Search Within
AB1541
Applied Filters:
Keyword:'AB1541'
Showing 1-30 of 74 results for "AB1541" within Papers
Punn Augsornworawat et al.
Cell reports, 32(8), 108067-108067 (2020-08-28)
Human pluripotent stem cells differentiated to insulin-secreting Ī² cells (SC-Ī² cells) in islet organoids could provide an unlimited cell source for diabetes cell replacement therapy. However, current SC-Ī² cells generated inĀ vitro are transcriptionally and functionally immature compared to native adult
Lluis Miquel-Rio et al.
iScience, 27(5), 109787-109787 (2024-05-07)
Depression is a devastating mood disorder that causes significant disability worldwide. Current knowledge of its pathophysiology remains modest and clear biological markers are lacking. Emerging evidence from human and animal models reveals persistent alterations in endoplasmic reticulum (ER) homeostasis, suggesting
Sheikh Mizanur Rahaman et al.
Frontiers in neuroscience, 16, 877054-877054 (2022-06-07)
GABAergic neurons in the ventral tegmental area (VTA) have brain-wide projections and are involved in multiple behavioral and physiological functions. Here, we revealed the responsiveness of Gad67+ neurons in VTA (VTAGad67+) to various neurotransmitters involved in the regulation of sleep/wakefulness
Jonas Broms et al.
The Journal of comparative neurology, 523(3), 359-380 (2014-08-15)
The habenula is a phylogenetically conserved brain structure in the epithalamus. It is a major node in the information flow between fronto-limbic brain regions and monoaminergic brainstem nuclei, and is thus anatomically and functionally ideally positioned to regulate emotional, motivational
JosƩ Tiago Costa-Pereira et al.
The European journal of neuroscience, 51(8), 1756-1769 (2019-11-07)
Chemotherapy-induced neuropathy (CIN) is a common complication of cancer treatment. Although CIN is treated with antidepressants that act at serotonin (5-HT) reuptake, the mechanisms of serotoninergic modulation of nociceptive transmission during CIN remain unknown, namely as to the involvement of
Dan Liu et al.
Molecular medicine reports, 20(3), 2954-2962 (2019-07-20)
A number of studies have linked abnormalities in the function of the serotonergic and noradrenergic systems to the pathophysiology of depression. It has been reported that selective serotonin reuptake inhibitors promote the expression of tryptophan hydroxylase (TPH), which is involved
Carla Frare et al.
Journal of neurochemistry, 151(3), 316-335 (2019-07-06)
Hibernation is a seasonal phenomenon characterized by a drop in metabolic rate and body temperature. Adenosine A1 receptor agonists promote hibernation in different mammalian species, and the understanding of the mechanism inducing hibernation will inform clinical strategies to manipulate metabolic
Mariano Soiza-Reilly et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(39), 15800-15805 (2013-09-11)
The dorsal raphe nucleus (DR) controls forebrain serotonin neurotransmission to influence emotional states. GABA neurotransmission in the DR has been implicated in regulating sleep/wake states and influencing anxiety and aggression. To gain insight into how GABA regulates DR activity, we
Identification of unique release kinetics of serotonin from guinea-pig and human enterochromaffin cells.
Raghupathi, R; Duffield, MD; Zelkas, L; Meedeniya, A; Brookes, SJ; Sia, TC; Wattchow et al.
The Journal of Physiology null
Shunpei Moriya et al.
Neural regeneration research, 17(4), 881-886 (2021-09-03)
In the central nervous system, the A6 noradrenaline (NA) and the B3 serotonin (5-HT) cell groups are well-recognized players in the descending antinociceptive system, while other NA/5-HT cell groups are not well characterized. A5/A7 NA and B2 5-HT cells project
J R Schank et al.
Neuropharmacology, 99, 106-114 (2015-07-19)
Substance P (SP) and its cognate neurokinin-1 receptor (NK1R) are involved in alcohol-related behaviors. We have previously reported that NK1R antagonism attenuates stress-induced reinstatement of alcohol seeking and suppresses escalated alcohol self-administration, but does not affect primary reinforcement or cue-induced
Daniel G Ehlinger et al.
The European journal of neuroscience, 46(8), 2416-2425 (2017-09-19)
Polymorphism in the gene CACNA1C, encoding the pore-forming subunit of Cav1.2 L-type calcium channels, has one of the strongest genetic linkages to schizophrenia, bipolar disorder and major depressive disorder: psychopathologies in which serotonin signaling has been implicated. Additionally, a gain-of-function
Benoit de Pins et al.
Scientific reports, 10(1), 6619-6619 (2020-04-22)
The striatum is critical for cocaine-induced locomotor responses. Although the role of D1 receptor-expressing neurons is established, underlying molecular pathways are not fully understood. We studied the role of Pyk2, a non-receptor, calcium-dependent protein-tyrosine kinase. The locomotor coordination and basal
Sun Jung Bang et al.
The Journal of comparative neurology, 520(18), 4157-4167 (2012-05-19)
The dorsal raphe nucleus (DR) contains serotonergic (5-HT) neurons that project widely throughout the forebrain. These forebrain regions also receive innervation from non-5-HT neurons in the DR. One of the main groups of non-5-HT neurons in the DR is Ī³-aminobutyric
Yue-Ping Guo et al.
Autism research : official journal of the International Society for Autism Research, 10(1), 66-77 (2016-08-02)
The inbred mouse strain BTBR T+ Itpr3tf /J (BTBR) is studied as a model of idiopathic autism because they are less social and more resistant to change than other strains. Forebrain serotonin receptors and the response to serotonin drugs are
Yuma Nagai et al.
International journal of molecular sciences, 21(6) (2020-04-05)
Reward processing is fundamental for animals to survive and reproduce. Many studies have shown the importance of dorsal raphe nucleus (DRN) serotonin (5-HT) neurons in this process, but the strongly correlative link between the activity of DRN 5-HT neurons and
Jessica A Babb et al.
Neuropharmacology, 141, 139-147 (2018-09-01)
Serotonin (5-HT) neurons are strongly implicated in mood disorders such as depression and are importantly regulated by feedback inhibition mediated by 5-HT1A receptors. These receptors may play a role, albeit a poorly understood one, in the generation of mood disorders
Amin Zahrai et al.
Translational psychiatry, 10(1), 334-334 (2020-10-02)
Chronic treatment with fluoxetine (FLX) is required for its antidepressant effects, but the role of serotonin (5-HT) axonal plasticity in FLX action is unknown. To address this, we examined mice with a stroke in the left medial prefrontal cortex (mPFC)
M Neus Fullana et al.
Glia, 67(6), 1122-1137 (2019-01-13)
Elevation of energy metabolism and disturbance of astrocyte number/function in the ventral anterior cingulate cortex (vACC) contributes to the pathophysiology of major depressive disorder (MDD). Functional hyperactivity of vACC may result from reduced astrocytic glutamate uptake and increased neuronal excitation.
Ekaterina Martianova et al.
iScience, 26(11), 108328-108328 (2023-11-29)
The lateral hypothalamus (LH) plays a critical role in sensory integration to organize behavior responses. However, how projection-defined LH neuronal outputs dynamically transmit sensorimotor signals to major downstream targets to organize behavior is unknown. Here, using multi-fiber photometry, we show
Hong-Bing Xiang et al.
International journal of clinical and experimental pathology, 7(6), 2987-2997 (2014-07-18)
Despite considerable interest in the mechanisms that control the hyperalgesia associated with muscle inflammation, the CNS descending pathways that coordinate autonomic circuits regulating lumbar muscles are not adequately understood. Here we used both pseudorabies virus (PRV)-614 retrograde transsynaptic tracing and
Mariano Soiza-Reilly et al.
Neuropharmacology, 89, 185-192 (2014-09-28)
5-HT1A receptors are widely expressed in the brain and play a critical role in feedback inhibition of serotonin (5-HT) neurons through multiple mechanisms. Yet, it remains poorly understood how these feedback mechanisms, particularly those involving long-range projections, adapt in mood
Han Zhu et al.
Developmental cell, 58(9), 727-743 (2023-04-12)
Pancreatic islet cells derived from human pluripotent stem cells hold great promise for modeling and treating diabetes. Differences between stem-cell-derived and primary islets remain, but molecular insights to inform improvements are limited. Here, we acquire single-cell transcriptomes and accessible chromatin
Anna Alwani et al.
Pharmacological reports : PR, 75(6), 1474-1487 (2023-09-19)
Parkinson's disease (PD) is a motor disorder characterized by the degeneration of dopaminergic neurons, putatively due to the accumulation of Ī±-synuclein (Ī±-syn) in Lewy bodies (LBs) in Substantia Nigra. PD is also associated with the formation of LBs in brain
Sharifuddin Rifat Ahmed et al.
Developmental neurobiology, 82(1), 41-63 (2021-10-28)
Mammalian TRPC5 channels are predominantly expressed in the brain, where they increase intracellular Ca2+ and induce depolarization. Because they augment presynaptic vesicle release, cause persistent neural activity, and show constitutive activity, TRPC5s could play a functional role in late developmental
Kimberly E Iceman et al.
Respiratory physiology & neurobiology, 203, 28-34 (2014-08-05)
Previous studies have reported subsets of medullary raphƩ neurons that are either stimulated or inhibited by CO2/pH in vitro, in situ, and in vivo. We tested the hypothesis that medullary raphƩ CO2-inhibited neurons are GABAergic. Extracellular recordings in unanesthetized juvenile
Raphe GABAergic neurons mediate the acquisition of avoidance after social defeat.
Challis, C; Boulden, J; Veerakumar, A; Espallergues, J; Vassoler, FM; Pierce, RC; Beck et al.
The Journal of Neuroscience null
Sandra Duperrier et al.
International journal of molecular sciences, 23(15) (2022-08-13)
Parkinson's disease (PD) is characterized by cell loss in the substantia nigra and the presence of alpha-synuclein (Ī±-syn)-containing neuronal Lewy bodies. While Ī±-syn has received major interest in the pathogenesis of PD, the function of beta- and gamma-synucleins (Ī²-syn and
Rafaella V ZƔrate et al.
Cells, 11(9) (2022-05-15)
Parkinson's disease (PD) is a neurodegenerative disease characterized by motor symptoms and dopaminergic cell loss. A pre-symptomatic phase characterized by non-motor symptoms precedes the onset of motor alterations. Two recent PET studies in human carriers of mutations associated with familial
Vesicular glutamate transporter 3-immunoreactive pericellular baskets ensheath a distinct population of neurons in the lateral septum.
Riedel, A; Westerholz, S; Braun, K; Edwards, RH; Arendt, T; Hartig, W
Journal of Chemical Neuroanatomy null
Page 1 of 3