRs), a family of pattern recognition receptors, are reported as potential modulators for neuropathic pain; however, the desired mechanism is still unexplained. Here, we operated on the sciatic nerve to establish a pre-clinical rodent model of chronic
Xing-Yun Song et al.
PloS one, 3(3), e1707-e1707 (2008-03-06)
The blood brain barrier (BBB) and truncated trkB receptor on astrocytes prevent the penetration of brain derived neurotrophic factor (BDNF) applied into the peripheral (PNS) and central nervous system (CNS) thus restrict its application in the treatment of nervous diseases.
Aline Dionizio et al.
Chemosphere, 273, 129607-129607 (2021-01-29)
Gastrointestinal signs and symptoms are the first signs of toxicity due to exposure to fluoride (F). This suggests the possibility that lower levels of subchronic F exposure may affect the gut. The aim of this study was to evaluate changes
Frank L Rice et al.
PloS one, 14(5), e0216527-e0216527 (2019-05-21)
In addition to large plexiform neurofibromas (pNF), NF1 patients are frequently disfigured by cutaneous neurofibromas (cNF) and are often afflicted with chronic pain and itch even from seemingly normal skin areas. Both pNFs and cNF consist primarily of benign hyperproliferating
Michał Bulc et al.
Journal of diabetes research, 2018, 4735659-4735659 (2018-08-25)
One of the most frequently reported disorders associated with diabetes is gastrointestinal (GI) disturbance. Although pathogenesis of these complications is multifactorial, the complicity of the enteric nervous system (ENS) in this respect has significant importance. Therefore, this paper analysed changes
A virus-like particle-based anti-nerve growth factor vaccine reduces inflammatory hyperalgesia: potential long-term therapy for chronic pain.
Rohn, TA; Ralvenius, WT; Paul, J; Borter, P; Hernandez, M; Witschi, R; Grest et al.
Journal of immunology (Baltimore, Md. : 1950) (1950)
Gulgun Sengul et al.
BioMed research international, 2020, 3689380-3689380 (2020-08-29)
The organization of the mouse spinal dorsal horn has been delineated in 2D for the six Rexed laminae in our publication Atlas of the Spinal Cord: Mouse, Rat, Rhesus, Marmoset, and Human. In the present study, the tissue clearing technique
Maria N Marangoni et al.
Cardiovascular diabetology, 13, 11-11 (2014-01-15)
Cardiomyopathy and distal symmetrical polyneuropathy (DSPN), including sensory and autonomic dysfunction, often co-occur in diabetic mellitus (DM) patients. However, the temporal relationship and progression between these two complications has not been investigated. Using a streptozotocin DM animal model that develops
Juan Sierra-Marquez et al.
Frontiers in cellular neuroscience, 16, 920075-920075 (2023-05-01)
ClC-3 Cl-/H+ exchangers are expressed in multiple endosomal compartments and likely modify intra-endosomal pH and [Cl-] via the stoichiometrically coupled exchange of two Cl- ions and one H+. We studied pain perception in Clcn3-/- mice and found that ClC-3 not
Devin M Barry et al.
Molecular pain, 12 (2016-04-14)
There are substantial disagreements about the expression of gastrin-releasing peptide (GRP) in sensory neurons and whether GRP antibody cross-reacts with substance P (SP). These concerns necessitate a critical revaluation of GRP expression using additional approaches. Here, we show that a
Erica Rodriguez et al.
Nature neuroscience, 20(12), 1734-1743 (2017-12-01)
Humans often rank craniofacial pain as more severe than body pain. Evidence suggests that a stimulus of the same intensity induces stronger pain in the face than in the body. However, the underlying neural circuitry for the differential processing of
Michał Bulc et al.
International journal of molecular sciences, 21(6) (2020-03-21)
Hyperglycemia is one of the main causes of diabetes complications. Gastrointestinal (GI) disturbances are one of the most frequent complications during diabetes. The porcine digestive tract possesses physiological and pathological similarities to the human digestive tract. This also applies to
Corinne A Lee-Kubli et al.
Experimental neurology, 278, 91-104 (2016-01-26)
Human SCI is frequently associated with chronic pain that is severe and refractory to medical therapy. Most rodent models used to assess pain outcomes in SCI apply moderate injuries to lower thoracic spinal levels, whereas the majority of human lesions
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